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https://www.readbyqxmd.com/read/29149696/clearance-of-plasmin-pn-1-complexes-by-vascular-smooth-muscle-cells-in-human-aneurysm-of-the-ascending-aorta
#1
Kamel Boukais, Luciano F Borges, Laurence Venisse, Ziad Touat, Déborah François, Véronique Arocas, Guillaume Jondeau, Paul Declerck, Marie-Christine Bouton, Jean-Baptiste Michel
Plasminogen is a circulating zymogen which enters the arterial wall by radial, transmural hydraulic conductance, where it is converted to plasmin by tissue plasminogen activator t-PA on an activation platform involving S100A4 on the vascular smooth muscle cell (vSMC) membrane. Plasmin is involved in the progression of human thoracic aneurysm of the ascending aorta (TAA). vSMCs protect the TAA wall from plasmin-induced proteolytic injury by expressing high levels of antiproteases. Protease nexin-1 (PN-1) is a tissue antiprotease belonging to the serpin superfamily, expressed in the vascular wall, and is able to form a covalent complex with plasmin...
October 24, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29116364/low-density-lipoprotein-receptor-related-protein-1-couples-%C3%AE-1-integrin-activation-to-degradation
#2
Lukasz Wujak, Ralph T Böttcher, Oleg Pak, Helena Frey, Elie El Agha, Ying Chen, Sigrid Schmitt, Saverio Bellusci, Liliana Schaefer, Norbert Weissmann, Reinhard Fässler, Malgorzata Wygrecka
Low density lipoprotein receptor-related protein (LRP) 1 modulates cell adhesion and motility under normal and pathological conditions. Previous studies documented that LRP1 binds several integrin receptors and mediates their trafficking to the cell surface and endocytosis. However, the mechanism by which LRP1 may regulate integrin activation remains unknown. Here we report that LRP1 promotes the activation and subsequent degradation of β1 integrin and thus supports cell adhesion, spreading, migration and integrin signaling on fibronectin...
November 7, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29115637/effect-of-linguizhugan-decoction-on-neuroinflammation-and-expression-disorder-of-the-amyloid-%C3%AE-%C3%A2-related-transporters-rage-and-lrp%C3%A2-1-in-a-rat-model-of-alzheimer-s-disease
#3
Qianfeng Hu, Beibei Yu, Qinlei Chen, Yi Wang, Yun Ling, Songxian Sun, Yinlong Shi, Chunxiang Zhou
Linguizhugan decoction (LGZG), a notable prescription in Traditional Chinese Medicine, is a classical formula for the treatment of Alzheimer's disease (AD), inflammatory injury and fluid retention. The present study aimed to investigate the neuroprotective effect of LGZG on an amyloid β (Aβ)‑induced AD rat model. Sprague‑Dawley rats were administered with Aβ1‑42 to induce AD and inflammatory responses, and subsequently with LGZG (4.8, 2.4 or 1.2 g/kg), donepezil (2 mg/kg) or distilled water for 30 consecutive days...
November 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29110349/sequence-controlled-polymers-from-a-novel-%C3%AE-cyclodextrin-core
#4
Yamin Abdouni, Gökhan Yilmaz, C Remzi Becer
In this work the synthesis and use of a novel β-cyclodextrin-based single electron transfer-living radical polymerization (SET-LRP) initiator are reported. Three different approaches toward the synthesis of this initiator, based on several "click"-like reactions (copper(I)-catalyzed azide-alkyne cycloaddition, nucleophilic thiol-ene reaction, and radical thiol-ene reaction), are explored and discussed. Synthesis via radical thiol-ene proves to be most successful in achieving this. The β-cyclodextrin-based initiator is subsequently used for the polymerization of several acrylates in a controlled fashion, yielding 7-arm multiblock copolymers...
