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Axillary sentinel lymph node biopsy

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https://www.readbyqxmd.com/read/27904514/intraoperative-diagnosis-of-sentinel-lymph-node-metastases-in-breast-cancer-treatment-with-one-step-nucleic-acid-amplification-assay-osna
#1
Paweł Szychta, Bogusław Westfal, Rafał Maciejczyk, Beata Smolarz, Hanna Romanowicz, Tomasz Krawczyk, Marek Zadrożny
INTRODUCTION: The aim of the study was to evaluate the clinical usefulness of a one-step nucleic acid amplification assay (OSNA) for intraoperative detection of metastases to sentinel lymph nodes (SLNs) in comparison to examination of frozen sections, and to summarize the results of previous studies. MATERIAL AND METHODS: We enrolled 98 patients aged 58.13 ±10.74 years treated surgically for breast cancer, and 99 biopsies of SLNs were followed by analysis of 105 SLNs...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27900818/healthcare-costs-reduced-after-incorporating-the-results-of-the-american-college-of-surgeons-oncology-group-z0011-trial-into-clinical-practice
#2
Michelle M Fillion, Katherine E Glass, Joe Hayek, Allison Wehr, Gary Phillips, Alicia Terando, Doreen M Agnese
The purpose of our study was to quantitate the changes in axillary lymph node dissection (ALND), frozen section (FS), and the impact on costs after the publication of the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial. We compared axillary nodal management and cost data in breast cancer patients who met Z0011 criteria and were treated with lumpectomy and sentinel lymph nodes (SLN) biopsy from 2007 to July 2013. Of 800 patients, 67 (13.5%) and 34 (12.5%) patients in the pre- and post-Z0011 era had 1-2 positive SLN...
November 30, 2016: Breast Journal
https://www.readbyqxmd.com/read/27896640/role-of-axillary-ultrasound-magnetic-resonance-imaging-and-ultrasound-guided-fine-needle-aspiration-biopsy-in-the-preoperative-triage-of-breast-cancer-patients
#3
I Barco, C Chabrera, A García-Fernández, M Fraile, S González, L Canales, J M Lain, C González, M C Vidal, E Vallejo, J Deu, A Pessarrodona, N Giménez, M García Font
PURPOSE: Roughly two-thirds of early breast cancer cases are associated with negative axillary nodes and do not benefit from axillary surgery at all. Accordingly, there is an ongoing search for non-surgical staging procedures to avoid lymph-node dissection or sentinel node biopsy (SNB). Non-invasive imaging techniques with very high sensitivity (Se) and negative predictive value (NPV) could eventually replace SNB. We aimed to establish the role of axillary US and MRI, alone or in combination, associated with ultrasound-guided fine-needle aspiration biopsy (US-FNAB) in the prediction of axillary node involvement...
November 28, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27889596/using-ultrasound-and-palpation-for-predicting-axillary-lymph-node-status-following-neoadjuvant-chemotherapy-results-from-the-multi-center-sentina-trial
#4
Lukas Schwentner, Gisela Helms, Valentina Nekljudova, Beyhan Ataseven, Ingo Bauerfeind, Nina Ditsch, Tanja Fehm, Barbara Fleige, Maik Hauschild, J Heil, Sherko Kümmel, Anette Lebeau, Sabine Schmatloch, Peter Schrenk, Anette Staebler, Sibylle Loibl, Michael Untch, Gunter Von Minckwitz, Cornelia Liedtke, Thorsten Kühn
BACKGROUND: With the growing importance of neoadjuvant systemic therapy (NST) the assessment of post neoadjuvant axillary status is of increasing importance especially in patients who presented initially with suspicious nodes (cN1). This study aims to investigate the predictive value of palpation and axillary ultrasound of formerly cN1 patients following NST. PATIENTS AND METHODS: The SENTINA trial (SENTinel NeoAdjuvant) is a 4-arm prospective multicenter study designed to evaluate the role of sentinel node biopsy (SLNB) in the context of neoadjuvant systemic treatment (NST) of breast cancer patients...
