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Exocrine pancreas

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https://www.readbyqxmd.com/read/29138633/influence-of-spk-with-enteric-drainage-on-the-pancreatic-exocrine-function-in-diabetic-patients-with-uremia
#1
Guanghui Pei, Wu Lv, Xiaohang Li, Guoqing Zhang, Jialin Zhang
Objective: This study aimed to determine the use of fecal elastase in evaluating the effect of simultaneous pancreas-kidney transplantation with enteric drainage on the pancreatic exocrine function of diabetic patients with uremia. Methods: A total of 19 patients with simultaneous pancreas-kidney transplantation (SPK) with enteric drainage, 31 diabetic patients with uremia (chronic renal failure (CRF)), 22 diabetic patients with uremia who underwent renal transplantation (RT), and 20 normal individuals (CON) were included in the study...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29135679/characterization-of-the-human-pancreas-side-population-as-a-potential-reservoir-of-adult-stem-cells
#2
Petra Augstein, Thomas Loudovaris, Esther Bandala-Sanchez, Peter Heinke, Gaetano Naselli, Lily Lee, Wayne J Hawthorne, L Jorge Góñez, Alana M Neale, François Vaillant, Helen E Thomas, Thomas W Kay, Ilia Banakh, Leonard C Harrison
OBJECTIVES: The side population (SP) contains cells with stem cell/progenitor properties. Previously, we observed that the mouse pancreas SP expanded after pancreatic injury. We aimed to characterize the SP in human pancreas as a potential source of stem cells. METHODS: Human organ donor pancreata were fractionated into islets and exocrine tissue, enriched by tissue culture and dispersed into single cells. Cells were phenotyped by flow cytometry, and the SP was defined by efflux of fluorescent dye Hoechst 33342 visualized by ultraviolet excitation...
November 10, 2017: Pancreas
https://www.readbyqxmd.com/read/29134356/secretin-stimulated-ultrasound-estimation-of-pancreatic-secretion-in-cystic-fibrosis-validated-by-magnetic-resonance-imaging
#3
Trond Engjom, Erling Tjora, Gaute Wathle, Friedemann Erchinger, Birger N Lærum, Odd H Gilja, Ingfrid Salvesen Haldorsen, Georg Dimcevski
OBJECTIVES: Secretin-stimulated magnetic resonance imaging (s-MRI) is the best validated radiological modality assessing pancreatic secretion. The purpose of this study was to compare volume output measures from secretin-stimulated transabdominal ultrasonography (s-US) to s-MRI for the diagnosis of exocrine pancreatic failure in cystic fibrosis (CF). METHODS: We performed transabdominal ultrasonography and MRI before and at timed intervals during 15 minutes after secretin stimulation in 21 CF patients and 13 healthy controls...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29131278/fractal-and-stereological-analyses-of-insulin-induced-rat-exocrine-pancreas-remodeling
#4
Mila Pajevic, Marija Aleksic, Igor Golic, Milica Markelic, Vesna Otasevic, Aleksandra Jankovic, Ana Stancic, Bato Korac, Aleksandra Korac
The effect of insulin on the endocrine pancreas has been the subject of extensive study, but quantitative morphometric investigations of the exocrine pancreas are scarce. This study was therefore undertaken to investigate the effect of acute and chronic insulin administration (two doses, 0.4 IU and 4 IU) on the morphology of rat pancreas acini. Semi-fine sections stained with methylene blue and basic fuchsine or hematoxylin- and eosin-stained 5-micrometer thick paraffin sections were used for fractal and stereological analysis of exocrine acini...