November 7, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29108253/identification-of-lrp-1-as-an-endocytosis-and-recycling-receptor-for-%C3%AE-1-integrin-in-thyroid-cancer-cells
#5
Louis Theret, Albin Jeanne, Benoit Langlois, Cathy Hachet, Marion David, Michel Khrestchatisky, Jérôme Devy, Emonard Hervé, Sébastien Almagro, Stéphane Dedieu
LRP-1 is a large endocytic receptor mediating the clearance of various molecules from the extracellular matrix. LRP-1 was reported to control focal adhesion turnover to optimize the adhesion-deadhesion balance to support invasion. To better understand how LRP-1 coordinates cell-extracellular matrix interface, we explored its ability to regulate cell surface integrins in thyroid carcinomas. Using an antibody approach, we demonstrated that β1-integrin levels were increased at the plasma membrane under LRP1 silencing or upon RAP treatment, used as LRP-1 antagonist...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107218/dual-targeting-wnt-and-upa-receptors-using-peptide-conjugated-ultra-small-nanoparticle-drug-carriers-inhibited-cancer-stem-cell-phenotype-in-chemo-resistant-breast-cancer
#6
Jasmine Miller-Kleinhenz, Xiangxue Guo, Weiping Qian, Hongyu Zhou, Erica N Bozeman, Lei Zhu, Xin Ji, Y Andrew Wang, Toncred Styblo, Ruth O'Regan, Hui Mao, Lily Yang
Heterogeneous tumor cells, high incidence of tumor recurrence, and decrease in overall survival are the major challenges for the treatment of chemo-resistant breast cancer. Results of our study showed differential chemotherapeutic responses among breast cancer patient derived xenograft (PDX) tumors established from the same patients. All doxorubicin(Dox)-resistant tumors expressed higher level of cancer stem-like cell biomarkers, including CD44, Wnt and its receptor LRP5/6, relative to Dox-sensitive tumors...
October 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/29100299/coupling-to-a-cancer-selective-heparan-sulfate-targeted-branched-peptide-can-by-pass-breast-cancer-cell-resistance-to-methotrexate
#7
Lorenzo Depau, Jlenia Brunetti, Chiara Falciani, Silvia Scali, Giulia Riolo, Elisabetta Mandarini, Alessandro Pini, Luisa Bracci
Cancer-selective tetra-branched peptides, named NT4, can be coupled to different functional units for cancer cell imaging or therapy. NT4 peptides specifically bind to lipoprotein receptor-related proteins (LRP) receptors and to heparan sulfate chains on membrane proteoglycans and can be efficiently internalized by cancer cells expressing these membrane targets. Since binding and internalization of NT4 peptides is mediated by specific NT4 receptors on cancer cell membranes and this may allow drug resistance produced by drug membrane transporters to be by-passed, we tested the ability of drug-armed NT4 to by-pass drug resistance in cancer cell lines...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29078398/plethora-transcription-factors-orchestrate-de-novo-organ-patterning-during-arabidopsis-lateral-root-outgrowth
#8
Yujuan Du, Ben Scheres
Plant development is characterized by repeated initiation of meristems, regions of dividing cells that give rise to new organs. During lateral root (LR) formation, new LR meristems are specified to support the outgrowth of LRs along a new axis. The determination of the sequential events required to form this new growth axis has been hampered by redundant activities of key transcription factors. Here, we characterize the effects of three PLETHORA (PLT) transcription factors, PLT3, PLT5, and PLT7, during LR outgrowth...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29077784/effects-of-high-intensity-focused-ultrasound-on-cisplatin-resistant-human-lung-adenocarcinoma-in-vitro-and-in-vivo
#9
Tao Zhang, Libin Chen, Shengmin Zhang, Youfeng Xu, Yabo Fan, Lizhong Zhang
It is widely accepted that high-intensity focused ultrasound (HIFU) is a minimally invasive treatment option for different tumors, but its roles and the corresponding mechanism in cisplatin (DDP) chemoresistance in lung adenocarcinoma (LA) remain unclear. In this study, we investigated the response of DDP-resistant LA cells to HIFU and its underlying molecular mechanisms using molecular biology techniques. It was found that HIFU exposure inhibited the proliferation of DDP-resistant A549 (A549/DDP) cells through arresting cell cycle at the G1/G0 phase via the Cyclin-dependent pathway and promoting apoptosis in a Bcl-2-dependent manner...
October 25, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29072565/positive-surgical-margin-rates-during-the-robot-assisted-laparoscopic-radical-prostatectomy-learning-curve-of-an-experienced-laparoscopic-surgeon
#10
Anthony F Adili, Julia Di Giovanni, Emma Kolesar, Nathan C Wong, Jen Hoogenes, Shawn Dason, Bobby Shayegan
INTRODUCTION: Since its introduction, robot-assisted laparoscopic radical prostatectomy (RARP) has gained widespread popularity, but is associated with a variable learning curve. Herein, we report the positive surgical margin (PSM) rates during the RARP learning curve of a single surgeon with significant previous laparoscopic radical prostatectomy (LRP) experience. METHODS: We performed a prospective cohort study of the first 400 men with prostate cancer treated with RARP by a single surgeon (BS) with significant LRP experience...
