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https://www.readbyqxmd.com/read/29152675/a-randomized-double-blind-placebo-controlled-trial-of-vitamin-d-supplementation-in-juvenile-onset-systemic-lupus-erythematosus-positive-effect-on-trabecular-microarchitecture-using-hr-pqct
#1
G L Lima, J A Paupitz, N E Aikawa, J C Alvarenga, R M Rodrigues Pereira
In this randomized double-blind placebo-controlled 24-week trial, cholecalciferol supplementation at 50,000 IU/week effectively improved bone microarchitecture parameters in juvenile-onset systemic lupus erythematosus (JoSLE) patients, as assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at tibia site. An increase in the trabecular number and a decrease in the trabecular separation were observed, suggesting that vitamin D supplementation may be recommended for JoSLE patients with its deficiency...
November 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29135395/pattern-and-predictors-of-paradoxical-response-in-patients-with-peripheral-lymph-node-tuberculosis
#2
Supreet Batra, Govind Singh Rajawat, Rajendra Prasad Takhar, Manohar Lal Gupta
Introduction: Many of the patients with lymph node tuberculosis show 'Paradoxical Response" in the form of appearance of new lymph node (LN) or increase in the size of existing LN, development of new disease in other organ and worsening of the disease while on treatment. Reason behind such response in only selective patients is not clearly understood. We evaluated the pattern and predictors for paradoxical response(s) (PR) in patients with peripheral lymph node tuberculosis (TB). Materials and Methods: Study included patients aged > 6 years with peripheral lymphadenopathy of tubercular etiology attending a tertiary care hospital from Jan 2010 to Dec 2010...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29116933/first-line-antituberculosis-drugs-disrupt-endocrine-balance-and-induce-ovarian-and-uterine-oxidative-stress-in-rats
#3
Olayinka A Adebayo, Omolola A Adesanoye, Olalekan A Abolaji, Aderemi O Kehinde, Oluwatosin A Adaramoye
BACKGROUND: The first-line antituberculosis (anti-TB) drugs, isoniazid (INH), rifampicin (RIF), ethambutol (EMB), and pyrazinamide (PZA), are effective in the treatment of pulmonary tuberculosis. However, the toxicity of these drugs in the clinical setting limits their use. Here, we evaluated the effects of anti-TB drugs on the reproductive system in female rats. METHODS: Thirty-five female Wistar rats were assigned into five groups of seven animals each. The control group received normal saline, whereas others received INH (5 mg/kg), RIF (10 mg/kg), EMB (15 mg/kg), and PZA (15 mg/kg) through gavage thrice a week for 8 consecutive weeks...
November 8, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29097336/a-case-of-subarachnoid-hemorrhage-caused-by-tuberculous-aneurysm
#4
Wei Liu, Chuanfeng Li, Xianming Liu, Zhiming Xu, Lu Kong
In this paper, we report a case of intracranial tuberculum with adjacent intracerebral inflammatory aneurysm, and include a brief discussion of the developmental mechanism of these pathologies. A 28-year-old man presented with sudden onset of severe headache. He was diagnosed with h pulmonary tuberculosis 8 year ago, and had been treated with anti-tuberculosis medications for 6 months. Head computed tomography (CT) showed a small hematoma in the left Sylvian fissure with subarachnoid hemorrhage. Cerebral digital subtraction angiograph (DSA) was performed and no aneurysm was found...
October 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29097030/benzofuran-dihydropyridine-hybrids-a-new-class-of-potential-bone-anabolic-agents
#5
Ram K Modukuri, Dharmendra Choudhary, Sampa Gupta, K Bhaskara Rao, Sulekha Adhikary, Tanuj Sharma, Mohammad Imran Siddiqi, Ritu Trivedi, Koneni V Sashidhara
A series of novel benzofuran-dihydropyridine hybrids were designed by molecular hybridization approach and evaluated for bone anabolic activities. Among the screened library, ethyl 4-(7-(sec-butyl)-2-(4-methylbenzoyl)benzofuran-5-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (compound 21) significantly enhanced the ALP production and mineralized nodule formation, which are primary requisites in the process of in vitro osteogenesis. Oral administration of compound 21 at 10 mg.kg(-1) day(-1) for two weeks led to restoration of trabecular bone microarchitecture in drill hole fracture model by significantly increasing BV/TV and Tb...
