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Claudio Bazzi, Tomoko Usui, Virginia Rizza, Daniela Casellato, Maurizio Gallieni, Masaomi Nangaku
BACKGROUND: The clinical course of idiopathic membranous nephropathy (IMN) varies from spontaneous remission of nephrotic syndrome (NS) to end-stage renal disease (ESRD). Selecting patients with high risk of progression for immunosuppressive therapy is mandatory. METHODS: 86 IMN subjects were followed for median of 69 months (range 6-253). Receiver operating characteristic curve and Cox proportional hazards model were used to evaluate prognostic factors for progression, defined as ESRD or eGFR reduction ≥50% of baseline...
October 20, 2016: Nephrology
Ana Vrdoljak, Vanja Ivković, Sandra Karanović, Živka Dika, Ivana Vuković, Jelena Kos, Mario Laganović, Tajana Željković Vrkić, Margareta Fištrek Prlić, Ivan Pećin, Bojan Jelaković
OBJECTIVE: It was observed that glomerular hyperfiltration (GHF) is associated with progression of kidney disease in diabetics, patients in stage 1 hypertension (HT), and we found previously that eGFR decreased faster also in prehypertensives (PHT) with GHF. Here we analyzed whether GHF in PHT is associated with other biomarkers of early renal impairment. DESIGN AND METHOD: From 954 subjects enrolled in ENAH follow-up study, 371(137 m;mean age = 46years) were eligible for further analysis:100 with optimal,72 with normal BP,70 with PHT(high normal BP),and 129 with newly diagnosed untreated HT...
September 2016: Journal of Hypertension
Dileep Nag Vinnakota, Krishna Chaitanya Kanneganti, Mahesh Pulagam, Gopala Krishna Keerthi
PURPOSE: To hypothesize a new theory based on soft tissue reference points on lateral profile photographs (LPPs) for determining the vertical dimension of occlusion (VDO), as there is need to explore for simple strategies. MATERIALS AND METHODS: Fifty-three participants in the age range of 20-27 years who met the inclusion criteria were recruited. LPPs were taken for all participants using standard protocol and duplicate copies obtained, on which five soft tissue reference points, nasion (Stn), subnasale (Stsn), porion (Stp), gnathion (Stgn), and gonion (Stg) (Stg prenoted on the face) were marked and joined to form angles; distance between Stsn and Stgn was considered as VDO in LPP (VDO-LP)...
October 2016: Journal of Indian Prosthodontic Society
Shrestha Priyadarsini, Tina B McKay, Akhee Sarker-Nag, Jeremy Allegood, Charles Chalfant, Jian-Xing Ma, Dimitrios Karamichos
Prolonged hyperglycemia during diabetes mellitus can cause severe ophthalmic complications affecting both the anterior and posterior ocular segments leading to impaired vision or blindness. Diabetes-induced corneal pathologies are associated with decreased wound healing capacity, corneal edema, and altered epithelial basement membrane. The mechanism by which diabetes modulates structure and function within the corneal stroma are unknown. In our study, we characterized the effects of diabetes on extracellular matrix, lipid transport, and cellular metabolism by defining the entire metabolome and lipidome of Type 1 and Type 2 human diabetic corneal stroma...
October 11, 2016: Experimental Eye Research
Puebla Cassini-Vieira, Mariane Felipetto, Leandro Barbosa Prado, Thiago Verano-Braga, Silvia Passos Andrade, Robson A S Santos, Mauro Martins Teixeira, Maria Elena de Lima, Adriano M C Pimenta, Luciola Silva Barcelos
We have previously described a 25mer anti-hypertensive peptide, previously named TsHpt-I (Tityus serrulatus Hypotensin-I), now Ts14, as an agonist of B2 kinin receptor. Bradykinin is known to play physiological roles in angiogenic, inflammatory, and fibrogenic processes, mostly mediated by B2 receptor. Therefore, we investigated whether Ts14 could modulate key events (neovascularization, inflammatory cell recruitment, and extracellular matrix deposition) of the fibrovascular tissue, induced by polyether-polyurethane sponge implants in mice...
October 9, 2016: Peptides
Atul Goel, Vijay Kumar, Yasmin Hemberger, Fateh V Singh, Pankaj Nag, Michael Knauer, Ruchir Kant, Resmi Raghunandan, Prakas Ranjan Maulik, Gerhard Bringmann
Sterically hindered naphthalene-substituted biphenyls and terphenyls were synthesized in good yields, by Michael addition of a conjugate base of core-substituted phenylacetones to substituted 2-oxo-2H-pyran-3-carbonitriles at room temperature under alkaline conditions. These diversely functionalized benzenes (1,2-teraryls or 1,3-teraryls), bearing naphthyl and substituted aryl rings, show the phenomenon of atropisomerism, with one or two stereogenic biaryl axes. The resolution of the respective four atropisomers of the naphthalene-substituted biphenyls and terphenyls bearing 1,2-type or 1,3-type chiral biaryl axes was achieved by HPLC on a chiral phase...
