keyword
https://read.qxmd.com/read/10798072/fetal-hydantoin-syndrome-with-rheumatic-valvular-heart-disease
#21
JOURNAL ARTICLE
K G Godbole, P S Gambhir, A S Deshpande, S U Kurlekar, M A Phadke
Research has shown that anticonvulsants are teratogens and pose a risk for fetal malformations. Though Fetal Hydantoin Syndrome (FHS) was first reported by Langhman and others, wide phenotypic variability of this syndrome has lead many clinicians to question its very existence. We report a twelve year old girl with FHS with rheumatic valvular heart disease.
March 1999: Indian Journal of Pediatrics
https://read.qxmd.com/read/10698674/pharmacokinetic-data-support-pharmacologically-induced-embryonic-dysrhythmia-as-explanation-to-fetal-hydantoin-syndrome-in-rats
#22
COMPARATIVE STUDY
B Danielsson, A C Sköld, F Azarbayjani, I Ohman, W Webster
New studies suggest that the teratogenicity of phenytoin (PHT) is linked to its membrane-stabilizing pharmacological action via the rapid component of the delayed rectified potassium channel (lkr), resulting in embryonic cardiac dysrhythmia during a restricted sensitive period. In order to further elucidate this theory, PHT was administered to Sprague-Dawley rats on gestation day (GD) 11 with either a single dose of 150 or 100 mg/kg ip or 150 mg/kg po and developmental toxicity at term (GD 21) was studied. In satellite animals blood samples were withdrawn (0...
March 1, 2000: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/10323545/atrioventricular-septal-defect-with-separate-right-and-left-atrioventricular-valvar-orifices-in-a-patient-with-foetal-hydantoin-syndrome
#23
JOURNAL ARTICLE
V Grech, C Vella
The teratogenic properties of phenytoin, including cardiac malformations, have been previously documented. We report one patient with foetal hydantoin syndrome and atrioventricular septal defect with common atrioventricular junction but separate right and left atrioventricular valves, an association that has not been described, to the best of our knowledge.
January 1999: Cardiology in the Young
https://read.qxmd.com/read/9988880/phenytoin-induced-alterations-in-craniofacial-gene-expression
#24
JOURNAL ARTICLE
J Gelineau-van Waes, G D Bennett, R H Finnell
In utero exposure to the anticonvulsant drug phenytoin has been shown to alter normal embryonic development, leading to a pattern of dysmorphogenesis known as the Fetal Hydantoin Syndrome. This embryopathy is characterized by growth retardation, microcephaly, mental deficiency, and craniofacial malformations, although the precise mechanism(s) by which phenytoin alters normal developmental pathways remains unknown. To better understand the molecular events involved in the pathogenesis of phenytoin-induced congenital defects, alterations in gene expression were examined during critical periods of craniofacial development...
January 1999: Teratology
https://read.qxmd.com/read/9677735/two-siblings-with-fetal-hydantoin-syndrome
#25
JOURNAL ARTICLE
F Ozkinay, A Yenigün, M Kantar, C Ozkinay, A Avanoğlu, I Ulman
An association between anticonvulsant drugs taken during pregnancy and congenital abnormalities was first identified by Meadow et al. in 1968. Manson and Frederic clarified teratogenic effects of hydantoin in their epidemiological studies in 1973. Varied malformations due to hydantoin intake during pregnancy include digit and nail hypoplasia, growth retardation, typical facial appearance, rib anomalies, abnormal palmar creases, hirsutism, and low hairlines. Ambiguous genitalia is rarely associated with this syndrome...
April 1998: Turkish Journal of Pediatrics
https://read.qxmd.com/read/9507275/fetal-hydantoin-syndrome-an-unusual-cause-of-hip-dysplasia
#26
JOURNAL ARTICLE
R T Trousdale
No abstract text is available yet for this article.
