keyword
https://read.qxmd.com/read/38398492/interactions-between-the-exocrine-and-the-endocrine-pancreas
#21
REVIEW
Roberto Valente, Alessandro Coppola, Chiara Maria Scandavini, Asif Halimi, Annelie Magnusson, Augusto Lauro, Ira Sotirova, Urban Arnelo, Oskar Franklin
The pancreas has two main functions: to produce and secrete digestive enzymes (exocrine function) and to produce hormones that regulate blood glucose and splanchnic secretion (endocrine function). The endocrine and exocrine portions of the pancreas are central regulators in digestion and metabolism, with continuous crosstalk between their deeply interconnected components, which plays a role in disease. Pancreatic neoplasms, inflammation, trauma, and surgery can lead to the development of type 3c diabetes when an insult simultaneously damages both acini and islets, leading to exocrine and endocrine dysfunction...
February 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38396339/a-case-report-of-pancreatic-exocrine-insufficiency-in-a-patient-with-parkinson-s-disease-a-coincidence-or-is-there-more-to-it-than-meets-the-eye
#22
JOURNAL ARTICLE
David Edwards, Babu Krishnan, Mustafa Jalal
Pancreatic exocrine insufficiency (PEI) is an under-diagnosed condition. Untreated PEI can result in developing gastrointestinal symptoms and long-term complications including weight loss, nutrient deficiencies, sarcopenia and osteoporosis. Current best practice recommends testing for PEI in certain disorders including chronic pancreatitis, cystic fibrosis, pancreatic cancer and post-pancreatic surgery. However, there is increasing evidence that PEI is associated with a number of conditions in addition to the aforementioned diseases...
February 23, 2024: Journal of the Royal College of Physicians of Edinburgh
https://read.qxmd.com/read/38389307/role-of-cftr-in-diabetes-induced-pancreatic-ductal-fluid-and-hco-3-secretion
#23
JOURNAL ARTICLE
Attila Ébert, Eleonóra Gál, Emese Tóth, Titanilla Szögi, Péter Hegyi, Viktória Venglovecz
Type 1 diabetes is a disease of the endocrine pancreas; however, it also affects exocrine function. Although most studies have examined the effects of diabetes on acinar cells, much less is known regarding ductal cells, despite their important protective function in the pancreas. Therefore, we investigated the effect of diabetes on ductal function. Diabetes was induced in wild-type and cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice following an i.p. administration of streptozotocin...
February 22, 2024: Journal of Physiology
https://read.qxmd.com/read/38388766/mechanism-exploration-and-biomarker-identification-of-glycemic-deterioration-in-patients-with-diseases-of-the-exocrine-pancreas
#24
JOURNAL ARTICLE
Zhen Wang, Guolin Zhang, Jixian Fu, Guangxing Li, Zhihao Zhao, HyokChol Choe, Kaiyue Ding, Junnan Ma, Jing Wei, Dong Shang, Lin Zhang
The damage to the endocrine pancreas among patients with diseases of the exocrine pancreas (DP) leads to reduced glycemic deterioration, ultimately resulting in diabetes of the exocrine pancreas (DEP). The present research aims to investigate the mechanism responsible for glycemic deterioration in DP patients, and to identify useful biomarkers, with the ultimate goal of enhancing clinical practice awareness. Gene expression profiles of patients with DP in this study were acquired from the Gene Expression Omnibus database...
February 22, 2024: Scientific Reports
https://read.qxmd.com/read/38382878/specific-localization-of-fibroblasts-at-the-intercalated-duct-in-the-major-salivary-glands-of-rats
#25
JOURNAL ARTICLE
Go Onozawa, Arata Nagasaka, Yasuhiko Bando, Koji Sakiyama, Nobuharu Yamamoto, Osamu Amano
OBJECTIVES: Immunohistochemical methods were employed to investigate the morphological heterogeneity and localization of fibroblasts associated with the function of major salivary glands in rats. METHODS: Histochemical and electron microscopic observations were made in rat parotid, submandibular, and sublingual glands and pancreas. Fibroblasts were immunostained using their specific marker, 47 kDa heat shock protein (Hsp47). RESULTS: Hsp47-immunopositive fibroblasts within the intralobular connective tissue exhibited a notably smaller size compared with the interlobular connective tissue...