October 17, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29078671/use-of-autologous-platelet-rich-plasma-prp-in-stopping-massive-hemoptysis-at-the-lung-center-of-the-philippines-a-pilot-study
#6
Armand Gregorio C Sarmiento, Jose Luis J Danguilan, Zenaida M Mariano, Maria Teresa A Barzaga
BACKGROUND: The purpose of this study is to determine the effect of using autologous platelet rich plasma (PRP) in patients having massive hemoptysis within a period of one week. METHODS: This is a prospective cohort study involving 20 consecutive patients admitted who met the criteria for massive hemoptysis from July to October 2011. After stabilizing the patient, fiberoptic bronchoscopy (FOB) was performed for localization of bleeding within 6 hours from diagnosis...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29071086/alcohol-drinking-and-cigarette-smoking-in-relation-to-risk-of-active-tuberculosis-prospective-cohort-study
#7
Avril Zixin Soh, Cynthia Bin Eng Chee, Yee-Tang Wang, Jian-Min Yuan, Woon-Puay Koh
INTRODUCTION: Heavy alcohol consumption increases the risk of active tuberculosis (TB). However, the relation between lower levels of alcohol intake and TB risk remains unclear. We aimed to evaluate the association between alcohol intake and risk of active TB and assess whether the associations were modified by smoking status, which is another risk factor for active TB. METHODS: The Singapore Chinese Health Study is a prospective cohort of 63 257 adults aged 45-74 years recruited from 1993 to 1998...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29069496/interim-outcomes-of-delamanid-for-the-treatment-of-mdr-and-xdr-tb-in-south-korea
#8
Jeongha Mok, Hyungseok Kang, Soo Hee Hwang, Jin Su Park, Bohyoung Kang, Taehoon Lee, Won-Jung Koh, Jae-Joon Yim, Doosoo Jeon
Objectives: Delamanid is a new anti-TB drug, but few data exist on its use outside clinical trials. The purpose of this study was to evaluate the efficacy as well as the safety and tolerability of a delamanid-containing regimen for 24 weeks in the treatment of MDR- and XDR-TB. Methods: We performed a retrospective cohort study among patients with MDR/XDR-TB who were treated with a delamanid-containing regimen in seven hospitals in South Korea. Results: A total of 32 patients with MDR-TB, of which 6 (18...
October 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29066256/-treatment-outcome-survival-and-their-risk-factors-among-new-tuberculosis-patients-co-infected-with-hiv-during-the-ebola-outbreak-in-conakry
#9
A Camara, M S Sow, A Touré, O H Diallo, I Kaba, B Bah, T H Diallo, M S Diallo, T Guilavogui, O Y Sow
BACKGROUND: Mortality among TB/HIV co-infected patients remains high in Africa. The study aimed to estimate survival and associated factors in a cohort of TB/HIV co-infected patients who started tuberculosis treatment during the Ebola outbreak in Conakry, Guinea. METHODS: A prospective cohort study was conducted from April 2014 to December 2015. TB patients with HIV co-infection were enrolled at the University Hospital of Conakry. Survival and risk factors were analyzed according to Kaplan-Meier's method, log-rank test and Cox's regression...