November 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29118967/cold-perfusion-decellularization-of-whole-organ-porcine-pancreas-supports-human-fetal-pancreatic-cell-attachment-and-expression-of-endocrine-and-exocrine-markers
#5
Erik Elebring, Vijay K Kuna, Niclas Kvarnström, Suchitra Sumitran-Holgersson
Despite progress in the field of decellularization and recellularization, the outcome for pancreas has not been adequate. This might be due to the challenging dual nature of pancreas with both endocrine and exocrine tissues. We aimed to develop a novel and efficient cold-perfusion method for decellularization of porcine pancreas and recellularize acellular scaffolds with human fetal pancreatic stem cells. Decellularization of whole porcine pancreas at 4°C with sodium deoxycholate, Triton X-100 and DNase efficiently removed cellular material, while preserving the extracellular matrix structure...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29117461/atrial-natriuretic-peptide-reduces-inflammation-and-enhances-apoptosis-in-rat-acute-pancreatitis
#6
Ana Clara Najenson, Ana Paula Courreges, Juan Carlos Perazzo, María Fernanda Rubio, Marcelo S Vatta, Liliana G Bianciotti
AIM: We previously reported that atrial natriuretic peptide (ANP) reduces serum amylase and intrapancreatic trypsinogen activation in the onset of acute pancreatitis whereas secretin increases them. In the present work, we sought to establish the effect of ANP and secretin on the inflammatory response and cell death in experimental acute pancreatitis. METHODS: The expression and activity of key inflammatory mediators and apoptosis were evaluated in the presence or absence of the atrial peptide, secretin or both in cerulein-induced acute pancreatitis in rats...
November 8, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29097865/staging-chronic-pancreatitis-with-exocrine-function-tests-are-we-better
#7
EDITORIAL
Cosimo Sperti, Lucia Moletta
Chronic pancreatitis (CP) is an inflammatory disease of the pancreas evolving in progressive fibrotic disruption of the gland with exocrine and endocrine pancreatic insufficiency. Although imaging features of CP are well known, their correlation with exocrine pancreatic function tests are not obvious, particularly in the early stage of the disease. There are many clinical classification of CP, all suggested for better distinguish and manage different forms based on etiological and clinical factors, and severity of the disease...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29096722/pdx1-neurogenin-3-and-mafa-critical-transcription-regulators-for-beta-cell-development-and-regeneration
#8
REVIEW
Yaxi Zhu, Qian Liu, Zhiguang Zhou, Yasuhiro Ikeda
Transcription factors regulate gene expression through binding to specific enhancer sequences. Pancreas/duodenum homeobox protein 1 (PDX1), Neurogenin-3 (NEUROG3), and V-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA) are transcription factors critical for beta cell development and maturation. NEUROG3 is expressed in endocrine progenitor cells and controls islet differentiation and regeneration. PDX1 is essential for the development of pancreatic exocrine and endocrine cells including beta cells...
November 2, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29089105/simultaneous-pancreas-kidney-transplantation-experience-of-the-doce-de-octubre-hospital
#9
Carlos Jiménez-Romero, Alberto Marcacuzco Quinto, Alejandro Manrique Municio, Iago Justo Alonso, Jorge Calvo Pulido, Félix Cambra Molero, Óscar Caso Maestro, Álvaro García-Sesma, Enrique Moreno González
INTRODUCTION: Simultaneous pancreas-kidney transplantation (SPKT) constitutes the therapy of choice for diabetes type1 or type2 associated with end-stage renal disease, because is the only proven method to restore normo-glicemic control in the diabetic patient. METHODS: Retrospective and descriptive study of a series of 175 patients who underwent SPKT from March 1995 to April 2016. We analyze donor and recipient characteristics, perioperative variables and immunosuppression, post-transplant morbi-mortality, patient and graft survival, and risk factors related with patient and graft survival...
