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Faecalibacterium prausnitzii

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https://www.readbyqxmd.com/read/28286571/we-are-not-alone-a-case-for-the-human-microbiome-in-extra-intestinal-diseases
#1
EDITORIAL
S Shivaji
BACKGROUND: "Dysbiosis" in the gut microbiome has been implicated in auto-immune diseases, in inflammatory diseases, in some cancers and mental disorders. The challenge is to unravel the cellular and molecular basis of dysbiosis so as to understand the disease manifestation. MAIN BODY: Next generation sequencing and genome enabled technologies have led to the establishment of the composition of gut microbiomes and established that "dysbiosis" is the cause of several diseases...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28262770/fecal-bacterial-communities-in-treated-hiv-infected-individuals-on-two-antiretroviral-regimens
#2
Sandra Pinto-Cardoso, Catherine Lozupone, Olivia Briceño, Selma Alva-Hernández, Norma Téllez, Aguilar Adriana, Akio Murakami-Ogasawara, Gustavo Reyes-Terán
Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targeted sequencing...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28255158/altered-intestinal-microbiota-in-patients-with-chronic-pancreatitis-implications-in-diabetes-and-metabolic-abnormalities
#3
Sai Manasa Jandhyala, A Madhulika, G Deepika, G Venkat Rao, D Nageshwar Reddy, Chivukula Subramanyam, Mitnala Sasikala, Rupjyoti Talukdar
Intestinal dysbiosis and its functional implications in chronic pancreatitis (CP) have not been elaborately studied. We evaluated the taxonomic and functional alterations in intestinal microbiota in 30 well-characterised patients with CP (16 without, 14 with diabetes) and 10 healthy controls. The patients with CP and diabetes had significantly longer disease duration and greater degree of malnutrition. There was increase in plasma endotoxin concentrations from controls to CP non-diabetics to CP diabetics. We observed significant differences in richness and alpha diversity between the groups...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28249045/pili-like-proteins-of-akkermansia-muciniphila-modulate-host-immune-responses-and-gut-barrier-function
#4
Noora Ottman, Justus Reunanen, Marjolein Meijerink, Taija E Pietilä, Veera Kainulainen, Judith Klievink, Laura Huuskonen, Steven Aalvink, Mikael Skurnik, Sjef Boeren, Reetta Satokari, Annick Mercenier, Airi Palva, Hauke Smidt, Willem M de Vos, Clara Belzer
Gut barrier function is key in maintaining a balanced response between the host and its microbiome. The microbiota can modulate changes in gut barrier as well as metabolic and inflammatory responses. This highly complex system involves numerous microbiota-derived factors. The gut symbiont Akkermansia muciniphila is positively correlated with a lean phenotype, reduced body weight gain, amelioration of metabolic responses and restoration of gut barrier function by modulation of mucus layer thickness. However, the molecular mechanisms behind its metabolic and immunological regulatory properties are unexplored...
2017: PloS One
https://www.readbyqxmd.com/read/28244658/nutritional-microbiological-and-psychosocial-implications-of-the-low-fodmap-diet
#5
REVIEW
Heidi Maria Staudacher
Dietary restriction of certain fermentable carbohydrates (low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet) is effective for managing symptoms of irritable bowel syndrome (IBS). However, there are potential consequences of this diet that relate to its impact on nutritional, microbiological, and health-related quality of life outcomes. Evidence suggests that the low FODMAP diet leads to some alterations in nutrient intake. For example, carbohydrate intake is reduced, and there is a decrease in the proportion of patients meeting the recommended intake for calcium...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28239378/enterococcus-durans-ep1-a-promising-anti-inflammatory-probiotic-able-to-stimulate-siga-and-to-increase-faecalibacterium-prausnitzii-abundance
#6
Paula Carasi, Silvia María Racedo, Claudine Jacquot, Anne Marie Elie, María de Los Ángeles Serradell, María C Urdaci
Enterococcus species, principally Enterococcus faecium are used as probiotics since a long time with preference in animal applications but safety considerations were updated and also new uses as probiotics can be envisaged. Fifteen Enterococcus strains isolated from different foods were identified and analyzed for virulence factors and antibiotic resistance. Three Enterococcus durans strains were selected to study their immunomodulatory properties on PBMC and Caco2 cells. Two strains presented a profile toward a mild inflammatory Th1 response considering TNF-α/IL-10 and IL-1β/IL-10 cytokines ratios...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28203226/microbial-anti-inflammatory-molecule-mam-from-faecalibacterium-prausnitzii-shows-a-protective-effect-on-dnbs-and-dss-induced-colitis-model-in-mice-through-inhibition-of-nf-%C3%AE%C2%BAb-pathway
#7
Natalia M Breyner, Cristophe Michon, Cassiana S de Sousa, Priscilla B Vilas Boas, Florian Chain, Vasco A Azevedo, Philippe Langella, Jean M Chatel
Faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F. prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-κB pathway in vitro and showed anti-inflammatory properties in vivo in a DiNitroBenzene Sulfate (DNBS)-induced colitis model. In this current proof we tested MAM effect on NF-κB pathway in vivo, using a transgenic model of mice producing luciferase under the control of NF-κB promoter...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28187199/differences-in-gut-microbiota-profile-between-women-with-active-lifestyle-and-sedentary-women
#8
Carlo Bressa, María Bailén-Andrino, Jennifer Pérez-Santiago, Rocío González-Soltero, Margarita Pérez, Maria Gregoria Montalvo-Lominchar, Jose Luis Maté-Muñoz, Raúl Domínguez, Diego Moreno, Mar Larrosa
Physical exercise is a tool to prevent and treat some of the chronic diseases affecting the world's population. A mechanism through which exercise could exert beneficial effects in the body is by provoking alterations to the gut microbiota, an environmental factor that in recent years has been associated with numerous chronic diseases. Here we show that physical exercise performed by women to at least the degree recommended by the World Health Organization can modify the composition of gut microbiota. Using high-throughput sequencing of the 16s rRNA gene, eleven genera were found to be significantly different between active and sedentary women...
