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https://www.readbyqxmd.com/read/29788790/eeg-differences-in-two-clinically-similar-rapid-dementias-voltage-gated-potassium-channel-complex-associated-autoimmune-encephalitis-and-creutzfeldt-jakob-disease
#1
Brin Freund, John C Probasco, Mackenzie C Cervenka, Raoul Sutter, Peter W Kaplan
Distinguishing treatable causes for rapidly progressive dementia from those that are incurable is vital. Creutzfeldt-Jakob disease (CJD) and voltage-gated potassium channel complex-associated autoimmune encephalitis (VGKC AE) are 2 such conditions with disparate outcomes and response to treatment. To determine the differences in electroencephalography between CJD and VGKC AE, we performed a retrospective review of medical records and examined clinical data, neuroimaging, and electroencephalographs performed in patients admitted for evaluation for rapidly progressive dementia diagnosed with CJD and VGKC AE at the Johns Hopkins Hospital and Bayview Medical Center between January 1, 2007 and December 31, 2015...
May 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29784830/structural-basis-of-o-glcnac-recognition-by-mammalian-14-3-3-proteins
#2
Clifford A Toleman, Maria A Schumacher, Seok-Ho Yu, Wenjie Zeng, Nathan J Cox, Timothy J Smith, Erik J Soderblom, Amberlyn M Wands, Jennifer J Kohler, Michael Boyce
O-GlcNAc is an intracellular posttranslational modification that governs myriad cell biological processes and is dysregulated in human diseases. Despite this broad pathophysiological significance, the biochemical effects of most O-GlcNAcylation events remain uncharacterized. One prevalent hypothesis is that O-GlcNAc moieties may be recognized by "reader" proteins to effect downstream signaling. However, no general O-GlcNAc readers have been identified, leaving a considerable gap in the field. To elucidate O-GlcNAc signaling mechanisms, we devised a biochemical screen for candidate O-GlcNAc reader proteins...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29782177/synthesis-of-%C3%AE-%C3%AE-difluorinated-phosphonate-pser-pthr-mimetics-via-rhodium-catalyzed-asymmetric-hydrogenation-of-%C3%AE-difluorophosphonomethyl-%C3%AE-acylamino-acrylates
#3
Hong-Xue Chen, Jie Kang, Rong Chang, Yun-Lai Zhang, Hua-Zhen Duan, Yan-Mei Li, Yong-Xiang Chen
A novel and facile synthetic strategy for α,α-difluorinated phosphonate mimetics of phosphoserine/phosphothreonine utilizing rhodium-catalyzed asymmetric hydrogenation was developed. The dehydrogenated substrate β-difluorophosphonomethyl α-(acylamino)acrylates were first prepared from protected serine/threonine followed by asymmetric hydrogenation using the rhodium-DuPhos catalytic system to generate the chiral center(s). These important phosphonate building blocks were successfully incorporated into phosphatase-resistant peptides, which displayed similar inhibition to the 14-3-3 ζ protein as the parent pSer/pThr peptides...
May 21, 2018: Organic Letters
https://www.readbyqxmd.com/read/29777688/proteomic-changes-during-adult-stage-in-pre-optic-hypothalamus-hippocampus-and-pituitary-regions-of-female-rat-brain-following-neonatal-exposure-to-estradiol-17%C3%AE
#4
Vijayakumar Govindaraj, Radhika Nagamangalam Shridharan, Addicam Jagannadha Rao
Although neonatal exposure to estrogen or estrogenic compounds results in irreversible changes in the brain function and reproductive abnormalities during adulthood but the underlying mechanisms are still largely unknown. The present study has attempted to compare the protein profiles of sexually dimorphic brain regions of adult female rats which were exposed to estradiol- 17β during neonatal period. The total proteins extracted from pre-optic area (POA), hypothalamus, hippocampus and pituitary of control and neonatally E2 treated female rats was subjected to 2D-SDS-PAGE and differentially expressed proteins were identification by MALDI TOF/TOF-MS...