November 11, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29063728/laparoscopic-and-robotic-assisted-versus-open-radical-prostatectomy-for-the-treatment-of-localised-prostate-cancer-a-cochrane-systematic-review
#11
Dragan Ilic, Sue M Evans, Christie Ann Allan, Jae Hung Jung, Declan Murphy, Mark Frydenberg
To determine the effects of laparoscopic radical prostatectomy (LRP), or robotic-assisted radical prostatectomy (RARP), compared to open radical prostatectomy (ORP) in men with localised prostate cancer. We performed a comprehensive search using multiple databases (CENTRAL, MEDLINE, EMBASE) and abstract proceedings with no restrictions on the language of publication or publication status, up until 9 June 2017. We included all randomised or pseudo-randomised controlled trials with a direct comparison of LRP and RARP to ORP...
October 24, 2017: BJU International
https://www.readbyqxmd.com/read/29050210/astaxanthin-acts-via-lrp-1-to-inhibit-inflammation-and-reverse-lipopolysaccharide-induced-m1-m2-polarization-of-microglial-cells
#12
Xiaojun Wen, Lijiao Xiao, Zhuoyan Zhong, Limin Wang, Ze Li, Xiaoping Pan, Zhonglin Liu
Microglia become activated during neuroinflammation and produce neurotoxic and neurotrophic factors, depending on whether they acquire M1 proinflammatory or M2 anti-inflammatory phenotypes. Astaxanthin (ATX), a natural carotenoid, has anti-inflammatory and neuroprotective effects. We investigated whether ATX could reverse M1/M2 polarization and suppress neuroinflammation via low-density lipoprotein receptor-related protein-1 (LRP-1). We observed increased expression of M1 (TNF-α, IL-1β, and CD86) and decreased expression of M2 (Arg-1, IL-10, and CD206) markers in BV2 microglial cells stimulated with lipopolysaccharide (LPS)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046872/swallow-breath-interaction-and-phase-of-respiration-with-swallow-during-non-nutritive-suck-in-infants-affected-by-neonatal-abstinence-syndrome
#13
Eric W Reynolds, Debbie Grider, Cynthia S Bell
BACKGROUND: The development of suck-swallow-breath rhythms during non-nutritive suck (NNS) may be an indicator of neurologic integrity. We have described swallow-breath (SwBr) interaction and phase of respiration (POR) with swallow during NNS in low-risk preterm (LRP) infants. NNS in infants with neonatal abstinence syndrome (NAS) has not been described with our method. METHOD: Suckle, swallow, thoracic motion, and nasal airflow were measured during NNS in 10 infants with NAS and 12 unaffected infants (control)...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29042013/inhibition-of-microsomal-prostaglandin-e-synthase-1-mpges-1-selectively-suppresses-pge2-in-an-in-vitro-equine-inflammation-model
#14
Emily M Martin, Samuel L Jones
Inhibition of prostaglandin E2 (PGE2) production effectively limits inflammation in horses, however nonspecific prostaglandin blockade via cyclooxygenase (COX) inhibition elicits deleterious gastrointestinal side effects in equine patients. Thus, more selective PGE2 targeting therapeutics are needed to treat inflammatory disease in horses. One potential target is microsomal prostaglandin E-synthase-1 (mPGES-1), which is the terminal enzyme downstream of COX-2 in the inducible PGE2 synthesis cascade. This enzyme has yet to be studied in equine leukocytes, which play a pivotal role in equine inflammatory disease...