October 12, 2016: Journal of Organic Chemistry
Vijaya Lakshmi Nag, Manodeep Sen, Nihar Ranjan Dash, R Bansal, Manoj Kumar, Anand Kumar Maurya
There are few reports of "microfilaria in the urine." We report an elderly woman with gross hematuria who was being investigated for urinary tract tuberculosis. Three consecutive urine samples showed microfilaria of Wuchereria bancrofti. However, she did not have chyluria. Treatment with diethylcarbamazine cleared up the hematuria within 3 days. Chyluria, hematuria, and hematochyluria are problems of Bancroftian filariasis reported worldwide. The literature review was made to present a simplified way for management...
July 2016: Tropical Parasitology
Hassan Norouzi-Arasi, Amlan K Pal, Samik Nag, Daniel Chartrand, Garry S Hanan
Facial Ru(ii)- and Re(i)-complexes of a novel face-capping tris(pyridyl)truxene ligand were synthesised and characterised by various analytical techniques including single crystal XRD. The Ru(ii) complex exhibits unusual green phosphorescence with a long excited-state lifetime.
October 6, 2016: Chemical Communications: Chem Comm
Min Soo Jung, Jae Yoon Kim, Hyun Seung Lee, Chul Gab Lee, Han Soo Song
BACKGROUND: To identify adverse renal effects due to air pollution derived from a cement plant in Korea. Urinary n-acetyl-B-glucosaminidase (U-NAG) levels in residents living near a cement plant were compared to those in a group who lived farther away from the plant. METHODS: From June to August 2013 and from August to November 2014, laboratory tests for U-NAG and heavy metal were conducted on 547 study participants. Based on the level of air pollution exposure, subjects were divided into the "less exposed group," (LEG) which consisted of 66 persons who lived more than 5 km away from the cement plant, the "more exposed group from the rural area" (MEG-R), which consisted of 272 persons, and the "more exposed group from downtown area" (MEG-D), which consisted of 209 persons who lived within a 1 km radius of the cement plant...
2016: Annals of Occupational and Environmental Medicine
Ki-Hyung Kim, Seong-Hwan Park, Kee Hun Do, Juil Kim, Kyung Un Choi, Yuseok Moon
Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy in developed countries. Chronic endogenous sterile pro-inflammatory responses are strongly linked to EOC progression and chemoresistance to anti-cancer therapeutics. In the present study, the activity of epithelial NF-κB, a key pro-inflammatory transcription factor, was enhanced with the progress of EOC. This result was mechanistically linked with an increased expression of NSAID-Activated Gene 1 (NAG-1) in MyD88-positive type I EOC stem-like cells, compared with that in MyD88-negative type II EOC cells...
September 30, 2016: Oncotarget
Ana-Paula-Rodrigues Magalhães, Francine-Couto-Lima Moreira, Denise-Ramos-Silveira Alves, Cyntia-Rodrigues-Araújo Estrela, Carlos Estrela, Marcus-Santos Carrião, Andris-Figueiroa Bakuzis, Lawrence-Gonzaga Lopes
BACKGROUND: Silver has a long history of use in medicine as an antimicrobial and anti-inflammatory agent. Silver nanoparticles (NAg) offer the possibility to control the formation oral biofilms through the use of nanoparticles with biocidal, anti-adhesive, and delivery abilities. This study aims to evaluate the antibacterial effect of resin luting cements with and without NAg, and their influence on color, sorption and solubility. MATERIAL AND METHODS: NAg were incorporated to two dual-cured resin cements (RelyX ARC (RA) color A1 and RelyX U200 (RU) color A2) in two concentrations (0...
October 2016: Journal of Clinical and Experimental Dentistry
Suryanarayan Biswal, Debashree Das, Kalpana Barhwal, Ashish Kumar, Tapas Chandra Nag, Mahendra Kumar Thakur, Sunil Kumar Hota, Bhuvnesh Kumar
Exposure to global hypoxia and ischemia has been reported to cause neurodegeneration in the hippocampus with CA3 neurons. This neuronal damage is progressive during the initial phase of exposure but maintains a plateau on prolonged exposure. The present study on Sprague Dawley rats aimed at understanding the underlying molecular and epigenetic mechanisms that lead to hypoxic adaptation of CA3 neurons on prolonged exposure to a global hypoxia. Our results show stagnancy in neurodegeneration in CA3 region beyond 14 days of chronic exposure to hypobaria simulating an altitude of 25,000 ft...
October 3, 2016: Molecular Neurobiology
Milagro Fernández-Delgado, Jackeline Cortez, Guiden Sulbarán, César Matos, Renzo Nino Incani, Diana E Ballén, Italo M Cesari
Schistosoma mansoni enzymes play important roles in host-parasite interactions and are potential targets for immunological and/or pharmacological attack. The aim of this study was to comparatively assess the presence of hydrolytic activities (phosphatases, glycosidases, aminopeptidases) in soluble (SF) and membrane (MF) fractions from different S. mansoni developmental stages (schistosomula 0 and 3h, juveniles, and adult worms of 28 and 45days-old, respectively), by using simple enzyme-substrate microassays...
