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14-3-3 protein

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https://www.readbyqxmd.com/read/28749249/an-autopsy-verified-case-of-steroid-responsive-encephalopathy-with-convulsion-and-a-false-positive-result-from-the-real-time-quaking-induced-conversion-assay
#1
Yuichi Hayashi, Yasushi Iwasaki, Nobuaki Yoshikura, Takahiko Asano, Maya Mimuro, Akio Kimura, Katsuya Satoh, Tetsuyuki Kitamoto, Mari Yoshida, Takashi Inuzuka
We report an autopsy-verified case of steroid-responsive encephalopathy with convulsion and a false-positive result from the real-time quaking-induced conversion (RT-QUIC) assay. A 61-year-old Japanese man presented with acute onset of consciousness disturbance, and convulsions, but without a past medical or family history of progressive dementia, epilepsy, or prion disease. Brain diffusion and fluid-attenuated inverted recovery MR images revealed edematous cortical hyper-intensity, which diminished after the acute phase...
July 27, 2017: Prion
https://www.readbyqxmd.com/read/28749191/disease-related-autoantibody-profile-in-patients-with-systemic-sclerosis
#2
Christos Liaskos, Emmanouela Marou, Theodora Simopoulou, Maria Barmakoudi, Georgios Efthymiou, Thomas Scheper, Wolfgang Meyer, Dimitrios P Bogdanos, Lazaros I Sakkas
BACKGROUND: Autoantibodies (autoAbs) help in diagnosis and predicting clinical phenotypes in systemic sclerosis (SSc). AIM OF THE STUDY: To determine the clinical utility of 13 SSc-related autoAbs in SSc patients. MATERIAL AND METHODS: A total of 131 consecutive patients with SSc (111 female, mean age 58.1 ± 14 years; 49 with diffused cutaneous SSc [dcSSc] and 82 with limited cutaneous SSc [lcSSc]) were analysed by a multiplex line immunoassay (Euroimmun) for autoantibodies (autoAbs) against 13 SSc-related antigens...
July 27, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28748853/pingyangmycin-pretreatment-influences-the-biological-behavior-of-ocular-venous-malformation-and-relates-with-galectin-3-expression
#3
Jin Li, Jun-Bo Qiao, Qiu-Yu Liu
BACKGROUND: Galectin-3 (Gal-3) plays a role in the mechanisms underlying ocular venous malformation. We conducted this study to investigate the effect of pingyangmycin pretreatment on the Gal-3 expressions and biological behavior of ocular venous malformation. METHODS: Tissue samples were collected from 136 patients with ocular venous malformation. Patients were randomly divided into pingyangmycin (n = 69) and nonpingyangmycin group (n = 67). Patients in the pingyangmycin group received a local injection of 0...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28747409/spot-urine-protein-measurements-in-normotensive-pregnancies-pregnancies-with-isolated-proteinuria-and-preeclampsia
#4
Andrea Kattah, Natasa Milic, Wendy M White, Vesna D Garovic
We performed a prospective, longitudinal study of pregnant women presenting to their first obstetrics visits to characterize the changes in spot urine protein-to-creatinine (UPCR) and albumin-to-creatinine ratios (UACR) in normotensive pregnancies, as well as identify clinical characteristics associated with isolated proteinuria and preeclampsia. We measured spot urinary albumin, protein, and creatinine at the first prenatal visit, end of the second trimester, and at delivery. In normotensive pregnancy (n=142), we found that from the beginning of pregnancy to delivery, UACR increased by a median (interquartile range (IQR)) of 14...
July 26, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28747251/serca-control-of-cell-death-and-survival
#5
REVIEW
Elie R Chemaly, Luca Troncone, Djamel Lebeche
Intracellular calcium (Ca(2+)) is a critical coordinator of various aspects of cellular physiology. It is increasingly apparent that changes in cellular Ca(2+) dynamics contribute to the regulation of normal and pathological signal transduction that controls cell growth and survival. Aberrant perturbations in Ca(2+) homeostasis have been implicated in a range of pathological conditions, such as cardiovascular diseases, diabetes, tumorigenesis and steatosis hepatitis. Intracellular Ca(2+) concentrations are therefore tightly regulated by a number of Ca(2+) handling enzymes, proteins, channels and transporters located in the plasma membrane and in Ca(2+) storage organelles, which work in concert to fine tune a temporally and spatially precise Ca(2+) signal...
