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https://www.readbyqxmd.com/read/28935557/combination-of-pth-1-34-with-anti-il17-prevents-bone-loss-by-inhibiting-il-17-n-cadherin-mediated-disruption-of-pthr1-lrp-6-interaction
#1
Mohd Nizam Mansoori, Priyanka Shukla, Divya Singh
Combinations of anabolic and anti-resorptive agents have potential to improve bone density more than either agent alone. In this study, we determine the combining effect of anti-IL17 antibody and PTH (1-34) in mitigation of ovariectomy induced bone loss. Ovariectomized BALB/c female mice were treated with anti-IL17 and iPTH monotherapies and their combination. Combination of iPTH and anti-IL17 has synergistic effect in the restoration of skeletal and immune parameters compared to mono-therapies. Immunofluorescence analysis shows decreased expression of PTHR1 in iPTH+anti-IL17 treated bone sections...
September 18, 2017: Bone
https://www.readbyqxmd.com/read/28927744/impact-of-resveratrol-on-bone-repair-in-rats-exposed-to-cigarette-smoke-inhalation-histomorphometric-and-bone-related-gene-expression-analysis
#2
F C Franck, B B Benatti, D C Andia, F R Cirano, R C Casarin, M G Corrêa, F V Ribeiro
This study investigated the effect of resveratrol on bone healing and its influence on the gene expression of bone-related markers in rats exposed to cigarette smoke. Two calvarial defects were created in each of 60 rats, which were assigned equally (n=20) to three groups: (1) resveratrol (10mg/kg)+smoke exposure (SMK+RESV); (2) placebo+smoke exposure (SMK+PLA); or (3) placebo+no smoke exposure (NS+PLA). Substances were administered daily for 30days following surgery. Smoke inhalation was started 7days before surgery and continued for 30days after surgery...
September 15, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28924601/incidental-colorectal-focal-18-f-fdg-uptake-a-novel-indication-for-colonoscopy
#3
Eugénie Rigault, Laurence Lenoir, Guillaume Bouguen, Mael Pagenault, Astrid Lièvre, Etienne Garin, Laurent Siproudhis, Jean-François Bretagne
BACKGROUND AND STUDY AIMS:  The relevance of incidental colorectal focal (18) F-FDG PET/CT uptake is debatable. All patients who were referred for colonoscopy because of incidental colonic focal FDG uptake were included in this retrospective study. PATIENTS AND METHODS:  PET/CT imaging characteristics were reviewed by a nuclear physician who was blinded to endoscopic and histopathological findings to determine the location of FDG uptake sites and to measure the maximum standardized uptake values (SUVmax) and metabolic volume (MV)...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28922626/the-typhi-colonization-factor-tcf-is-encoded-by-multiple-non-typhoidal-salmonella-serovars-but-exhibits-a-varying-expression-profile-and-interchanging-contribution-to-intestinal-colonization
#4
Shalhevet Azriel, Alina Goren, Inna Shomer, Gili Aviv, Galia Rahav, Ohad Gal-Mor
Salmonella enterica serovars Typhi and Paratyphi A are human-restricted pathogens and the leading causative agents of enteric fever. The Typhi colonization factor (Tcf) is a chaperone-usher fimbria, thought to play a role in the host-specificity of typhoidal serovars. Here we show that the tcf cluster (tcfABCD tinR tioA) is present in at least 25 non-typhoidal Salmonella (NTS) serovars and demonstrate its native expression in clinically-important serovars including Schwarzengrund, 9,12:l,v:-, Choleraesuis, Bredeney, Heidelberg, Montevideo, Virchow and Infantis...
September 18, 2017: Virulence
https://www.readbyqxmd.com/read/28912890/glioma-dual-targeting-nanohybrid-protein-toxin-constructed-by-intein-mediated-site-specific-ligation-for-multistage-booster-delivery
#5
Yingzhi Chen, Meng Zhang, Hongyue Jin, Dongdong Li, Fan Xu, Aihua Wu, Jinyu Wang, Yongzhuo Huang
Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the impermeable nature of BBB against effective delivery of biologics. Indeed, it is a long unsolved problem for brain delivery of macromolecular drugs, which becomes the Holy Grail in medical and pharmaceutical sciences...
