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Faecalibacterium prausnitzii

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https://www.readbyqxmd.com/read/28382453/metabolic-adaptation-to-the-aqueous-leaf-extract-of-moringa-oleifera-lam-supplemented-diet-is-related-to-the-modulation-of-gut-microbiota-in-mice
#1
Xiaoyu Gao, Qiuhong Xie, Ling Liu, Ping Kong, Jun Sheng, Hongyu Xiang
The aqueous leaf extract of Moringa oleifera Lam. (LM-A) is reported to have many health beneficial bioactivities and no obvious toxicity, but have mild adverse effects. Little is known about the mechanism of these reported adverse effects. Notably, there has been no report about the influence of LM-A on intestinal microecology. In this study, animal experiments were performed to explore the relationships between metabolic adaptation to an LM-A-supplemented diet and gut microbiota changes. After 8-week feeding with normal chow diet, the body weight of mice entered a stable period, and one of the group received daily doses of 750-mg/kg body weight LM-A by gavage for 4 weeks (assigned as LM); the other group received the vehicle (assigned as NCD)...
April 5, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28375212/faecalibacterium-prausnitzii-treatment-improves-hepatic-health-and-reduces-adipose-tissue-inflammation-in-high-fat-fed-mice
#2
Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters...
April 4, 2017: ISME Journal
https://www.readbyqxmd.com/read/28368458/baseline-gut-microbiota-predicts-clinical-response-and-colitis-in-metastatic-melanoma-patients-treated-with-ipilimumab
#3
N Chaput, P Lepage, C Coutzac, E Soularue, K Le Roux, C Monot, L Boselli, E Routier, L Cassard, M Collins, T Vaysse, L Marthey, A Eggermont, V Asvatourian, E Lanoy, C Mateus, C Robert, F Carbonnel
Background: HASH(0x41d4fc8) Ipilimumab, an immune checkpoint inhibitor targeting CTLA-4, prolongs survival in a subset of patients with metastatic melanoma but can induce immune-related adverse events, including enterocolitis. We hypothesized that baseline gut microbiota could predict ipilimumab anti-tumor response and/or intestinal toxicity. Patients and Methods: HASH(0x41ddaf0) Twenty-six patients with metastatic melanoma treated with ipilimumab were prospectively enrolled...
March 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28361745/short-term-impact-of-a-classical-ketogenic-diet-on-gut-microbiota-in-glut1-deficiency-syndrome-a-3-month-prospective-observational-study
#4
Anna Tagliabue, Cinzia Ferraris, Francesca Uggeri, Claudia Trentani, Simona Bertoli, Valentina de Giorgis, Pierangelo Veggiotti, Marina Elli
BACKGROUND&AIMS: The classical ketogenic diet (KD) is a high-fat, very low-carbohydrate normocaloric diet used for drug-resistant epilepsy and Glucose Transporter 1 Deficiency Syndrome (GLUT1 DS). In animal models, high fat diet induces large alterations in microbiota producing deleterious effects on gut health. We carried out a pilot study on patients treated with KD comparing their microbiota composition before and after three months on the diet. METHODS: Six patients affected by GLUT1 DS were asked to collect fecal samples before and after three months on the diet...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28355361/anaerobic-bacteria-in-the-intestinal-microbiota-of-brazilian-children
#5
Silvia T Talarico, Florenza E Santos, Katia Galeão Brandt, Marina B Martinez, Carla R Taddei
OBJECTIVE: Changes in the neonatal gut environment allow for the colonization of the mucin layer and lumen by anaerobic bacteria. The aim of the present study was to evaluate Bifidobacterium, Lactobacillus and Lactococcus colonization through the first year of life in a group of 12 Brazilian infants and to correlate these data with the levels of Escherichia coli. The presence of anaerobic members of the adult intestinal microbiota, including Eubacterium limosum and Faecalibacterium prausnitzii, was also evaluated...