February 1998: Orthopedics
https://read.qxmd.com/read/9212184/polydactyly-and-fetal-hydantoin-syndrome-an-additional-component-of-the-syndrome
#27
JOURNAL ARTICLE
C Yalçinkaya, B Tüysüz, G Somay, A Cenani
We report a 3-year-old girl with fetal hydantoin syndrome (FHS) whose mother had received phenytoin 600 mg/day throughout gestation. She had growth retardation, mental deficiency, craniofacial dysmorphism and iris colomobata specific to FHS. However, the patient did not have the distal phalangeal hypoplasia which is associated with FHS; instead, she had polydactyly of the right foot. This seems to be the first FHS case in the literature with polydactyly.
May 1997: Clinical Genetics
https://read.qxmd.com/read/9088972/phenytoin-mediated-oxidative-stress-in-serum-of-female-epileptics-a-possible-pathogenesis-in-the-fetal-hydantoin-syndrome
#28
JOURNAL ARTICLE
C S Liu, H M Wu, S H Kao, Y H Wei
1. The concentration of serum malondialdehyde (MDA) was measured as the index of lipid peroxidation in female epileptics with phenytoin (PHT) monotherapy. Sera from 20 female epileptics with PHT monotherapy, 12 female epileptics without anticonvulsant therapy and 20 female healthy controls were sampled. The levels of serum copper (S-Cu), serum zinc (S-Zn), copper/zinc superoxide dismutase (CuZn-SOD), and reduced glutathione (GSH) were analyzed as interactive factors of the oxidative stress. 2. For the female epileptics with PHT monotherapy, serum MDA concentration (2...
March 1997: Human & Experimental Toxicology
https://read.qxmd.com/read/8846150/lymphoblastic-lymphoma-following-prenatal-exposure-to-phenytoin
#29
REVIEW
J C Murray, R M Hill, S Hegemier, R L Hurwitz
PURPOSE: Oncogenesis has been associated with prenatal exposure to phenytoin, concomitant with or independent of the fetal hydantoin syndrome. The majority of reported cases have been embryonal tumors of neural crest origin and have occurred in the first 3 years of life. PATIENTS AND METHODS: We report a boy who was exposed to phenytoin throughout gestation and later developed T-lymphocyte lymphoblastic lymphoma, a previously unreported malignancy associated with in utero phenytoin exposure...
May 1996: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/8825077/induction-of-microsomal-epoxide-hydrolase-activity-in-inbred-mice-by-chronic-phenytoin-exposure
#30
JOURNAL ARTICLE
J K Hartsfield, S A Benford, D R Hilbelink
A lower microsomal epoxide hydrolase (mEH) activity has been associated with increased likelihood of fetal hydantoin syndrome. While phenytoin anticonvulsive regimens are long-term, there are no data regarding induction of mEH by chronic phenytoin exposure. Two inbred mouse strains which differ in their susceptibility (A/J > C57BL/6J) to phenytoin-induced oral clefting were treated with an oral gavage of phenytoin for 14 consecutive days. The mice were sacrificed on the 15th day, and hepatic microsomes were prepared...
December 1995: Biochemical and Molecular Medicine
https://read.qxmd.com/read/8711731/kids-are-different-developmental-variability-in-toxicology
#31
REVIEW
L J Graeter, M E Mortensen
Data on the impact of many environmental compounds to human health is often lacking, particularly when considering the risk to the unborn and developing child. The stage of development of the individual at the time of exposure to a toxicant has not always been considered. For example, a higher percentage of ingested lead is absorbed from the gastrointestinal tract of infants than adults. Renal elimination also follows a developmental pattern, being very limited during the newborn period, increasing during infancy and childhood, and declining gradually after puberty...
July 17, 1996: Toxicology
https://read.qxmd.com/read/8555731/phenytoin-serum-concentration-monitoring-during-pregnancy-and-puerperium-in-mexican-epileptic-women
#32
JOURNAL ARTICLE
C Rodríguez-Palomares, A Belmont-Gómez, O Amancio-Chassin, A Estrada-Altamirano, T Herrerías-Cunedo, M Hernández-Serrano
Phenytoin serum concentrations were evaluated in 88 epileptic women at different stages of pregnancy and 40 women during postnatal periods. In addition, concentrations were determined from the umbilical cords of 27 neonates. On average, the dose of phenytoin was increased by 130 +/- 54 mg in 67% of the patients in order to control seizures. In 76% of the women during pregnancy and 95% in the postnatal periods, dose adjustment was achieved for the control of the seizures. Therapeutic clinical concentrations ( < 9...
