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Axillary sentinel lymph node biopsy

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https://www.readbyqxmd.com/read/29780827/sentinel-lymph-node-biopsy-in-breast-cancer-patients-by-means-of-indocyanine-green-using-the-karl-storz-vitom%C3%A2-fluorescence-camera
#1
Thomas Papathemelis, Evi Jablonski, Anton Scharl, Tanja Hauzenberger, Michael Gerken, Monika Klinkhammer-Schalke, Matthias Hipp, Sophia Scharl
Currently, the use of radioisotope and blue dye for sentinel lymph node biopsy (SLNB) for axillary staging in breast cancer is common. Recently, indocyanine green (ICG) has been proposed as an alternative sentinel lymph node (SLN) tracking agent. We evaluated the clinical value of ICG as an additional tracer in combination with Technetium99m and as an alternative to Technetium99m for the identification of SLN in 104 breast cancer patients. 21 patients had at least 1 histologically tumor-positive SLN. All 21 patients were detected by ICG; in one of these 21 sentinel-positive patients, Technetium99m was unable to identify lymph node involvement...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29776842/-risk-of-axillary-recurrence-after-sentinel-lymph-node-biopsy-before-neoadjuvant-chemotherapy-in-breast-cancer
#2
A Tardieu, C Mesnard, F Margueritte, J Mollard, A Lacorre, Y Aubard, E Deluche, T Gauthier
OBJECTIVES: In case of large breast cancer, neoadjuvant chemotherapy (NAC) can be performed to reduce the size of the tumor and thus perform a conservative surgery. The place of the sentinel lymph node biopsy (SLNB) in case of NAC is still debated. The main aim of this study is to assess the risk of axillary recurrence after negative SLNB before NAC. METHODS: It is a retrospective, observational and uni-centric study. We included 18 to 80-year-old patients with unilateral breast cancer requiring a NAC and with a negative SLNB before NAC...
May 15, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29770313/management-of-the-axilla-in-metaplastic-breast-carcinoma
#3
Brittany L Murphy, Robert T Fazzio, Tanya L Hoskin, Katrina N Glazebrook, Michael G Keeney, Elizabeth B Habermann, Tina J Hieken
Background: Metaplastic breast cancer (MBC), characterized by admixed epithelial, squamous or mesenchymal elements, constitutes <1% of breast cancers and has a poor prognosis but a paradoxically low reported rate of axillary lymph node (LN) involvement. Due to its rarity, data on appropriate axillary management is lacking, prompting this investigation of LN status and outcomes. Methods: We identified 41 MBC patients treated at our institution 2001-2011 who were followed for a median of 66 months...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29756115/severe-decrease-in-spo-2-and-methemoglobinemia-following-subareolar-isosulfan-blue-administration-and-clinical-relevance
#4
Esra Yüksel, Dilek Duman, Levent Yeniay, Sezgin Ulukaya
The level of axillary lymph node involvement in breast cancer is a critical decision factor for adjuvant therapy and the most important indicator of prognosis and survival. Sentinel lymph node biopsy is a minimally invasive technique with low morbidity in axillary staging of breast cancer. Radiocolloid substances (Technetium-99m) and/or blue dyes such as methylene blue or isosulfan blue are used during sentinel lymph node biopsy. Isosulfan blue stain is frequently used in sentinel lymph node biopsy and rarely causes complications...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29746624/contemporary-evaluation-of-breast-lymph-nodes-in-anatomic-pathology
#5
Beth T Harrison, Jane E Brock
Objectives: Management of the axilla in breast cancer patients has evolved considerably since the introduction of the sentinel lymph node (SLN) biopsy in the 1990s. Several new clinical and technological developments in the last decade warrant special consideration due to their impact on pathology practice. Methods: This review covers the SLN biopsy procedure, issues in the histopathologic and molecular diagnosis of the SLN, and most importantly, evidence from recent practice-changing clinical trials...