March 2017: Clinics
https://www.readbyqxmd.com/read/28286571/we-are-not-alone-a-case-for-the-human-microbiome-in-extra-intestinal-diseases
#6
EDITORIAL
S Shivaji
BACKGROUND: "Dysbiosis" in the gut microbiome has been implicated in auto-immune diseases, in inflammatory diseases, in some cancers and mental disorders. The challenge is to unravel the cellular and molecular basis of dysbiosis so as to understand the disease manifestation. MAIN BODY: Next generation sequencing and genome enabled technologies have led to the establishment of the composition of gut microbiomes and established that "dysbiosis" is the cause of several diseases...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28262770/fecal-bacterial-communities-in-treated-hiv-infected-individuals-on-two-antiretroviral-regimens
#7
Sandra Pinto-Cardoso, Catherine Lozupone, Olivia Briceño, Selma Alva-Hernández, Norma Téllez, Aguilar Adriana, Akio Murakami-Ogasawara, Gustavo Reyes-Terán
Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targeted sequencing...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28255158/altered-intestinal-microbiota-in-patients-with-chronic-pancreatitis-implications-in-diabetes-and-metabolic-abnormalities
#8
Sai Manasa Jandhyala, A Madhulika, G Deepika, G Venkat Rao, D Nageshwar Reddy, Chivukula Subramanyam, Mitnala Sasikala, Rupjyoti Talukdar
Intestinal dysbiosis and its functional implications in chronic pancreatitis (CP) have not been elaborately studied. We evaluated the taxonomic and functional alterations in intestinal microbiota in 30 well-characterised patients with CP (16 without, 14 with diabetes) and 10 healthy controls. The patients with CP and diabetes had significantly longer disease duration and greater degree of malnutrition. There was increase in plasma endotoxin concentrations from controls to CP non-diabetics to CP diabetics. We observed significant differences in richness and alpha diversity between the groups...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28249045/pili-like-proteins-of-akkermansia-muciniphila-modulate-host-immune-responses-and-gut-barrier-function
#9
Noora Ottman, Justus Reunanen, Marjolein Meijerink, Taija E Pietilä, Veera Kainulainen, Judith Klievink, Laura Huuskonen, Steven Aalvink, Mikael Skurnik, Sjef Boeren, Reetta Satokari, Annick Mercenier, Airi Palva, Hauke Smidt, Willem M de Vos, Clara Belzer
Gut barrier function is key in maintaining a balanced response between the host and its microbiome. The microbiota can modulate changes in gut barrier as well as metabolic and inflammatory responses. This highly complex system involves numerous microbiota-derived factors. The gut symbiont Akkermansia muciniphila is positively correlated with a lean phenotype, reduced body weight gain, amelioration of metabolic responses and restoration of gut barrier function by modulation of mucus layer thickness. However, the molecular mechanisms behind its metabolic and immunological regulatory properties are unexplored...