November 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29028973/safety-and-immunogenicity-of-newborn-mva85a-vaccination-and-selective-delayed-bacille-calmette-guerin-bcg-for-infants-of-hiv-infected-mothers-a-phase-2-randomized-controlled-trial
#10
Elisa Nemes, Anneke C Hesseling, Michele Tameris, Katya Mauff, Katrina Downing, Humphrey Mulenga, Penelope Rose, Marieke van der Zalm, Sharon Mbaba, Danelle Van As, Willem A Hanekom, Gerhard Walzl, Thomas J Scriba, Helen McShane, Mark Hatherill
Background: Vaccination of HIV-infected infants with bacille Calmette-Guérin (BCG) is contraindicated. HIV-exposed newborns need a new tuberculosis (TB) vaccination strategy that protects against TB early in life; and avoids the potential risk of BCG disease until after HIV infection has been excluded. Methods: This double-blind randomized controlled trial compared newborn MVA85A prime vaccination (1 x10 8 PFU) vs. Candin® control, followed by selective deferred BCG vaccination at 8 weeks of age for HIV-uninfected infants, and 12 months follow-up for safety and immunogenicity...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29022526/cytomegalovirus-retinitis-and-hiv-case-reviews-from-kwazulu-natal-province-south-africa
#11
R Hassan-Moosa, T Chinappa, L Jeena, L Visser, K Naidoo
BACKGROUND: Retinal cytomegalovirus (CMV) infection is a common opportunistic infection and remains a significant contributor to visual loss in patients with AIDS. We highlight the poor outcomes of CMV retinitis in three HIV-infected patients who were initiated on antiretroviral therapy (ART). We conducted a retrospective chart review of advanced stage HIV-infected patients with known CMV retinitis.Case 1. A 37-year-old man, with a CD4+ cell count of 35 cells/µL, presented for ART initiation with a 5-month history of visual loss in his left eye...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28968350/coexistence-of-bilirubin-%C3%A2-10-mg-dl-and-prothrombin-time-international-normalized-ratio-%C3%A2-1-6-on-day-7-a-strong-predictor-of-early-graft-loss-after-living-donor-liver-transplantation
#12
Yusuke Okamura, Shintaro Yagi, Toshiya Sato, Koichiro Hata, Eri Ogawa, Atsushi Yoshizawa, Naoko Kamo, Noriyo Yamashiki, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
BACKGROUND: Early allograft dysfunction (EAD) defined by serum total bilirubin (TB) ≥10 mg/dL or prothrombin time-international normalized ratio (PT-INR) ≥1.6 on postoperative day 7 (POD7) or aminotransferase >2000 IU/L within the first week, is associated with early graft loss after deceased-donor liver transplantation. We aimed to determine the prognostic impact of the EAD definition in living-donor liver transplantation (LDLT). METHODS: We analyzed the validity of the EAD definition and its impact on early graft survival in 260 adult recipients who underwent primary LDLT...
September 29, 2017: Transplantation
https://www.readbyqxmd.com/read/28951731/minimal-sex-differential-modulation-of-reactivity-to-pathogens-and-toll-like-receptor-ligands-following-infant-bacillus-calmette-gu%C3%A3-rin-russia-vaccination
#13
Fatoumatta Darboe, Jane U Adetifa, John Reynolds, Safayet Hossin, Magdalena Plebanski, Mihai G Netea, Sarah L Rowland-Jones, Jayne S Sutherland, Katie L Flanagan
Bacillus Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis, has been shown to provide heterologous protection against unrelated pathogens and enhance antibody responses to several routine expanded program on immunization (EPI) vaccines. Understanding these heterologous effects is important for the development of optimal vaccination strategies. We set out to assess the effect of vaccination with BCG Russia of 6-week-old infants on in vitro reactivity to a panel of toll-like receptor (TLR) agonists (TLR2, 4, and 7/8) and heat-killed pathogens [Streptococcus pneumoniae, Candida albicans (CA), and Escherichia coli], and antibody responses to other EPI vaccines compared to BCG naïve infants...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28920417/effects-of-deoxynivalenol-and-zearalenone-contaminated-feed-on-the-gene-expression-profiles-in-the-kidneys-of-piglets
#14
Kondreddy Eswar Reddy, Woong Lee, Jin Young Jeong, Yookyung Lee, Hyun-Jeong Lee, Min Seok Kim, Dong-Woon Kim, Dongjo Yu, Ara Cho, Young Kyoon Oh, Sung Dae Lee
Objective: Fusarium mycotoxins deoxynivalenol (DON) and zearalenone (ZEN), common contaminants in the feed of farm animals, cause immune function impairment and organ inflammation. Consequently, the main objective of this study was to elucidate DON and ZEN effects on the mRNA expression of pro-inflammatory cytokines and other immune related genes in the kidneys of piglets. Methods: Fifteen 6-week-old piglets were randomly assigned to three dietary treatments for 4 weeks: control diet, and diets contaminated with either 8 mg DON/kg feed or 0...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28919720/text-messaging-to-decrease-tuberculosis-treatment-attrition-in-tb-hiv-coinfection-in-uganda
#15