May 9, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29730916/-the-influence-of-lumpectomy-on-the-axillary-lymph-node-status-of-breast-cancer-patients
#6
D C Jiao, J J Zhu, J H Qiao, L N Wang, Y Z Ma, Z D Lu, Z Z Liu
Objective: To investigate the influence of lumpectomy on axillary lymph node status of breast cancer patients. Methods: The clinical data of 738 invasive breast cancer patients with non-palpable axillary lymph node and sentinel lymph node (SLN) biopsy from November 2011 to August 2013 in Henan Provincial Cancer Hospital were collected and retrospectively analyzed. Among them, 136 patients underwent preoperative lumpectomy (lumpectomy group) and 602 patients underwent puncture biopsy only (biopsy group). The difference of axillary lymph node status and positive ratio of SLN detected by color Doppler ultrasound were compared between these two groups...
April 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29721480/practical-consensus-recommendations-regarding-the-management-of-sentinel-lymph-node-issues-in-early-breast-cancer
#7
Vedant Kabra, R Aggarwal, S Vardhan, M Singh, R Khandelwal, S Jain, S Sahani, S Saini, N Deo, R Kaul, P M Parikh, S Aggarwal
Axillary lymph node involvement is a very important poor prognostic factor in the clinical staging and management of breast cancer patients. Traditionally, axillary lymph node dissection (ALND) has been used for determining the status of the axillary lymph nodes. More recently the sentinel lymph node biopsy (SLNB) procedure has gained wider acceptance as the standard of care, having the advantage of being less invasivewhile providing good accuracy. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at these practical consensus recommendations in regards with the use of the two different procedures and other issues in patients with early breast cancer for the benefit of community oncologists...
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29719391/combined-use-of-fluorescence-with-a-magnetic-tracer-and-dilution-effect-upon-sentinel-node-localization-in-a-murine-model
#8
Akihiro Kuwahata, Muneer Ahmed, Kohei Saeki, Shinichi Chikaki, Miki Kaneko, Wenqi Qiu, Zonghao Xin, Shinji Yamaguchi, Akiko Kaneko, Michael Douek, Moriaki Kusakabe, Masaki Sekino
Background: Sentinel node biopsy using radioisotope and blue dye remains a gold standard for axillary staging in breast cancer patients with low axillary burden. However, limitations in the use of radioisotopes have resulted in emergence of novel techniques. This is the first in vivo study to assess the feasibility of combining the two most common novel techniques of using a magnetic tracer and indocyanine green (ICG) fluorescence. Materials and methods: A total of 48 mice were divided into eight groups...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29707452/pedicled-descending-branch-latissimus-dorsi-mini-flap-for-repairing-partial-mastectomy-defect-a-new-technique
#9
Ruizhao Cai, Zeming Xie, Lihuan Zhou, Jin Wang, Xing Li, Junhao Huang, Yan Wang, Mingtian Yang, Edward I Chang, Jun Tang
Volume loss is 1 of the major factors influencing cosmetic outcomes of breast after partial mastectomy (PM), especially for smaller breasts, and therefore, volume replacement is critical for optimizing the final aesthetic outcome. We present a novel technique of raising a pedicled descending branch latissimus dorsi (LD) mini-flap for reconstruction of PM defects via an axillary incision. After PM, the LD mini-flap is harvested through the existing axillary incision of the axillary dissection or the sentinel lymph node biopsy...
March 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29705286/preoperative-predictors-of-high-and-low-axillary-nodal-burden-in-z0011-eligible-breast-cancer-patients-with-a-positive-lymph-node-needle-biopsy-result
#10
Geok Hoon Lim, Vidya S Upadhyaya, Hannah Angela Acosta, Jayne Michelley Adolfo Lim, John C Allen, Lester Chee Hao Leong
BACKGROUND: Z0011 trial showed that early breast cancer patients with low axillary nodal burden, may be spared an axillary lymph node dissection with no survival compromise. Axillary lymph node dissection can be reserved for patients with a high axillary nodal burden. We aim to determine the preoperative factors that could distinguish between low and high axillary nodal burden in Z0011 eligible patients with a needle biopsy proven metastatic node. METHOD: Patients who fulfilled Z0011 trial criteria with a positive lymph node needle biopsy and had axillary lymph node dissection (ALND) were recruited...
