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Faecalibacterium prausnitzii

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https://www.readbyqxmd.com/read/28782508/circulating-and-tissue-resident-cd4-t-cells-with-reactivity-to-intestinal-microbiota-are-abundant-in-healthy-individuals-and-function-is-altered-during-inflammation
#1
Ahmed N Hegazy, Nathaniel R West, Michael J T Stubbington, Emily Wendt, Kim I M Suijker, Angeliki Datsi, Sebastien This, Camille Danne, Suzanne Campion, Sylvia H Duncan, Benjamin M J Owens, Holm H Uhlig, Andrew McMichael, Andreas Bergthaler, Sarah A Teichmann, Satish Keshav, Fiona Powrie
BACKGROUND & AIMS: Interactions between commensal microbes and the immune system are tightly regulated and maintain intestinal homeostasis, but little is known about these interactions in humans. We investigated responses of human CD4(+) T cells to the intestinal microbiota. We measured the abundance of T cells in circulation and intestinal tissues that respond to intestinal microbes and determined their clonal diversity. We also assessed their functional phenotypes and effects on intestinal resident cell populations, and studied alterations in microbe-reactive T cells in patients with chronic intestinal inflammation...
August 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28749657/a-deep-metaproteomics-approach-for-the-study-of-human-microbiomes
#2
Xu Zhang, Wendong Chen, Zhibin Ning, Janice Mayne, David R Mack, Alain Stintzi, Ruijun Tian, Daniel Figeys
Host-microbiome interactions have been shown to play important roles in human health and diseases. Most of the current studies of the microbiome have been performed by genomic approaches through next-generation sequencing. Technologies, such as metaproteomics, for functional analysis of the microbiome are needed to better understand the intricate host-microbiome interactions. However, significant efforts to improve the depth and resolution of gut metaproteomics are still required. In this study, we combined an efficient sample preparation technique, high resolution mass spectrometry and metaproteomic bioinformatics tools to perform ultra-deep metaproteomic analysis of human gut microbiome from stool...
July 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28740337/eubiotic-properties-of-rifaximin-disruption-of-the-traditional-concepts-in-gut-microbiota-modulation
#3
REVIEW
Francesca Romana Ponziani, Maria Assunta Zocco, Francesca D'Aversa, Maurizio Pompili, Antonio Gasbarrini
Antibiotics are usually prescribed to cure infections but they also have significant modulatory effects on the gut microbiota. Several alterations of the intestinal bacterial community have been reported during antibiotic treatment, including the reduction of beneficial bacteria as well as of microbial alpha-diversity. Although after the discontinuation of antibiotic therapies it has been observed a trend towards the restoration of the original condition, the new steady state is different from the previous one, as if antibiotics induced some kind of irreversible perturbation of the gut microbial community...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28739439/the-association-of-type-ii-diabetes-with-gut-microbiota-composition
#4
Fatemeh Navab-Moghadam, Mansour Sedighi, Mohammad E Khamseh, Fariba Alaei-Shahmiri, Malihe Talebi, Shabnam Razavi, Nour Amirmozafari
It is known that type 2 diabetes (T2D) in humans could be linked to the composition of gut microbiota. The aim of this study was to evaluate three faecal bacterial species, including Bacteroides fragilis, Bifidobacterium longum and Faecalibacterium prausnitzii in patients with T2D. This case control study included 18 patients with T2D and 18 matched persons without diabetes. The concentrations of B. fragilis, B. longum and F. prausnitzii were determined by quantitative Real-Time PCR. Quantitative PCR analysis revealed that the gut bacterial composition in patients with T2D was partially different from that in the healthy individuals...