November 24, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27882235/intraoperative-molecular-analysis-of-sentinel-lymph-nodes-following-neoadjuvant-chemotherapy-in-patients-with-clinical-node-negative-breast-cancer-an-institutional-study
#5
David Parada, Karla B Peña, F Francesc Riu, A Esther Aguilar, Sebastian Cohan
Sentinel lymph node biopsy (SLNB) is an accurate, safe method for determining the axillary lymph node status. However, insufficient evidence exists to support the recommendation of SLNB in patients who have had neoadjuvant chemotherapy (NAC) to downsize tumours and allow for breast conservation surgery. The present study aimed to use molecular approaches to evaluate the feasibility and accuracy of SLNB in patients treated with NAC prior to SLN mapping and surgery. A total of 50 consecutive patients with operable invasive breast carcinomas who had received prior NAC were assessed using the one-step nucleic acid amplification (OSNA) method...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27872527/role-of-axillary-ultrasound-fine-needle-aspiration-cytology-and-sentinel-lymph-node-biopsy-in-clinically-n0-breast-cancer
#6
Gaurav Goel, P D Janaki, N V Smitha, Rajanbabu Anupama, P Shanmugha Sundaram, Y S Nataraj, D K Vijaykumar
This study evaluates the combined role of axillary ultrasound, fine needle aspiration cytology and sentinel lymph node biopsy in clinically N0 axilla. Between January 2014 and June 2015, 150 women with early breast cancer underwent axillary ultrasound as a first investigation for nodal status. Suspicious nodes were subjected to image guided fine needle aspiration cytology. Non-suspicious and fine needle aspiration cytology negative axillary nodes proceeded to sentinel lymph node biopsy at time of primary breast surgery...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27856352/internal-mammary-sentinel-lymph-node-biopsy-in-clinical-practice
#7
EDITORIAL
Mehdi Asadi, David Krag
Almost all recent studies confirmed internal mammary sentinel lymph node biopsy (IM-SLNB) as an accurate and valuable technique to determine stage, prognosis, and best treatment option in breast cancer patients. Decision about local treatment of internal mammary lymph nodes (IMLN) is still being made based on Axillary lymph node (ALN) status. According to study results, there will be patients in positive ALN subgroup who just face complications of an unnecessary radiation to IMLNs and there will be patients in negative ALN subgroup who do not receive adjuvant radiation therapy they really need, if we insist to continue planning IMLN treatment based on ALN status...
November 14, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27856201/daily-practice-management-of-pt1a-b-pn0-breast-carcinoma-a-prospective-french-odissee-cohort-study
#8
Florence Dalenc, Frédérique Penault-Llorca, Monique Cohen, Gilles Houvenaeghel, Jean-Marc Piat, Philippe Liegeois, Laurent Puyuelo, Jean-Philippe Suchaud, Mohammed Zouai, Magali Lacroix-Triki, Nina Radosevic-Robin, Chahinez Benkanoun, Hanane Attar-Rabia, Marie-Pierre Chauvet, Joseph Gligorov, Yazid Belkacemi
BACKGROUND: Most breast cancer (BC) tumors ≤10 mm have an excellent prognosis. The subgroups with a higher risk for distant recurrence requiring adjuvant systemic therapy are not precisely defined in current international guidelines. PATIENTS AND METHODS: The OBSERVATOIRE DES PETITS CANCERS DU SEIN HER2 +/- (ODISSEE) study was a prospective, multicenter, cohort study that aimed to describe the daily adjuvant management and outcome of 616 patients with unifocal, invasive pT1a-b pN0 nonmetastatic BC who underwent surgery...
August 31, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27852049/a-nomogram-to-predict-the-probability-of-axillary-lymph-node-metastasis-in-female-patients-with-breast-cancer-in-china-a-nationwide-multicenter-10-year-epidemiological-study
#9
Jian Zhang, Xiao Li, Rong Huang, Wei-Liang Feng, Ya-Nan Kong, Feng Xu, Lin Zhao, Qing-Kun Song, Jing Li, Bao-Ning Zhang, Jin-Hu Fan, You-Lin Qiao, Xiao-Ming Xie, Shan Zheng, Jian-Jun He, Ke Wang
Axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB) alone may lead to postoperative complications. Among patients with positive ALN in the preoperative examination, approximately 40% patients do not have SLN metastasis. Herein, we aimed to develop a model to predict the probability of ALN metastasis as a preoperative tool to support clinical decision-making. We retrospectively analyzed the clinicopathological features of 4211 female patients with breast cancer who were diagnosed in seven breast cancer centers representing entire China, over 10 years (1999-2008)...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27848050/sentinel-lymph-node-based-management-or-routine-axillary-clearance-five-year-outcomes-of-the-racs-sentinel-node-biopsy-versus-axillary-clearance-snac-1-trial-assessment-and-incidence-of-true-lymphedema
#10
Neil Wetzig, Peter Grantley Gill, David Espinoza, Rebecca Mister, Martin R Stockler, Val J Gebski, Owen A Ung, Ian Campbell, John Simes
PURPOSE: To determine whether the benefits of sentinel-node-based management (SNBM) over routine axillary clearance (RAC) persisted to 5 years. METHODS: A total of 1088 women with breast cancer less than 3 cm in diameter and clinically negative axillary nodes were randomized to SNBM with axillary clearance if the sentinel node was positive or RAC preceded by sentinel-node biopsy. The outcomes were: (1) objectively measured change in the volume of the operated and contralateral nonoperated arms; (2) the proportion with an increase in arm volume <15%; and (3) subjectively assessed arm morbidity for the domains swelling, symptoms, dysfunction, and disability...
