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https://www.readbyqxmd.com/read/29232710/stabilizing-patterns-in-time-neural-network-approach
#1
Nadav Ben-Shushan, Misha Tsodyks
Recurrent and feedback networks are capable of holding dynamic memories. Nonetheless, training a network for that task is challenging. In order to do so, one should face non-linear propagation of errors in the system. Small deviations from the desired dynamics due to error or inherent noise might have a dramatic effect in the future. A method to cope with these difficulties is thus needed. In this work we focus on recurrent networks with linear activation functions and binary output unit. We characterize its ability to reproduce a temporal sequence of actions over its output unit...
December 12, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29232688/genotype-and-cell-specific-dynamics-of-tandem-repeat-patterns-in-aegilops-speltoides-tausch-poaceae-triticeae
#2
Olga Raskina
In wild plant populations, chromosome rearrangements lead to the wide intraspecific polymorphisms in the abundance and patterns of highly repetitive DNA. However, despite the large amount of accumulated data, the impact of the complex repetitive DNA fraction on genome reorganization and functioning and the mechanisms balancing and maintaining the structural integrity of the genome are not fully understood. Homologous recombination is thought to play a key role in both genome reshuffling and stabilization, while the contribution of nonhomologous recombination seems to be undervalued...
December 13, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29232637/copper-ii-complexes-based-on-tripodal-pyrazolyl-amines-synthesis-structure-magnetic-properties-and-anticancer-activity
#3
Salah S Massoud, Febee R Louka, Gerard T Ducharme, Roland C Fischer, Franz A Mautner, Ján Vančo, Radovan Herchel, Zdeněk Dvořák, Zdeněk Trávníček
The Cu(II) complexes [Cu(bpdmpz)Cl]ClO4 (1), [Cu(bdmpzp)Cl]ClO4 (2-ClO4), [Cu(bdmpzp)Cl]PF6 (2-PF6) and [Cu(tdmpza)Cl]ClO4 (3), bpdmpzp=[bis[((2-pyridylmethyl)-di(3,5-dimethyl-1H-pyrazolyl)methyl)]amine, bdmpzp=[bis((di(3,5-dimethyl-1H-pyrazolyl)methyl)-(2-pyridylmethyl)]amine and tdmpza=tris[di(3,5-dimethyl-1H-pyrazolyl)-methyl)]amine were synthesized and characterized by elemental analysis, magnetic and conductivity measurements, electrospray-ionization mass spectrometry, infrared and electronic spectroscopy, and X-ray crystallography...
December 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29232629/on-lithium-doping-in-two-stable-nano-flakes-of-the-b24-the-double-ring-versus-the-quasiplanar-configuration
#4
A Hosseinian, E Vessally, M Babazadeh, L Edjlali, M Es'haghi
The stable local minima due to the addition of the Li atom to the double-ring and the quasiplanar configurations of the B24 molecule have been searched on the doublet potential energy surface to reveal the structural and electronic features of the Li@B24 system. We report two and seven stable local minima without imaginary vibrational frequency for the Li@B24(double-ring) and the Li@B24(quasiplanar) systems, respectively. The criteria of the adsorption energy, the vertical ionization (VI) energy, the deformation energy, the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy gap, the atomic charges, the spin density distribution, the electron transfer (ET), atoms in molecules (AIM) analysis and the nonlinear optical (NLO) properties have been investigated for all the reported molecules of the Li@B24 system in the present paper...
December 7, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29232619/engineering-of-protein-nanopores-for-sequencing-chemical-or-protein-sensing-and-disease-diagnosis
#5
REVIEW
Shaoying Wang, Zhengyi Zhao, Farzin Haque, Peixuan Guo
Biological systems contain highly-ordered structures performing diverse functions. The elegant structures of biomachines have inspired the development of nanopores as single molecule sensors. Over the years, the utility of nanopores for detecting a wide variety of analytes have rapidly emerged for sensing, sequencing and diagnostic applications. Several protein channels with diverse shapes and sizes, such as motor channels from bacteriophage Phi29, SPP1, T3, and T4, as well as α-hemolysin, MspA, aerolysin, FluA, OmpF/G, CsgG, ClyA, have been continually investigated and developed as nanopores...