July 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28713353/functional-characterization-of-novel-faecalibacterium-prausnitzii-strains-isolated-from-healthy-volunteers-a-step-forward-in-the-use-of-f-prausnitzii-as-a-next-generation-probiotic
#5
Rebeca Martín, Sylvie Miquel, Leandro Benevides, Chantal Bridonneau, Véronique Robert, Sylvie Hudault, Florian Chain, Olivier Berteau, Vasco Azevedo, Jean M Chatel, Harry Sokol, Luis G Bermúdez-Humarán, Muriel Thomas, Philippe Langella
Faecalibacterium prausnitzii is a major member of the Firmicutes phylum and one of the most abundant bacteria in the healthy human microbiota. F. prausnitzii depletion has been reported in several intestinal disorders, and more consistently in Crohn's disease (CD) patients. Despite its importance in human health, only few microbiological studies have been performed to isolate novel F. prausnitzii strains in order to better understand the biodiversity and physiological diversity of this beneficial commensal species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28702003/reduced-mass-and-diversity-of-the-colonic-microbiome-in-patients-with-multiple-sclerosis-and-their-improvement-with-ketogenic-diet
#6
Alexander Swidsinski, Yvonne Dörffel, Vera Loening-Baucke, Christoph Gille, Önder Göktas, Anne Reißhauer, Jürgen Neuhaus, Karsten-Henrich Weylandt, Alexander Guschin, Markus Bock
Background: Colonic microbiome is thought to be involved in auto-immune multiple sclerosis (MS). Interactions between diet and the colonic microbiome in MS are unknown. Methods: We compared the composition of the colonic microbiota quantitatively in 25 MS patients and 14 healthy controls.Fluorescence in situ hybridization (FISH) with 162 ribosomal RNA derived bacterial FISH probes was used. Ten of the MS patients received a ketogenic diet for 6 months. Changes in concentrations of 35 numerically substantial bacterial groups were monitored at baseline and at 2, 12, and 23/24 weeks...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28698467/effect-of-soy-isoflavones-on-growth-of-representative-bacterial-species-from-the-human-gut
#7
Lucía Vázquez, Ana Belén Flórez, Lucía Guadamuro, Baltasar Mayo
The present work aimed to assess the susceptibility of dominant and representative bacterial populations from the human gut to isoflavones and their metabolites. To do so, the minimum inhibitory concentration (MIC) of isoflavone glycosides, isoflavone aglycones, and equol to 37 bacterial strains was determined by broth microdilution. Additionally, for 10 representative strains, growth curves, growth rate (μ), and optical density (OD600 nm) of the cultures at 24 h were also determined. MICs of daidzin, genistin, daidzein, and genistein were >2048 μg mL(-1) for all strains assayed, while that of equol ranged from 16 μg mL(-1) for Bifidobacterium animalis subsp...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28683448/gut-microbiota-in-health-diverticular-disease-irritable-bowel-syndrome-and-inflammatory-bowel-diseases-time-for-microbial-marker-of-gastrointestinal-disorders
#8
Loris Riccardo Lopetuso, Valentina Petito, Cristina Graziani, Elisa Schiavoni, Francesco Paroni Sterbini, Andrea Poscia, Eleonora Gaetani, Francesco Franceschi, Giovanni Cammarota, Maurizio Sanguinetti, Luca Masucci, Franco Scaldaferri, Antonio Gasbarrini
Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the differences in gut microbiota composition among uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) patients. DD, IBS, and IBD patients along with healthy controls (CT) were enrolled in our Italian GI outpatient clinic. Stool samples were collected. Microbiota composition was evaluated through a metagenomic gene-targeted approach...
July 7, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28668239/association-of-altered-gut-microbiota-composition-with-chronic-urticaria
#9
Edris Nabizadeh, Nima Hosseini Jazani, Morteza Bagheri, Shahram Shahabi
BACKGROUND: An altered gut microbiota composition has recently been linked to some types of allergies. OBJECTIVE: To compare the relative amounts of Akkermansia muciniphila, Clostridium leptum, Faecalibacterium prausnitzii, and Enterobacteriaceae as members of gut microbiota among patients with chronic urticaria (CU) and healthy controls. METHODS: A total of 20 patients with CU and 20 healthy individuals matched by age and sex participated in the study...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28633443/nod2-genetic-variants-predispose-one-of-two-familial-adenomatous-polyposis-siblings-to-pouchitis-through-microbiome-dysbiosis
#10
Kathleen M Schieffer, Justin R Wright, Leonard R Harris, Sue Deiling, Zhaohai Yang, Regina Lamendella, Gregory S Yochum, Walter A Koltun
Background and Aims: Individuals with familial adenomatous polyposis (FAP) may undergo a total proctocolectomy with ileal pouch-anal anastomosis (IPAA) to surgically treat their disease. Inflammation of the ileal pouch, termed pouchitis, is uncommon in FAP patients but prevalent in patients who received IPAA for ulcerative colitis, a type of inflammatory bowel disease (IBD). Methods and Results: We report on two FAP siblings, living in the same household, who underwent IPAA surgery within one week of each other...
