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https://www.readbyqxmd.com/read/29785553/antituberculosis-drug-induced-fixed-drug-eruption-a-case-report
#1
Jitendra H Vaghela, Vivek Nimbark, Manish Barvaliya, Hita Mehta, Bhavesh Chavada
Fixed drug eruption (FDE) was caused by fixed-dose combination (FDC) of antituberculosis drugs in the form of tablet Forecox® (rifampicin [rifampin] 225 mg + isoniazid 150 mg + pyrazinamide 750 mg + ethambutol 400 mg) in a 40-year-old male patient with a history of drug allergy. The patient developed FDE after taking the third dose of tablet Forecox® for pulmonary tuberculosis. Tablet Forecox® was withdrawn and the patient recovered from the reaction after 15 days of treatment for FDE. As per World Health Organization-Uppsala Monitoring Centre (WHO-UMC) and Naranjo causality assessment criteria, the association between the reaction and tablet Forecox® was possible and probable, respectively...
May 21, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29785388/genital-tuberculosis-in-postmenopausal-women-with-variable-clinical-presentations-a-report-of-3-cases
#2
Ashima Arora, Shameema Anvar Sadath
Genital tuberculosis is usually diagnosed in young women being assessed for infertility. After menopause it usually presents with symptoms resembling endometrial malignancy, such as postmenopausal bleeding, persistent vaginal discharge and pyometra. The diagnosis is made by detection of acid-fast bacilli on microscopy or bacteriological culture and/or presence of epithelioid granuloma on biopsy. Anti-tubercular therapy involves the use of rifampicin, isoniazid, pyrazinamide and ethambutol. Surgery is indicated if a pelvic mass and recurrence of pain or bleeding persist after 9 months of treatment...
April 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29785129/performance-of-the-abbott-realtime-mtb-rif-inh-resistance-assay-when-used-to-test-mycobacterium-tuberculosis-specimens-from-bangladesh
#3
Joshua Kostera, Gregor Leckie, Klara Abravaya, Hong Wang
Introduction: The Abbott RealTime MTB RIF/INH Resistance Assay (RT MTB RIF/INH) is an assay for the detection of rifampicin (RIF)- and/or isoniazid (INH)-resistant Mycobacterium tuberculosis (MTB). The assay can be used to test sputum, bronchial alveolar lavage, and N-Acetyl-L-Cysteine (NALC)/NaOH pellets prepared from these samples. The assay can be used in direct testing mode, or in reflex mode following a MTB positive result produced by its companion assay, Abbott RT MTB. Methods: In this study, the direct testing mode was used to test paired sputum and NALC/NaOH pellets prepared from sputum collected from Bangladesh TB patients...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29783201/n-4-18-f-fluorobenzyl-cholylglycine-a-novel-tracer-for-pet-of-enterohepatic-circulation-of-bile-acids-radiosynthesis-and-proof-of-concept-studies-in-rats
#4
Kim Frisch, Damion H R Stimson, Taracad Venkatachalam, Gregory K Pierens, Susanne Keiding, David Reutens, Rajiv Bhalla
INTRODUCTION: Enterohepatic circulation (EHC) of conjugated bile acids is an important physiological process crucial for regulation of intracellular concentrations of bile acids and their function as detergents and signal carriers. Only few bile acid-derived imaging agents have been synthesized and hitherto none have been evaluated for studies of EHC. We hypothesized that N-(4-[18 F]fluorobenzyl)cholylglycine ([18 F]FBCGly), a novel fluorine-18 labeled derivative of endogenous cholylglycine, would be a suitable tracer for PET of the EHC of conjugated bile acids, and we report here a radiosynthesis of [18 F]FBCGly and a proof-of-concept study by PET/MR in rats...