April 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29696563/a-mathematical-prediction-model-incorporating-molecular-subtype-for-risk-of-non-sentinel-lymph-node-metastasis-in-sentinel-lymph-node-positive-breast-cancer-patients-a-retrospective-analysis-and-nomogram-development
#11
Na-Na Wang, Zheng-Jun Yang, Xue Wang, Li-Xuan Chen, Hong-Meng Zhao, Wen-Feng Cao, Bin Zhang
BACKGROUND: Molecular subtype of breast cancer is associated with sentinel lymph node status. We sought to establish a mathematical prediction model that included breast cancer molecular subtype for risk of positive non-sentinel lymph nodes in breast cancer patients with sentinel lymph node metastasis and further validate the model in a separate validation cohort. METHODS: We reviewed the clinicopathologic data of breast cancer patients with sentinel lymph node metastasis who underwent axillary lymph node dissection between June 16, 2014 and November 16, 2017 at our hospital...
April 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29696472/axillary-lymph-node-evaluation-utilizing-convolutional-neural-networks-using-mri-dataset
#12
Richard Ha, Peter Chang, Jenika Karcich, Simukayi Mutasa, Reza Fardanesh, Ralph T Wynn, Michael Z Liu, Sachin Jambawalikar
The aim of this study is to evaluate the role of convolutional neural network (CNN) in predicting axillary lymph node metastasis, using a breast MRI dataset. An institutional review board (IRB)-approved retrospective review of our database from 1/2013 to 6/2016 identified 275 axillary lymph nodes for this study. Biopsy-proven 133 metastatic axillary lymph nodes and 142 negative control lymph nodes were identified based on benign biopsies (100) and from healthy MRI screening patients (42) with at least 3 years of negative follow-up...
April 25, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29673015/analysis-of-246-sentinel-lymph-node-biopsies-of-patients-with-clinical-primary-breast-cancer-by-application-of-carbon-nanoparticle-suspension
#13
Shi-Xin Yang, Wen-Song Wei, Qi-Hua Jiang, Yu-Feng Zhou, Wei Qu, Jian-Hong Tu, Qian-Wen Ou-Yang, Zhi-Bing Zhou, Hao-Long Ding, Chun-Wei Xie
AIM: This study aims to explore the accuracy, specificity and laws of axillary lymph node metastasis predicted by sentinel lymph node biopsy (SLNB) by comparing axillary lymph node status via SLNB and axillary lymph node dissection (ALND) with nanocarbon as the tracer. METHODS: Forty six patients were retrospectively analyzed. These patients underwent SLNB with nanocarbon as the tracer from March 2013 to April 2014. RESULTS: Two hundred and forty six patients of sentinel lymph node (SLN) were successfully detected...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29670364/-99m-tc-labeled-sodium-phytate-and-stannous-chloride-injection-accurately-detects-sentinel-lymph-node-in-axillary-of-early-stage-breast-cancer-a-randomized-controlled-study
#14
Suisheng Yang, Weiyu Bao, Xiaorong Bai, Chen Gao, Binming Zhang, Zhuanji Jiang
Aim: The aim of this study was to assess the sentinel lymph node (SLN) detection rate and accuracy of 99m Tc-labeled sodium phytate and stannous chloride (99m Tc-PHY) injection versus 99m Tc-labeled sulfur colloid (99m Tc-SC) injection in sentinel lymph node biopsy (SLNB) in patients with early stage breast cancer. Methods: A total of 146 consecutive female patients with early stage breast cancer were recruited in this open-labeled, randomized, controlled study...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29658338/chyle-leak-following-an-axillary-sentinel-lymph-node-biopsy-for-breast-cancer-in-a-patient-with-superior-vena-caval-thrombosis-a-case-report-and-review-of-the-literature
#15
Z Al-Ishaq, S Gupta, M A Collins, T Sircar
Chyle leak is a very rare complication following an axillary lymph node dissection. We report a case of chyle leak following sentinel lymph node biopsy in a patient with breast cancer with superior vena caval thrombosis. To our knowledge, this is the first case report of chyle leakage following axillary sentinel lymph node biopsy. We describe the aetiology, prevention and treatment strategy that can be adopted in these patients.
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29651594/prospective-study-of-shoulder-strength-shoulder-range-of-motion-and-lymphedema-in-breast-cancer-patients-from-pre-surgery-to-5-years-after-alnd-or-slnb
#16
Roser Belmonte, Monique Messaggi-Sartor, Montse Ferrer, Angels Pont, Ferran Escalada
OBJECTIVE: Determine the changes in shoulder strength, shoulder range of motion, and arm volume in breast cancer patients treated with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) METHOD: Sixty-eight SLNB and 44 ALND patients were followed up from pre-surgery to 5 years after surgery. Primary outcomes were the differences between affected and non-affected sides for the following: shoulder strength measured by dynamometry, shoulder range of motion measured by goniometry, and lymphedema measured by volume...