December 9, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29232602/cooperative-protein-unfolding-a-statistical-mechanical-model-for-the-action-of-denaturants
#6
J Seelig
Knowledge of protein stability is of utmost importance in various fields of biotechnology. Protein stability can be assessed in solution by increasing the concentration of denaturant and recording the structural changes with spectroscopic or thermodynamic methods. The standard interpretation of the experimental data is to assume a 2-state equilibrium between completely folded and completely unfolded protein molecules. Here we propose a cooperative model based on the statistical-mechanical Zimm-Bragg theory...
December 5, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/29232520/controlling-the-dynamic-instability-of-capped-metal-nanoparticles-on-metallic-surfaces
#7
Evangelina Laura Pensa, Tim Albrecht
Small metal nanoparticles (NPs) with core-sizes ranging from 1-3 nm constitute a bridge between molecules and colloids with unique electronic, catalytic and other properties. Many applications entail immobilization onto solid supports, but while NP behavior in solution is well studied, the effect of the interaction between NPs and the substrate surface is understood less. Here, we follow the structural evolution of thiolated monolayer-protected AuNPs on Au(111) substrates at the single-particle level in real-time using high-resolution in situ Scanning Tunneling Microscopy...
December 12, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29232510/synthesis-and-thermoelectric-properties-of-charge-compensated-sypdxco4-xsb12-skutterudites
#8
Shun Wan, Pengfei Qiu, Xiangyang Huang, Qingfeng Song, Shengqiang Bai, Xun Shi, Lidong Chen
Recently, the electronegative elements (e.g. S, Se, Cl, and Br) filled skutterudites have attracted great attentions in thermoelectric community. Via doping some electron donors at the Sb sites, these electronegative elements can be filled into the voids of CoSb3 forming thermodynamically stable compounds, which greatly extend the scope of filled skutterudites. In this study, we show that doping appropriate elements at the Co sites can also stabilize the electronegative elements in the voids of CoSb3. A series of SyPdxCo4-xSb12 compounds were successfully fabricated by a traditional solid state reaction method combined with a spark plasma sintering technique...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29232484/juvenile-social-experience-and-differential-age-related-changes-in-the-dendritic-morphologies-of-subareas-of-the-prefrontal-cortex-in-rats
#9
B T Himmler, R Mychasiuk, A Nakahashi, S M Himmler, S M Pellis, B Kolb
Juvenile social interactions have been shown to influence the dendritic complexity of neurons in the prefrontal cortex. In particular, social play induces pruning of the cells in the medial prefrontal cortex (mPFC), whereas interacting with multiple partners, whether those interactions involve play or not, increases the complexity of cells in the orbital frontal cortex (OFC). Previous studies suggest that these changes differ in their stability during adulthood. In the present study, rats were reared in groups of either four (quads) or two (pairs) and the brains of the rats from each rearing condition were then harvested at 60 days (i...
December 12, 2017: Synapse
https://www.readbyqxmd.com/read/29232418/nano-emulsions-as-vehicles-for-topical-delivery-of-forskolin
#10
Małgorzata Miastkowska, Elżbieta Sikora, Elwira Lasoń, Maria Jose Garcia-Celma, Elvira Escribano-Ferrer, Conxita Solans, Meritxell Llinas
Two O/W forskolin-loaded nano-emulsions (0.075% wt.) based on medium chain triglycerides (MCT) and stabilized by a nonionic surfactant (Polysorbate 80 or Polysorbate 40) were studied as forskolin delivery systems. The nano-emulsions were prepared by the PIC method. The mean droplet size of the nano-emulsions with Polysorbate 80 and Polysorbate 40 with oil/surfactant (O/S) ratios of 20/80 and 80% water concentration, measured by Dynamic Light Scattering (DLS), was of 118 nm and 111 nm, respectively. Stability of the formulations, as assessed by light backscattering for 24 h, showed that both nano-emulsions were stable at 25ºC...
