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https://www.readbyqxmd.com/read/29454386/telomere-elongation-protects-heart-and-lung-tissue-cells-from-fatal-damage-in-rats-exposed-to-severe-hypoxia
#1
Yaping Wang, Zhen Zhao, Zhiyong Zhu, Pingying Li, Xiaolin Li, Xiaohong Xue, Jie Duo, Yingcai Ma
BACKGROUND: The effects of acute hypoxia at high altitude on the telomere length of the cells in the heart and lung tissues remain unclear. This study aimed to investigate the change in telomere length of rat heart and lung tissue cells in response to acute exposure to severe hypoxia and its role in hypoxia-induced damage to heart and lung tissues. METHODS: Forty male Wistar rats (6-week old) were randomized into control group (n = 10) and hypoxia group (n = 30)...
February 17, 2018: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/29428576/ganglioside-gm1-protects-against-high-altitude-cerebral-edema-in-rats-by-suppressing-the-oxidative-stress-and-inflammatory-response-via-the-pi3k-akt-nrf2-pathway
#2
Gu Gong, Liang Yin, Libang Yuan, Daming Sui, Yangyang Sun, Haiyu Fu, Liang Chen, Xiaowu Wang
High altitude cerebral edema (HACE) is a severe type of acute mountain sickness (AMS) that occurs in response to a high altitude hypobaric hypoxic (HH) environment. GM1 monosialoganglioside can alleviate brain injury under adverse conditions including amyloid-β-peptide, ischemia and trauma. However, its role in HACE-induced brain damage remains poorly elucidated. In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h...
February 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29373484/mechanisms-of-cardiovascular-protection-associated-with-intermittent-hypobaric-hypoxia-exposure-in-a-rat-model-role-of-oxidative-stress
#3
Miguel Aguilar, Alejandro González-Candia, Jorge Rodríguez, Catalina Carrasco-Pozo, Daniel Cañas, Claudio García-Herrera, Emilio A Herrera, Rodrigo L Castillo
More than 140 million people live and works (in a chronic or intermittent form) above 2500 m worldwide and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 55,000 persons work in high altitude shifts, where stays at lowlands and interspersed with working stays at highlands. Acute exposure to high altitude has been shown to induce oxidative stress in healthy human lowlanders, due to an increase in free radical formation and a decrease in antioxidant capacity. However, in animal models, intermittent hypoxia (IH) induce preconditioning, like responses and cardioprotection...
January 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29352676/cardiorespiratory-dynamics-of-rescuers-during-cardiopulmonary-resuscitation-in-a-hypoxic-environment
#4
Tomonobu Sato, Tomonori Takazawa, Masahiro Inoue, Yasunori Tada, Takashi Suto, Masaru Tobe, Shigeru Saito
OBJECTIVE: We had previously experienced a case involving prolonged cardiopulmonary resuscitation (CPR) on Mt. Fuji (3776 m), demanding strenuous work by the rescuers. The objective of this study was to compare the effect of compression-only and conventional CPR on oxygen saturation of rescuers in a hypoxemic environment. METHODS: Changes in percutaneous arterial oxygen saturation (SpO2) and heart rate during CPR action were measured in a hypobaric chamber with barometric pressure adjusted to be equivalent to 3700 m above sea level (630-640 hPa)...
January 8, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29325918/bioactive-fraction-of-rhodiola-algida-against-chronic-hypoxia-induced-pulmonary-arterial-hypertension-and-its-anti-proliferation-mechanism-in-rats
#5
Xingmei Nan, Shanshan Su, Ke Ma, Xiaodong Ma, Ximeng Wang, Dongzhu Zhaxi, Rili Ge, Zhanqiang Li, Dianxiang Lu
BACKGROUND: Rhodiola algida has long been used to prevent acute and chronic altitude sickness. In our previous study, we screened for a bioactive fraction from R. algida. However, the effects and mechanisms of this bioactive fraction on chronic hypoxia-induced pulmonary arterial hypertension remain to be elucidated. OBJECTIVE: The aim of this study was to determine the effect of bioactive fraction from R. algida (ACRT) on chronic hypoxia-induced pulmonary arterial hypertension (HPAH) and to understand the possible mechanism of its pharmacodynamic actions...
