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Axillary sentinel lymph node biopsy

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https://www.readbyqxmd.com/read/29352595/axillary-tumour-burden-in-women-with-one-abnormal-node-on-ultrasound-compared-to-women-with-multiple-abnormal-nodes
#1
S Puri, N Sharma, R G Newcombe, M Kaushik, M Al-Attar, S Pascaline, M Hajaj, M G Wallis, B Elsberger, A Goyal
AIM: To determine if the number of abnormal nodes seen on preoperative axillary ultrasound (AUS) is a predictor of the number of positive nodes at histology for women with needle-biopsy-proven positive nodes. MATERIALS AND METHODS: This prospective multicentre cohort study included consecutive patients with early breast cancer who had needle-biopsy-proven positive nodes on AUS and underwent axillary lymph node dissection (ALND) between October 2015 and July 2016...
January 15, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29349757/management-of-the-axilla-in-early-breast-cancer
#2
Monica G Valero, Mehra Golshan
Management of the axilla in early breast cancer patients has significantly evolved in the last several decades. With the arrival of the sentinel lymph node biopsy, surgical practice for axillary staging in patients with early breast cancer has become gradually less invasive and formal axillary lymph node dissection has been confined to selected patients. Over the last two decades, evidence from randomized clinical trials have allowed for the de-escalation of axillary surgery in the management of early stage breast cancer...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29329752/role-of-frozen-section-in-sentinel-lymph-node-biopsy-for-breast-cancer-in-the-era-of-the-acosog-z0011-and-ibcsg-23-10-trials
#3
Augusto Lombardi, Giuseppe Nigri, Stefano Maggi, Gianluca Stanzani, Valeria Vitale, Andrea Vecchione, Alessandro Nania, Claudio Amanti
BACKGROUND: Intraoperative frozen sections (FS) of sentinel lymph nodes (SLN) were evaluated to avoid the need for deferred axillary lymph node dissection (ALND) in patients with early breast cancer (EBC). However, FS has low sensitivity for detecting micro-metastases (<2 mm), resulting in patients who later undergo deferred ALND. The aim of the study was to determine the best clinical approach for selecting patients who would derive real benefit from ALND, as well as to minimize the functional and psychological damage caused by delayed surgery, and the risk of undertreating EBC patients...
January 9, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29289334/does-preoperative-axillary-staging-lead-to-overtreatment-of-women-with-screen-detected-breast-cancer
#4
M G Wallis, F Kilburn-Toppin, S Taylor-Phillips
AIM: To determine the impact of preoperative axillary ultrasound staging in a screen-detected breast cancer population. MATERIALS AND METHODS: Ultrasound and needle biopsy staging results alongside reference standard sentinel lymph node biopsy and axillary lymph node dissection were extracted retrospectively from the unit's computer records between 1 April 2008 and 31 March 2015. Axillary staging was compared with final histopathology and treatment. RESULTS: Of the 215,661 screening examinations performed, 780 invasive cancers were diagnosed, which had preoperative axillary staging data, of which 162 (20...
December 27, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29286917/protein-and-dna-evidences-of-hcmv-infection-in-primary-breast-cancer-tissues-and-metastatic-sentinel-lymph-nodes
#5
Jian Cui, Qian Wang, Hai-Bo Wang, Bin Wang, Ling Li
BACKGROUND AND OBJECTIVE: Breast cancer is the leading cause of death in women worldwide. There are evidences that human cytomegalovirus (HCMV) infection is associated with several malignant tumors. This study aims to investigate the infection of human cytomegalovirus (HCMV) in a large sample of breast cancer patients, and conduct a correlation analysis of clinical and pathological factors, to provide evidence for whether HCMV infection is associated with breast cancer development, progression and metastasis...