July 12, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28747201/intravenous-superoxide-dismutase-as-a-protective-agent-to-prevent-impairment-of-lung-function-induced-by-high-tidal-volume-ventilation
#6
Nan-Chun Wu, Fan-Ting Liao, Hao-Min Cheng, Shih-Hsien Sung, Yu-Chun Yang, Jiun-Jr Wang
BACKGROUND: Positive-pressure mechanical ventilation is essential in assisting patients with respiratory failure in the intensive care unit and facilitating oxygenation in the operating room. However, it was also recognized as a primary factor leading to hospital-acquired pulmonary dysfunction, in which pulmonary oxidative stress and lung inflammation had been known to play important roles. Cu/Zn superoxide dismutase (SOD) is an important antioxidant, and possesses anti-inflammatory capacity...
July 26, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28747155/indole-3-acetic-acid-indoxyl-sulfate-and-paracresyl-sulfate-do-not-influence-anemia-parameters-in-hemodialysis-patients
#7
Stanislas Bataille, Marion Pelletier, Marion Sallée, Yvon Berland, Nathalie McKay, Ariane Duval, Stéphanie Gentile, Yosra Mouelhi, Philippe Brunet, Stéphane Burtey
BACKGROUND: The main reason for anemia in renal failure patients is the insufficient erythropoietin production by the kidneys. Beside erythropoietin deficiency, in vitro studies have incriminated uremic toxins in the pathophysiology of anemia but clinical data are sparse. In order to assess if indole 3-acetic acid (IAA), indoxyl sulfate (IS), and paracresyl sulfate (PCS) -three protein bound uremic toxins- are clinically implicated in end-stage renal disease anemia we studied the correlation between IAA, IS and PCS plasmatic concentrations with hemoglobin and Erythropoietin Stimulating Agents (ESA) use in hemodialysis patients...
July 26, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28746924/cyclin-dependent-kinase-inhibitor-p21waf1-cip1-facilitates-the-development-of-cardiac-hypertrophy
#8
Yang-Fei Tong, Yan Wang, Yuan-Yuan Ding, Jing-Mei Li, Xi-Chun Pan, Xiao-Lan Lu, Xiao-Hong Chen, Ya Liu, Hai-Gang Zhang
BACKGROUND/AIMS: Adult cardiomyocytes can re-enter cell cycle as stimulated by prohypertrophic factors although they withdraw from cell cycle soon after birth. p21WAF1/CIP1, a cyclin-dependent kinase inhibitor, has been implicated in cardiac hypertrophy, however, its precise contribution to this process remains largely unclear. METHODS: The gene expression profile in left ventricle (LV) of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was determined using quantitative PCR array and verified by real-time PCR and Western blotting...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28745975/identification-of-chemical-compounds-that-inhibit-the-function-of-histidyl-trna-synthetase-from-pseudomonas-aeruginosa
#9
Yanmei Hu, Stephanie O Palmer, Sara T Robles, Tahyra Resto, Frank B Dean, James M Bullard
Pseudomonas aeruginosa histidyl-tRNA synthetase (HisRS) was selected as a target for antibiotic drug development. The HisRS protein was overexpressed in Escherichia coli and kinetically evaluated. The KM values for interaction of HisRS with its three substrates, histidine, ATP, and tRNA(His), were 37.6, 298.5, and 1.5 μM, while the turnover numbers were 8.32, 16.8, and 0.57 s(-1), respectively. A robust screening assay was developed, and 800 natural products and 890 synthetic compounds were screened for inhibition of activity...