January 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29288803/cardioprotection-after-acute-exposure-to-simulated-high-altitude-in-rats-role-of-nitric-oxide
#6
Pablo H La Padula, Melisa Etchegoyen, Analia Czerniczyniec, Barbara Piotrkowski, Silvia Lores Arnaiz, Jose Milei, Lidia E Costa
AIM: In previous studies, upregulation of NOS during acclimatization of rats to sustained hypobaric hypoxia was associated to cardioprotection, evaluated as an increased tolerance of myocardium to hypoxia/reoxygenation. The objective of the present work was to investigate the effect of acute hypobaric hypoxia and the role of endogenous NO concerning cardiac tolerance to hypoxia/reoxygenation under β-adrenergic stimulation. METHODS: Rats were submitted to 58.7 kPa in a hypopressure chamber for 48 h whereas their normoxic controls remained at 101...
December 27, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29161094/the-effect-of-resistance-training-in-a-hypoxic-chamber-on-physical-performance-in-elite-rugby-athletes
#7
Brad Mayo, Cory Miles, Stacy Sims, Matthew Driller
Mayo, Brad, Cory Miles, Stacy Sims, and Matthew Driller. The effect of resistance training in a hypoxic chamber on physical performance in elite rugby athletes. High Alt Med Biol 00:000-000, 2017.-Limited research suggests that muscle adaptations may be enhanced through resistance training in a hypoxic environment. Seventeen professional rugby union athletes (age [mean ± SD], 24 ± 3 years; body mass, 98.7 ± 12.8 kg; and height, 188.9 ± 7.9 cm), performed 12 resistance training sessions over a 3-week period...
November 21, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29157337/simulated-high-altitude-helium-oxygen-diving
#8
Lu Shi, Yan-Meng Zhang, Katsuura Tetsuo, Zhong-Yuan Shi, Yi-Qun Fang, Petar J Denoble, Yang-Yang Li
BACKGROUND: Experience with commercial heliox diving at high altitude is limited. The purpose of this study was to evaluate the effects of acute high-altitude exposure on fitness to dive and the safety of decompression after heliox diving while using U.S. Navy heliox decompression tables with Cross correction. METHOD: Four professional male divers were consecutively decompressed in a hypo- and hyperbaric chamber to altitudes of 3000 m (9842.5 ft), 4000 m (13,123...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29130497/ubc-nepal-expedition-acclimatization-to-high-altitude-increases-spinal-motoneurone-excitability-during-fatigue-in-humans
#9
Luca Ruggiero, Alexandra F Yacyshyn, Jane Nettleton, Chris J McNeil
KEY POINTS: Acute exposure and acclimatization to hypoxia are associated with an impairment and partial recovery, respectively, of the capability of the central nervous system to drive muscles during prolonged efforts. Motoneurones play a vital role in muscle contraction and in fatigue, although the effect of hypoxia on motoneurone excitability during exercise has not been assessed in humans. We studied the impact of fatigue on motoneurone excitability in normoxia, acute and chronic exposure (5050 m) to hypoxia...
November 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29125912/an-in-vitro-examination-of-the-effects-of-altitude-on-dry-powder-inhaler-performance
#10
Conor A Ruzycki, Andrew R Martin, Reinhard Vehring, Warren H Finlay
BACKGROUND: The effects of altitude on dry powder inhaler (DPI) performance remain understudied. As existing standardized testing methodologies do not consider altitude, inhalation devices may be used in environments in which their performance has not been sufficiently characterized. METHODS: Six DPIs spanning a range of device resistances were examined in vitro in an environmental chamber mimicking a high-altitude environment equivalent to an altitude of 4200 m, with controls established at an altitude of 700 m...
