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Zh I Islamova, V N Syrov, Z A Khushbaktova, S O Osipova
Ecdisten, the drug designed on the basis of the phytoecdisteroid ecdisterone isolated from Rhaponticum carthamoides, was used in the treatment of first diagnosed (primary) and persistent (resistant to traditional lambliacides) lambliasis. A control group received metronidazole. Daily parasitological monitoring of lamblia elimination while treating with ecdisten in a daily dose of 20 mg for 10 days indicated the absence of lamblia in 70% of the patients with primary lambliasis on days 3 to 5; in the remaining 30%, parasitic elimination was accomplished on days 6-7 of treatment...
April 2010: Meditsinskaia Parazitologiia i Parazitarnye Bolezni
V N Syrov, Z A Khushbaktova, A S Komarin, A B Abidov, T V Pechenitsina, F A Aripkhodzhaeva
The properties of ecdysten, an exdysterone-based preparation, were studied under experimental (of heliotrine induced hepatitis model in rats) and clinical (chronic viral hepatitis B) conditions. A 2-week treatment with ecdysten in a daily dose of 5 mg/kg (p.o.) significantly improved the state of rat liver, as manifested by normalization of the enzymatic activity of blood serum, stimulation of the protein and glycogen synthesis, inhibition of lipid peroxidation, and activation of all chains of microsomal oxidation of hepatocytes...
September 2004: Eksperimental'naia i Klinicheskaia Farmakologiia
L R Emirova, E A Rozhkova, V V Paniushkin, R S Mirzoian, N R Seĭfulla
Cytamines (hepatamin, epifamin, and suprenamin) administered in various combinations increase the working ability of high-rank athletes in experiments. These cytamines also potentiate the effects of apilak, ecdystene, vitamax, and essentiale preparations on the exercise tolerance.
May 2004: Eksperimental'naia i Klinicheskaia Farmakologiia
S O Osipova, Zh I Islamova, V N Syrov, N S Badalova, Z A Khushbaktova
The drug ecdisten as tablets is the natural compound ecdisteron was extracted from Rhaponticum carthamoides (Willd.) Jljin. Ecdisten was tested in the treatment of 32 and 3 patients with persistent and acute giardiasis, respectively. A ten-day course of ecdisten, 5 mg 3 or 4 times a day, resulted in a clinical and parasitological recovery in 22 (68.7%) and 3 patients, respectively. After the reuse of a ecdisten course in 4 patients with persistent giardiasis wherein its initial dose was increased, recovery was achieved in 3 cases, the efficacy of the agent was 78...
January 2002: Meditsinskaia Parazitologiia i Parazitarnye Bolezni
C Tsitsimpikou, G D Tsamis, P A Siskos, M H Spyridaki, C G Georgakopoulos
A study of excretion in human urine of ecdysterone, which is the active component of several over-the-counter supplements such as "Ecdysten", reportedly used by athletes, is presented. The study was performed after oral administration of 20 mg of ecdysterone. The collected urine samples were prepared using the standard screening extraction procedure for the free and conjugated fraction of anabolic steroids, and analyzed by gas chromatography (GC) coupled with quadrupole mass spectrometry (MS) and also with high-resolution mass spectrometry (HRMS)...
2001: Rapid Communications in Mass Spectrometry: RCM
Iu R Mirzaev, V N Syrov, S A Khrushev, S D Iskanderova
The effects of ecdysterone and the related drug ecdysten on the sexual activity were studied under experimental and clinical conditions. A 10-day administration of ecdysterone (5 and 10 mg/kg, p.o.) improved behavioral characteristics of the sexual function in rats, the effect being especially pronounced during the fist days of experiment. The administration of ecdysten to men with the infertility diagnosis (disturbed spermatogenesis as a complication of some urologic diseases) increased the copulative function and improved the sperm quality...
July 2000: Eksperimental'naia i Klinicheskaia Farmakologiia
R M Gadzhieva, S N Portugalov, V V Paniushkin, I I Kondrat'eva
A new class of anabolic substances includes different saponins, originated from Leuzea rhaponticum sp. The effect of these substances on the human body was studied by caliperometric measurements of body folds. All tested substances taken orally for three weeks diminished fat content under conditions of daily aerobic-anaerobic training. Ekdisten and Prime Plus (combination of ekdisten and pure protein) elevated the muscle mass. The same effect of leventon was less pronounced. We showed that all substances studied elevated the magnitude of "total work", estimated per 1 kg of body weight...
September 1995: Eksperimental'naia i Klinicheskaia Farmakologiia
P V Sergeev, A V Semeĭkin, A S Dukhanin, E Iu Stonans
In in vivo and in vitro experiments, androgen anabolic steroid agents (testosterone, methandrostenolone) and dexamethasone showed a dose-dependent inhibition of PHA-stimulated proliferation of C57BL/6 mice thymocytes. The phytoecdysteroidal anabolic steroid ecdystene failed to inhibit thymocytic proliferation. The competitive radioligand analysis was used to show that testosterone and methandrostenolone displace the androgenic steroid mibolerone from lymphocytes. The findings provide evidence that lymphocytes have specific binding sites for androgen-anabolic steroids...
May 1994: Eksperimental'naia i Klinicheskaia Farmakologiia
A N Aripov, N M Akbarova
Impairments of the cAMP system in rat liver tissue are of importance in pathogenesis of acute heliotrin hepatitis. Such drugs as phosphatidylcholine, ecdystene, unithiol promote the impaired lipid environment restoration which makes it possible to normalize the adenylate cyclase system and cyclic nucleotides functions.
July 1994: Voprosy Medit︠s︡inskoĭ Khimii
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