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Ting Hu, Qilin Huang, Kahing Wong, Hong Yang
Four polysaccharide fractions, LRP-1, LRP-2, LRP-3 and LRP-4 were extracted stepwise from Lignosus rhinocerotis sclerotia with distilled water at 25, 95, 120°C and 1.0M NaOH solution at 4°C. Their structure, molecular size and chain conformation were clarified using SEC-MALLS-RI, GC, FT-IR and UV-VIS. Furthermore, their immunomodulatory activities were evaluated by the model of cyclophosphamide (Cy)-induced immunosuppression. The LRP-1 and LRP-2 were polysaccharide-protein complexes (46-68% β-D-glucan and 27-48% protein), while LRP-3 and LRP-4 were absolutely composed of β-D-glucose...
October 18, 2016: International Journal of Biological Macromolecules
Bianka Swiderska, Sylwia Kedracka-Krok, Barbara Plytycz
The data described are related to the article "Lysenin family proteins in earthworm coelomocytes - comparative approach" (B. Swiderska, S. Kedracka-Krok, T. Panz, A.J. Morgan, A. Falniowski, P.Grzmil, B. Plytycz, 2016) [1]. Lysenin family proteins were identified based on unique peptides sequenced by tandem mass spectrometry coupled with liquid chromatography (LC-MS/MS) in lumbricid earthworms Eisenia andrei and E. fetida, the latter with or without the MUG-like fluorophore. Lysenin and lysenin-related protein 2 (LRP-2, fetidin) were identified in all 9 investigated specimens of Eisenia sp...
December 2016: Data in Brief
Ying Li, Xuemin Zheng, Min Gong, Jianning Zhang
The challenge of effectively delivering therapeutic agents to the brain has created an entire field of active research devoted to overcoming the blood brain barrier (BBB) and efficiently delivering drugs to the brain. Angiopep-2 can trigger transcytosis and traverse the BBB by recognizing low-density lipoprotein related protein-1 (LRP-1) expressed on the brain capillary endothelial cells. Here, we designed a novel strategy for the delivery of drugs to the brain. The novel drug delivery system was a combination of a receptor-targeting ligand, such as low-density lipoprotein related protein 1, and a cell-penetrating peptide (CPP)...
October 17, 2016: Oncotarget
Irene Sturm, Sebastian Lapuschkin, Wojciech Samek, Klaus-Robert Müller
BACKGROUND: In cognitive neuroscience the potential of Deep Neural Networks (DNNs) for solving complex classification tasks is yet to be fully exploited. The most limiting factor is that DNNs as notorious 'black boxes' do not provide insight into neurophysiological phenomena underlying a decision. Layer-wise Relevance Propagation (LRP) has been introduced as a novel method to explain individual network decisions. NEW METHOD: We propose the application of DNNs with LRP for the first time for EEG data analysis...
October 13, 2016: Journal of Neuroscience Methods
Kerstin Jost, Mike Wendt, Aquiles Luna-Rodriguez, Andreas Löw, Thomas Jacobsen
In choice reaction time (RT) tasks, performance is often influenced by the presence of nominally irrelevant stimuli, referred to as distractors. Recent research provided evidence that distractor processing can be adjusted to the utility of the distractors: Distractors predictive of the upcoming target/response were more attended to and also elicited stronger motor responses. In an event-related potential (ERP) study, we investigated whether not only the extent of distractor processing (as suggested by these previous results), but also the timing of distractor-based response activation is subject to strategic control...
October 10, 2016: Journal of Experimental Psychology. Learning, Memory, and Cognition
Yaguang Zhao, Xu Liu, Yuchu Liu, Zhenqiang Wu, Xianyuan Zhao, Xuefeng Fu
Photo responsive polyethyl vinyl ketone (PEVK) and various block copolymers were prepared through the visible light induced cobalt mediated radical polymerization (CMRP) process. The first order kinetics and linear increase in molecular weight with conversion demonstrated a well-behaved system. Chain extension experiments showed the retention of the living end of PEVK.
October 4, 2016: Chemical Communications: Chem Comm
Y Q Jiang, X P Xu, Q M Guo, X C Xu, Q Y Liu, S H An, J L Xu, F Su, J B Tai
Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer cells (H460) enriched for stem cell growth in a defined serum-free medium. Taxus-treated stem cells were also analyzed for Rhodamine 123 (Rh-123) expression by flow cytometry, and used as a standard functional indicator of MDR...