November 10, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29054452/mechanism-of-aquaporin-4-aqp-4-up-regulation-in-rat-cerebral-edema-under-hypobaric-hypoxia-and-the-preventative-effect-of-puerarin
#11
Chi Wang, Muyang Yan, Hui Jiang, Qi Wang, Shang He, Jingwen Chen, Chengbin Wang
AIM: We aim to investigate the mechanism of aquaporin 4 (AQP 4) up-regulation during high-altitude cerebral edema (HACE) in rats under hypobaric hypoxia and preventative effect of puerarin. METHODS: Rats were exposed to a hypobaric chamber with or without the preventative treatment of puerarin or dexamethasone. Morriz water maze was used to evaluate the spatial memory injury. HE staining and W/D ratio were used to evaluate edema injury. Rat astrocytes and microglia were co-cultured under the condition of hypoxia with the administration of p38 inhibitor, NF-κB inhibitor or puerarin...
October 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/29046183/you-re-the-flight-surgeon
#12
(no author information available yet)
Pelligra S. You're the flight surgeon: decompression illness following altitude chamber exposure. Aerosp Med Hum Perform. 2017; 88(11):1052-1055.
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29030379/right-ventricular-pacing-increases-risk-of-appropriate-implantable-cardioverter-defibrillator-shocks-asymmetrically-an-analysis-of-the-altitude-database
#13
Edmond M Cronin, Paul Jones, Milan C Seth, Niraj Varma
BACKGROUND: Right ventricular pacing (RVP) increases risk of atrial fibrillation in patients with implantable cardioverter-defibrillators (ICDs), but ventricular proarrhythmia is less clear. We analyzed a large remote monitoring database to assess this question. METHODS AND RESULTS: Patients with single- or dual-chamber ICDs, engaged in remote monitoring for at least 6 months and with unchanged tachycardia programming, were included. %RVP was derived for each weekly transmission...
October 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28923145/pulmonary-effects-from-a-simulated-long-duration-mission-in-a-confined-cockpit
#14
Jeremy Beer, Todd S Dart, Joseph Fischer, James Kisner
INTRODUCTION: A recent U-2 fatigue study, in which 10 subjects completed 2 simulated long-duration missions breathing either 100% oxygen or air in a hypobaric chamber, offered an opportunity to compare subjects' pulmonary function before and after remaining seated in a confined cockpit for 12 h. METHODS: In one U-2 mission configuration, the subject wore a full pressure suit and breathed aviator's breathing oxygen while chamber pressure was maintained at 4572 m (15,000 ft) above mean sea level...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28886787/evaluation-of-intensive-care-unit-ventilators-at-altitude
#15
Thomas Blakeman, Dario Rodriquez, Michael Petro, Richard Branson
INTRODUCTION: Devices may forgo US military air worthiness and safety testing in an attempt to expedite the availability of critical assets such as mechanical ventilators with a waiver for one-time use in extenuating circumstances. METHODS: We evaluated two Intensive Care Unit (ICU) level ventilators: Drager Evita XL and Puritan Bennett (PB) 840 in an altitude chamber at sea level and altitudes of 8,000 and 16,000 feet. RESULTS: Altitude affected delivered tidal volumes (VTs) in volume control mode (VCV) and Pressure Regulated Volume Controlled (PRVC) mode at altitude with the Evita XL but the differences were not considered clinically important with the PB 840...