October 28, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29078656/robotic-central-pancreatectomy
#10
REVIEW
Ahmad Hamad, Stephanie Novak, Melissa E Hogg
Central pancreatectomy (CP) is a parenchyma-sparing procedure that can be utilized in the resection of tumors of the neck or the proximal body of the pancreas. Among 872 open CP reported since 1993, the mean rate of morbidity was 43.2% and mean rate of mortality was 0.24%. The mean pancreatic fistula rate was 28%. The rate of clinically significant pancreatic fistulas with ISGPF Grades B and C was 19%. The rate of development of post-operative diabetes mellitus was at 2% and the average incidence of exocrine insufficiency experienced by patients undergoing open CP was 4...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29073149/intrapancreatic-injection-of-human-bone-marrow-derived-mesenchymal-stem-stromal-cells-alleviates-hyperglycemia-and-modulates-the-macrophage-state-in-streptozotocin-induced-type-1-diabetic-mice
#11
Norimitsu Murai, Hirokazu Ohtaki, Jun Watanabe, Zhifang Xu, Shun Sasaki, Kazumichi Yagura, Seiji Shioda, Shoichiro Nagasaka, Kazuho Honda, Masahiko Izumizaki
Type 1 diabetes mellitus is a progressive disease caused by the destruction of pancreatic β-cells, resulting in insulin dependency and hyperglycemia. While transplanted bone marrow-derived mesenchymal stem/stromal cells (BMMSCs) have been explored as an alternative therapeutic approach for diseases, the choice of delivery route may be a critical factor determining their sustainability. This study evaluated the effects of intrapancreatic and intravenous injection of human BMMSCs (hBMMSCs) in streptozotocin (STZ)-induced type 1 diabetic mouse model...
2017: PloS One
https://www.readbyqxmd.com/read/29069049/glucagonoma-syndrome-with-serous-oligocystic-adenoma-a-rare-case-report
#12
Yun Gao, Chun Wang, Yunyi Gao, Huijiao Chen, Bing Peng, Weixia Chen, Xingwu Ran
RATIONALE: Glucagonoma and pancreatic serous oligocystic adenoma (SOA) are rare neuroendocrine and exocrine tumors of the pancreas, respectively. The coexistence of glucagonoma syndrome (GS) and SOA is a rare clinical condition and has not yet been reported. Additionally, necrolytic migratory erythema (NME), a hallmark clinical sign of GS, is often misdiagnosed as other skin lesions by clinicians due to their lack of related knowledge, which delays diagnosis of GS and thus exacerbates the prognosis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29064047/pancreatic-imaging-using-an-antibody-fragment-targeting-the-zinc-transporter-type-8-a-direct-comparison-with-radio-iodinated-exendin-4
#13
Olof Eriksson, Olle Korsgren, Ram Kumar Selvaraju, Marjorie Mollaret, Yann de Boysson, Fabrice Chimienti, Mohamed Altai
AIM: The zinc transporter 8 (ZnT8) has been suggested as a suitable target for non-invasive visualization of the functional pancreatic beta cell mass, due to both its pancreatic beta cell restricted expression and tight involvement in insulin secretion. METHODS: In order to examine the potential of ZnT8 as a surrogate target for beta cell mass, we performed mRNA transcription analysis in pancreatic compartments. A novel ZnT8 targeting antibody fragment Ab31 was radiolabeled with iodine-125, and evaluated by in vitro autoradiography in insulinoma and pancreas as well as by in vivo biodistribution...
October 24, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29057588/gub06-046-a-novel-secretin-glucagon-like-peptide-1-co-agonist-decreases-food-intake-improves-glycemic-control-and-preserves-beta-cell-mass-in-diabetic-mice
#14
Søren B van Witteloostuijn, Louise S Dalbøge, Gitte Hansen, Søren Roi Midtgaard, Grethe Vestergaard Jensen, Knud J Jensen, Niels Vrang, Jacob Jelsing, Søren L Pedersen
Bariatric surgery is currently the most effective treatment of obesity, which has spurred an interest in developing pharmaceutical mimetics. It is thought that the marked body weight-lowering effects of bariatric surgery involve stimulated secretion of appetite-regulating gut hormones, including glucagon-like peptide 1. We here report that intestinal expression of secretin is markedly upregulated in a rat model of Roux-en-Y gastric bypass, suggesting an additional role of secretin in the beneficial metabolic effects of Roux-en-Y gastric bypass...