September 2, 2016: Genetics and Molecular Research: GMR
Daniel B Drachman
The basic abnormality in myasthenia gravis (MG) is a reduction in acetylcholine receptors (AChRs) at neuromuscular junctions due to the effects of autoantibodies that are directed against the AChRs in most patients, or against neighboring proteins involved in the clustering of AChRs (MuSK, LRP-4, or agrin). Clinically, MG is characterized by muscle weakness and fatigue, often in typical patterns. The diagnosis may be missed early, and depends on the recognition of clinical manifestations, the measurement of autoantibodies, and/or electrophysiological features...
October 2016: Seminars in Neurology
Santiago Galdo-Alvarez, Fidel M Bonilla, Alberto J González-Villar, María T Carrillo-de-la-Peña
Early neuroimaging and electrophysiological studies suggested that motor imagery recruited a different network than motor execution. However, several studies have provided evidence for the involvement of the same circuits in motor imagery tasks, in the absence of overt responses. The present study aimed to test whether imagined performance of a stop-signal task produces a similar pattern of motor-related EEG activity than that observed during real performance. To this end, mu and beta event-related desynchronization (ERD) and the Lateralized Readiness Potential (LRP) were analyzed...
2016: Frontiers in Human Neuroscience
Amanda W Scarbrough, Marianne Moore, Steve R Shelton, Regina J Knox
To reduce health professional shortage areas, the National Health Service Corps has attempted to increase the number of primary care providers in underserved communities through scholarships and loan repayment. Program evaluations assessed Loan Repayment Program (LRP) propensity to work in underserved communities. The National Health Service Corps LRPs were asked about preferences for particular retention strategies and which strategies were utilized by their clinical sites. Loan Repayment Programs were asked to rank retention strategies...
September 26, 2016: Health Care Manager
Ja Yoon Ku, Chan Ho Lee, Jeong Zoo Lee, Hong Koo Ha
AIM: To compare the functional outcomes after laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic radical prostatectomy (RARP). METHODS: Between September 2008 and January 2016, 712 patients underwent radical prostatectomy (RP; 614 LRP and 98 RARP). Recovery of incontinence was evaluated through a 24-h pad test. Urinary and erectile function was evaluated using the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function-5...
September 26, 2016: Asia-Pacific Journal of Clinical Oncology
M Chen, Q R Dong, Q Huang, W Xu, C She
Objective: To investigate the molecular mechanism of low-dose X-ray irradiation on osteoblasts by detecting the gene expression profiles of osteoblasts radiated with 0.5 Gy X-ray. Methods: Microarray analyses to value the changes of gene expression of MC3T3-E1 osteoblasts after 0.5 Gy X-ray irradiation were conducted.The end points included modulation of key markers, and pathway and gene ontology through transcriptomic profiling and bioinformatics analysis. Several major genes during osteoblasts differentiation were selected for Real-time PCR analysis...
September 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Mark William Louie-Johnsun, Marcus M Handmer, Ross John Spero Calopedos, Charles Chabert, Ronald J Cohen, Troy R J Gianduzzo, Paul A Kearns, Daniel A Moon, Jason Ooi, Tom Shannon, David Sofield, Andrew H H Tan
OBJECTIVES: To analyse the Australian experience of high-volume Fellowship-trained Laparoscopic Radical Prostatectomy (LRP) surgeons. MATERIALS AND METHODS: 2943 LRP cases were performed by nine Australian surgeons. The inclusion criteria were a prospectively collected database with a minimum of 100 consecutive LRP cases. The surgeons' LRP experience commenced at various times from July 2003 to September 2009. Data were analysed for demographic, peri-operative, oncological and functional outcomes...
September 23, 2016: BJU International
La Ode Muhammad Muchdar Davis, Nobuo Ogita, Soichi Inagaki, Naoki Takahashi, Masaaki Umeda
Lateral roots (LRs) are an important organ for water and nutrient uptake from soil. Thus, control of LR formation is crucial in the adaptation of plant growth to environmental conditions. However, the underlying mechanism controlling LR formation in response to external factors has remained largely unknown. Here, we found that LR formation was inhibited by DNA damage. Treatment with zeocin, which causes DNA double-strand breaks, up-regulated several DNA repair genes in the LR primordium (LRP) through the signaling pathway mediated by the transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1)...