2017: PloS One
https://www.readbyqxmd.com/read/28244658/nutritional-microbiological-and-psychosocial-implications-of-the-low-fodmap-diet
#10
REVIEW
Heidi Maria Staudacher
Dietary restriction of certain fermentable carbohydrates (low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet) is effective for managing symptoms of irritable bowel syndrome (IBS). However, there are potential consequences of this diet that relate to its impact on nutritional, microbiological, and health-related quality of life outcomes. Evidence suggests that the low FODMAP diet leads to some alterations in nutrient intake. For example, carbohydrate intake is reduced, and there is a decrease in the proportion of patients meeting the recommended intake for calcium...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28239378/enterococcus-durans-ep1-a-promising-anti-inflammatory-probiotic-able-to-stimulate-siga-and-to-increase-faecalibacterium-prausnitzii-abundance
#11
Paula Carasi, Silvia María Racedo, Claudine Jacquot, Anne Marie Elie, María de Los Ángeles Serradell, María C Urdaci
Enterococcus species, principally Enterococcus faecium are used as probiotics since a long time with preference in animal applications but safety considerations were updated and also new uses as probiotics can be envisaged. Fifteen Enterococcus strains isolated from different foods were identified and analyzed for virulence factors and antibiotic resistance. Three Enterococcus durans strains were selected to study their immunomodulatory properties on PBMC and Caco2 cells. Two strains presented a profile toward a mild inflammatory Th1 response considering TNF-α/IL-10 and IL-1β/IL-10 cytokines ratios...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28203226/microbial-anti-inflammatory-molecule-mam-from-faecalibacterium-prausnitzii-shows-a-protective-effect-on-dnbs-and-dss-induced-colitis-model-in-mice-through-inhibition-of-nf-%C3%AE%C2%BAb-pathway
#12
Natalia M Breyner, Cristophe Michon, Cassiana S de Sousa, Priscilla B Vilas Boas, Florian Chain, Vasco A Azevedo, Philippe Langella, Jean M Chatel
Faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F. prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-κB pathway in vitro and showed anti-inflammatory properties in vivo in a DiNitroBenzene Sulfate (DNBS)-induced colitis model. In this current proof we tested MAM effect on NF-κB pathway in vivo, using a transgenic model of mice producing luciferase under the control of NF-κB promoter...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28187199/differences-in-gut-microbiota-profile-between-women-with-active-lifestyle-and-sedentary-women
#13
Carlo Bressa, María Bailén-Andrino, Jennifer Pérez-Santiago, Rocío González-Soltero, Margarita Pérez, Maria Gregoria Montalvo-Lominchar, Jose Luis Maté-Muñoz, Raúl Domínguez, Diego Moreno, Mar Larrosa
Physical exercise is a tool to prevent and treat some of the chronic diseases affecting the world's population. A mechanism through which exercise could exert beneficial effects in the body is by provoking alterations to the gut microbiota, an environmental factor that in recent years has been associated with numerous chronic diseases. Here we show that physical exercise performed by women to at least the degree recommended by the World Health Organization can modify the composition of gut microbiota. Using high-throughput sequencing of the 16s rRNA gene, eleven genera were found to be significantly different between active and sedentary women...
2017: PloS One
https://www.readbyqxmd.com/read/28179092/altered-molecular-signature-of-intestinal-microbiota-in-irritable-bowel-syndrome-patients-compared-with-healthy-controls-a-systematic-review-and-meta-analysis
#14
REVIEW
Hai-Ning Liu, Hao Wu, Yu-Zhuo Chen, Yan-Jie Chen, Xi-Zhong Shen, Tao-Tao Liu
BACKGROUND: Many studies have reported significant changes in intestinal microbiota in irritable bowel syndrome (IBS) patients based on quantitative real-time PCR analysis. AIMS: We aimed to review the alterations in intestinal microbiota. METHODS: An online search up to June 9, 2016, was conducted. This systematic review and meta-analysis included differential expression of intestinal microbiota in patients with IBS versus healthy controls (HCs) and subgroup analysis...
April 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28175005/p143-from-biopsies-to-fecal-samples-challenging-faecalibacterium-prausnitzii-and-related-phylogroups-as-potential-biomarkers-for-ibd
#15
J Amoedo, M Serra-Pagès, M Serrano, A Bahí, M Malagόn, P Gilabert, J Guardiola, D Busquets, X Aldeguer, J Garcia-Gil
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167665/microbial-strain-level-population-structure-and-genetic-diversity-from-metagenomes
#16
Duy Tin Truong, Adrian Tett, Edoardo Pasolli, Curtis Huttenhower, Nicola Segata
Among the human health conditions linked to microbial communities, phenotypes are often associated with only a subset of strains within causal microbial groups. Although it has been critical for decades in microbial physiology to characterize individual strains, this has been challenging when using culture-independent high-throughput metagenomics. We introduce StrainPhlAn, a novel metagenomic strain identification approach, and apply it to characterize the genetic structure of thousands of strains from more than 125 species in more than 1500 gut metagenomes drawn from populations spanning North and South American, European, Asian, and African countries...