2017: Theranostics
https://www.readbyqxmd.com/read/28899658/knockdown-of-lrp-lr-induces-apoptosis-in-pancreatic-cancer-and-neuroblastoma-cells-through-activation-of-caspases
#6
Carryn J Chetty, Eloise Ferreira, Katarina Jovanovic, Stefan F T Weiss
The 37kDa/67kDa laminin receptor (LRP/LR) serves various physiological and pathological roles such as enhancing tumour-related processes including metastasis, angiogenesis, cellular viability and telomerase activation in cancerous cell lines. The present study investigates the effect of siRNA mediated downregulation of LRP/LR on pancreatic cancer (AsPC-1) and neuroblastoma (IMR-32) cells. MTT and BrdU assays revealed that siRNA mediated downregulation of LRP resulted in a significant reduction in cell viability and cell proliferation...
September 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28895658/laparoscopic-and-robotic-assisted-versus-open-radical-prostatectomy-for-the-treatment-of-localised-prostate-cancer
#7
REVIEW
Dragan Ilic, Sue M Evans, Christie Ann Allan, Jae Hung Jung, Declan Murphy, Mark Frydenberg
BACKGROUND: Prostate cancer is commonly diagnosed in men worldwide. Surgery, in the form of radical prostatectomy, is one of the main forms of treatment for men with localised prostate cancer. Prostatectomy has traditionally been performed as open surgery, typically via a retropubic approach. The advent of laparoscopic approaches, including robotic-assisted, provides a minimally invasive alternative to open radical prostatectomy (ORP). OBJECTIVES: To assess the effects of laparoscopic radical prostatectomy or robotic-assisted radical prostatectomy compared to open radical prostatectomy in men with localised prostate cancer...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28892254/transcriptional-regulation-of-ectoine-catabolism-in-response-to-multiple-metabolic-and-environmental-cues
#8
Annina Schulz, Lucas Hermann, Sven-Andreas Freibert, Tobias Bönig, Tamara Hoffmann, Ramona Riclea, Jeroen S Dickschat, Johann Heider, Erhard Bremer
Ectoine and hydroxyectoine are effective microbial osmostress protectants, but can also serve as versatile nutrients for bacteria. We have studied the genetic regulation of ectoine and hydroxyectoine import and catabolism in the marine Roseobacter species Ruegeria pomeroyi and identified three transcriptional regulators involved in these processes: the GabR/MocR-type repressor EnuR, the feast and famine-type regulator AsnC, and the two-component system NtrYX. The corresponding genes are widely associated with ectoine and hydroxyectoine uptake and catabolic gene clusters (enuR, asnC), and with microorganisms predicted to consume ectoines (ntrYX)...
September 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28891645/set-lrp-in-the-neoteric-ethyl-lactate-alcohol
#9
Adrian Moreno, Diego Garcia, Marina Galia, Joan Carlos Ronda, Virginia Cadiz, Gerard Lligadas, Virgil Percec
Ethyl lactate (EtLa), a green and safe agrochemical solvent, is gifted with some properties that make it a good candidate for SET-LRP. It dissolves CuBr2, mediates an efficient disproportionation of CuBr in the presence of tris(2-(dimethylamino)ethyl)amine (Me6-TREN), and is capable to dissolve both aqueous (polar) and hydrocarbon (non-polar) soluble monomers and polymers. Here, we report that EtLa is an excellent solvent for the Cu(0) wire-catalyzed SET-LRP to produce both hydrophilic and hydrophobic polyacrylates that exhibit precise chain end functionality...
September 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28869936/synergistic-effect-of-baicalin-and-adriamycin-in-resistant-hl-60-adm-leukaemia-cells
#10
Jing Zheng, Tetsuya Asakawa, Yingyu Chen, Zhihong Zheng, Buyuan Chen, Minhui Lin, Tingbo Liu, Jianda Hu
BACKGROUND/AIMS: The present study was designed to investigate the expression of multidrug resistance (MDR)-related genes, verify the synergistic effects of baicalin and Adriamycin (ADM) and investigate the related mechanisms in ADM-resistant leukaemic HL-60/ADM cells. METHODS: We used a HL-60/ADM cell line. Cytotoxicity and flow cytometry assays were employed to verify the cytotoxic effects of baicalin. Real-time polymerase chain reaction and Western blotting assays were used to assess the expression of MDR-related genes and the changes in gene expression (both MDR-related and PI3K/Akt pathway-related) induced by administration of baicalin...