May 16, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29773844/identification-of-differentially-accumulated-proteins-involved-in-regulating-independent-and-combined-osmosis-and-cadmium-stress-response-in-brachypodium-seedling-roots
#5
Ziyan Chen, Dong Zhu, Jisu Wu, Zhiwei Cheng, Xing Yan, Xiong Deng, Yueming Yan
In this study, we aimed to identify differentially accumulated proteins (DAPs) involved in PEG mock osmotic stress, cadmium (Cd2+ ) stress, and their combined stress responses in Brachypodium distachyon seedling roots. The results showed that combined PEG and Cd2+ stresses had more significant effects on Brachypodium seedling root growth, physiological traits, and ultrastructures when compared with each individual stress. Totally, 106 DAPs were identified that are responsive to individual and combined stresses in roots...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772231/roles-of-14-3-3%C3%AE-and-%C3%AE-in-regulation-of-the-glucocorticoid-receptor-transcriptional-activation-and-hepatic-gluconeogenesis
#6
Yunhee Hwang, Hyoung-Tae An, Minsoo Kang, Jesang Ko
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that mediates the effects of glucocorticoids, and plays a crucial role in cell growth, development, inflammation, and gluconeogenesis. The 14-3-3 proteins bind to target proteins via phosphorylation, and influence many cellular events by altering their subcellular localization or by acting as chaperones. However, the mechanisms by which 14-3-3 proteins regulate GR transactivation and their involvement in gluconeogenesis remain uncharacterized...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29771335/loss-of-fragile-x-protein-fmrp-impairs-homeostatic-synaptic-downscaling-through-tumor-suppressor-p53-and-ubiquitin-e3-ligase-nedd4-2
#7
Kwan Young Lee, Kathryn A Jewett, Hee Jung Chung, Nien-Pei Tsai
Synaptic scaling allows neurons to homeostatically readjust synaptic strength upon chronic neural activity perturbations. Although altered synaptic scaling has been implicated to underlie imbalanced brain excitability in neurological disorders such as autism spectrum disorders and epilepsy, the molecular dysregulation and restoration of synaptic scaling in those diseases have not been demonstrated. Here, we showed that the homeostatic synaptic downscaling is absent in the hippocampal neurons of Fmr1 KO mice, the mouse model of the most common inherited autism, Fragile X Syndrome (FXS)...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29766773/effects-of-a-structured-physical-activity-program-on-habitual-physical-activity-and-body-composition-in-patients-with-chronic-kidney-disease-and-in-kidney-transplant-recipients
#8
Anna Masajtis-Zagajewska, Katarzyna Muras, Michał Nowicki
OBJECTIVES: In this study, we compared the effects of an individualized physical activity program on lifestyle, metabolic profile, body composition, and quality of life in kidney transplant recipients and patients with chronic kidney disease. MATERIALS AND METHODS: Our study included 24 kidney transplant recipients and 15 patients with chronic kidney disease at stage 3/4. Body composition (impedance spectroscopy) and habitual physical activity (accelerometry) assessed at baseline were used to prepare the individualized physical activity program...
May 16, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29760697/hookworm-secreted-extracellular-vesicles-interact-with-host-cells-and-prevent-inducible-colitis-in-mice
#9
Ramon M Eichenberger, Stephanie Ryan, Linda Jones, Geraldine Buitrago, Ramona Polster, Marcela Montes de Oca, Jennifer Zuvelek, Paul R Giacomin, Lindsay A Dent, Christian R Engwerda, Matthew A Field, Javier Sotillo, Alex Loukas
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm to their hosts, allowing them to establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, hookworms are such potent suppressors of inflammation that they have been used in clinical trials to treat inflammatory bowel diseases (IBD) and celiac disease. Since the recent description of helminths (worms) secreting extracellular vesicles (EVs), exosome-like EVs from different helminths have been characterized and their salient roles in parasite-host interactions have been highlighted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755395/early-onset-creutzfeldt-jakob-disease-mimicking-immune-mediated-encephalitis
#10
Wietse A Wiels, Stephanie Du Four, Laura Seynaeve, Anja Flamez, Thomas Tousseyn, Dietmar Thal, Miguel D'Haeseleer
Objectives: The objective of this study is to explore the clinical, radiological, and pathological manifestations of a rare subtype of prion disease and their implication for differential diagnosis in case of an early onset neuropsychiatric deterioration. Methods: We discuss a patients' clinical history, as well as the string of investigations and symptomatological evolution that finally led to a pathological diagnosis. Results: Our patient had the extremely rare VV1 type sporadic Creutzfeldt-Jakob disease (sCJD)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29754899/dynamic-fluctuations-in-subcellular-localization-of-the-hippo-pathway-effector-yorkie-in-vivo
#11
Samuel A Manning, Lucas G Dent, Shu Kondo, Ziqing W Zhao, Nicolas Plachta, Kieran F Harvey
The Hippo pathway is an evolutionarily conserved signaling network that integrates diverse cues to control organ size and cell fate. The central downstream pathway protein in Drosophila is the transcriptional co-activator Yorkie (YAP and TAZ in humans), which regulates gene expression with the Scalloped/TEA domain family member (TEAD) transcription factors [1-8]. A central regulatory step in the Hippo pathway is phosphorylation of Yorkie by the NDR family kinase Warts, which promotes Yorkie cytoplasmic localization by stimulating association with 14-3-3 proteins [9-12]...