April 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29649327/evaluation-of-intraoperative-touch-imprint-cytology-on-axillary-sentinel-lymph-nodes-in-invasive-breast-carcinomas-a-retrospective-study-of-1227-patients-comparing-sensitivity-in-the-different-tumor-subtypes
#17
Hafsteinn Ingi Pétursson, Anikó Kovács, Jan Mattsson, Roger Olofsson Bagge
BACKGROUND: Intraoperative evaluation of the axillary sentinel lymph node (SLN) in patients with breast carcinoma reduces the need of re-operations in cases where an axillary completion lymph node dissection (CLND) is indicated. Different methods have been used to determine the SLN status intraoperatively, e.g. frozen section histology (FS) and touch imprint cytology (TIC). The sensitivity of intraoperative TIC examination on SLN is not consistent between different studies and varies according to different tumor histologic subtypes, tumor size and the age of the patient...
2018: PloS One
https://www.readbyqxmd.com/read/29605705/nsqip-analysis-of-axillary-lymph-node-dissection-rates-for-breast-cancer-implications-for-resident-and-fellow-participation
#18
Nadia F Nocera, Bryan J Pyfer, Lucy M De La Cruz, Abhishek Chatterjee, Paul T Thiruchelvam, Carla S Fisher
INTRODUCTION: Management of the axilla in invasive breast cancer (IBC) has shifted away from more radical surgery such as axillary lymph node dissection (ALND), towards less invasive procedures, such as sentinel lymph node biopsy. Because of this shift, we hypothesize that there has been a national downward trend in ALND procedures, subsequently impacting surgical trainee exposure to this procedure using the ACS-NSQIP database to evaluate this. METHODS: Women with IBC were identified in the ACS-NSQIP database from 2007 to 2014...
March 28, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29599329/additional-nodal-disease-prediction-in-breast-cancer-with-sentinel-lymph-node-metastasis-based-on-clinicopathological-features
#19
Paolo Orsaria, Emanuele Caredda, Federica Genova, Marco Materazzo, Ilaria Capuano, Gianluca Vanni, Alessandra Vittoria Granai, Adriano DE Majo, Ilaria Portarena, Pierpaolo Sileri, Giuseppe Petrella, Leonardo Palombi, Oreste Claudio Buonomo
AIM: The standard-of-care in breast cancer (BC) with positive sentinel lymph node (SLN) metastasis includes complete axillary lymph node dissection (ALND); however, almost half of such cases have no further tumor burden. This study aimed to assess the clinicopathological factors that predict non-SLN metastasis to define subgroups of SLN-positive patients in whom the axilla may be staged by SLN biopsy alone, while avoiding unnecessary overtreatment. PATIENTS AND METHODS: The records of 191 patients with histologically-proven primary BC who underwent a positive (SLN) biopsy between 2005 and 2017 were reviewed...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29594495/evaluation-of-sentinel-lymph-node-biopsy-prior-to-axillary-lymph-node-dissection-the-role-of-isolated-tumor-cells-micrometastases-and-multifocality-multicentricity-a-retrospective-study-of-1214-breast-cancer-patients
#20
Lars Schröder, Roland Fricker, Roland Gregor Stein, Thomas Rink, Hartmut Fitz, Sebastian Blasius, Achim Wöckel, Thomas Müller
PURPOSE: Sentinel lymph node biopsy (SLNB) alone has thus become an accepted surgical approach for patients with limited axillary metastatic disease. We investigated to what extent isolated tumor cells (ITC) or micrometastasis in SLNBs is associated with proven tumor cells or metastasis in non-sentinel lymph nodes. Furthermore, we investigated the feasibility of SLNB in multifocal and multicentric tumors as both entities have been considered a contraindication for this technique. METHODS: 1214 women suffering from T1 and T2 invasive breast cancer, with clinically and sonographically insuspect axillary status and undergoing primary breast cancer surgery including SLNB and axillary staging in case of SLN (sentinel lymph node) metastases, were recruited into this multicentered study...
March 29, 2018: Archives of Gynecology and Obstetrics
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