May 4, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29779781/tag-array-gene-chip-rapid-diagnosis-anti-tuberculosis-drug-resistance-in-pulmonary-tuberculosis-a-feasibility-study
#5
Wenjie Wu, Peng Cheng, Jingtong Lyu, Zehua Zhang, Jianzhong Xu
OBJECTIVE: We developed a Tag Array chip for detecting first- and second-line anti tuberculosis drug resistance in pulmonary tuberculosis and compared the analytical performance of the gene chip to that of phenotypic drug susceptibility testing (DST). METHODS: From November 2011 to April 2016.234 consecutive culture-confirmed, clinically and imaging diagnosed patients with pulmonary tuberculosis from Southwest Hospital, Chongqing were enrolled into the study. Specimens collected during sputum or bronchoalveolar lavage fluid from the pulmonary tuberculosis patients were subjected to M...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779779/evaluation-of-pyrosequencing-for-extensive-drug-resistance-defining-anti-tuberculosis-drugs-for-use-in-public-healthcare
#6
Remya Nambiar, Daksha Shah, Kanchan Ajbani, Mubin Kazi, Meeta Sadani, Anjali Shetty, Padmaja Keskar, Sanjeev Kamble, Alex van Belkum, Camilla Rodrigues
MGIT 960 drug susceptibility testing (DST) for Mycobacterium tuberculosis was compared for performance and speed with pyrosequencing (PSQ). Pulmonary samples (n = 100), from GeneXpert/MTB/Rifampicin-resistant patients receiving second-line treatment for 1-3 months, were subjected to DST and PSQ for seven drugs (isoniazid, rifampicin, kanamycin, amikacin, capreomycin, moxifloxacin, and ofloxacin). The mean time-to-result was 35 and two days for DST and PSQ, respectively. Average concordancy was 92.7%. Theoretically, PSQ showed substantial incremental value over the commercial Genotype MTBDRplus/sl...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779776/rd-rio-mycobacterium-tuberculosis-lineage-in-the-brazil-paraguay-argentina-triple-border
#7
Aryadne Larissa de Almeida, Regiane Bertin de Lima Scodro, Hayalla Corrêa de Carvalho, Giovana Ferreira Costacurta, Vanessa Pietrowski Baldin, Nathally Claudiane Souza Santos, Luciana Dias Ghiraldi-Lopes, Paula Aline Zanetti Campanerut-Sá, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Flávia Kazumi Shibata, Andressa Sprada, Rosilene Fressatti Cardoso
The high tuberculosis (TB) incidence rates, the closeness of the cities and the high migration flux on the Brazil/Paraguay/Argentina border deserves an in-depth study, using Mycobacterial Interspersed Repetitive Unit (MIRU) and Spoligotyping genetic markers to explore the impact of the Mycobacterium tuberculosis RDRio lineage on disease transmission and resistance to anti-TB drugs in this setting. Although without the totality of M. tuberculosis isolates causing TB in this studied setting, a number of 97 isolates obtained from sputa samples culture of patients with confirmed TB, from 2013 to 2015, were submitted to 24 loci MIRU, Spoligotyping, detection of RDRio lineage and detection of mutation related to isoniazid and rifampicin resistance by MTBDRplus/DNA STRIP...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779775/accuracy-of-whole-genome-sequencing-versus-phenotypic-mgit-and-commercial-molecular-tests-for-detection-of-drug-resistant-mycobacterium-tuberculosis-isolated-from-patients-in-brazil-and-mozambique
#8
Cinara Silva Feliciano, Evangelina Inacio Namburete, Jéssica Rodrigues Plaça, Kamila Peronni, Anzaan Dippenaar, Robin Mark Warren, Wilson Araújo Silva, Valdes Roberto Bollela
BACKGROUND: The fast and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is critical to reducing the spread of disease. Although commercial genotypic drug-susceptibility tests (DST) are close to the goal, they are still not able to detect all relevant DR-TB related mutations. Whole genome sequencing (WGS) allows better comprehension of DR-TB with a great discriminatory power. We aimed to evaluate WGS in M. tuberculosis isolates compared with phenotypic and genotypic DST. METHODS: This cross-sectional study evaluated 30 isolates from patients with detected DR-TB in Brazil and Mozambique...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779771/genetic-diversity-of-mycobacterium-tuberculosis-isoniazid-monoresistant-and-multidrug-resistant-in-rio-grande-do-sul-a-tuberculosis-high-burden-state-in-brazil
#9
Leonardo Souza Esteves, Elis Regina Dalla Costa, Sidra Ezidio Gonçalves Vasconcellos, Andrei Vargas, Sérgio Luis Montego Ferreira Junior, Maria Laura Halon, Marta Osorio Ribeiro, Rodrigo Rodenbusch, Harrison Magdinier Gomes, Philip N Suffys, Maria Lucia R Rossetti
Tuberculosis (TB) remains a major public health problem in the world and Brazil is among the countries with the highest incidence and prevalence rates, and Rio Grande do Sul, a Brazilian state, occupy a prominent position. Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) further aggravates this scenario, making it more difficult to treat and control the disease. Isoniazid monoresistance (IMR) may increase the risk of progression to MDR-TB and treatment failure. However, most drug resistance molecular tests only focus on detecting rifampicin (RIF) resistance...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29776838/hot-aqueous-leaf-extract-of-lasianthera-africana-icacinaceae-attenuates-rifampicin-isoniazid-induced-hepatotoxicity
#10
Lucky Legbosi Nwidu, Raphael Ellis Teme
OBJECTIVES: The aim of this study is to evaluate the hepatoprotective effect of Lasianthera africana (Icacinaceae) against isoniazid (INH) and rifampicin (RIF)-induced liver damage in rats. METHODS: The hepatoprotective effects of hot aqueous L. africana (HALA) leaf extract (0.1-1 g/kg) and silymarin (50 mg/kg) were assessed in a model of oxidative liver damage induced by RIF and INH (100 mg/kg each) in Wistar rats for 28 days. Biochemical markers of hepatic damage such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were assessed...
