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Severe acute malnutrition

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https://www.readbyqxmd.com/read/28916577/evaluation-of-nutrition-interventions-in-children-in-conflict-zones-a-narrative-review
#1
REVIEW
Grace J Carroll, Sonam D Lama, Josefa L Martinez-Brockman, Rafael Pérez-Escamilla
Food and nutrition insecurity becomes increasingly worse in areas affected by armed conflict. Children affected by conflict, or in war-torn settings, face a disproportionate burden of malnutrition and poor health outcomes. As noted by humanitarian response reviews, there is a need for a stronger evidence-based response to humanitarian crises. To achieve this, we systematically searched and evaluated existing nutrition interventions carried out in conflict settings that assessed their impact on children's nutrition status...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28912050/pancreatic-enzyme-replacement-therapy-in-children-with-severe-acute-malnutrition-a-randomized-controlled-trial
#2
Rosalie H Bartels, Céline Bourdon, Isabel Potani, Brian Mhango, Deborah A van den Brink, John S Mponda, Anneke C Muller Kobold, Robert H Bandsma, Michael Boele van Hensbroek, Wieger P Voskuijl
OBJECTIVE: To assess the benefits of pancreatic enzyme replacement therapy (PERT) in children with complicated severe acute malnutrition. STUDY DESIGN: We conducted a randomized, controlled trial in 90 children aged 6-60 months with complicated severe acute malnutrition at the Queen Elizabeth Central Hospital in Malawi. All children received standard care; the intervention group also received PERT for 28 days. RESULTS: Children treated with PERT for 28 days did not gain more weight than controls (13...
September 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28905406/thiamine-content-of-f-75-therapeutic-milk-for-complicated-severe-acute-malnutrition-time-for-a-change
#3
Laurent Hiffler, Bola Adamolekun, Philip R Fischer, Aviva Fattal-Vavleski
Since community-based management of severe acute malnutrition has become the standard of care, the clinical profile of severe acutely malnourished patients admitted to hospitals or inpatient therapeutic feeding centers has changed significantly. These patients are usually very ill and often present with several comorbidities, such as shock, sepsis, and pneumonia. Complicated severe acute malnutrition patients are at risk of thiamine insufficiency, and critically ill patients have higher thiamine requirements...
September 14, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28905004/gastroenteritis-aggressive-versus-slow-treatment-for-rehydration-gastro-a-pilot-rehydration-study-for-severe-dehydration-who-plan-c-versus-slower-rehydration
#4
Kirsty A Houston, Jack G Gibb, Ayub Mpoya, Nchafatso Obonyo, Peter Olupot-Olupot, Margeret Nakuya, Jennifer A Evans, Elizabeth C George, Diana M Gibb, Kathryn Maitland
BACKGROUND: The World Health Organization (WHO) rehydration management guidelines (Plan C) for children with acute gastroenteritis (AGE) and severe dehydration are widely practiced in resource-poor settings, yet have never been formally evaluated in a clinical trial. A recent audit of outcome of AGE at Kilifi County Hospital, Kenya noted that 10% of children required high dependency care (20% mortality) and a number developed fluid-related complications. The fluid resuscitation trial, FEAST, conducted in African children with severe febrile illness, demonstrated higher mortality with fluid bolus therapy and raised concerns regarding the safety of rapid intravenous rehydration therapy...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28903096/early-screening-parameters-for-dysphagia-in-acute-ischemic-stroke
#5
Christian Henke, Christian Foerch, Sriramya Lapa
BACKGROUND: Dysphagia is a frequent symptom in patients with acute stroke. It is associated with malnutrition, aspiration and mortality. The identification of early screening parameters for dysphagia promptly leading to a professional swallowing examination is therefore of utmost importance. This study aimed to detect early and easily assessable predictors of dysphagia in a large cohort of patients with acute ischemic stroke. METHODS: Our analysis was based on data from a prospective in-hospital registry...
