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https://www.readbyqxmd.com/read/29161094/the-effect-of-resistance-training-in-a-hypoxic-chamber-on-physical-performance-in-elite-rugby-athletes
#1
Brad Mayo, Cory Miles, Stacy Sims, Matthew Driller
Mayo, Brad, Cory Miles, Stacy Sims, and Matthew Driller. The effect of resistance training in a hypoxic chamber on physical performance in elite rugby athletes. High Alt Med Biol 00:000-000, 2017.-Limited research suggests that muscle adaptations may be enhanced through resistance training in a hypoxic environment. Seventeen professional rugby union athletes (age [mean ± SD], 24 ± 3 years; body mass, 98.7 ± 12.8 kg; and height, 188.9 ± 7.9 cm), performed 12 resistance training sessions over a 3-week period...
November 21, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29157337/simulated-high-altitude-helium-oxygen-diving
#2
Lu Shi, Yan-Meng Zhang, Katsuura Tetsuo, Zhong-Yuan Shi, Yi-Qun Fang, Petar J Denoble, Yang-Yang Li
BACKGROUND: Experience with commercial heliox diving at high altitude is limited. The purpose of this study was to evaluate the effects of acute high-altitude exposure on fitness to dive and the safety of decompression after heliox diving while using U.S. Navy heliox decompression tables with Cross correction. METHOD: Four professional male divers were consecutively decompressed in a hypo- and hyperbaric chamber to altitudes of 3000 m (9842.5 ft), 4000 m (13,123...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29130497/ubc-nepal-expedition-acclimatization-to-high-altitude-increases-spinal-motoneurone-excitability-during-fatigue-in-humans
#3
Luca Ruggiero, Alexandra F Yacyshyn, Jane Nettleton, Chris J McNeil
The fatigue-induced failure of the motor cortex to drive muscles maximally increases in acute hypoxia (AH) compared to normoxia (N) but improves with acclimatization (chronic hypoxia; CH). Despite their importance to muscle output, it is unknown how locomotor motoneurones in humans are affected by hypoxia and acclimatization. Eleven participants performed 16 min of submaximal (25% maximal torque, MVC) intermittent isometric elbow flexions in N, AH (environmental chamber), and CH (7-14 days at 5050 m) (PI O2 =  140, 74, and 76 mmHg, respectively)...
November 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29125912/an-in-vitro-examination-of-the-effects-of-altitude-on-dry-powder-inhaler-performance
#4
Conor A Ruzycki, Andrew R Martin, Reinhard Vehring, Warren H Finlay
BACKGROUND: The effects of altitude on dry powder inhaler (DPI) performance remain understudied. As existing standardized testing methodologies do not consider altitude, inhalation devices may be used in environments in which their performance has not been sufficiently characterized. METHODS: Six DPIs spanning a range of device resistances were examined in vitro in an environmental chamber mimicking a high-altitude environment equivalent to an altitude of 4200 m, with controls established at an altitude of 700 m...
November 10, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29054452/mechanism-of-aquaporin-4-aqp-4-up-regulation-in-rat-cerebral-edema-under-hypobaric-hypoxia-and-the-preventative-effect-of-puerarin
#5
Chi Wang, Muyang Yan, Hui Jiang, Qi Wang, Shang He, Jingwen Chen, Chengbin Wang
AIM: We aim to investigate the mechanism of aquaporin 4 (AQP 4) up-regulation during high-altitude cerebral edema (HACE) in rats under hypobaric hypoxia and preventative effect of puerarin. METHODS: Rats were exposed to a hypobaric chamber with or without the preventative treatment of puerarin or dexamethasone. Morriz water maze was used to evaluate the spatial memory injury. HE staining and W/D ratio were used to evaluate edema injury. Rat astrocytes and microglia were co-cultured under the condition of hypoxia with the administration of p38 inhibitor, NF-κB inhibitor or puerarin...