April 2017: Genome Research
https://www.readbyqxmd.com/read/28125667/profiling-living-bacteria-informs-preparation-of-fecal-microbiota-transplantations
#17
Nathaniel D Chu, Mark B Smith, Allison R Perrotta, Zain Kassam, Eric J Alm
Fecal microbiota transplantation is a compelling treatment for recurrent Clostridium difficile infections, with potential applications against other diseases associated with changes in gut microbiota. But variability in fecal bacterial communities-believed to be the therapeutic agent-can complicate or undermine treatment efficacy. To understand the effects of transplant preparation methods on living fecal microbial communities, we applied a DNA-sequencing method (PMA-seq) that uses propidium monoazide (PMA) to differentiate between living and dead fecal microbes, and we created an analysis pipeline to identify individual bacteria that change in abundance between samples...
2017: PloS One
https://www.readbyqxmd.com/read/28125651/the-association-of-specific-constituents-of-the-fecal-microbiota-with-immune-mediated-brain-disease-in-dogs
#18
Nick D Jeffery, Andrew K Barker, Cody J Alcott, Jon M Levine, Ilyssa Meren, Jane Wengert, Albert E Jergens, Jan S Suchodolski
Meningoencephalomyelitis of unknown origin (MUO) is a common, naturally-occurring, clinical disease of pet dogs. It is an immune-mediated condition that has many similarities with experimental autoimmune encephalitis (EAE) in rodents and so investigation of its pathogenesis may aid in understanding factors that contribute to development of multiple sclerosis in people. Gut microbiota are known to modulate immune responses that influence susceptibility to immune-mediated brain disease. In this study we aimed to compare abundance of specific constituents of the fecal microbiota, namely Faecalibacterium prausnitzii and Prevotellaceae, between dogs diagnosed with MUO and matched controls...
2017: PloS One
https://www.readbyqxmd.com/read/28112583/the-gut-microbiota-of-siblings-offers-insights-into-microbial-pathogenesis-of-inflammatory-bowel-disease
#19
Charlotte R Hedin, Christopher J van der Gast, Andrew J Stagg, James O Lindsay, Kevin Whelan
Siblings of patients with Crohn's disease (CD) have elevated risk of developing CD and display aspects of disease phenotype, including faecal dysbiosis. In our recent article we have used 16S rRNA gene targeted high-throughput sequencing to comprehensively characterize the mucosal microbiota in healthy siblings of CD patients, and determine the influence of genotypic and phenotypic factors on the gut microbiota (dysbiosis). We have demonstrated that the core microbiota of both patients with CD and healthy siblings is significantly less diverse than controls...
January 23, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28094590/effects-of-supernatants-from-escherichia-coli-nissle-1917-and-faecalibacterium-prausnitzii-on-intestinal-epithelial-cells-and-a-rat-model-of-5-fluorouracil-induced-mucositis
#20
Hanru Wang, Yoga D Jatmiko, Susan E P Bastian, Suzanne Mashtoub, Gordon S Howarth
Faecalibacterium prausnitzii (Fp) and Escherichia coli Nissle 1917 (EcN) are probiotics, which have been reported to ameliorate certain gastrointestinal disorders. We evaluated the effects of supernatants (SN) derived from Fp and EcN on 5-fluorouracil (5-FU)-treated intestinal cells and in a rat model of mucositis. In vitro: IEC-6, Caco-2, and T-84 cells were analyzed for viability and monolayer permeability. In vivo: Female dark agouti rats were gavaged with Fp or EcN SN and injected intraperitoneally with saline (control) or 5-FU to induce mucositis...
February 2017: Nutrition and Cancer
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