August 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28867618/leucine-responsive-regulatory-protein-is-involved-in-methionine-metabolism-and-polyamine-homeostasis-in-acetic-acid-bacterium-komagataeibacter-europaeus
#11
Yuri Ishii, Naoki Akasaka, Hisao Sakoda, Ryota Hidese, Shinsuke Fujiwara
The leucine responsive regulatory protein (Lrp) is a global transcription factor that regulates the expression of genes involved in amino acid metabolism. To identify metabolic pathways and related genes under the control of Lrp in the acetic acid bacterium Komagataeibacter europaeus, the Kelrp null mutant (KGMA7110), which requires supplementation of all 20 amino acids for normal growth, was cultivated in minimal media containing or lacking particular amino acids. The results confirmed that KGMA7110 was auxotrophic for methionine and its catabolites S-adenosylmethionine (SAM) and spermidine (SPD)...
August 31, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28860147/blockade-of-extracellular-heat-shock-protein-90-alpha-by-1g6-d7-attenuates-pulmonary-fibrosis-through-inhibiting-erk-signaling
#12
Hangming Dong, Lishan Luo, Mengchen Zou, Chaowen Huang, Xuan Wan, Yahui Hu, Yanqing Le, Haijin Zhao, Wei Li, Fei Zou, Shaoxi Cai
Pulmonary fibrosis is characterized by lung fibroblast activation and ECM deposition and has a poor prognosis.Heat shock protein 90 (Hsp90) participates in organ fibrosis and extracellular Hsp90α (eHsp90α) promotes fibroblast activation and migration. This study aimed to investigate whether a selective anti-Hsp90α monoclonal antibody, 1G6-D7, could attenuate lung fibrosis and whether 1G6-D7 presents protective effect by inactivating profibrotic pathway.Our results showed that eHsp90α was increased in mice with BLM-induced pulmonary fibrosis and that 1G6-D7 attenuated inflammation and collagen deposition in the lung...
August 31, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28858817/learning-low-rank-decomposition-for-pan-sharpening-with-spatial-spectral-offsets
#13
Shuyuan Yang, Kai Zhang, Min Wang
Finding accurate injection components is the key issue in pan-sharpening methods. In this paper, a low-rank pan-sharpening (LRP) model is developed from a new perspective of offset learning. Two offsets are defined to represent the spatial and spectral differences between low-resolution multispectral and high-resolution multispectral (HRMS) images, respectively. In order to reduce spatial and spectral distortions, spatial equalization and spectral proportion constraints are designed and cast on the offsets, to develop a spatial and spectral constrained stable low-rank decomposition algorithm via augmented Lagrange multiplier...
August 25, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28853815/a-safe-teaching-protocol-of-lrp-laparoscopic-radical-prostatectomy
#14
Marcos Tobias-Machado, Cristiano Linck Pazeto, Oseas Castro Neves-Neto, Igor Nunes-Silva, Hamilton de Campos Zampolli
PURPOSE: The LRP has a steep learning curve to obtain proficiency during which patient safety may be compromised. We present an adapted modular training system which purpose to optimize the learning curve and perform a safe surgery. MATERIALS AND METHODS: A retrospective analysis of the LRP safe learning protocol applied during a fellowship program over eight years (2008-2015). The surgery was divided in 12 steps and 5 levels of difficulty. A maximum time interval was stipulated in 240 minutes...
August 30, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28833753/lactoferrin-induces-tropoelastin-expression-by-activating-the-lipoprotein-receptor-related-protein-1-mediated-phosphatidylinositol-3-kinase-akt-pathway-in-human-dermal-fibroblasts
#15
Mizuyuki Ryu, Asuka Nogami, Tomoya Kitakaze, Naoki Harada, Yasushi A Suzuki, Ryoichi Yamaji
Dermal fibroblasts generate the extracellular matrix component elastin, which is synthesized as tropoelastin (TE) and play a critical role in maintaining skin elasticity. Lactoferrin (Lf), an 80-kDa iron-binding glycoprotein, has biological functions such as antibacterial, antiinflammatory, and anticancer activities. We previously reported that bovine Lf increases TE mRNA expression in human dermal fibroblasts. However, it remains unclear how Lf up-regulates TE expression. Here, we investigated molecular mechanisms underlying this effect...