April 24, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29734943/low-mood-visual-hallucinations-and-falls-heralding-the-onset-of-rapidly-progressive-probable-sporadic-creutzfeldt-jakob-disease-in-a-73-year-old-a-case-report
#12
Daniel Martin Klotz, Rose Sarah Penfold
BACKGROUND: Creutzfeldt-Jakob disease is a rare and rapidly fatal neurodegenerative disease. Since clinicians may see only very few cases during their professional career, it is important to be familiar with the clinical presentation and progression, to perform appropriate investigations, and allow for quick diagnosis. CASE PRESENTATION: A 73-year-old British Caucasian woman presented with acute confusion of 2 weeks' duration on a background of low mood following a recent bereavement...
May 8, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29731901/tetrandrine-suppresses-adhesion-migration-and-invasion-of-human-colon-cancer-sw620-cells-via-inhibition-of-nuclear-factor-%C3%AE%C2%BAb-matrix-metalloproteinase-2-and-matrix-metalloproteinase-9-signaling-pathways
#13
Ta-Kuo Juan, Kuo-Ching Liu, Chao-Lin Kuo, Mei-Due Yang, Yung-Lin Chu, Jiun-Long Yang, Ping-Ping Wu, Yi-Ping Huang, Kuang-Chi Lai, Jing-Gung Chung
Tetrandrine (TET) exhibits biological activities, including anticancer activity. In Chinese medicine, TET has been used to treat hypertensive and arrhythmic conditions and has been demonstrated to induce cytotoxic effects on human cancer cell lines. However, to the best of the author's knowledge, no previous studies have revealed that TET affects cell metastasis in SW620 human colon cancer cells. The present study demonstrated that TET decreased the cell number and inhibited cell adhesion and mobility of SW620 cells...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29729850/distinct-changes-in-the-proteome-profile-of-endometrial-tissues-in-polycystic-ovary-syndrome-compared-with-healthy-fertile-women
#14
Fatemehsadat Amjadi, Mehdi Mehdizadeh, Mahnaz Ashrafi, Davood Nasrabadi, Sara Taleahmad, Mehdi Mirzaei, Vivek Gupta, Ghasem Hosseini Salekdeh, Reza Aflatoonian
RESEARCH QUESTION: What is the molecular basis of infertility related to uterine dysfunction in women with polycystic ovary syndrome (PCOS)? DESIGN: In this study, differences in protein expression between PCOS and normal endometrium were identified using a proteomic approach based on two-dimensional electrophoresis (2-DE) coupled with mass spectrometry (MS). The proteome of endometrium were analysed during the proliferative (on day 2 or 3 before ovulation, n = 6) and luteal phases (on day 3-5 after ovulation, n = 6) from healthy women and PCOS patients (12-14 days after spontaneous bleeding, n = 12)...