October 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/29046183/you-re-the-flight-surgeon
#6
(no author information available yet)
Pelligra S. You're the flight surgeon: decompression illness following altitude chamber exposure. Aerosp Med Hum Perform. 2017; 88(11):1052-1055.
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29030379/right-ventricular-pacing-increases-risk-of-appropriate-implantable-cardioverter-defibrillator-shocks-asymmetrically-an-analysis-of-the-altitude-database
#7
Edmond M Cronin, Paul Jones, Milan C Seth, Niraj Varma
BACKGROUND: Right ventricular pacing (RVP) increases risk of atrial fibrillation in patients with implantable cardioverter-defibrillators (ICDs), but ventricular proarrhythmia is less clear. We analyzed a large remote monitoring database to assess this question. METHODS AND RESULTS: Patients with single- or dual-chamber ICDs, engaged in remote monitoring for at least 6 months and with unchanged tachycardia programming, were included. %RVP was derived for each weekly transmission...
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28923145/pulmonary-effects-from-a-simulated-long-duration-mission-in-a-confined-cockpit
#8
Jeremy Beer, Todd S Dart, Joseph Fischer, James Kisner
INTRODUCTION: A recent U-2 fatigue study, in which 10 subjects completed 2 simulated long-duration missions breathing either 100% oxygen or air in a hypobaric chamber, offered an opportunity to compare subjects' pulmonary function before and after remaining seated in a confined cockpit for 12 h. METHODS: In one U-2 mission configuration, the subject wore a full pressure suit and breathed aviator's breathing oxygen while chamber pressure was maintained at 4572 m (15,000 ft) above mean sea level...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28886787/evaluation-of-intensive-care-unit-ventilators-at-altitude
#9
Thomas Blakeman, Dario Rodriquez, Michael Petro, Richard Branson
INTRODUCTION: Devices may forgo US military air worthiness and safety testing in an attempt to expedite the availability of critical assets such as mechanical ventilators with a waiver for one-time use in extenuating circumstances. METHODS: We evaluated two Intensive Care Unit (ICU) level ventilators: Drager Evita XL and Puritan Bennett (PB) 840 in an altitude chamber at sea level and altitudes of 8,000 and 16,000 feet. RESULTS: Altitude affected delivered tidal volumes (VTs) in volume control mode (VCV) and Pressure Regulated Volume Controlled (PRVC) mode at altitude with the Evita XL but the differences were not considered clinically important with the PB 840...
September 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28885964/cervical-joint-position-sense-in-hypobaric-conditions-a-randomized-double-blind-controlled-trial
#10
Diana Bagaianu, Damien Van Tiggelen, N Duvigneaud, Veerle Stevens, Danny Schroyen, Dirk Vissenaeken, Gino D'Hondt, Laurent Pitance
Well-adapted motor actions require intact and well-integrated information from all of the sensory systems, specifically the visual, vestibular, and somatosensory systems, including proprioception. Proprioception is involved in the sensorimotor control by providing the central nervous system with an updated body schema of the biomechanical and spatial properties of the body parts. With regard to the cervical spine, proprioceptive information from joint and muscle mechanoreceptors is integrated with vestibular and visual feedback to control head position, head orientation, and whole body posture...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28879713/impact-of-moderate-altitude-on-pro-inflammatory-cytokines-in-healthy-volunteers
#11
Christoph Edlinger, Catharina Schreiber, Bjoern Goebel, Rudin Pistulli, Vera Paar, Christiana Schernthaner, Ilonka Rohm, Hans-Reiner Figulla, Uta C Hoppe, Marcus Franz, Christian Jung, Michael Lichtenauer