December 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29285043/improved-model-for-predicting-axillary-response-to-neoadjuvant-chemotherapy-in-patients-with-clinically-node-positive-breast-cancer
#6
Hyung Suk Kim, Man Sik Shin, Chang Jong Kim, Sun Hyung Yoo, Tae Kyung Yoo, Yong Hwa Eom, Byung Joo Chae, Byung Joo Song
Purpose: Pathological complete response (pCR) of axillary lymph node (LN) is frequently achieved in patients with clinically node-positive breast cancer after neoadjuvant chemotherapy (NAC). Treatment of the axilla after NAC is not well established and the value of sentinel LN biopsy following NAC remains unclear. This study investigated the predictive value of axillary response following NAC and evaluated the predictive value of a model based on axillary response. Methods: Data prospectively collected on 201 patients with clinically node-positive breast cancer who were treated with NAC and underwent axillary LN dissection (ALND) were retrieved...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29279156/the-impact-of-axillary-ultrasound-with-biopsy-in-overtreatment-of-early-breast-cancer
#7
Javier Del Riego, María Jesús Diaz-Ruiz, Milagros Teixidó, Judit Ribé, Mariona Vilagran, Lydia Canales, Melcior Sentís
PURPOSE: (a) To compare the axillary tumor burden detected by fine-needle aspiration cytology (FNAC) versus sentinel lymph node biopsy (SLNB). (b) To evaluate the relationship between axillary tumor burden and the number of suspicious lymph nodes detected by axillary ultrasonography (US). (c) To calculate the false-positive and false-negative rates for FNAC in patients fulfilling ACOSOG Z0011 criteria. METHODS: Retrospective multicenter cross-sectional study of 355 pT1 breast cancers...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29246739/surgical-site-infection-following-lymph-node-excision-indicates-susceptibility-for-lymphedema-a-retrospective-cohort-study-of-malignant-melanoma-patients
#8
Mads Gustaf Jørgensen, Navid Mohamadpour Toyserkani, Jørn Bo Thomsen, Jens Ahm Sørensen
BACKGROUND AND OBJECTIVES: Cancer-related lymphedema is a common complication following lymph node excision. Prevention of lymphedema is essential, as treatment options are limited. Known risk factors are firmly anchored to the cancer treatment itself; however potentially preventable factors such as seroma and surgical-site infection (SSI) have yet to be asserted. METHODS: All malignant melanoma patients treated with sentinel lymph node biopsy (SNB) and/or complete lymph node dissection (CLND) in the axilla or groin between January 2008 and December 2014 were retrospectively identified...
November 28, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29246403/considerations-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-with-biopsy-proven-axillary-disease-prior-to-neoadjuvant-treatment
#9
Linda T Qu, Stephanie Peters, Adrienne N Cobb, Constantine V Godellas, Claudia B Perez, Faaiza T Vaince
BACKGROUND: Axillary disease can be downstaged with neoadjuvant treatment for breast cancer. We attempted to identify factors to consider in determining whether to perform a sentinel lymph node biopsy in patients with biopsy proven axillary metastases (cN+) prior to neoadjuvant treatment. METHODS: A retrospective chart review was conducted on patients at a single tertiary care center who underwent neoadjuvant treatment followed by surgery between 9/2013 and 2/2017...
November 13, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29246402/selective-sentinel-lymph-node-biopsy-in-male-breast-cancer
#10
J J Martin-Marcuartu, R M Alvarez-Perez, J M Sousa Vaquero, J M Jimenez-Hoyuela García
OBJECTIVE: To evaluate the reproducibility of the sentinel lymph node (SLN) technique in male breast cancer. MATERIAL AND METHODS: We retrospectively analysed 21 male patients diagnosed with breast cancer in our hospital from 2008 to 2016 with, at least, 18 months follow-up. Fifteen patients underwent selective sentinel lymph node biopsy (SLNB) following the usual protocols with peritumoral injection of 18.5-111MBq of 99mTc-nanocoloides and acquisition of planar images 2hours after the injection...