December 13, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29232402/chagas-disease-vector-blood-meal-sources-identified-by-protein-mass-spectrometry
#11
Judith I Keller, Bryan A Ballif, Riley M St Clair, James J Vincent, M Carlota Monroy, Lori Stevens
Chagas disease is a complex vector borne parasitic disease involving blood feeding Triatominae (Hemiptera: Reduviidae) insects, also known as kissing bugs, and the vertebrates they feed on. This disease has tremendous impacts on millions of people and is a global health problem. The etiological agent of Chagas disease, Trypanosoma cruzi (Kinetoplastea: Trypanosomatida: Trypanosomatidae), is deposited on the mammalian host in the insect's feces during a blood meal, and enters the host's blood stream through mucous membranes or a break in the skin...
2017: PloS One
https://www.readbyqxmd.com/read/29232392/experimental-and-numerical-study-of-the-failure-process-and-energy-mechanisms-of-rock-like-materials-containing-cross-un-persistent-joints-under-uniaxial-compression
#12
Rihong Cao, Ping Cao, Hang Lin, Xiang Fan
Joints and fissures in natural rocks have a significant influence on the stability of the rock mass, and it is often necessary to evaluate strength failure and crack evolution behavior. In this paper, based on experimental tests and numerical simulation (PFC2D), the macro-mechanical behavior and energy mechanism of jointed rock-like specimens with cross non-persistent joints under uniaxial loading were investigated. The focus was to study the effect of joint dip angle α and intersection angle γ on the characteristic stress, the coalescence modes and the energy release of jointed rock-like specimens...
2017: PloS One
https://www.readbyqxmd.com/read/29232391/studies-of-the-structure-antioxidant-activity-relationships-and-antioxidant-activity-mechanism-of-iridoid-valepotriates-and-their-degradation-products
#13
Feifei Wang, Yumei Zhang, Shouhai Wu, Yi He, Zhong Dai, Shuangcheng Ma, Bin Liu
Oxidative stress has been associated with diverse diseases, including obesity, cancer and neurodegeneration. In fact, Valeriana jatamansi Jones (valerian) and its extracts possess strong antioxidant activities that extend their application in clinical practice to the treatment of these illnesses, even though the underlying mechanisms are not well understood. Iridoid valepotriate, a characteristic iridoid ester in valerian with poor chemical stability, possesses considerable antioxidant components. The original compounds and their degradation products have been found to exhibit strong antioxidant activities...
2017: PloS One
https://www.readbyqxmd.com/read/29232209/recent-progress-in-understanding-hiv-reservoirs
#14
Hsiao-Hsuan Kuo, Mathias Lichterfeld
PURPOSE OF REVIEW: Reservoirs of HIV-1-infected cells persist long-term despite highly effective antiretroviral suppression therapy and represent the main barrier against a cure for HIV-1. This review summarizes recent advances in understanding the complexity and diversity of viral reservoir cells. RECENT FINDINGS: Latently infected memory CD4 T cells are the predominant cell compartment responsible for viral persistence, but some studies suggest that myeloid cells, and possibly hematopoietic progenitors, can also serve as long-term viral reservoirs...
December 11, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/29232197/dna-based-construction-at-the-nanoscale-emerging-trends-and-applications
#15
Lourdu Xavier Paulraj, Arun Richard Chandrasekaran
The field of structural DNA nanotechnology has reached adolescence - starting with the creation of artificial immobile junctions leading to the recent DNA-protein hybrid nanoscale shapes - in a span of about 35 years. It is now possible to create complex DNA-based nanoscale shapes and assemblies with greater stability and predictability, thanks to the development of computational tools and advances in experimental techniques. Although started with the original goal of DNA-assisted structure determination of difficult-to-crystallize molecules, DNA nanotechnology has found its applications in a myriad of fields...