February 19, 2024: Journal of Oral Biosciences
https://read.qxmd.com/read/38363191/point-shear-wave-elastography-generated-by-acoustic-radiation-force-impulse-in-chronic-pancreatitis
#26
JOURNAL ARTICLE
Maximilian Wekerle, Katharina Murillo, Manuel vonBoscamp, Veronika Hauber, Matthias P Ebert, Christoph Antoni, Michael Hirth
BACKGROUND: Transcutaneous point-shear wave elastography (p-SWE) performed using an acoustic radiation force impulse can be used to quantify pancreatic stiffness in chronic pancreatitis (CP). We aimed to evaluate its usefulness to diagnose and monitor CP. METHODS: 175 participants were included in this prospective study including patients with CP (n = 65), liver cirrhosis (LC; n = 60), alcohol abuse (n = 10) and healthy controls (n = 40)...
February 16, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38355041/solid-pseudopapillary-neoplasms-of-the-pancreas-multicenter-vasepa-study
#27
JOURNAL ARTICLE
Xiomara Duque Alvarez, Cándido Fernando Alcázar, Ana Hernando Sanz, Isabel Mora-Oliver, Laura Granel, José A Barreras, Alicia Calero, Silvia Carbonell-Morote, Carlos Domingo, Rafael Estevan, Israel Oliver, Rafael López Andujar, Luis Sabater, Antonio Compañ, José M Ramia
INTRODUCTION: Solid pseudopapillary tumors (SPT) of the pancreas are rare exocrine neoplasms of the pancreas. Correct preoperative diagnosis is not always feasible. The treatment of choice is surgical excision. These tumors have a good prognosis with a high disease-free survival rate. OBJECTIVE: To describe the clinicopathological and radiological characteristics as well as short- and long-term follow-up results of patients who have undergone SPT resection. METHODS: Multicenter retrospective observational study in patients with SPT who had undergone surgery from January 2000-January 2022...
February 12, 2024: Cirugia española
https://read.qxmd.com/read/38354358/the-signal-intensity-ratio-of-pancreas-to-spleen-in-magnetic-resonance-imaging-can-predict-nonalcoholic-fatty-liver-disease-after-pancreaticoduodenectomy
#28
JOURNAL ARTICLE
Masashi Tsunematsu, Koichiro Haruki, Yoshihiro Shirai, Shinji Onda, Kenei Furukawa, Norimitsu Okui, Kyohei Abe, Taro Sakamoto, Takeshi Gocho, Toru Ikegami
OBJECTIVES: Signal intensity ratio of pancreas to spleen (SI ratiop/s) on fat-suppressed T1-weighted images of magnetic resonance imaging has been associated with pancreatic exocrine function. We here investigated the predictive value of the SI ratiop/s for the development of nonalcoholic fatty liver disease (NAFLD) after pancreaticoduodenectomy (PD). MATERIALS AND METHODS: This study comprised 208 patients who underwent PD. NAFLD was defined as a liver-to-spleen attenuation ratio of <0...
February 14, 2024: Pancreas
https://read.qxmd.com/read/38352895/case-report-retroperitoneal-solid-pseudopapillary-neoplasm-associated-with-multiple-hepatic-metastases
#29
Lin Chen, Mengchen Yuan, Meng Wang, Chenglong Luo, Mengyu Gao, Qingbo Huang, Zhenqian Li, Zhigang Zhou
Solid pseudopapillary neoplasm (SPN) is a rare tumor mostly occurring in the pancreas. They are low-grade malignant tumors of the exocrine pancreas that occasionally metastasize, usually to the liver or peritoneum. Additionally, multiple metastases of extrapancreatic SPN to the liver are extremely rare and have been reported before. This study presents a case of a 13-year-old male patient with retroperitoneal SPN and multiple hepatic metastases. The patient presented with abdominal trauma and underwent enhanced CT, which revealed upper pancreatic occupancy and three hypodense foci in the right lobe of the liver...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38351473/exploring-the-variations-of-the-pancreatic-ductal-system-a-systematic-review-and-meta-analysis-of-observational-studies
#30
JOURNAL ARTICLE
Adil Asghar, Ravi Kant Narayan, Nagavalli Basavanna Pushpa, Apurba Patra, Kumar Satish Ravi, R Shane Tubbs
The exocrine part of the pancreas has a duct system called the pancreatic ductal system (PDS). Its mechanism of development is complex, and any reorganization during early embryogenesis can give rise to anatomical variants. The aim of this study is to collect, classify, and analyze published evidence on the importance of anatomical variants of the PDS, addressing gaps in our understanding of such variations. The MEDLINE, Web of Science, Embase, and Google Scholar databases were searched to identify publications relevant to this review...