November 15, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27842679/routine-use-of-standard-breast-mri-compared-to-axillary-ultrasound-for-differentiating-between-no-limited-and-advanced-axillary-nodal-disease-in-newly-diagnosed-breast-cancer-patients
#11
T J A van Nijnatten, E H Ploumen, R J Schipper, B Goorts, E H Andriessen, S Vanwetswinkel, M Schavemaker, P Nelemans, B de Vries, R G H Beets-Tan, M L Smidt, M B I Lobbes
OBJECTIVES: To compare standard breast MRI to dedicated axillary ultrasound (with or without tissue sampling) for differentiating between no, limited and advanced axillary nodal disease in breast cancer patients. METHODS: All patients who underwent breast MRI and dedicated axillary ultrasound between 2009 and 2014 were eligible. Exclusion criteria were recurrent disease, neoadjuvant systemic therapy and not receiving completion axillary lymph node dissection after positive sentinel lymph node biopsy (SLNB)...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27810698/intraoperative-assessment-of-sentinel-lymph-node-by-one-step-nucleic-acid-amplification-in-breast-cancer-patients-after-neoadjuvant-treatment-reduces-the-need-for-a-second-surgery-for-axillary-lymph-node-dissection
#12
Martin Espinosa-Bravo, Joaquin Navarro-Cecilia, Manuel Ramos Boyero, Sebastian Diaz-Botero, Basilio Dueñas Rodríguez, Carolina Luque López, Teresa Ramos Grande, Ricardo Ruano Perez, Vicente Peg, Isabel T Rubio
PURPOSE: Sentinel lymph node (SLN) biopsy has been shown to be both accurate and feasible for women who receive neoadjuvant chemotherapy (NAC). Intraoperative assessment of SLN by frozen sections can produce false negative results. The aim of this study was to compare two different techniques of intraoperative assessment of SLN in breast cancer patients treated with NAC: frozen section (FS) and molecular assay (OSNA). METHODS: A multicenter cohort of 320 consecutive breast cancer patients treated with NAC between 2010 and 2014 was analyzed...
October 28, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27787592/contribution-of-spect-ct-for-sentinel-node-localization-in-patients-with-ipsilateral-breast-cancer-relapse
#13
Pablo Borrelli, Maarten L Donswijk, Marcel P Stokkel, Suzana C Teixeira, Harm van Tinteren, Emiel J Th Rutgers, Renato A Valdés Olmos
BACKGROUND: In recent years repeat sentinel node (SN) biopsy has been proven to be feasible in local breast cancer recurrence (LBCR). However, in these patients SNs outside the ipsilateral axilla are frequently observed. This study evaluates the contribution of SPECT/CT for SN localization and surgical adjustment in LBCR patients. METHODS: SN biopsy was performed in 122 LBCR patients (median age 60.5 years, range 24-87), enrolled from August 2006 to July 2015. Median disease-free time lapse was 109...
October 27, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27782005/a-handheld-spio-based-sentinel-lymph-node-mapping-device-using-differential-magnetometry
#14
S Waanders, M Visscher, R R Wildeboer, T O B Oderkerk, H J G Krooshoop, B Ten Haken
Sentinel lymph node biopsy has become a staple tool in the diagnosis of breast cancer. By replacing the morbidity-plagued axillary node clearance with removing only those nodes most likely to contain metastases, it has greatly improved the quality of life of many breast cancer patients. However, due to the use of ionizing radiation emitted by the technetium-based tracer material, the current sentinel lymph node biopsy has serious drawbacks. Most urgently, the reliance on radioisotopes limits the application of this procedure to small parts of the developed world, and it imposes restrictions on patient planning and hospital logistics...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27778360/sentinel-lymph-node-biopsy-and-aberrant-lymphatic-drainage-in-recurrent-breast-cancer-findings-likely-to-change-treatment-decisions
#15
Hasan Karanlik, Ilker Ozgur, Berkay Kilic, Alisan Fathalizadeh, Yasemin Sanli, Semen Onder, Pinar Saip, Fatma Sen, Bahadir M Gulluoglu
BACKGROUND AND OBJECTIVES: It is not clear whether sentinel lymph node biopsy (SLNB) can be applied to patients with a second breast cancer or recurrence occurring at previously treated breast. The purpose of this study was to assess the feasibility of SLNB procedure in patients with recurrent breast cancer. METHODS: Patients with non-metastatic recurrent N0 breast cancer at ipsilateral breast were included. Patients were grouped according to their initial breast, axilla, and overall surgery...
