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https://www.readbyqxmd.com/read/27834163/is-not-just-right-experience-njre-in-obsessive-compulsive-disorder-part-of-an-autistic-phenotype
#1
Josselyn Hellriegel, Caroline Barber, Maheshi Wikramanayake, Naomi A Fineberg, William Mandy
OBJECTIVE: Harm avoidance (HA) and "not just right experience" (NJRE) have been proposed to be 2 core motivational processes underlying obsessive-compulsive disorder (OCD). The objective of this study was to explore whether NJRE demarcates a neurodevelopmental OCD subgroup distinct from HA related to autistic traits and/or to a broader phenotype of cognitive rigidity and sensory processing difficulties associated with an earlier age of OCD onset. METHODS: A correlational design investigated whether NJRE and HA are distinct entities in OCD and explored their relationship to autism spectrum disorder (ASD) traits measured by the Autism Quotient (AQ), sensory processing, set-shifting, and age of OCD onset in an OCD sample (N=25)...
November 11, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27774879/strong-anti-tumorous-potential-of-nardostachys-jatamansi-rhizome-extract-on-glioblastoma-and-in-silico-analysis-of-its-molecular-drug-targets
#2
Himanshi Kapoor, Nalini Yadav, Madhu Chopra, Sushil Chandra Mahapatra, Veena Agrawal
Glioblastoma has been reckoned as the prime cause of death due to brain tumours, being most invasive and lethal. Available treatment options, i.e. surgery, radiotherapy, chemotherapy and targeted therapies are not effective in improving prognosis, so an alternate therapy is insistent. Plant based drugs are efficient due to their synergistic action, multi-targeted approach and least side effects. Present investigation reports the strong anti-tumorous potential of Nardostachys jatamansi rhizome extract (NJRE) on U87 MG glioblastoma cells...
October 19, 2016: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/26795870/incompleteness-and-not-just-right-experiences-in-the-explanation-of-obsessive-compulsive-disorder
#3
Amparo Belloch, Gertrudis Fornés, Angel Carrasco, Clara López-Solá, Pino Alonso, Jose M Menchón
In the past decade, not just right experiences (NJRE) and incompleteness (INC) have attracted renewed interest as putative motivators of symptoms in obsessive-compulsive disorder (OCD), beyond harm avoidance (HA). This study examines, in 267 non-clinical undergraduates and 47 OCD patients, the differential contributions of HA, INC, and NJRE to the different OCD symptom dimensions and the propensity to have the disorder. The results indicate that although both the NJRE and INC range from normality to OCD, their number and intensity significantly increase as the obsessional tendencies increase, which suggests that they are vulnerability markers for OCD...
February 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/25743760/-not-just-right-experiences-are-specific-to-obsessive-compulsive-disorder-further-evidence-from-italian-clinical-samples
#4
Claudio Sica, Gioia Bottesi, Antonella Orsucci, Caterina Pieraccioli, Cecilia Sighinolfi, Marta Ghisi
Not Just Right Experiences (NJREs) are considered to be a perceptually tinged phenomenon mainly related to obsessive-compulsive disorder (OCD). The evidence of an association between NJREs and OCD or OC symptoms have been accumulating in the last few years, whereas there is a paucity of studies about the role of this construct in other clinical conditions considered part of the "OCD spectrum". In the current study, the NJRE-Q-R Severity scale (a well-validated measure of NJREs) was administered to 41 patients with OCD, 53 with hair-pulling disorder (HPD), 38 with gambling disorder (GD) and 43 with eating disorders (ED) along with measures of OC symptoms and general distress...
April 2015: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/25185938/harmonic-expectancy-violations-elicit-not-just-right-experiences-a-paradigm-for-investigating-obsessive-compulsive-characteristics
#5
Judith Buse, Denise Dörfel, Hannah Lange, Stefan Ehrlich, Alexander Münchau, Veit Roessner
Obsessive-compulsive disorder (OCD)-like symptoms are commonly associated with sensations of incompleteness and not-just-right experiences (NJRE). Although NJRE have gained much attention in recent years, most studies have not gone beyond a description of their phenomenology and prevalence also in healthy adults. We applied a validated harmonic expectancy violation paradigm to experimentally investigate NJRE evoked by deviant auditory perceptions. We assessed reaction times (RT) to harmonic and disharmonic chord sequences as well as their emotional appraisal in 64 healthy young adults...