September 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28892883/a-case-of-hyperargininaemia-presenting-at-unusually-low-age
#6
Vanita Lal, Daisy Khera, Garima Gupta, Kuldeep Singh, Praveen Sharma
Arginase or ARG1 gene deficiency is a Type V Urea Cycle Disorder (UCD) (catalysing the fifth reaction of urea cycle), associated with hyperammonaemia. Here, we discuss a rare case of a 13-month-old female, having Severe Acute Malnutrition (SAM) and failure to thrive, with serial high plasma ammonia, normal plasma lactate with high arginine and glutamine levels on Amino Acid Assay (AAA) which was performed on 1220 Agilent HPLC. She was admitted for about a month and eventually succumbed to her ailment after a month of discharge...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28871471/impact-of-maternal-nutrition-in-hepatitis-e-infection-in-pregnancy
#7
Ashok Kumar, Sheetal Sharma, Premashish Kar, Sarita Agarwal, Siddhartha Ramji, Syed Akhtar Husain, Sudha Prasad, Shashi Sharma
BACKGROUND AND AIM: The basis of host response in hepatitis E virus (HEV)-related liver disease during pregnancy-is still unclear. The study aims to evaluate anthropometric parameters and biochemical nutritional parameters in hepatitis E infection during pregnancy and correlate it with severity of the disease. METHODS: A total of consecutive 267 pregnant women with jaundice were recruited. The jaundiced patients were classified as acute viral hepatitis (AVH) or acute liver failure (ALF)...
September 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28857414/predictive-factors-of-rehospitalization-for-worsening-heart-failure-and-cardiac-death-within-1%C3%A2-year-in-octogenarians-hospitalized-for-heart-failure
#8
Tomoyuki Hamada, Toru Kubo, Naohito Yamasaki, Hiroaki Kitaoka
AIM: To investigate the predictive factors of cardiac events including rehospitalization for worsening heart failure (HF) and cardiac death within 1 year after hospital discharge in octogenarians hospitalized for HF. METHODS: We retrospectively analyzed in detail clinical data for patients aged >80 years who were admitted to Kochi University, Kochi, Japan, for acute decompensated HF in order to identify predictive factors for cardiac events within 1 year. RESULTS: A total of 67 patients (mean age of 85 ± 4 years, 39 men) were included, and 28 patients (41...
August 30, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28854929/transition-from-f-75-to-ready-to-use-therapeutic-food-in-children-with-severe-acute-malnutrition-an-observational-study-in-uganda
#9
Betty Lanyero, Hanifa Namusoke, Nicolette Nabukeera-Barungi, Benedikte Grenov, Ezekiel Mupere, Kim Fleischer Michaelsen, Christian Mølgaard, Vibeke Brix Christensen, Henrik Friis, André Briend
BACKGROUND: World Health Organization now recommends the transition from F-75 to ready-to-use therapeutic foods (RUTF) in the management of severe acute malnutrition (SAM). We described the transition from F-75 to RUTF and identified correlates of failed transition. METHODS: We conducted an observational study among children aged 6-59 months treated for SAM at Mulago hospital, Kampala, Uganda. Therapeutic feeding during transition phase was provided by first offering half of the energy requirements from RUTF and the other half from F-75 and then increasing gradually to RUTF as only energy source...