September 28, 2016: Parasitology International
Somnath Mazumder, Rudranil De, Souvik Sarkar, Asim Azhar Siddiqui, Shubhra Jyoti Saha, Chinmoy Banerjee, Mohd Shameel Iqbal, Shiladitya Nag, Subhashis Debsharma, Uday Bandyopadhyay
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat multiple inflammatory diseases and pain but severe gastric mucosal damage is the worst outcome of NSAID-therapy. Here we report that mitoTEMPO, a mitochondrially targeted superoxide (O2(-)) scavenger protected as well as healed gastric injury induced by diclofenac (DCF), the most commonly used NSAID. Common existing therapy against gastric injury involves suppression of gastric acid secretion by proton pump inhibitors and histamine H2 receptor antagonists; however, dyspepsia, vitamin B12 deficiency and gastric microfloral dysbalance are the major drawbacks of acid suppression...
September 28, 2016: Biochemical Pharmacology
Elzbieta Zieminska, Jacek Lenart, Jerzy W Lazarewicz
A presynaptic protein SNAP-25 belonging to SNARE complex which is instrumental in intracellular vesicular trafficking and exocytosis, has been implicated in hyperactivity and cognitive abilities in some neuropsychiatric disorders. The unclear etiology of the behavior disrupting neurodevelopmental disabilities in addition to genetic causes most likely involves environmental factors. The aim of this in vitro study was to test if various suspected developmental neurotoxins can alter SNAP-25 mRNA and protein expression in neurons...
September 28, 2016: Toxicology
Ashima Dua, Swati Joshi, T Satyanarayana
Chitinase from the thermophilic mould Myceliopthora thermophila BJA (MtChit) is an acid tolerant, thermostable and organic solvent stable biocatalyst which does not require any metal ions for its activity. In order to produce high enzyme titres, reduce fermentation time and overcome the need for induction, this enzyme has been heterologously expressed under GAP promoter in the GRAS yeast, Pichia pastoris. The production medium supplemented with the permeabilizing agent Tween-20 supported 2-fold higher rMtChit production (5...
September 30, 2016: Biotechnology Progress
Alexander R Opotowsky, Fernando R Baraona, Finnian R Mc Causland, Brittani Loukas, Elizabeth Landzberg, Michael J Landzberg, Venkata Sabbisetti, Sushrut S Waikar
OBJECTIVES: To define whether adults with a Fontan circulation, who have lifelong venous congestion and limited cardiac output, have impaired glomerular filtration rate (GFR) or elevated urinary biomarkers of kidney injury. METHODS: We measured circulating cystatin C and creatinine (n=70) and urinary creatinine, albumin, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL) and N-acetyl glucosaminidase (NAG) (n=59) in ambulatory adult Fontan patients and 20 age-matched and sex-matched controls...
September 26, 2016: Heart: Official Journal of the British Cardiac Society
Emil Gatchev, Natalia Petkova, Manfred Braeter, Christian de Mey
BACKGROUND: Propiverine hydrochloride (P4) is an antimuscarinic drug used in overactive bladder syndrome. METHODS: Two studies were performed: one in 24 patients with open-angle glaucoma (OAG) treated with topical β-blockers, one in 24 patients with narrow-angle glaucoma (NAG) treated with pilocarpine ± topical β-blockers. Patients were treated in randomized, placebo-controlled, double-blind parallel-group fashion (15 : 9 attribution to P4 vs. placebo (PL))...
September 26, 2016: International Journal of Clinical Pharmacology and Therapeutics
Gheorghe Gluhovschi, Florica Gadalean, Cristina Gluhovschi, Silvia Velciov, Ligia Petrica, Flaviu Bob, Gheorghe Bozdog, Adriana Kaycsa
The solitary kidney (SK) undergoes adaptive phenomena of hyperfunction and hyperfiltration. These secondary adaptive phenomena can make it more vulnerable to potentially nephrotoxic therapies. Adverse reactions of the kidneys to ciprofloxacin are rare, but sometimes severe. Therefore, our study sought to assess the reactions to ciprofloxacin of patients with solitary kidney (SK) and urinary tract infection (UTI) by means of urinary biomarkers. We studied 19 patients with SK and urinary tract infection (UTI) who had been administered a 7-day treatment with intravenous ciprofloxacin...
September 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ritu Karwasra, Prerna Kalra, T C Nag, Y K Gupta, Surender Singh, Anuj Panwar
Cisplatin (Cis-diaminedichloroplatinum II) is a chemotherapeutic agent having well documented adverse effect as nephrotoxicity. This study was designed to evaluate the nephroprotective role of Boerhaavia diffusa in cisplatin-induced acute kidney injury. Wistar rats (n = 6) were allocated into six groups constituting normal control, cisplatin-induced, Boerhaavia diffusa root extract in doses 50, 100 and 200 mg/kg and Boerhaavia diffusa per se group, administered orally for a period of ten days. Intraperitoneal injection of cisplatin was administered on day 7, to all groups except normal control and Boerhaavia diffusa per se group...
September 22, 2016: Regulatory Toxicology and Pharmacology: RTP
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