2015: Cognitive Neuroscience
https://www.readbyqxmd.com/read/23850205/-not-just-right-experiences-in-patients-with-tourette-syndrome-complex-motor-tics-or-compulsions
#6
Matthew Neal, Andrea Eugenio Cavanna
Tourette syndrome (TS) is a chronic tic disorder often accompanied by specific obsessive-compulsive symptoms (OCS) or full-blown obsessive-compulsive disorder (OCD). Repetitive behaviours are commonly reported by patients with TS, who experience the urge to perform an action until it has been done "just right". This study investigated the clinical correlates of "not just right experiences" (NJREs) in this clinical population. A standardised battery of self-report psychometric measures was administered to 71 adult patients with TS recruited from a specialist TS clinic...
December 15, 2013: Psychiatry Research
https://www.readbyqxmd.com/read/23807544/-not-just-right-experiences-in-adolescents-phenomenology-and-associated-characteristics
#7
Ariel Ravid, Martin E Franklin, Muniya Khanna, Eric A Storch, Meredith E Coles
Efforts to understand the nature of "Not Just Right Experiences" (NJREs) have expanded the scientific understanding of obsessive-compulsive (OC) behavior. Approximately 80% of unselected adults report experiencing NJREs and these experiences have been found to highly correlate with OC behavior. The purpose of this study was to assess NJREs in an unselected sample of adolescents (ages 14-17; N = 152), to compare their experience with adults (N = 237), and to assess the relation between NJREs and OC symptoms...
2014: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/21549560/termination-of-washing-compulsions-a-problem-of-internal-reference-criteria-or-not-just-right-experience
#8
Jesse R Cougle, Amy R Goetz, Kristin E Fitch, Kirsten A Hawkins
Recent research suggests that obsessive-compulsive washers are more likely than individuals without washing compulsions to use conscious, internal reference criteria when deciding when to terminate compulsions (Wahl, Salkovskis, & Cotter, 2008). An alternative view is that they possess tendencies towards non-cognitive, automatic 'not just right' experiences (NJREs) that influence compulsion duration. The current study sought to investigate the latter explanation using valid behavioral tasks. Non-clinical participants (N=133) completed self-report measures, immersed their hands in a dirt mixture, and afterwards were allowed to wash their hands...
August 2011: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/20627224/in-search-of-specificity-not-just-right-experiences-and-obsessive-compulsive-symptoms-in-non-clinical-and-clinical-italian-individuals
#9
Marta Ghisi, Luigi Rocco Chiri, Igor Marchetti, Ezio Sanavio, Claudio Sica
The cognitive model of OCD proposes that certain beliefs may contribute to the development and maintenance of this disorder. To date, however, it is not yet clear which beliefs are more relevant for explaining OCD symptomatology; moreover, their causal status is yet to be clearly established. In the effort to identify other constructs and processes related to OCD, the phenomenon labeled "not just right experiences" (NJREs) has received increasing attention. In this study, measures of NJREs (the NJRE-Q-R), OCD symptoms, general distress (i...
December 2010: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/17466263/not-just-right-experience-is-it-influenced-by-feelings-of-guilt
#10
RANDOMIZED CONTROLLED TRIAL
Francesco Mancini, Amelia Gangemi, Claudia Perdighe, Chiara Marini
Individuals with obsessive-compulsive disorder (OCD) experience increased guilt. Further, these individuals often report uncomfortable sensations of things being not quite right ("not just right experiences"--NJREs). As to the relation between these psychological phenomena, it was hypothesized that feelings of guilt may enhance NJRE. In two experiments, we demonstrated that the induction of a guilty emotion resulted in increased NJRE, and this finding was qualified by an interaction with trait guilt. Induced guilt was followed by stronger feelings of things being not just right only in high-trait-guilt participants...
June 2008: Journal of Behavior Therapy and Experimental Psychiatry
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