Sabine M Hermans, Sawsan Elbireer, Harriet Tibakabikoba, Bas J Hoefman, Yukari C Manabe
BACKGROUND: Low tuberculosis (TB) treatment completion rates in sub-Saharan Africa are an important driver of multidrug resistance. Mobile technology-based interventions have been shown to improve adherence to antiretroviral therapy in sub-Saharan Africa. We aimed to test the effect of a short-message service (SMS) intervention on loss to follow-up (LFU). MATERIALS AND METHODS: In this quasi-experimental study, all adult, literate, HIV-infected patients with mobile phone access diagnosed with TB between November 2010 and October 2011 in an urban clinic in Uganda were eligible to receive adherence and appointment reminders and educational quizzes during the first 8 weeks of TB treatment...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28911359/interferon-gamma-response-to-the-treatment-of-active-pulmonary-and-extra-pulmonary-tuberculosis
#16
L Liang, R Shi, X Liu, X Yuan, S Zheng, G Zhang, W Wang, J Wang, K England, L E Via, Y Cai, L C Goldfeder, L E Dodd, C E Barry, R Y Chen
BACKGROUND: Interferon-gamma (IFN-γ) release assays (IGRAs) are used to diagnose tuberculosis (TB) but not to measure treatment response. OBJECTIVE: To measure IFN-γ response to active anti-tuberculosis treatment. DESIGN: Patients from the Henan Provincial Chest Hospital, Henan, China, with TB symptoms and/or signs were enrolled into this prospective, observational cohort study and followed for 6 months of treatment, with blood and sputum samples collected at 0, 2, 4, 6, 8, 16 and 24 weeks...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28903160/safety-of-systemic-agents-for-the-treatment-of-pediatric-psoriasis
#17
Inge M G J Bronckers, Marieke M B Seyger, Dennis P West, Irene Lara-Corrales, Megha Tollefson, Wynnis L Tom, Marcia Hogeling, Leah Belazarian, Claus Zachariae, Emmanuel Mahé, Elaine Siegfried, Sandra Philipp, Zsuzsanna Szalai, Ruth Ann Vleugels, Kristen Holland, Ruth Murphy, Eulalia Baselga, Kelly Cordoro, Jo Lambert, Alex Alexopoulos, Ulrich Mrowietz, Wietske Kievit, Amy S Paller
Importance: Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited. Objective: To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. Design, Setting, and Participants: A retrospective review was conducted at 20 centers in North America and Europe, and included all consecutive children with moderate to severe psoriasis who used systemic medications or phototherapy for at least 3 months from December 1, 1990, to September 16, 2014...
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28885972/use-of-rifapentine-and-isoniazid-directly-observed-therapy-for-the-treatment-of-latent-tuberculosis-infection-in-a-military-clinic
#18
Janelle Jinbo, Michael Lustik, Gordon F West, Megan Kloetzel
BACKGROUND: There are 8.6 million cases of active tuberculosis (TB) worldwide, and an estimated one-third of the world population has latent tuberculosis infection (LTBI). In the United States, up to 80% of active cases may be caused by untreated reactivated latent infection. A case of TB can spread rapidly impacting the readiness of a unit. To prevent the development of TB, it is critical that active duty service members with LTBI complete treatment. The use of isoniazid (INH) and rifapentine (RPT) as a directly observed therapy (DOT) treatment option was recommended by the Centers for Disease Control and Prevention in late 2011...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28879157/evaluation-of-the-sd-bioline-tb-ag-mpt64-test-for-identification-of-mycobacterium-tuberculosis-complex-from-liquid-cultures-in-southwestern-uganda
#19
Patrick Orikiriza, Dan Nyehangane, Daniel Atwine, John J Kisakye, Kennedy Kassaza, Juliet-Mwanga Amumpaire, Yap Boum
BACKGROUND: To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that requires sub-culturing of clinical isolates and two to three weeks to give results. Rapid identification tests have improved turnaround times for mycobacterial culture results. Considering the challenges of the PNB method, we assessed the performance of the SD Bioline TB Ag MPT64 assay by using PNB as gold standard to detect M...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28874368/immunodeficiency-and-intermittent-dosing-promote-acquired-rifamycin-monoresistance-in-murine-tuberculosis
#20
Sang-Won Park, Rokeya Tasneen, Paul J Converse, Eric L Nuermberger
More-permissive preclinical models may be useful in evaluating antituberculosis regimens for their propensity to select drug-resistant mutants. To evaluate whether acquired rifamycin monoresistance could be recapitulated in mice and, if so, to evaluate the effects of immunodeficiency, intermittent dosing, and drug exposures, athymic nude and BALB/c mice were infected. Controls received daily rifapentine alone or 2 months of rifampin, isoniazid, pyrazinamide, and ethambutol, followed by 4 months of rifampin/isoniazid, either daily or twice weekly with one of two isoniazid doses...
November 2017: Antimicrobial Agents and Chemotherapy
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