February 14, 2024: Anatomy & Cell Biology
https://read.qxmd.com/read/38348975/the-role-of-surgery-in-chronic-pancreatitis
#31
JOURNAL ARTICLE
Miloš Kňazovický, Veronika Roškovičová, Tomáš Gajdzik, Tomáš Hildebrand, Jana Kaťuchová, Jozef Radoňák
Chronic pancreatitis is an inflammatory disease characterized by the progressive replacement of the functional pancreatic parenchyma with fibrotic tissue. This leads to exocrine and endocrine insufficiency. A typical clinical feature is recurrent, severe upper abdominal pain, which negatively affects the patient's quality of life. Conservative treatment as the method of first choice does not prevent irreversible changes in the pancreatic tissue. While endoscopic drainage can have some benefits in the early stages of the disease, it is generally unsuccessful in the long term...
November 16, 2023: Polski Przeglad Chirurgiczny
https://read.qxmd.com/read/38344778/differential-diagnosis-of-post-pancreatitis-diabetes-mellitus-based-on-pancreatic-and-gut-hormone-characteristics
#32
JOURNAL ARTICLE
Yingqi Lv, Xuejia Lu, Gaifang Liu, Liang Qi, Zihang Zhong, Xiaoyuan Wang, Weizhen Zhang, Ruihua Shi, Mark O Goodarzi, Stephen J Pandol, Ling Li
PURPOSE: Distinguishing different types of diabetes is important in directing optimized treatment strategies and correlated epidemiological studies. Through detailed analysis of hormone responses to mixed meal tolerance test (MMTT), we aimed to find representing characteristics of post-acute pancreatitis diabetes mellitus (PPDM-A) and post-chronic pancreatitis diabetes mellitus (PPDM-C). METHODS: Participants with PPDM-A, PPDM-C, type 1 diabetes, type 2 diabetes and normal controls underwent MMTT...
February 12, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38337814/the-role-of-endoscopic-ultrasound-in-early-chronic-pancreatitis
#33
REVIEW
Jimil Shah, Abhirup Chatterjee, Truptesh H Kothari
Chronic pancreatitis (CP) is an irreversible and progressive inflammation of the pancreas that can involve both pancreatic parenchyma and the pancreatic duct. CP results in morphological changes in the gland in the form of fibrosis and calcification along with functional impairment in the form of exocrine and endocrine insufficiency. Studies on the natural history of CP reveal the irreversibility of the condition and the resultant plethora of complications, of which pancreatic adenocarcinoma is the most dreaded one...
January 30, 2024: Diagnostics
https://read.qxmd.com/read/38337806/diagnostic-differentiation-between-pancreatitis-and-pancreatic-cancer-a-scoping-review
#34
REVIEW
Fusi Madela, Lucien Ferndale, Colleen Aldous
Pancreatitis, encompassing acute and chronic forms, and pancreatic cancer pose significant challenges to the exocrine tissue of the pancreas. Recurrence rates and complications following acute pancreatitis episodes can lead to long-term risks, including diabetes mellitus. Chronic pancreatitis can develop in approximately 15% of cases, regardless of the initial episode's severity. Alcohol-induced pancreatitis, idiopathic causes, cigarette smoking, and hereditary pancreatitis contribute to the progression to chronic pancreatitis...
January 29, 2024: Diagnostics
https://read.qxmd.com/read/38336506/maintenance-steroid-therapy-is-associated-with-decreased-risk-of-malignancy-and-better-prognosis-of-patients-with-autoimmune-pancreatitis-a-multicenter-cohort-study-in-japan
#35
JOURNAL ARTICLE
Tetsuya Takikawa, Kazuhiro Kikuta, Takanori Sano, Tsukasa Ikeura, Nao Fujimori, Takeji Umemura, Itaru Naitoh, Hiroshi Nakase, Hiroyuki Isayama, Atsushi Kanno, Ken Kamata, Yuzo Kodama, Dai Inoue, Akio Ido, Toshiharu Ueki, Hiroshi Seno, Hiroaki Yasuda, Eisuke Iwasaki, Takayoshi Nishino, Kensuke Kubota, Toshihiko Arizumi, Atsushi Tanaka, Kazushige Uchida, Ryotaro Matsumoto, Shin Hamada, Seiji Nakamura, Kazuichi Okazaki, Yoshifumi Takeyama, Atsushi Masamune
BACKGROUND/OBJECTIVES: The association between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) remains controversial. This study aimed to clarify the long-term prognosis and risk of malignancies in AIP patients in Japan. METHODS: We conducted a multicenter retrospective cohort study on 1364 patients with type 1 AIP from 20 institutions in Japan. We calculated the standardized incidence ratio (SIR) for malignancies compared to that in the general population...