September 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28885964/cervical-joint-position-sense-in-hypobaric-conditions-a-randomized-double-blind-controlled-trial
#16
Diana Bagaianu, Damien Van Tiggelen, N Duvigneaud, Veerle Stevens, Danny Schroyen, Dirk Vissenaeken, Gino D'Hondt, Laurent Pitance
Well-adapted motor actions require intact and well-integrated information from all of the sensory systems, specifically the visual, vestibular, and somatosensory systems, including proprioception. Proprioception is involved in the sensorimotor control by providing the central nervous system with an updated body schema of the biomechanical and spatial properties of the body parts. With regard to the cervical spine, proprioceptive information from joint and muscle mechanoreceptors is integrated with vestibular and visual feedback to control head position, head orientation, and whole body posture...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28879713/impact-of-moderate-altitude-on-pro-inflammatory-cytokines-in-healthy-volunteers
#17
Christoph Edlinger, Catharina Schreiber, Bjoern Goebel, Rudin Pistulli, Vera Paar, Christiana Schernthaner, Ilonka Rohm, Hans-Reiner Figulla, Uta C Hoppe, Marcus Franz, Christian Jung, Michael Lichtenauer
BACKGROUND: The induction of microvascular inflammation and the effects on cytokine production in blood due to hypoxia has been shown in the past. We have previously reported a statistically significant increase of the pro-inflammatory cytokine interleukin-8 (IL-8) in normobaric hypoxia in the setting of a hypoxia-chamber. In the present study, we sought to analyze plasma levels of inflammatory cytokines in a real-life stetting in order to foster our knowledge on hypoxia induced microvascular inflammation at moderate altitude...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28858246/thirty-minutes-of-hypobaric-hypoxia-provokes-alterations-of-immune-response-haemostasis-and-metabolism-proteins-in-human-serum
#18
Jochen Hinkelbein, Stefanie Jansen, Ivan Iovino, Silvia Kruse, Moritz Meyer, Fabrizio Cirillo, Hendrik Drinhaus, Andreas Hohn, Corinna Klein, Edoardo De Robertis, Dirk Beutner
Hypobaric hypoxia (HH) during airline travel induces several (patho-) physiological reactions in the human body. Whereas severe hypoxia is investigated thoroughly, very little is known about effects of moderate or short-term hypoxia, e.g. during airline flights. The aim of the present study was to analyse changes in serum protein expression and activation of signalling cascades in human volunteers staying for 30 min in a simulated altitude equivalent to airline travel. After approval of the local ethics committee, 10 participants were exposed to moderate hypoxia (simulation of 2400 m or 8000 ft for 30 min) in a hypobaric pressure chamber...
August 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28839003/acute-hypoxia-in-a-simulated-high-altitude-airdrop-scenario-due-to-oxygen-system-failure
#19
William Ottestad, Tor Are Hansen, Gaurav N Pradhan, Jan Stepanek, Lars Øivind Høiseth, Jan Ivar Kåsin
High Altitude High Opening (HAHO) is a military operational procedure in which parachute jumps are performed at high altitude requiring supplemental oxygen, putting personnel at risk of acute hypoxia in the event of oxygen equipment failure. This study was initiated by the Norwegian Army in order to evaluate potential outcomes during failure of oxygen supply, and to explore physiology during acute severe hypobaric hypoxia. A simulated HAHO without supplemental oxygen was carried out in a hypobaric chamber with decompression to 30 000 ft (9144 m) and then recompression to ground level with a descent rate of 1000 ft/min (305 m/min)...
August 24, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28810963/treating-decompression-sickness-military-flight-simulation-site-community-hospital-partnership
#20
Whitney C Rhodes, George Hertner, Robert Price, Lani Finck, Claudia Temmer, Tracy Cushing, Kathleen Flarity
BACKGROUND: High-altitude flight simulation familiarizes military trainees with the symptoms of hypoxia to prepare them for emergency situations. Decompression sickness (DCS) can occur as a result of these simulations. In cases when ground-level supplemental oxygen does not resolve symptoms, hyperbaric oxygen (HBO) therapy is indicated. Many military hyperbaric chambers have been closed because of cost reductions, necessitating partnerships with community hospitals to ensure access to treatment...
July 2017: Military Medicine
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