1995: Archives of Medical Research
https://read.qxmd.com/read/8161117/-hydantoin-fetal-syndrome
#33
JOURNAL ARTICLE
P M Dang, B Dufetelle, J M Bonnetblanc
We report a case of distal finger hypoplasia associated with foetal hydantoin syndrome (FHS). The occurrence of this syndrome is thought to be due to abnormalities of collagen, cytochrome P 450 and arachidonic acid metabolism. The risk of developing FHS could be evaluated by counting the glucocorticoid receptors of lymphocytes or by measuring epoxide hydrolase activity through amniocentesis. FHS can be prevented by taking folates during pregnancy.
1993: Annales de Dermatologie et de Vénéréologie
https://read.qxmd.com/read/7845340/biochemical-and-molecular-teratology-of-fetal-hydantoin-syndrome
#34
REVIEW
B A Buehler, V Rao, R H Finnell
Animal and human research has clearly shown that anticonvulsants are teratogens and pose a risk for fetal malformations. In the case of dilantin it appears that fetal susceptibility correlates with the fetal level of the microsomal detoxifying enzyme epoxide hydrolase. The genetics of seizures in the parents does not predict the risk for fetal teratogenesis. The clinician must work with a mother who has seizures prior to conception to achieve the best control of seizures with a single anticonvulsant at the lowest effective dose to minimize the teratogenic potential, but even if this is done there is still a risk of fetal malformations and developmental delays...
November 1994: Neurologic Clinics
https://read.qxmd.com/read/7455686/phenytoin-induced-teratogenesis-a-mouse-model
#35
JOURNAL ARTICLE
R H Finnell
Malformations associated with the fetal hydantoin syndrome have been reproduced in a mouse model. The occurrence of these defects was correlated with maternal serum concentrations, but not with maternal or fetal genotype or the presence of a seizure disorder.
January 30, 1981: Science
https://read.qxmd.com/read/7420637/fetal-hydantoin-syndrome-neuroblastoma-and-hemorrhagic-disease-in-a-neonate
#36
JOURNAL ARTICLE
R W Allen, B Ogden, F L Bentley, A L Jung
This is the first patient report of maternal ingestion of anticonvulsants associated with the triad of fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease. The neuroblastoma, a neural crest tumor, is the fourth of such origin reported after in utero exposure to phenytoin, suggesting that phenytoin is a transplacental carcinogen. Infants of epileptic mothers receiving anticonvulsants should be closely examined at birth for the fetal hydantoin syndrome and monitored for hemorrhagic problems. The neural crest tumor may be found at birth or later in childhood...
September 26, 1980: JAMA
https://read.qxmd.com/read/7406368/-neuroblastoma-in-a-child-with-hydantoinic-syndrome
#37
JOURNAL ARTICLE
A Delgado, J Molina, M Muñóz, J Egüés, J M Martínez Peñuela
No abstract text is available yet for this article.
May 1980: Anales Españoles de Pediatría
https://read.qxmd.com/read/7350289/association-of-hemorrhagic-disease-and-the-syndrome-of-persistent-fetal-circulation-with-the-fetal-hydantoin-syndrome
#38
JOURNAL ARTICLE
W E Truog, J H Feusner, D L Baker
No abstract text is available yet for this article.
January 1980: Journal of Pediatrics
https://read.qxmd.com/read/7317808/-fetal-hydantoin-syndrome-author-s-transl
#39
JOURNAL ARTICLE
F Cisarik, O Pallayová
No abstract text is available yet for this article.
December 1981: Bratislavské Lekárske Listy
https://read.qxmd.com/read/7294852/fetal-hydantoin-syndrome
#40
JOURNAL ARTICLE
R Nagy
No abstract text is available yet for this article.
September 1981: Archives of Dermatology
keyword
keyword
64238
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.