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Gene expression in peripheral blood monocytes to predict ischemic stroke

Huichun Xu, Yang Tang, Da-Zhi Liu, Ruiqiong Ran, Bradley P Ander, Michelle Apperson, Xin She Liu, Jane C Khoury, Jeffrey P Gregg, Arthur Pancioli, Edward C Jauch, Kenneth R Wagner, Piero Verro, Joseph P Broderick, Frank R Sharp
There are no biomarkers that differentiate cardioembolic from large-vessel atherosclerotic stroke, although the treatments differ for each and approximately 30% of strokes and transient ischemic attacks have undetermined etiologies using current clinical criteria. We aimed to define gene expression profiles in blood that differentiate cardioembolic from large-vessel atherosclerotic stroke. Peripheral blood samples were obtained from healthy controls and acute ischemic stroke patients (<3, 5, and 24 h). RNA was purified, labeled, and applied to Affymetrix Human U133 Plus 2...
July 2008: Journal of Cerebral Blood Flow and Metabolism
Francesco Cipollone, Elena Toniato, Stefano Martinotti, Maria Fazia, Annalisa Iezzi, Chiara Cuccurullo, Barbara Pini, Sebastiano Ursi, Gianfranco Vitullo, Maurizio Averna, Marcello Arca, Anna Montali, Filomena Campagna, Sante Ucchino, Francesco Spigonardo, Stefano Taddei, Agostino Virdis, Giovanni Ciabattoni, Alberto Notarbartolo, Franco Cuccurullo, Andrea Mezzetti
CONTEXT: Myocardial infarction (MI) and ischemic stroke are thought to be caused by matrix digestion by metalloproteinases (MMPs) leading to rupture of atherosclerotic plaques. Production of macrophage MMP-2 and MMP-9 is induced by cyclooxygenase 2 (COX-2) and prostaglandin E(2) synthesis. Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and stroke is unclear. OBJECTIVE: To investigate the relationship between the -765G-->C polymorphism of the COX-2 gene and clinically evident plaque rupture...
May 12, 2004: JAMA: the Journal of the American Medical Association
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