July 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28745693/-efficiency-of-different-celecoxib-regimens-in-patients-with-active-axial-spondyloarthritis-results-of-the-4-week-pilot-open-label-comparative-single-center-study-aim
#10
I Z Gaydukova, К A Gamayunova, K D Dorogoykina, A P Rebrov
AIM: To compare the efficiency and safety of two celecoxib regimens in the short-term treatment of patients with axial spondyloarthritis (axSpA). SUBJECTS AND METHODS: Examinations were made in 40 patients with axSpA (the 2009 ASAS criteria; age, 38.5±12.1 years; 29 (72.5%) men; axSpA duration, 6.67±5.8 years; BASDAI ≥4.0), who were randomly divided into two groups: 1) 20 patients who received celecoxib 400 mg/day for 30 days; 2) 20 patients who took celecoxib 600 mg/day for 7 days, then the drug was continued at a dose of 200 mg/day for 1 month...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28745688/-risk-factors-for-anemia-in-the-early-stages-of-chronic-kidney-disease
#11
Yu S Milovanov, L V Kozlovskaya, L Yu Milovanova, M M Markina, V V Kozlov, M V Taranova, V V Fomin
AIM: To identify the early markers of anemia in chronic kidney disease (CKD) in patients with chronic glomerulonephritis (CGN) and glomerulonephritis (GN) in systemic diseases. SUBJECTS AND METHODS: Seventy-nine patients with some male preponderance who were aged 21 to 65 years (45.3±11.1 years) and had CKD (CGN and GN) in systemic diseases (systemic lupus erythematosus and Wegener's granulomatosis) in the early stages (Stages I-II) of CKD were examined. GN was diagnosed by a lifetime renal biopsy...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28745630/subpial-adeno-associated-virus-9-aav9-vector-delivery-in-adult-mice
#12
Takahiro Tadokoro, Atsushi Miyanohara, Michael Navarro, Kota Kamizato, Stefan Juhas, Jana Juhasova, Silvia Marsala, Oleksandr Platoshyn, Erik Curtis, Brandon Gabel, Joseph Ciacci, Nada Lukacova, Katarina Bimbova, Martin Marsala
The successful development of a subpial adeno-associated virus 9 (AAV9) vector delivery technique in adult rats and pigs has been reported on previously. Using subpially-placed polyethylene catheters (PE-10 or PE-5) for AAV9 delivery, potent transgene expression through the spinal parenchyma (white and gray matter) in subpially-injected spinal segments has been demonstrated. Because of the wide range of transgenic mouse models of neurodegenerative diseases, there is a strong desire for the development of a potent central nervous system (CNS)-targeted vector delivery technique in adult mice...
July 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28745364/expediting-dynamics-approach-to-understand-the-influence-of-14-3-3%C3%AE-causing-metastatic-cancer-through-the-interaction-of-yap1-and-%C3%AE-trcp
#13
Kamalesh D, Sriroopreddy Ramireddy, Raguraman P, Sudandiradoss C
The 14-3-3ζ protein acts as a molecular switch in regulating the TGF-β pathway, which alters from a tumor suppressor in the early stage of breast cancer to a promoter of metastasis in the late stage. This change is due to the binding of 14-3-3ζ with YAP1 and β-TRCP in premalignant and cancer cells, respectively. Owing to this inappropriate role of 14-3-3ζ when involved in cancer and metastasis, we predicted that Gln15, Glu17, Tyr211, and Gln219 are hotspot residues of 14-3-3ζ during its interaction with YAP1 protein...
July 26, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28745354/soybean-isoflavones-ameliorate-ischemic-cardiomyopathy-by-activating-nrf2-mediated-antioxidant-responses
#14
Yang Li, Haiyan Zhang
Ischemic cardiomyopathy (IC) is the major cause of heart failure. Conventional medicine has been proved ineffective with adverse effects. Soybean presents exciting adjunctive therapies and shows protective benefits for IC. However, the molecular mechanisms remain unclear. Isoflavones are the main bioactive components of soybean and may be protective against heart disease. Isoflavones were extracted by using an acidic-ethanol method and analyzed by HPLC. All patients with ischemic stroke were randomly and evenly assigned to two groups: the isoflavone group (80 mg day(-1), n = 100) and control group (80 mg day(-1) placebo, n = 100), and the whole period of the experiment was 24 weeks...
July 26, 2017: Food & Function
https://www.readbyqxmd.com/read/28745316/elevation-of-adenylate-energy-charge-by-angiopoietin-like-4-enhances-epithelial-mesenchymal-transition-by-inducing-14-3-3%C3%AE-expression
#15
Z Teo, M K Sng, J S K Chan, M M K Lim, Y Li, L Li, T Phua, J Y H Lee, Z W Tan, P Zhu, N S Tan
Metastatic cancer cells acquire energy-intensive processes including increased invasiveness and chemoresistance. However, how the energy demand is met and the molecular drivers that coordinate an increase in cellular metabolic activity to drive epithelial-mesenchymal transition (EMT), the first step of metastasis, remain unclear. Using different in vitro and in vivo EMT models with clinical patient's samples, we showed that EMT is an energy-demanding process fueled by glucose metabolism-derived adenosine triphosphate (ATP)...