August 30, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28851796/determinants-of-severe-acute-malnutrition-among-children-under-5-years-of-age-in-nepal-a-community-based-case-control-study
#10
Nilesh Kumar Pravana, Suneel Piryani, Surendra Prasad Chaurasiya, Rasmila Kawan, Ram Krishna Thapa, Sumina Shrestha
BACKGROUND: Malnutrition is one of the leading causes of morbidity and mortality among children under the age of 5 years in low and middle income countries like Nepal. Children with severe acute malnutrition (SAM) are nine times more likely to die than children without malnutrition. The prevalence of SAM has increased in Nepal over the past 15 years; however, the determinants of SAM have not been clearly assessed in the country. OBJECTIVE: To assess the determinants of SAM among children aged 6-59 months in the Bara district of Nepal...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28814393/soya-maize-and-sorghum-based-ready-to-use-therapeutic-food-with-amino-acid-is-as-efficacious-as-the-standard-milk-and-peanut-paste-based-formulation-for-the-treatment-of-severe-acute-malnutrition-in-children-a-noninferiority-individually-randomized-controlled
#11
Paluku Bahwere, Peter Akomo, Mwawi Mwale, Hitoshi Murakami, Chrissy Banda, Sylvester Kathumba, Chimwemwe Banda, Solomon Jere, Kate Sadler, Steve Collins
Background: Development of more cost-effective ready-to-use therapeutic food (RUTF) is a global public health priority. To date, previous lower-cost recipes have been less effective than the standard peanut and milk (PM)-based RUTF, particularly in children aged <24 mo.Objective: We aimed to compare the efficacy of the PM-RUTF to a milk-free soya, maize, and sorghum (FSMS)-RUTF enriched with crystalline amino acids without cow milk powder and a milk, soya, maize, and sorghum (MSMS)-RUTF containing 9.3% skim cow milk powder...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28810666/monitoring-and-discharging-children-being-treated-for-severe-acute-malnutrition-using-mid-upper-arm-circumference-secondary-data-analysis-from-rural-gambia
#12
Alice Burrell, Marko Kerac, Helen Nabwera
Background: Severe acute malnutrition (SAM) is a major public health problem. Mid-upper arm circumference (MUAC) is widely used to admit children to treatment programmes. However, insufficient data supporting MUAC discharge criterion limits its use as a stand-alone tool. Our aim was to evaluate MUAC for monitoring nutritional recovery and discharge. Methods: This was a secondary analysis of clinical data from children 6-59 months-old treated for SAM from January 2003 to December 2013 at the Nutritional Rehabilitation Unit in rural Gambia...
July 1, 2017: International Health
https://www.readbyqxmd.com/read/28803356/the-prognostic-impact-of-malnutrition-in-patients-with-severely-decompensated-acute-heart-failure-as-assessed-using-the-prognostic-nutritional-index-pni-and-controlling-nutritional-status-conut-score
#13
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Suguru Nishigoori, Saori Uchiyama, Kuniya Asai, Wataru Shimizu
Patients with heart failure (HF) are sometimes classified as malnourished, but the prognostic value of nutritional status in acute HF (AHF) remains largely unstudied. 1214 patients who were admitted to the intensive care unit between January 2000 and June 2016 were screened based on their serum albumin, lymphocyte count, and total cholesterol measures. A total of 458 HF patients were enrolled in this study. The Prognostic Nutritional Index (PNI) is calculated as 10 × serum albumin (g/dL) + 0.005 × lymphocyte count (per mm(3)) (lower = worse)...
August 12, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28797300/can-routine-clinical-data-identify-older-patients-at-risk-of-poor-healthcare-outcomes-on-admission-to-hospital
#14
Kinda Ibrahim, Charlotte Owen, Harnish P Patel, Carl May, Mark Baxter, Avan A Sayer, Helen C Roberts
OBJECTIVE: Older patients who are at risk of poor healthcare outcomes should be recognised early during hospital admission to allow appropriate interventions. It is unclear whether routinely collected data can identify high-risk patients. The aim of this study was to define current practice with regard to the identification of older patients at high risk of poor healthcare outcomes on admission to hospital. RESULTS: Interviews/focus groups were conducted to establish the views of 22 healthcare staff across five acute medicine for older people wards in one hospital including seven nurses, four dieticians, seven doctors, and four therapists...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28768898/morphological-and-functional-consequences-and-quality-of-life-following-severe-acute-pancreatitis
#15
Dorota Koziel, Edyta Suliga, Urszula Grabowska, Stanislaw Gluszek
In this study, we evaluated pancreatic morphology and function as well as nutritional status and quality of life among patients who experienced severe acute pancreatitis (SAP). MATERIALS AND METHODS: We enrolled 99 patients with SAP and 51 with mild acute pancreatitis (MAP). Computed tomography was performed one year following the disease. Endocrine function was evaluated by measuring hemoglobin A1c, insulin, and C peptide levels. Pancreatic exocrine insufficiency (PEI) was diagnosed by the concentration of fecal elastase-1...