October 25, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27773373/is-sentinel-lymph-node-biopsy-indicated-in-patients-with-a-diagnosis-of-ductal-carcinoma-in%C3%A2-situ-a-systematic-literature-review-and-meta-analysis
#16
Hiba El Hage Chehade, Hannah Headon, Umar Wazir, Houssam Abtar, Abdul Kasem, Kefah Mokbel
BACKGROUND: Recent discussion has suggested that some cases of ductal carcinoma in situ (DCIS) with high risk of invasive disease may require sentinel lymph node biopsy (SLNB). METHODS: Systematic literature review identified 48 studies (9,803 DCIS patients who underwent SLNB). Separate analyses for patients diagnosed preoperatively by core sampling and patients diagnosed postoperatively by specimen pathology were conducted to determine the percentage of patients with axillary nodal involvement...
September 6, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27769634/upper-outer-boundaries-of-the-axillary-dissection-result-of-the-sentibras-protocol-multicentric-protocol-using-axillary-reverse-mapping-in-breast-cancer-patients-requiring-axillary-dissection
#17
C Nos, K B Clough, P Bonnier, S Lasry, G Le Bouedec, B Flipo, J-M Classe, M-C Missana, V Doridot, S Giard, H Charitansky, A Charles-Nelson, A-S Bats, C Ngo
BACKGROUND: Two thirds of node-positive breast cancer patients have limited pN1 disease and could benefit from a less extensive axillary lymph node dissection (ALND). METHODS: 172 breast cancers patients requiring an ALND were prospectively enrolled in the Sentibras Protocol of Axillary Reverse Mapping (ARM). Radioisotope was injected in the ipsilateral hand the day before surgery. ALND was standard. Removed lymph nodes were classified into non radioactive nodes and radioactive nodes (ARM nodes)...
August 26, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27756234/sentinel-lymph-node-biopsy-after-neoadjuvant-chemotherapy-for-breast-cancer-retrospective-comparative-evaluation-of-clinically-axillary-lymph-node-positive-and-negative-patients-including-those-with-axillary-lymph-node-metastases-confirmed-by-fine-needle-aspiration
#18
Yue Yu, Ning Cui, Heng-Yu Li, Yan-Mei Wu, Lu Xu, Min Fang, Yuan Sheng
BACKGROUND: To evaluate the accuracy of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) in breast cancer patients with axillary lymph node (ALN) metastasis. METHODS: A total of 122 patients with operable breast cancer were enrolled in this single-center retrospective study. Eighty patients were clinically diagnosed with a positive axillary lymph node (ALN) via imaging or physical examination (including 66 patients with biopsy-proven metastasis)...
October 18, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27756051/preparation-of-99m-tc-isosulfan-blue-for-lymph-node-localization-in-rats-99m-tc-isosulfan-blue-for-lymph-node-localization
#19
Derya İlem-Özdemir, Ulkem Yararbas, Baha Zengel, Gökhan Ertan, Makbule Asikoglu
The sentinel lymph node (SLN) is defined as the first regional lymph node to receive lymphatic drainage from a malignant tumor. Therefore, this node is a "sentinel" for second metastatic lymph node stations and for labeling regional tumor spread. For SLN detection, many surgeons preferred a combination of a preoperative injection of radiolabeled colloid and the intraoperative injection of blue dye. Under this combination protocol, nodes are considered to be "sentinel nodes" if they are radioactive and blue...
October 11, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27738336/axillary-and-internal-mammary-sentinel-lymph-node-biopsy-in-breast-cancer-after-neoadjuvant-chemotherapy
#20
Xiao-Shan Cao, Hui-Juan Li, Bin-Bin Cong, Xiao Sun, Peng-Fei Qiu, Yan-Bing Liu, Chun-Jian Wang, Yong-Sheng Wang
With the improvement of neoadjuvant chemotherapy (NAC), the proportion of pathological complete response (pCR) in the breast and axillary lymph node (ALN) is increasing. The evaluation of pCR does not include the status of internal mammary lymph node (IMLN). This study is to evaluate the roles of both axillary sentinel lymph node biopsy (ASLNB) and internal mammary sentinel lymph node biopsy (IM-SLNB) in breast cancer patients after NAC. There were 74 patients enrolled into this study. IM-SLNB was performed on patients with radioactive internal mammary sentinel lymph node (IM-SLN)...
October 12, 2016: Oncotarget
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