October 23, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29050937/integrated-expression-profiling-of-potassium-channels-identifys-kcnn4-as-a-prognostic-biomarker-of-pancreatic-cancer
#15
Shuheng Jiang, Lili Zhu, Jianyu Yang, Lipeng Hu, Jianren Gu, Xin Xing, Yongwei Sun, Zhigang Zhang
Dysregulated potassium (K(+)) channels have previously been shown to promote the development and progression of many types of cancers. Meanwhile, K(+) channels are particularly important in regulating the endocrine and exocrine functions of pancreas. However, the expression pattern and prognostic significance of K(+) channels in pancreatic ductal adenocarcinoma (PDAC) remain unknown. In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K(+) channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29044779/exocrine-pancreas-function-decreases-during-the-progression-of-the-beta-cell-damaging-process-in-young-prediabetic-children
#16
Anita Kondrashova, Noora Nurminen, Jussi Lehtonen, Marja Hyöty, Jorma Toppari, Jorma Ilonen, Riitta Veijola, Mikael Knip, Heikki Hyöty
OBJECTIVE: The function of the exocrine pancreas is decreased in patients with type 1 diabetes but it is not known when this defect develops. The current study set out to determine whether the reduced exocrine function becomes manifest after the initiation of islet autoimmunity. METHODS: The study was nested in the prospective Type 1 Diabetes Prediction and Prevention study where children with human leukocyte antigen (HLA)-conferred susceptibility are observed from birth...
October 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29033770/acinar-cell-cystadenocarcinoma-of-the-pancreas
#17
Keita Aoto, Tatsuo Shimura, Yasuhide Kofunato, Ryo Okada, Rei Yashima, Yuichiro Kiko, Seiichi Takenoshita
Acinar cell cystadenocarcinoma is a rare malignant epithelial neoplasm of the pancreas with a diffusely cystic, gross architecture in which the cysts are lined with neoplastic epithelial cells that demonstrate evidence of pancreatic exocrine enzyme production. This is the 10th case that has been reported in the literature. A 77-year-old male complaining of left hypochondrial pain was referred to our hospital for treatment of a pancreatic tumor. A huge, honeycomb-structured tumor was detected in the pancreatic tail...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28992886/tailored-pancreatic-reconstruction-after-pancreaticoduodenectomy-a-single-center-experience-of-892-cases
#18
Ayman El Nakeeb, Ahmad M Sultan, Ehab Atef, Ali Salem, Mostaffa Abu Zeid, Ahmed Abu El Eneen, Gamal El Ebidy, Mohamed Abdel Wahab
BACKGROUND: Pancreatic reconstruction following pancreaticoduodenectomy (PD) is still debatable even for pancreatic surgeons. Ideally, pancreatic reconstruction after PD should reduce the risk of postoperative pancreatic fistula (POPF) and its severity if developed with preservation of both exocrine and endocrine pancreatic functions. It must be tailored to control the morbidity linked to the type of reconstruction. This study was to show the best type of pancreatic reconstruction according to the characters of pancreatic stump...
October 15, 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28991838/the-relation-between-malnutrition-and-the-exocrine-pancreas-a-systematic-review
#19
Rosalie H Bartels, Deborah A van den Brink, Robert H Bandsma, Michael Boele van Hensbroek, Merit M Tabbers, Wieger P Voskuijl
OBJECTIVE: The relation between malnutrition and exocrine pancreatic insufficiency (EPI) has been described previously, but it is unclear if malnutrition leads to EPI or vice versa. We systematically synthesized current evidence evaluating the association between malnutrition and EPI in children. METHODS: Pubmed, Embase, and Cochrane databases were searched from inception until February 2017. We included cohort or case- controlled studies in children reporting on prevalence or incidence of EPI and malnutrition...
October 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28990381/enucleation-of-non-invasive-tumors-in-the-proximal-pancreas-indications-and-outcomes-compared-with-standard-resections
#20
Wen-Jie Lu, Hao-Lei Cai, Ma-Dong Ye, Yu-Lian Wu, Bin Xu
OBJECTIVE: The aim of this study was to evaluate the safety and efficiency of enucleation (EU) for proximal pancreatic non-invasive neoplasms. METHODS: Patients with solitary non-invasive neoplasms in the proximal pancreas from January 1998 to April 2014 at the Second Affiliated Hospital of Zhejiang University, Hangzhou, China were included. Different operations and outcomes were analyzed. RESULTS: A total of 123 patients were enrolled. Forty patients (32...
2017: Journal of Zhejiang University. Science. B
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