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Immunology of stroke:from mechanism to translation

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https://www.readbyqxmd.com/read/22064429/ischemia-and-reperfusion-from-mechanism-to-translation
#1
REVIEW
Holger K Eltzschig, Tobias Eckle
Ischemia and reperfusion-elicited tissue injury contributes to morbidity and mortality in a wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. Ischemia-reperfusion injury is also a major challenge during organ transplantation and cardiothoracic, vascular and general surgery. An imbalance in metabolic supply and demand within the ischemic organ results in profound tissue hypoxia and microvascular dysfunction...
2011: Nature Medicine
https://www.readbyqxmd.com/read/21738161/the-immunology-of-stroke-from-mechanisms-to-translation
#2
REVIEW
Costantino Iadecola, Josef Anrather
Immunity and inflammation are key elements of the pathobiology of stroke, a devastating illness second only to cardiac ischemia as a cause of death worldwide. The immune system participates in the brain damage produced by ischemia, and the damaged brain, in turn, exerts an immunosuppressive effect that promotes fatal infections that threaten the survival of people after stroke. Inflammatory signaling is involved in all stages of the ischemic cascade, from the early damaging events triggered by arterial occlusion to the late regenerative processes underlying post-ischemic tissue repair...
July 7, 2011: Nature Medicine
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