January 19, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38325760/novel-approach-for-pancreas-transcriptomics-reveals-the-cellular-landscape-in-homeostasis-and-acute-pancreatitis
#36
JOURNAL ARTICLE
Katherine J Aney, Woo-Jeong Jeong, Andres F Vallejo, Cassandra Burdziak, Ethan Chen, Austin Wang, Pal Koak, Kellie Wise, Kirk Jensen, Dana Pe'er, Stephanie K Dougan, Luciano Martelotto, Sahar Nissim
BACKGROUND & AIMS: Acinar cells produce digestive enzymes that impede transcriptomic characterization of the exocrine pancreas. Thus, single-cell RNA-sequencing studies of the pancreas underrepresent acinar cells relative to histological expectations, and a robust approach to capture pancreatic cell responses in disease states is needed. We sought to innovate a method that overcomes these challenges to accelerate study of the pancreas in health and disease. METHODS: We introduce FixNCut, a single-cell RNA-sequencing approach in which tissue is reversibly fixed with dithiobis(succinimidyl propionate) before dissociation and single-cell preparation...
February 6, 2024: Gastroenterology
https://read.qxmd.com/read/38324000/dietary-supplementation-of-water-extract-of-eucommia-ulmoides-bark-improved-caecal-microbiota-and-parameters-of-health-in-white-feathered-broilers
#37
JOURNAL ARTICLE
Min Lu, Zhong-Tao Zhao, Ye Xin, Guoxun Chen, Fang Yang
Eucommia ulmoides has been used as a food and medicine homologue for a long time in China. We hypothesize that Eucommia ulmoides achieves its health-promoting effects via altering gut microbiota. Here, we investigated the effects of water extract of Eucommia ulmoides bark on caecal microbiota and growth performance, antioxidant activity, and immunity in white-feathered broilers treated for 42 days. A total of 108 one-day-old Cobb white-feathered broilers were randomly assigned to three treatment groups: control diet, 0...
February 7, 2024: Journal of Animal Physiology and Animal Nutrition
https://read.qxmd.com/read/38310529/analysis-of-biochemical-parameters-in-an-experimental-model-of-chronic-pancreatitis-in-rats
#38
JOURNAL ARTICLE
Patrycja Bronowicka-Adamska, Tomasz Hutsch, Dominika Szlęzak, Anna Bentke-Imiolek, Kinga Kaszuba, Piotr Ceranowicz, Beata Kuśnierz-Cabala
BACKGROUND: Despite advanced research and great progress in understanding the chronic pancreatitis (CP) pathogenesis, no current causal treatment for the condition is available. For preclinical studies, the existence of a well-characterized CP animal model is essential. The aim of the study was to assess the impact of chronic pancreatitis on the antioxidant enzymes activity in rat blood serum and on the level of glutathione (intracellular antioxidant) in rat pancreas. METHODS: The experiments were carried out on the Wistar Kyoto rats in two groups: control and study group (CP), in which chemical induction of pancreatitis with dibutyl dichloride was performed...
October 30, 2023: Folia Medica Cracoviensia
https://read.qxmd.com/read/38306542/emergency-hybrid-surgery-for-transection-of-pancreas-at-the-head-and-neck-after-blunt-abdominal-trauma-a-case-report-and-review-of-the-literature
#39
REVIEW
Yanan Xu, Tao Ai
INTRODUCTION: A complete disruption of main pancreatic duct (MPD) presents a significant challenge to the surgeon. Historically, the standard surgical approach for addressing a complete disruption of the MPD involved distal pancreatic resection and pancreaticojejunostomy Roux-en-Y anastomosis. Nevertheless, there have been no reported cases of hybrid surgery being employed for the complete disruption of the MPD. PATIENT CONCERNS: A 63-year-old male patient presented with blunt trauma in the upper abdomen and was transferred to our trauma center 10 hours after injury...
February 2, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38275322/selective-and-concentrative-enteropancreatic-recirculation-of-antibiotics-by-pigs
#40
JOURNAL ARTICLE
Karyl K Buddington, Stefan G Pierzynowski, William E Holmes, Randal K Buddington
Antibiotics that are efficacious for infectious pancreatitis are present in pancreatic exocrine secretion (PES) after intravenous administration and above minimal inhibitory concentrations. We measured concentrations of four antibiotics by tandem liquid chromatography-mass spectroscopy in plasma and PES after enteral administration to juvenile pigs with jugular catheters and re-entrant pancreatic-duodenal catheters. Nystatin, which is not absorbed by the intestine nor used for infectious pancreatitis (negative control), was not detected in plasma or PES...
December 21, 2023: Antibiotics
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