December 12, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29235045/axillary-staging-for-breast-cancer-during-pregnancy-feasibility-and-safety-of-sentinel-lymph-node-biopsy
#11
S N Han, F Amant, E H Cardonick, S Loibl, F A Peccatori, O Gheysens, C A Sangalli, V Nekljudova, K Dahl Steffensen, M Mhallem Gziri, C P Schröder, C A R Lok, A Verest, P Neven, A Smeets, G Pruneri, M Cremonesi, O Gentilini
BACKGROUND: Safety of sentinel lymph node (SLN) biopsy for breast cancer during pregnancy is insufficiently explored. We investigated efficacy and local recurrence rate in a large series of pregnant patients. PATIENTS AND METHODS: Women diagnosed with breast cancer who underwent SLN biopsy during pregnancy were identified from the International Network on Cancer, Infertility and Pregnancy, the German Breast Group, and the Cancer and Pregnancy Registry. Chart review was performed to record technique and outcome of SLN biopsy, locoregional and distant recurrence, and survival...
December 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29234253/evaluation-of-sentinel-lymph-node-biopsy-and-axillary-lymph-node-dissection-for-breast-cancer-treatment-concepts-a-retrospective-study-of-1-214-breast-cancer-patients
#12
Roland G Stein, Roland Fricker, Thomas Rink, Hartmut Fitz, Sebastian Blasius, Joachim Diessner, Sebastian F M Häusler, Tanja N Stüber, Victoria Andreas, Achim Wöckel, Thomas Müller
Background: Most breast cancer patients require lumpectomy with axillary sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND). The ACOSOG Z0011-trial failed to detect significant effects of ALND on disease-free and overall survival among patients with limited sentinel lymph node (SLN) metastases. Intense dose-dense chemotherapy and supraclavicular fossa radiation (SFR) are indicated for patients with extensive axillary metastases. In this multicentered study, we investigated the relevance of ALND after positive SLNB to determine adequate adjuvant therapy...
October 2017: Breast Care
https://www.readbyqxmd.com/read/29228459/axillary-reverse-mapping-with-indocyanine-green-or-isosulfan-blue-demonstrate-similar-crossover-rates-to-radiotracer-identified-sentinel-nodes
#13
Deshka Foster, Nicole Choy, Catherine Porter, Shushmita Ahmed, Irene Wapnir
BACKGROUND: Sentinel lymph node (SLN) resection is imperative for breast cancer staging. Axillary reverse mapping (ARM) can preserve arm draining nodes and lymphatics during surgery. ARM is generally performed with isosulfan blue (ISB), restricting its use for concurrent SLN biopsy. Indocyanine green (ICG) could serve as an alternative to ISB for ARM procedures. METHODS: SLN mapping and biopsy was performed via periareolar injection of 99 technetium-sulfur colloid (99m TcSc, TSC)...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29227250/oncoplastic-surgery-of-multicentric-multifocal-breast-cancer-case-report
#14
I Kokhreidze
The multicentric/multifocal form of breast cancer has been considered as relative contraindicationfor breast conserving surgery. According to the results of the studies conducted in the last century, the local recurrence rate of the disease after breast conserving surgeries of multicentric/multifocal breast cancer exceeds 40%. Thus these data were considered as main argument for mastectomy advocates, as non-alternative surgical treatment in these cases. Wide clinical application of oncoplastic surgical techniques gave us possibilities to resolve dilemma: excise tumor - containing quadrant with achieving clear margins and satisfactory cosmetic outcome, without increasing risk of disease-related complications...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29209873/99mtc-rituximab-as-a-tracer-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-a-single-center-analysis
#15
Jiwei Wang, Tie Fan, Yingjian He, Xue Chen, Zhaoqing Fan, Yuntao Xie, Tianfeng Wang, Jinfeng Li, Tao Ouyang
PURPOSE: This study aimed to determine the long-term prognosis of breast cancer patients with 99mTc-rituximab for sentinel lymph node biopsy (SLNB). METHODS: A total of 2947 patients with negative sentinel lymph nodes (SLNs) omitting axillary lymph node dissection (ALND), treated between June 2005 and December 2013, were retrospectively analyzed. SLNB was performed prior to adjuvant therapy. RESULTS: After a median follow-up of 62 months, 22 cases of axillary recurrence (AR) were observed...