July 24, 2017: Oncogene
https://www.readbyqxmd.com/read/28745050/fibronectin-conformation-and-assembly-analysis-of-fibronectin-deletion-mutants-and-fibronectin-glomerulopathy-gfnd-mutants
#16
Tomoo Ohashi, Christopher Lemmon, Harold P Erickson
To study fibronectin (FN) conformation and assembly, we generated several deletion mutants: FNΔ(I)1-5, FNΔ(III)1-3, FNΔ(III)4-8 and FNΔ(III)11-14. A monomeric form, FNmono, which lacked the C-terminal dimerization region, was also created. FNtnA-D was generated by swapping FNIII domains 1-8 in FNΔ(III)11-14 with seven FNIII domains from tenascin-C. The conformations of these mutants were analyzed by glycerol gradient sedimentation in low salt (20 mM NaCl) and high salt (200 mM NaCl). Surprisingly, most of the mutants showed a compact conformation in low salt, except for FNtnA-D...
July 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28743834/mid-arm-muscle-circumference-as-a-substantial-factor-against-mortality-among-people-with-elevated-gamma-gaps
#17
Yuan-Ping Chao, Yi-Fen Lai, Tung-Wei Kao, Tao-Chun Peng, Yuan-Yung Lin, Mu-Tsun Shih, Wei-Liang Chen, Li-Wei Wu
Gamma gap is the difference in total serum proteins and albumin and an elevated gamma gap is related to infections, malignancy, and rheumatic diseases. An elevated gamma gap is also associated with higher mortality due to the correlation with inflammatory status. The study aimed to utilize mid-arm muscle circumference (MAMC) to assist in predicting all-cause mortality, cancer mortality, and cardiovascular mortality in people with elevated gamma gaps. Data were obtained from the third U.S. National Health and Nutrition Examination Survey (1988-1994), which contained 14,011 adults aged 20 to 90 years during up to 14...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28743636/valproate-increases-dopamine-transporter-expression-through-histone-acetylation-and-enhanced-promoter-binding-of-nurr1
#18
Ashley L Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L Guo, Jason R Richardson
The dopamine transporter (DAT) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. Previously, we identified a prominent role for histone deacetylases in the regulation of DAT expression. Here, we utilized a rat dopaminergic cell line (N27) to probe the responsiveness of DAT mRNA expression to inhibitors of histone acetylation. Inhibition of histone deacetylases (HDACs) by valproate, butyrate and Trichostatin A led to a 3-10-fold increase in DAT mRNA expression, a 50% increase in protein levels, which were accompanied by increased H3 acetylation levels...
July 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28743625/a-single-wap-domain-containing-protein-from-litopenaeus-vannamei-possesses-antiproteinase-activity-against-subtilisin-and-antimicrobial-activity-against-ahpnd-inducing-vibrio-parahaemolyticus
#19
Suwattana Visetnan, Premruethai Supungul, Anchalee Tassanakajon, Suchao Donpudsa, Vichien Rimphanitchayakit
The single WAP domain-containing protein (SWD) is a type III crustin antimicrobial peptide whose function is to defense the host animal against the bacterial infection by means of antimicrobial and antiproteinase activities. A study of SWD from Litopenaeus vannamei (LvSWD) is reported herein about its activities and function against bacteria, particularly the AHPND-inducing Vibrio parahaemolyticus (VPAHPND) that causes acute hepatopancreatic necrosis disease (AHPND). The LvSWD is mainly synthesized in hemocytes and up-regulated in response to VPAHPND infection...
July 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28743337/-effect-of-multidrug-resistant-associated-protein-4-overexpression-on-lipopolysaccharide-induced-vascular-endothelial-hyperpermeability-and-its-mechanism
#20
Wenfang Xia, Huanming Zhang, Yanlei Zheng, Qingshan Zhou, Bin Su
OBJECTIVE: To investigate the effect of multidrug resistance protein 4 (MRP4) overexpression on lipopolysaccharide (LPS)-induced vascular endothelial hyperpermeability of rat pulmonary micro-vascular endothelial cells (PMVECs) and its molecule mechanism. METHODS: Three to six passages of PMVECs were cultured in vitro, and they were divided into three groups: the cells in LPS group were only challenged by LPS 10 μg/mL after being cultured in serum-free medium for 24 hours; the cells in Ad-shRNA and Ad-MRP4 groups were infected with the empty virus control or recombinant adenovirus expressing MRP4 for 2 hours, and then were cultured in serum-free medium for 24 hours followed by stimulation of LPS 10 μg/mL...
July 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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