September 23, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
Sebastian M Franco, Fernando de C Tavernari, Rosana C Maia, Victor R S M Barros, Luiz F T Albino, Horacio S Rostagno, Guilherme R Lelis, Arele A Calderano, Ryan Neil Dilger
Three experiments were carried out to estimate the optimal ratios of digestible phenylalanine + tyrosine (Phe + Tyr), histidine (His), and leucine (Leu) relative to digestible lysine (Lys) for performance and carcass criteria of Cobb-500 broilers from 8 to 17 d of age. In each experiment, 160 male chicks were allocated to a completely randomized experimental design with eight replicate pens, each receiving five dietary treatments. A common, semi-purified basal diet was formulated to meet all dietary recommendations except for those of the tested amino acids (i...
September 19, 2016: Poultry Science
Deniz Atasoy, Afag Aghayeva, Onur Bayraktar, Volkan Ozben, Bilgi Baca, Ismail Hamzaoglu, Tayfun Karahasanoglu
INTRODUCTION: After its description in 1980, restorative proctocolectomy has become the procedure of choice for ulcerative colitis (UC). The supposed advantages of the laparoscopy have proven beneficial for colorectal operations but a standard technique in laparoscopic restorative proctocolectomy (LRP) is still lacking. In this study, we present our technique of LRP with vascular high ligation (VHL) and embryological dissection (ED). MATERIALS AND METHODS: This retrospective study reviewed patients who underwent LRP with VHL for UC from January 2009 to June 2015...
September 14, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Leila Vania, Carryn J Chetty, Eloise Ferreira, Stefan F T Weiss
Cancer is a highly complex disease that has become one of the leading causes of death globally. Metastasis, a major cause of cancer deaths, requires two crucial events known as adhesion and invasion. The 37kDa/67kDa laminin receptor [laminin receptor precursor/high-affinity laminin receptor (LRP/LR)] enhances these two steps, consequently aiding in cancer progression. In this study, the role of LRP/LR in adhesion and invasion of early (SW-480 & HT-29) and late (DLD-1) stage colorectal cancer cells has been investigated...
September 8, 2016: Molecular Medicine
Sandra Rother, Sergey A Samsonov, Ute Hempel, Sarah Vogel, Stephanie Moeller, Joanna Blaszkiewicz, Sebastian Köhling, Matthias Schnabelrauch, Jörg Rademann, M Teresa Pisabarro, Vera Hintze, Dieter Scharnweber
Sulfated glycosaminoglycans (sGAGs) modulate cellular processes via their interaction with extracellular matrix (ECM) proteins. We revealed a direct binding of tissue inhibitor of metalloproteinase-3 (TIMP-3) to the endocytic receptor low-density lipoprotein receptor-related protein (LRP-1) clusters II and IV using surface plasmon resonance. Sulfated hyaluronan (sHA) and chondroitin sulfate (sCS) derivatives interfered with TIMP-3/LRP-1 complex formation in a sulfation-dependent manner stronger than heparin...
October 10, 2016: Biomacromolecules
Silvana Porco, Antoine Larrieu, Yujuan Du, Allison Gaudinier, Tatsuaki Goh, Kamal Swarup, Ranjan Swarup, Britta Kuempers, Anthony Bishopp, Julien Lavenus, Ilda Casimiro, Kristine Hill, Eva Benkova, Hidehiro Fukaki, Siobhan M Brady, Ben Scheres, Benjamin Péret, Malcolm J Bennett
Lateral root primordia (LRP) originate from pericycle stem cells located deep within parental root tissues. LRP emerge through overlying root tissues by inducing auxin-dependent cell separation and hydraulic changes in adjacent cells. The auxin-inducible auxin influx carrier LAX3 plays a key role concentrating this signal in cells overlying LRP. Delimiting LAX3 expression to two adjacent cell files overlying new LRP is crucial to ensure that auxin-regulated cell separation occurs solely along their shared walls...
September 15, 2016: Development
Bianka Swiderska, Sylwia Kedracka-Krok, Tomasz Panz, A John Morgan, Andrzej Falniowski, Pawel Grzmil, Barbara Plytycz
Sphingomyelin-binding proteins of the lysenin family were originally identified in earthworms belonging to the genus Eisenia comprised of at least two distinct species, E. andrei and E. fetida, until recently considered subspecies or morphotypes of E. foetida (sic). In the present study the presence of lysenin and lysenin-related protein 2 (LRP-2, known also as fetidin) was detected in coelomocytes retrieved from all investigated adult specimens of E. andrei, and E. fetida. They were accompanied by LRP-3 and LRP-1 in some specimens of E...
August 24, 2016: Developmental and Comparative Immunology
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