December 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29204531/axillary-lymph-node-coverage-with-3-dimensional-tangential-field-irradiation-and-correlation-with-heart-and-lung-dose
#16
Geraldine Jacobson, Nicole Bunda-Randall, Sijin Wen, Matthew Miller
Purpose: The American College of Surgeons Oncology Group Z0011 trial indicated no benefit from axillary lymph node (LN) dissection after a positive sentinel LN biopsy in patients receiving breast irradiation, suggesting that level I-II LNs were covered in tangential fields. Methods and materials: We evaluated 50 computed tomography-based tangential breast plans and contoured level I-III axillary LNs using the Radiation Therapy Oncology Group guidelines. The volumes of level I-III LN regions covered by 90% and 95% of the prescription dose (PD) were calculated and correlated with the V20 ipsilateral lung and mean heart dose...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29201278/axillary-nodal-staging-with-contrast-enhanced-ultrasound
#17
REVIEW
Nisha Sharma, Karina Cox
Purpose of Review: Axillary staging in the context of breast cancer is a contentious topic due to the varied practices across UK, Europe, and America. The ACOSOG Z0011 trial has questioned the role of axillary ultrasound in women with breast cancer. Published data has shown that women with ultrasound-positive lymph nodes have a worse prognosis than those with ultrasound-negative lymph nodes. Axillary ultrasound is limited as the sentinel lymph node (SLN) cannot be identified using B-mode ultrasound; however, with the advent of contrast-enhanced ultrasound (CEUS), this has now changed...
2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/29197044/intraoperative-ultrasound-guided-excision-of-axillary-clip-in-patients-with-node-positive-breast-cancer-treated-with-neoadjuvant-therapy-ilina-trial-a-new-tool-to-guide-the-excision-of-the-clipped-node-after-neoadjuvant-treatment
#18
Christian Siso, Juan de Torres, Antonio Esgueva-Colmenarejo, Martin Espinosa-Bravo, Neus Rus, Octavi Cordoba, Roberto Rodriguez, Vicente Peg, Isabel T Rubio
BACKGROUND: The accuracy of sentinel lymph node biopsy (SLNB) after neoadjuvant therapy (NAT) has been improved with the placement of a clip in the positive node prior to treatment. Several methods have been described for clipped node excision during SLNB after NAT. We assessed the feasibility of intraoperative ultrasound (IOUS)-guided excision of the clipped node during SLNB and investigated whether the accuracy of SLNB is improved. METHODS: After approval by the Institutional Ethics Committee, all breast cancer patients undergoing NAT had an US-visible clip placed in the positive node...
December 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29181071/application-of-artificial-neural-networks-for-predicting-presence-of-non-sentinel-lymph-node-metastases-in-breast-cancer-patients-with-positive-sentinel-lymph-node-biopsies
#19
Tomasz Nowikiewicz, Paweł Wnuk, Bogdan Małkowski, Andrzej Kurylcio, Janusz Kowalewski, Wojciech Zegarski
Introduction: The aim of this study was to present a new predictive tool for non-sentinel lymph node (nSLN) metastases. Material and methods: One thousand five hundred eighty-three patients with early-stage breast cancer were subjected to sentinel lymph node biopsy (SLNB) between 2004 and 2012. Metastatic SLNs were found in 348 patients - the retrospective group. Selective axillary lymph node dissection (ALND) was performed in 94% of cases. Involvement of the nSLNs was identified in 32...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29175020/sentinel-lymph-node-biopsy-validation-for-large-tumors
#20
Gilles Houvenaeghel, Olivia Quilichini, Monique Cohen, Fabien Reyal, Jean-Marc Classe, Chafika Mazouni, Sylvie Giard, Nicolas Carrabin, Hélène Charitansky, Emile Darai, Delphine Hudry, Pierre Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon-DE-Lara, Eric Lambaudie
BACKGROUND: Sentinel lymph node biopsy (SLNB) remains under discussion for large size tumors. The aim of this work has been to study the false negative rate (FNR) of SLNB for large tumors and predictive factors of false negative (FN). MATERIALS AND METHODS: A study of a multicentric cohort, involved patients presenting N0 breast cancer with a SLNB eventually completed by complementary axillary lymph node dissection (cALND). The main criteria were the FNR and the predictive factors of FN...
December 2017: International Journal of Surgery
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