June 23, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28762594/evaluation-of-outpatient-therapeutic-programme-otp-for-treatment-of-severe-acute-malnutrition-in-yemen-a-focus-on-treatment-default-and-its-risk-factors
#16
Mohammed Al Amad, Lina Al-Eryani, Abdulwahed Al Serouri, Yousef S Khader
OBJECTIVES: This study aimed to measure the treatment default rate among children with severe acute malnutrition (SAM) who were admitted to the outpatient therapeutic programme (OTP) in Yemen and determine its risk factors. METHODS: A prospective study was conducted among children with SAM who were newly admitted to the 11 OTPs in primary health centres of Sana'a city. A pretested semistructured questionnaire was used for data collection at admission and at after 2 months of admission to the OTP...
August 1, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28750860/impaired-barrier-function-and-autoantibody-generation-in-malnutrition-enteropathy-in-zambia
#17
Beatrice Amadi, Ellen Besa, Kanekwa Zyambo, Patrick Kaonga, John Louis-Auguste, Kanta Chandwe, Phillip I Tarr, Donna M Denno, James P Nataro, William Faubion, Anne Sailer, Sunil Yeruva, Tricia Brantner, Joseph Murray, Andrew J Prendergast, Jerrold R Turner, Paul Kelly
Intestinal damage in malnutrition constitutes a threat to the survival of many thousands of children globally. We studied children in Lusaka, Zambia, with severe acute malnutrition (SAM) and persistent diarrhea using endoscopy, biopsy and analysis of markers and protective proteins in blood and intestinal secretions. We carried out parallel investigations in apparently healthy adults, and analyzed biomarkers only in apparently healthy children. Villus height and crypt depth did not differ in children with SAM and adult controls, but epithelial surface was reduced in children with SAM (median 445, interquartile range (IQR) 388, 562μm per 100μm muscularis mucosae) compared to adults (578, IQR 465,709; P=0...
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28707849/malnutrition-after-bariatric-surgery
#18
Nicolas Taton, Anne-Laure Borel, Marine Chobert Bakouline, Jérôme Fauconnier, Catherine Arvieux, Fabian Reche
BACKGROUND: Malnutrition is a rare but severe complication following obesity surgery. Our objective was to analyze these cases of malnutrition and their management at the Grenoble University Hospital. METHODS: Retrospective data between 2006 to 2016 was analyzed from Department of Medical Information, Severe Obesity Outcome Network, and register of the Department of Artificial Nutrition. Data collected concerned age, sex, anthropometric data, surgical procedures and history of obesity surgery, initial surgical follow-up, delay from surgery, nutritional characteristics, nutritional and surgical management, follow up and outcomes...
July 12, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28705254/correlates-of-whole-blood-polyunsaturated-fatty-acids-among-young-children-with-moderate-acute-malnutrition
#19
C W Yaméogo, B Cichon, C Fabiansen, M J H Rytter, D Faurholt-Jepsen, K D Stark, A Briend, S Shepherd, A S Traoré, V B Christensen, K F Michaelsen, H Friis, L Lauritzen
BACKGROUND: Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs. METHODS: We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa...
July 13, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28699610/survival-and-recovery-in-severely-wasted-under-five-children-without-community-management-of-acute-malnutrition-programme
#20
Harshpal Singh Sachdev, Sikha Sinha, Neha Sareen, R M Pandey, Umesh Kapil
OBJECTIVE: To evaluate recovery and survival of severely wasted children without community management of acute malnutrition programme. DESIGN: Single time point follow-up (24th December 2013 - 2nd April, 2014) of severely wasted children identified in a community-based cross-sectional survey (September 2012 - October 2013). SETTING: Rural Meerut District, Uttar Pradesh, India. PARTICIPANTS: 409 severely wasted (WHO weight-for-height <-3Z), 6- to 59-month-old children...
July 11, 2017: Indian Pediatrics
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