May 8, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29773408/discrepancy-in-the-genotypic-versus-phenotypic-testing-for-resistance-to-rifampicin-in-mycobacterium-tuberculosis-a-case-report
#11
Loreto Rapún Mas, Itziar Angulo López, Álvaro Cecilio Irazola, Ana Isabel Betrán Escartín
No abstract text is available yet for this article.
May 14, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29772696/the-effect-of-negative-pressure-wound-therapy-with-and-without-instillation-on-mature-biofilms-in-vitro
#12
Shamaila Tahir, Matthew Malone, Honghua Hu, Anand Deva, Karen Vickery
BACKGROUND: To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. METHODS: Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC biofilm reactor for 3 days. Coupons containing biofilms were placed in a sterile petri dish and sealed using NPWT or NPWTi. Coupons were exposed to treatment for 24 h with NPWT alone or with instillation of: Povidone iodine solution (PVP-I) (10% w / v equivalent to 1% w / v available iodine, BETADINE® , Mundipharma, Singapore), surfactant based antimicrobial solution with polyhexamethylene biguanide (SBPHMB) (Prontosan® , B Braun Medical, Melsungen, Germany), Gentamicin 1 µg/mL (GM) (G1264 Sigma-Aldrich Pty Ltd...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29771932/a-multi-center-preclinical-study-of-gadoxetate-dce-mri-in-rats-as-a-biomarker-of-drug-induced-inhibition-of-liver-transporter-function
#13
Anastassia Karageorgis, Stephen C Lenhard, Brittany Yerby, Mikael F Forsgren, Serguei Liachenko, Edvin Johansson, Mark A Pilling, Richard A Peterson, Xi Yang, Dominic P Williams, Sharon E Ungersma, Ryan E Morgan, Kim L R Brouwer, Beat M Jucker, Paul D Hockings
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), combined with pharmacokinetic modelling, to measure hepatobiliary transporter function in vivo in rats. The sensitivity and robustness of the method was tested by evaluating the effect of a clinical dose of the antibiotic rifampicin in four different preclinical imaging centers...
2018: PloS One
https://www.readbyqxmd.com/read/29771727/modeling-gadoxetate-liver-uptake-and-efflux-using-dynamic-contrast-enhanced-magnetic-resonance-imaging-enables-preclinical-quantification-of-transporter-drug-drug-interactions
#14
Leonidas Georgiou, Jeffrey Penny, Glynis Nicholls, Neil Woodhouse, François-Xavier Blé, Josephine H Naish, Penny L Hubbard Cristinacce
OBJECTIVES: The aim of this study was to model the in vivo transporter-mediated uptake and efflux of the hepatobiliary contrast agent gadoxetate in the liver. The efficacy of the proposed technique was assessed for its ability to provide quantitative insights into drug-drug interactions (DDIs), using rifampicin as inhibitor. MATERIALS AND METHODS: Three groups of C57 mice were scanned twice with a dynamic gadoxetate-enhanced magnetic resonance imaging protocol, using a 3-dimensional spoiled gradient-echo sequence for approximately 72 minutes...