BACKGROUND: The induction of microvascular inflammation and the effects on cytokine production in blood due to hypoxia has been shown in the past. We have previously reported a statistically significant increase of the pro-inflammatory cytokine interleukin-8 (IL-8) in normobaric hypoxia in the setting of a hypoxia-chamber. In the present study, we sought to analyze plasma levels of inflammatory cytokines in a real-life stetting in order to foster our knowledge on hypoxia induced microvascular inflammation at moderate altitude...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28858246/thirty-minutes-of-hypobaric-hypoxia-provokes-alterations-of-immune-response-haemostasis-and-metabolism-proteins-in-human-serum
#12
Jochen Hinkelbein, Stefanie Jansen, Ivan Iovino, Silvia Kruse, Moritz Meyer, Fabrizio Cirillo, Hendrik Drinhaus, Andreas Hohn, Corinna Klein, Edoardo De Robertis, Dirk Beutner
Hypobaric hypoxia (HH) during airline travel induces several (patho-) physiological reactions in the human body. Whereas severe hypoxia is investigated thoroughly, very little is known about effects of moderate or short-term hypoxia, e.g. during airline flights. The aim of the present study was to analyse changes in serum protein expression and activation of signalling cascades in human volunteers staying for 30 min in a simulated altitude equivalent to airline travel. After approval of the local ethics committee, 10 participants were exposed to moderate hypoxia (simulation of 2400 m or 8000 ft for 30 min) in a hypobaric pressure chamber...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28839003/acute-hypoxia-in-a-simulated-high-altitude-airdrop-scenario-due-to-oxygen-system-failure
#13
William Ottestad, Tor Are Hansen, Gaurav N Pradhan, Jan Stepanek, Lars Øivind Høiseth, Jan Ivar Kåsin
High Altitude High Opening (HAHO) is a military operational procedure in which parachute jumps are performed at high altitude requiring supplemental oxygen, putting personnel at risk of acute hypoxia in the event of oxygen equipment failure. This study was initiated by the Norwegian Army in order to evaluate potential outcomes during failure of oxygen supply, and to explore physiology during acute severe hypobaric hypoxia. A simulated HAHO without supplemental oxygen was carried out in a hypobaric chamber with decompression to 30 000 ft (9144 m) and then recompression to ground level with a descent rate of 1000 ft/min (305 m/min)...
August 24, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28810963/treating-decompression-sickness-military-flight-simulation-site-community-hospital-partnership
#14
Whitney C Rhodes, George Hertner, Robert Price, Lani Finck, Claudia Temmer, Tracy Cushing, Kathleen Flarity
BACKGROUND: High-altitude flight simulation familiarizes military trainees with the symptoms of hypoxia to prepare them for emergency situations. Decompression sickness (DCS) can occur as a result of these simulations. In cases when ground-level supplemental oxygen does not resolve symptoms, hyperbaric oxygen (HBO) therapy is indicated. Many military hyperbaric chambers have been closed because of cost reductions, necessitating partnerships with community hospitals to ensure access to treatment...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28744643/involvement-of-autonomic-nervous-system-in-antiarrhythmic-effect-of-intermittent-hypobaric-hypoxia
#15
N V Naryzhnaya, A V Mukhamedzyanov, T V Lasukova, L N Maslov
We studied the involvement of the autonomic nervous system in the antiarrhythmic effect of intermittent hypobaric hypoxia modeled by daily placing the rats into an altitude chamber at 405 mm Hg (5000 m above sea level). The antiarrhythmic effect of hypoxia was observed on the model of acute coronary occlusion/reperfusion in vivo, but not during simulation of total ischemia/reperfusion of the isolated myocardium. Intravenous injection of ganglionic blocker hexamethonium (30 mg/kg) 15 min prior to in vivo coronary occlusion modeling abolished the antiarrhythmic effect of intermittent hypobaric hypoxia, which suggests that this effect is mediated via activation of the autonomic nervous system...