April 21, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29722962/inhibition-of-14-3-3-tau-by-hybrid-small-molecule-peptides-operating-via-two-different-binding-modes
#15
Sebastian Alexandru Andrei, Femke Meijer, Joao Neves, Luc Brunsveld, Isabelle Landrieu, Christian Ottmann, Lech-Gustav Milroy
Current molecular hypotheses have yet to deliver marketable treatments for Alzheimer's disease (AD), arguably due to a lack of basic knowledge of AD biology, and an overreliance on conventional drug modalities. Protein-protein interactions (PPIs) are emerging drug targets, which show promise for the treatment of e.g. cancer, but are still underexploited for treating neurodegenerative diseases. 14-3-3 binding to phosphorylated Tau is a promising PPI drug target based on its reported destabilizing effect on microtubules, leading to enhanced neurofibrillary tangle formation as a potential cause of AD-related neurodegeneration...
May 3, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29713601/a-novel-b-and-helper-t-cell-epitopes-based-prophylactic-vaccine-against-echinococcus-granulosus
#16
Mohammad M Pourseif, Gholamali Moghaddam, Hossein Daghighkia, Ahmad Nematollahi, Yadollah Omidi
Introduction: In this study, we targeted the worm stage of Echinococcus granulosus to design a novel multi-epitope B- and helper T-cell based vaccine construct for immunization of dogs against this multi-host parasite. Methods: The vaccine was designed based on the local Eg14-3-3 antigen (Ag). DNA samples were extracted from the protoscoleces of the infected sheep's liver, and then subjected to the polymerase chain reaction (PCR) with 14-3-3 specific forward and reverse primers. For the vaccine designing, several in silico steps were undertaken...
2018: BioImpacts: BI
https://www.readbyqxmd.com/read/29710713/rapidly-progressive-alzheimer-s-disease-contributions-to-clinical-pathological-definition-and-diagnosis
#17
Samir Abu-Rumeileh, Sabina Capellari, Piero Parchi
Rapidly progressive Alzheimer's disease (rpAD) has recently been recognized as a clinical disease subtype characterized by rapidly progressive cognitive decline and/or short disease duration, and the possible occurrence of early focal neurological signs. Consistently, rpAD represents a relatively frequent alternative diagnosis among cases referred as possible or probable Creutzfeldt-Jakob disease (CJD) to surveillance centers for prion disease worldwide. Indeed, the early clinical differential diagnosis between the two disorders can be challenging given the partial overlap in clinical features and cerebrospinal fluid (CSF) levels of the protein surrogate markers 14-3-3 and total-tau...
April 25, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29703169/case-series-of-creutzfeldt-jakob-disease-in-a-third-level-hospital-in-quito
#18
Germaine Eleanor Torres Herrán, Andrés Damián Ortega Herrera, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos, Edgar Patricio Correa Díaz
BACKGROUND: Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder that affects mammals and humans. The prevalence of this disease in the United States is 0.5 to 1 per million inhabitants. So far in Ecuador, we do not know what the prevalence or incidence is, and only one case report has been written. CASE PRESENTATION: We present a case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito. The average age of symptom onset in our patients was 58...
April 27, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29698910/tomato-plants-ectopically-expressing-arabidopsis-grf9-show-enhanced-resistance-to-phosphate-deficiency-and-improved-fruit-production-in-the-field
#19
Lili Zhang, Guangjie Li, Yilin Li, Ju Min, Herbert J Kronzucker, Weiming Shi
Agronomic performance of transgenic tomato overexpressing functional genes has rarely been investigated in the field. In an attempt to improve low-phosphate (P) stress tolerance of tomato (Solanum lycopersicum) plants and promote tomato fruit production in the field, an expression vector containing cDNA to an Arabidopsis 14-3-3 protein, General Regulatory Factor 9 (GRF9), driven by a cauliflower mosaic virus 35S promoter, was transferred into tomato plants. Transgenic expression of GRF9 was ascertained by quantitative real-time PCR analysis...
April 17, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29689550/hidradenitis-suppurativa-associated-with-down-syndrome-is-characterized-by-early-age-at-diagnosis
#20
Giulia Giovanardi, Andrea Chiricozzi, Luca Bianchi, Clara De Simone, Valentina Dini, Chiara Franceschini, Simone Garcovich, Teresa Oranges, Cosimo Di Raimondo, Dante Raffaele Caposiena Caro, Marco Romanelli, Ketty Peris
BACKGROUND/AIMS: The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features. METHODS: We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. RESULTS: A total of 257 HS patients were enrolled, 62% females and 38% males (mean age [±SD]: 23...
April 24, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
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