May 15, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29771345/sucrose-metabolism-alters-lactobacillus-plantarum-survival-and-interactions-with-the-microbiota-in-the-digestive-tract
#15
Xiaochen Yin, Dustin D Heeney, Yanin Tab Srisengfa, Shin-Yu Chen, Carolyn M Slupsky, Maria L Marco
We investigated whether sucrose metabolism by probiotic Lactobacillus plantarum influences the intestinal survival and microbial responses to this organism when administered to mice fed a sucrose-rich, Western diet. A L. plantarum mutant unable to metabolize sucrose was constructed by deleting scrB, coding for beta-fructofuranosidase, in a rifampicin-resistant strain of L. plantarum NCIMB8826. The ScrB deficient mutant survived in 8-fold higher numbers compared to the wild-type strain when measured 24 h after administration on two consecutive days...
May 16, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29770076/the-use-of-technology-to-improve-health-care-to-saskatchewan-s-first-nations-communities
#16
I Khan, N Ndubuka, K Stewart, V McKinney, I Mendez
Background: Saskatchewan is a province of over one million people and over 13% are Indigenous peoples, many of whom live on reserve lands. Despite continued efforts, access to health care remains a significant challenge for these Indigenous people, especially those in the North. Objective: To address this challenge, Saskatchewan's health care providers have been incorporating the use of technology for various health services. This paper describes various ways technology has been used in First Nations communities in Saskatchewan...
June 1, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769511/an-elderly-lady-with-neurobrucellosis-and-multiple-co-morbid-conditions
#17
M N Islam
Neurobrucellosis is a rare (1.7-7.0% of prevalence) neurological complication of brucellosis which has neither a typical clinical picture nor specific cerebrospinal fluid (CSF) findings and mimics other neurological disorders leading to clinical diagnostic dilemmas. This study describes one elderly patient of neurobrucellosis with fever, irrelevant behavior, sweating, fatigue, drowsiness, neck stiffness inability to speak and reduced activity for about 10 days hailing from Beanibazar, Sylhet, Bangladesh admitted in Mount Adora Hospital, Sylhet, Bangladesh on 16th October 2016...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29768812/sensitive-detection-of-rifampicin-based-on-au-carbon-nanocomposite
#18
Ruimin Xing, Xiaoyu Zhao, Yanli Xu, Haitang Yang, Zhixian Chang, Jianying Qu, Xiuhua Liu, Jing-He Yang, Shanhu Liu
Gold nanoparticles-supported Cabot Vulcan XC72R (Au/VXC72R) nanocomposite was synthesized by chemical reduction of gold (III) chloride with VXC72R. A novel electrochemical sensor based on the Au/VXC72R nanocomposite has been fabricated for the sensitive detection of rifampicin (RIF). Field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray powder diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS) were used to characterize the morphology, structure and compositions of the nanocomposite...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768561/the-role-of-the-xpert-mtb-rif-assay-among-adolescents-suspected-of-pulmonary-tuberculosis-in-rio-de-janeiro-brazil
#19
Thania Luiza de Andrade Sieiro, Rafaela Baroni Aurílio, Elizabeth Cristina C Soares, Silvia S Chiang, Clemax Couto Sant Anna
INTRODUCTION: The teste rápido molecular para tuberculose (TRM-TB) was introduced in 2014 in Brazil for tuberculosis screening. However, its role in adolescents in Brazil has not been studied. METHODS: A descriptive study of adolescents with suspected tuberculosis using National Laboratory software. RESULTS: Of 852 (15.4%) suspected cases, 131 were positive by TRM-TB and 2% were resistant to rifampicin. Among TRM-TB-positive cases, 105 (91...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29767993/multi-metallic-microparticles-increase-the-potency-of-rifampicin-against-intracellular-mycobacterium-tuberculosis
#20
Timothy Ellis, Michele Chiappi, Andres Garcia-Trenco, Maryam Al-Ejji, Srijata Sarkar, Theoni K Georgiou, Milo Sebastian Peter Shaffer, Teresa D Tetley, Stephan Schwander, Mary P Ryan, Alexandra E Porter
Mycobacterium tuberculosis (M.tb) has the extraordinary ability to adapt to the administration of antibiotics through the development of resistance mechanisms. By rapidly exporting drugs from within the cytosol, these pathogenic bacteria diminish antibiotic potency and drive the presentation of drug tolerant tuberculosis (TB). The membrane integrity of M.tb is pivotal in retaining these drug-resistant traits. Silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) are established antimicrobial agents that effectively compromise membrane stability, giving rise to increased bacterial permeability to antibiotics...
May 16, 2018: ACS Nano
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