June 19, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28589947/gut-microbiota-composition-in-relation-to-the-metabolic-response-to-12-week-combined-polyphenol-supplementation-in-overweight-men-and-women
#11
J Most, J Penders, M Lucchesi, G H Goossens, E E Blaak
BACKGROUND/OBJECTIVES: The intestinal microbiota may have a profound impact on host metabolism. As evidence suggests that polyphenols affect substrate utilization, the present study aimed to investigate the effects of polyphenol supplementation on intestinal microbiota composition in humans. Furthermore, we examined whether (changes in) gut microbiota composition may determine the metabolic response to polyphenol supplementation. SUBJECTS/METHODS: In this randomized, double-blind, placebo (PLA)-controlled trial, 37 overweight and obese men and women (18 males/19 females, 37...
June 7, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28588309/alteration-of-the-gut-microbiota-in-chinese-population-with-chronic-kidney-disease
#12
Shuanghong Jiang, Shan Xie, Dan Lv, Pu Wang, Hanchang He, Ting Zhang, Youlian Zhou, Qianyun Lin, Hongwei Zhou, Jianping Jiang, Jing Nie, Fanfan Hou, Ye Chen
We evaluated differences in the compositions of faecal microbiota between 52 end stage renal disease (ESRD) patients and 60 healthy controls in southern China using quantitative real-time polymerase chain reaction (qPCR) and high-throughput sequencing (16S ribosomal RNA V4-6 region) methods. The absolute quantification of total bacteria was significantly reduced in ESRD patients (p < 0.01). In three enterotypes, Prevotella was enriched in the healthy group whereas Bacteroides were prevalent in the ESRD group (LDA score > 4...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28568309/effect-of-soybean-husk-supplementation-on-the-fecal-fermentation-metabolites-and-microbiota-of-dogs
#13
Htun Myint, Yu Iwahashi, Satoshi Koike, Yasuo Kobayashi
In vitro fermentation and in vivo feeding experiments were conducted to characterize the effects of soybean (Glycine max) husk on the fecal fermentation metabolites and microbiota of dogs. An in vitro fermentation study using feces from three Toy Poodle dogs (6.5 ± 3.5 months in age and 2.9 ± 0.4 kg in body weight) revealed that the fecal inoculum was able to ferment soybean husk (supplemented at 0.01 g/mL culture) and increased levels of short chain fatty acids (SCFA) and Bifidobacterium, irrespective of pre-digestion of the husk by pepsin and pancreatin...
June 1, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28558792/a-diet-change-from-dry-food-to-beef-induces-reversible-changes-on-the-faecal-microbiota-in-healthy-adult-client-owned-dogs
#14
Kristin M V Herstad, Karina Gajardo, Anne Marie Bakke, Lars Moe, Jane Ludvigsen, Knut Rudi, Ida Rud, Monika Sekelja, Ellen Skancke
BACKGROUND: Diet has a major influence on the composition of the gut microbiota, whose importance for gut health and overall well-being is increasingly recognized. Knowledge is limited regarding health implications, including effects on the faecal microbiota, of feeding a diet with high content of red meat to dogs, despite some owners' apparent preference to do so. The aim of this study was to evaluate how a diet change from commercial dry food to one with a high content of boiled minced beef and vice versa influenced the faecal microbiota, and short chain fatty acid profile in healthy, adult, client-owned dogs...
May 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28548573/inulin-type-fructan-degradation-capacity-of-clostridium-cluster-iv-and-xiva-butyrate-producing-colon-bacteria-and-their-associated-metabolic-outcomes
#15
F Moens, L De Vuyst
Four selected butyrate-producing colon bacterial strains belonging to Clostridium cluster IV (Butyricicoccus pullicaecorum DSM 23266(T) and Faecalibacterium prausnitzii DSM 17677(T)) and XIVa (Eubacterium hallii DSM 17630 and Eubacterium rectale CIP 105953(T)) were studied as to their capacity to degrade inulin-type fructans and concomitant metabolite production. Cultivation of these strains was performed in bottles and fermentors containing a modified medium for colon bacteria, including acetate, supplemented with either fructose, oligofructose, or inulin as the sole energy source...