August 18, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28829982/pre-movement-planning-processes-in-people-with-congenital-mirror-movements
#16
E A Franz, Y Fu
OBJECTIVE: Pre-movement processes were investigated in people with Congenital mirrormovement (CMM), a rare disorder in which bilateral movement (mirroring) occurs in the upper distal extremities (primarily the hands and fingers) during intended unilateral movements. Abnormal density of ipsilateral corticospinal projections is an established hallmark of CMM. This study tested whether the Lateralised Readiness Potential (LRP), which reflects movement planning and readiness, is also abnormal in people with CMM...
August 2, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28817673/the-plasmid-encoded-ipf-and-klf-fimbriae-display-different-expression-and-varying-roles-in-the-virulence-of-salmonella-enterica-serovar-infantis-in-mouse-vs-avian-hosts
#17
Gili Aviv, Laura Elpers, Svetlana Mikhlin, Helit Cohen, Shaul Vitman Zilber, Guntram A Grassl, Galia Rahav, Michael Hensel, Ohad Gal-Mor
Salmonella enterica serovar Infantis is one of the prevalent Salmonella serovars worldwide. Different emergent clones of S. Infantis were shown to acquire the pESI virulence-resistance megaplasmid affecting its ecology and pathogenicity. Here, we studied two previously uncharacterized pESI-encoded chaperone-usher fimbriae, named Ipf and Klf. While Ipf homologs are rare and were found only in S. enterica subspecies diarizonae and subspecies VII, Klf is related to the known K88-Fae fimbria and klf clusters were identified in seven S...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28805931/mrp1-protein-expression-in-leukemic-stem-cells-as-a-negative-prognostic-marker-in-acute-myeloid-leukemia-patients
#18
Maria Paprocka, Aleksandra Bielawska-Pohl, Joanna Rossowska, Agnieszka Krawczenko, Danuta Duś, Marek Kiełbiński, Olga Haus, Maria Podolak-Dawidziak, Kazimierz Kuliczkowski
BACKGROUND: It is well established that expression of multi-drug resistance (MDR) proteins (MDR1, BCRP, MDR3, MRP1 and LRP) in leukemic blasts correlates with AML patients clinical response. Assuming that leukemic stem cells (LSC) are resistant to chemotherapy and responsible for relapse it might be clinically relevant to evaluate the expression level of MDR proteins in LSC and relate it to the clinical outcome. METHODS: Bone marrow samples from 26 patients with de novo AML were labeled with antibodies to distinguish CD34+CD38-CD123+ LSC population and with antibodies against MDR1, BCRP, MDR3, MRP1 or LRP proteins...
August 14, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28800764/lrp-a-global-regulator-regulates-the-virulence-of-vibrio-vulnificus
#19
Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto, Lien-I Hor
BACKGROUND: An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cytotoxicity, migration on soft agar and virulence in the mouse. The purpose of this study was to map the mutation in this attenuated mutant and further explore how the gene thus identified is involved in virulence. METHODS: The whole genome sequence of mutant NY303 determined by next-generation sequencing was compared with that of strain YJ016 to map the mutations...
August 11, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28800619/-what-is-relevant-in-a-text-document-an-interpretable-machine-learning-approach
#20
Leila Arras, Franziska Horn, Grégoire Montavon, Klaus-Robert Müller, Wojciech Samek
Text documents can be described by a number of abstract concepts such as semantic category, writing style, or sentiment. Machine learning (ML) models have been trained to automatically map documents to these abstract concepts, allowing to annotate very large text collections, more than could be processed by a human in a lifetime. Besides predicting the text's category very accurately, it is also highly desirable to understand how and why the categorization process takes place. In this paper, we demonstrate that such understanding can be achieved by tracing the classification decision back to individual words using layer-wise relevance propagation (LRP), a recently developed technique for explaining predictions of complex non-linear classifiers...
2017: PloS One
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