July 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28730606/technical-note-empirical-altitude-correction-factors-for-well-chamber-measurements-of-permanent-prostate-and-breast-seed-implant-sources
#16
Elizabeth Watt, David P Spencer, Tyler Meyer
PURPOSE: Previous studies in the literature have measured an altitude effect for low-energy brachytherapy seeds; a correction factor applied in addition to PTP to account for the breakdown of Bragg-Gray cavity theory at low energies in well-type ionization chambers. In clinical practice, many centers use altitude correction factors that are not seed-model-specific. The purpose of this work is to present altitude correction factors for several seed models without documented factors in the literature...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/28720186/flight-performance-during-exposure-to-acute-hypobaric-hypoxia
#17
Yuval Steinman, Marieke H A H van den Oord, Monique H W Frings-Dresen, Judith K Sluiter
INTRODUCTION: The purpose of the present study was to examine the influence of hypobaric hypoxia (HH) on a pilot's flight performance during exposure to simulated altitudes of 91, 3048, and 4572 m (300, 10,000, and 15,000 ft) and to monitor the pilot's physiological reactions. METHOD: In a single-blinded counter-balanced design, 12 male pilots were exposed to HH while flying in a flight simulator that had been placed in a hypobaric chamber. Flight performance of the pilots, pilot's alertness level, Spo2, heart rate (HR), minute ventilation (VE), and breathing frequency (BF) were measured...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28705998/is-normobaric-hypoxia-an-effective-treatment-for-sustaining-previously-acquired-altitude-acclimatization
#18
Beth A Beidleman, Charles S Fulco, Bruce S Cadarette, Allen Cymerman, Mark J Buller, Roy M Salgado, Alexander M Posch, Janet E Staab, Ingrid V Sils, Beau R Yurkevicius, Adam J Luippold, Alexander P Welles, Stephen R Muza
This study examined whether normobaric hypoxia (NH) treatment is more efficacious for sustaining high altitude (HA) acclimatization during re-introduction to altitude (RA) than no treatment at all. Seventeen sea level (SL) residents (age=23±6yrs; mean±SE) completed in the following order: 1)4d of SL testing, 2)12d of high altitude (HA) acclimatization at 4300m, 3)12d at SL post HA acclimatization (Post) where each received either NH (n=9;FiO2=0.122) or Sham (n=8;FiO2=0.207) treatment, and 4)24-h re-introduction to 4300m altitude (RA) in a hypobaric chamber...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28689024/a-high-fat-breakfast-attenuates-the-suppression-of-appetite-and-acylated-ghrelin-during-exercise-at-simulated-altitude
#19
Jamie Matu, Kevin Deighton, Theocharis Ispoglou, Oliver M Shannon, Lauren Duckworth
High-altitude exposure induces a negative energy balance by increasing resting energy expenditure and decreasing energy intake. This diminished energy intake is likely caused by altitude-induced anorexia and can have detrimental effects for those travelling to high-altitude. We aimed to investigate whether altering the macronutrient composition of breakfast could attenuate altitude-induced anorexia and augment energy intake at high-altitude. Twelve healthy men (aged 26 (8) years, body mass index 23.9 (2.7) kg·m(-2)) completed two, 305min experimental trials at 4300m simulated altitude (~11...
July 5, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28653390/interventions-for-preventing-high-altitude-illness-part-1-commonly-used-classes-of-drugs
#20
REVIEW
Víctor H Nieto Estrada, Daniel Molano Franco, Roger David Medina, Alejandro G Gonzalez Garay, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez
BACKGROUND: High altitude illness (HAI) is a term used to describe a group of cerebral and pulmonary syndromes that can occur during travel to elevations above 2500 metres (8202 feet). Acute hypoxia, acute mountain sickness (AMS), high altitude cerebral oedema (HACE) and high altitude pulmonary oedema (HAPE) are reported as potential medical problems associated with high altitude. In this review, the first in a series of three about preventive strategies for HAI, we assess the effectiveness of six of the most recommended classes of pharmacological interventions...
June 27, 2017: Cochrane Database of Systematic Reviews
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