May 30, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28538678/effects-of-commercial-apple-varieties-on-human-gut-microbiota-composition-and-metabolic-output-using-an-in-vitro-colonic-model
#16
Athanasios Koutsos, Maria Lima, Lorenza Conterno, Mattia Gasperotti, Martina Bianchi, Francesca Fava, Urska Vrhovsek, Julie A Lovegrove, Kieran M Tuohy
Apples are a rich source of polyphenols and fiber. A major proportion of apple polyphenols escape absorption in the small intestine and together with non-digestible polysaccharides reach the colon, where they can serve as substrates for bacterial fermentation. Animal studies suggest a synergistic interaction between apple polyphenols and the soluble fiber pectin; however, the effects of whole apples on human gut microbiota are less extensively studied. Three commercial apple varieties-Renetta Canada, Golden Delicious and Pink Lady-were digested and fermented in vitro using a batch culture colonic model (pH 5...
May 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28455781/reduction-in-fecal-microbiota-diversity-and-short-chain-fatty-acid-producers-in-methicillin-resistant-staphylococcus-aureus-infected-individuals-as-revealed-by-pacbio-single-molecule-real-time-sequencing-technology
#17
J Zhao, L Nian, L Y Kwok, T Sun, J Zhao
Methicillin-resistant Staphylococcus aureus (MRSA) may cause potentially lethal infections. Increasing evidence suggests that the gut microbiota is associated with human health. Yet, whether patients with MRSA infections carry specific signatures in their fecal microbiota composition has not been determined. Thus, this study aimed to compare the fecal microbiota profile of MRSA-positive patients (n=15) with individuals without MRSA infection (n=15) by using the PacBio single molecule, real-time (SMRT) DNA sequencing system and real-time quantitative polymerase chain reaction (qPCR)...
August 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28382453/metabolic-adaptation-to-the-aqueous-leaf-extract-of-moringa-oleifera-lam-supplemented-diet-is-related-to-the-modulation-of-gut-microbiota-in-mice
#18
Xiaoyu Gao, Qiuhong Xie, Ling Liu, Ping Kong, Jun Sheng, Hongyu Xiang
The aqueous leaf extract of Moringa oleifera Lam. (LM-A) is reported to have many health beneficial bioactivities and no obvious toxicity, but have mild adverse effects. Little is known about the mechanism of these reported adverse effects. Notably, there has been no report about the influence of LM-A on intestinal microecology. In this study, animal experiments were performed to explore the relationships between metabolic adaptation to an LM-A-supplemented diet and gut microbiota changes. After 8-week feeding with normal chow diet, the body weight of mice entered a stable period, and one of the group received daily doses of 750-mg/kg body weight LM-A by gavage for 4 weeks (assigned as LM); the other group received the vehicle (assigned as NCD)...
April 5, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28375212/faecalibacterium-prausnitzii-treatment-improves-hepatic-health-and-reduces-adipose-tissue-inflammation-in-high-fat-fed-mice
#19
Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters...
April 4, 2017: ISME Journal
https://www.readbyqxmd.com/read/28368458/baseline-gut-microbiota-predicts-clinical-response-and-colitis-in-metastatic-melanoma-patients-treated-with-ipilimumab
#20
N Chaput, P Lepage, C Coutzac, E Soularue, K Le Roux, C Monot, L Boselli, E Routier, L Cassard, M Collins, T Vaysse, L Marthey, A Eggermont, V Asvatourian, E Lanoy, C Mateus, C Robert, F Carbonnel
Background: Ipilimumab, an immune checkpoint inhibitor targeting CTLA-4, prolongs survival in a subset of patients with metastatic melanoma (MM) but can induce immune-related adverse events, including enterocolitis. We hypothesized that baseline gut microbiota could predict ipilimumab anti-tumor response and/or intestinal toxicity. Patients and methods: Twenty-six patients with MM treated with ipilimumab were prospectively enrolled. Fecal microbiota composition was assessed using 16S rRNA gene sequencing at baseline and before each ipilimumab infusion...
June 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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