October 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29039554/microrna-23a-3p-inhibitor-decreases-osteonecrosis-incidence-in-a-rat-model
#15
Yulei Dong, Tao Li, Yulong Li, Shaoda Ren, Junfen Fan, Xisheng Weng
The mechanism of steroid-associated femoral head necrosis remains unclear. The present study investigated the role of microRNA-23a-3p (miR-23a-3p) in the incidence of osteonecrosis in a rat model. An miR-23a-3p mimic, an inhibitor and a negative control were transfected into bone mesenchymal stem cells using a lentiviral vector, and then injected into the steroid-induced femoral head necrosis model. Osteonecrosis incidence was assessed by micro computed tomography and histopathology. Low-density lipoprotein receptor-related protein 5 (LRP-5) expression was assessed by immunohistochemistry...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29035832/new-insights-into-vinca-alkaloids-resistance-mechanism-and-circumvention-in-lung-cancer
#16
REVIEW
Ying Zhang, Shao-Hui Yang, Xiu-Li Guo
Nowadays, lung cancer, as a health problem in worldwide, has high mortality both in men and women. Despite advances in diagnosis and surgical techniques of lung cancer in recent decades, chemotherapy is still a fundamentally and extensively useful strategy. Vinca alkaloids are a class of important and widely used drugs in the treatment of lung cancer, targeting on the Vinca binding site at the exterior of microtubule plus ends. Either intrinsic or acquired resistance to chemotherapy of Vinca alkaloids has been a major obstacle to the treatment of lung cancer, which arose great interests in studies of understanding and overcoming resistance...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29034249/misoprostol-inhibits-lipopolysaccharide-induced-pro-inflammatory-cytokine-production-by-equine-leukocytes
#17
Emily Medlin Martin, Kristen M Messenger, Mary Katherine Sheats, Samuel L Jones
Pro-inflammatory cytokines including tumor necrosis factor α (TNFα), IL-1β, IL-6, and IL-8 are potent immune mediators that exacerbate multiple equine diseases such as sepsis and laminitis. Unfortunately, safe and effective cytokine-targeting therapies are lacking in horses; therefore, novel mechanisms of inhibiting cytokine production are critically needed. One potential mechanism for inhibiting cytokine synthesis is elevation of intracellular cyclic AMP (cAMP). In human leukocytes, intracellular cAMP production is induced by activation of E-prostanoid (EP) receptors 2 and 4...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29032582/national-cohort-study-comparing-severe-medium-term-urinary-complications-following-radical-prostatectomy-robot-assisted-versus-laparoscopic-versus-retropubic-open-radical-prostatectomy
#18
A Sujenthiran, J Nossiter, M Parry, S C Charman, A Aggarwal, H Payne, P Dasgupta, N W Clarke, J van der Meulen, P Cathcart
OBJECTIVES: Despite the rapid adoption of robot-assisted radical prostatectomy (RARP), there is little evidence about the occurrence of medium-term urinary complications with this type of surgery compared to laparoscopic (LRP) or retropubic open radical prostatectomy (ORP). The aim of this study was to evaluate the occurrence of severe urinary complications within two years of surgery in men undergoing RARP, LRP or ORP. PATIENTS AND METHODS: Population-based cohort study of men who underwent RARP (n=4,947), LRP (n= 5,479), or ORP (n=6,873) between 2008 and 2012 in the English National Health Service (NHS) using national cancer registry records linked to Hospital Episodes Statistics - an administrative database of admissions to NHS hospitals...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/28992266/lateral-root-formation-and-the-multiple-roles-of-auxin
#19
Yujuan Du, Ben Scheres
Root systems can display variable architectures that contribute to survival strategies of plants. The model plant Arabidopsis thaliana possesses a tap root system, in which the primary root and lateral roots (LRs) are major architectural determinants. The phytohormone auxin fulfils multiple roles throughout LR development. In this review, we summarize recent advances in our understanding of four aspects of LR formation: (i) LR positioning, which determines the spatial distribution of lateral root primordia (LRP) and LRs along primary roots; (ii) LR initiation, encompassing the activation of nuclear migration in specified lateral root founder cells (LRFCs) up to the first asymmetric cell division; (iii) LR outgrowth, the 'primordium-intrinsic' patterning of de novo organ tissues and a meristem; and (iv) LR emergence, an interaction between LRP and overlaying tissues to allow passage through cell layers...
July 20, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28982647/multimodality-intracoronary-imaging-with-near-infrared-spectroscopy-and-intravascular-ultrasound-in-asymptomatic-individuals-with-high-calcium-scores
#20
Ryan D Madder, Stacie VanOosterhout, David Klungle, Abbey Mulder, Matthew Elmore, Jeffrey M Decker, David Langholz, Thomas F Boyden, Jessica Parker, James E Muller
BACKGROUND: This study sought to determine the frequency of large lipid-rich plaques (LRP) in the coronary arteries of individuals with high coronary artery calcium scores (CACS) and to determine whether the CACS correlates with coronary lipid burden. METHODS AND RESULTS: Combined near-infrared spectroscopy and intravascular ultrasound was performed in 57 vessels in 20 asymptomatic individuals (90% on statins) with no prior history of coronary artery disease who had a screening CACS ≥300 Agatston units...
October 2017: Circulation. Cardiovascular Imaging
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