December 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29232194/persistent-ventricular-bigeminy-during-anesthesia-in-pediatric-patients-a-case-report-of-an-11-year-old-child
#16
Sheetal Dalal, Vikas Chaudhari
An 11-year-old male child with fractures in both bones in his left forearm presented for open reduction and internal fixation. The pre-anesthetic check-up and investigations did not reveal any pre-existing underlying cardio-respiratory disease. The patient had an uneventful peri-operative period during the operation and was comfortable without any anxiety or restlessness. After an uneventful induction and intubation as per routine protocol, the patient received 600 mg of amoxicillin+clavunate intravenously as an antibiotic...
December 12, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29232186/cemented-or-cementless-total-knee-arthroplasty-comparative-results-of-200-cases-at-a-minimum-follow-up-of-11-years
#17
Jean-Louis Prudhon, Régis Verdier
INTRODUCTION: Since 1996 we have been using cementless fixation with hydroxyapatite (HA) coating. The purpose of this paper is to compare survivorship of a series of 100 cemented Total Knee Arthroplasty (TKA) to a similar series of 100 cementless with a follow up of 11-16 years. Material methods: Both TKA are mobile bearing total knee postero-stabilized. They can be used with cement or without cement. Among 1030 New Wave TKATM implanted from 2002 to 2015 we have identified 100 cemented TKAs and 100 cementless TKAs...
2017: SICOT-J
https://www.readbyqxmd.com/read/29232150/unusual-ferroelectricity-in-two-dimensional-perovskite-oxide-thin-films
#18
Jinlian Lu, Wei Luo, Junsheng Feng, Hongjun Xiang
Two-dimensional (2D) ferroelectricity have attracted much attention due to their applications in novel miniaturized devices such as non-volatile memories, field effect transistors and sensors. Since most of the commercial ferroelectric (FE) devices are based on ABO3 perovskite oxides, it is important to investigate the properties of 2D ferroelectricity in perovskite oxides thin films. Here, based on density functional theory (DFT) calculations, we find that there exist three kinds of in-plane ferroelectric states which originate from different microscopic mechanisms: (i) a proper FE state with the polarization along [110] due to the second-order Jahn-Teller effect related to the B ion with empty d-orbitals; (ii) a robust FE state with the polarization along [100] induced by the surface effect; (iii) a hybrid improper FE state with the polarization along [110] that is induced by the tri-linear coupling between two rotational modes and the A-site displacement...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29232145/patterning-conjugated-polymers-by-laser-synergy-of-nanostructure-formation-in-the-all-polymer-heterojunction-p3ht-pcdtbt
#19
Álvaro Rodriguez-Rodriguez, Esther Rebollar, Tiberio A Ezquerra, Marta Castillejo, Jose Vicente Garcia-Ramos, Mari Cruz García-Gutiérrez
In this work we report a broad scenario for the patterning of semiconducting polymers by laser-induced periodic surface structures (LIPSS). Based on the LIPSS formation in the semicrystalline poly(3-hexylthiophene) (P3HT), we have extended the LIPSS fabrication to an essentially amorphous semiconducting polymer like poly[N-90-heptadecanyl-2,7-carbazole-alt-5,5-(40,70-di-2-thienyl-20,10,30 benzothiadiazole)] (PCDTBT). This polymer shows a good quality and well-ordered nanostructures not only at the 532 nm laser wavelength, as in the case of P3HT, but also at 266 nm providing gratings with smaller pitch...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29232136/insights-into-solid-electrolyte-interphase-induced-li-ion-degradation-from-in-situ-auger-electron-spectroscopy
#20
Ching-Yen Tang, Yonghui Ma, Richard T Haasch, Jia-Hu Ouyang, Shen J Dillon
Surface reactions occurring on LiMn2O4, LiCoO2, LiNiO2, Li[Ni1/3Mn1/3Co1/3]O2, and LiFePO4 during charging and overcharging are studied by in situ and ex situ Auger electron spectroscopy. Carbon surface stability at the cathode solid-electrolyte interphas (SEI), associated with carbonate formation, decomposition, and CO/CO2 evolution, on different electrodes during cycling correlates with their cycle life. To understand how associated CO and CO2 evolution affects cycle stability, LiMn2O4 is cycled in flowing gas...
December 12, 2017: Journal of Physical Chemistry Letters
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