2017: PloS One
https://www.readbyqxmd.com/read/28179092/altered-molecular-signature-of-intestinal-microbiota-in-irritable-bowel-syndrome-patients-compared-with-healthy-controls-a-systematic-review-and-meta-analysis
#9
REVIEW
Hai-Ning Liu, Hao Wu, Yu-Zhuo Chen, Yan-Jie Chen, Xi-Zhong Shen, Tao-Tao Liu
BACKGROUND: Many studies have reported significant changes in intestinal microbiota in irritable bowel syndrome (IBS) patients based on quantitative real-time PCR analysis. AIMS: We aimed to review the alterations in intestinal microbiota. METHODS: An online search up to June 9, 2016, was conducted. This systematic review and meta-analysis included differential expression of intestinal microbiota in patients with IBS versus healthy controls (HCs) and subgroup analysis...
January 21, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28175005/p143-from-biopsies-to-fecal-samples-challenging-faecalibacterium-prausnitzii-and-related-phylogroups-as-potential-biomarkers-for-ibd
#10
J Amoedo, M Serra-Pagès, M Serrano, A Bahí, M Malagόn, P Gilabert, J Guardiola, D Busquets, X Aldeguer, J Garcia-Gil
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167665/microbial-strain-level-population-structure-and-genetic-diversity-from-metagenomes
#11
Duy Tin Truong, Adrian Tett, Edoardo Pasolli, Curtis Huttenhower, Nicola Segata
Among the human health conditions linked to microbial communities, phenotypes are often associated with only a subset of strains within causal microbial groups. While it has been critical for decades in microbial physiology to characterize individual strains, this has been challenging when using culture-independent high-throughput metagenomics. We introduce StrainPhlAn, a novel metagenomic strain identification approach, and apply it to characterize the genetic structure of thousands of strains from >125 species in >1,500 gut metagenomes drawn from populations spanning North/South American, European, Asian, and African countries...
February 6, 2017: Genome Research
https://www.readbyqxmd.com/read/28125667/profiling-living-bacteria-informs-preparation-of-fecal-microbiota-transplantations
#12
Nathaniel D Chu, Mark B Smith, Allison R Perrotta, Zain Kassam, Eric J Alm
Fecal microbiota transplantation is a compelling treatment for recurrent Clostridium difficile infections, with potential applications against other diseases associated with changes in gut microbiota. But variability in fecal bacterial communities-believed to be the therapeutic agent-can complicate or undermine treatment efficacy. To understand the effects of transplant preparation methods on living fecal microbial communities, we applied a DNA-sequencing method (PMA-seq) that uses propidium monoazide (PMA) to differentiate between living and dead fecal microbes, and we created an analysis pipeline to identify individual bacteria that change in abundance between samples...
2017: PloS One
https://www.readbyqxmd.com/read/28125651/the-association-of-specific-constituents-of-the-fecal-microbiota-with-immune-mediated-brain-disease-in-dogs
#13
Nick D Jeffery, Andrew K Barker, Cody J Alcott, Jon M Levine, Ilyssa Meren, Jane Wengert, Albert E Jergens, Jan S Suchodolski
Meningoencephalomyelitis of unknown origin (MUO) is a common, naturally-occurring, clinical disease of pet dogs. It is an immune-mediated condition that has many similarities with experimental autoimmune encephalitis (EAE) in rodents and so investigation of its pathogenesis may aid in understanding factors that contribute to development of multiple sclerosis in people. Gut microbiota are known to modulate immune responses that influence susceptibility to immune-mediated brain disease. In this study we aimed to compare abundance of specific constituents of the fecal microbiota, namely Faecalibacterium prausnitzii and Prevotellaceae, between dogs diagnosed with MUO and matched controls...
2017: PloS One
https://www.readbyqxmd.com/read/28112583/the-gut-microbiota-of-siblings-offers-insights-into-microbial-pathogenesis-of-inflammatory-bowel-disease
#14
Charlotte R Hedin, Christopher J van der Gast, Andrew J Stagg, James O Lindsay, Kevin Whelan
Siblings of patients with Crohn's disease (CD) have elevated risk of developing CD and display aspects of disease phenotype, including faecal dysbiosis. In our recent article we have used 16S rRNA gene targeted high-throughput sequencing to comprehensively characterize the mucosal microbiota in healthy siblings of CD patients, and determine the influence of genotypic and phenotypic factors on the gut microbiota (dysbiosis). We have demonstrated that the core microbiota of both patients with CD and healthy siblings is significantly less diverse than controls...
January 23, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28094590/effects-of-supernatants-from-escherichia-coli-nissle-1917-and-faecalibacterium-prausnitzii-on-intestinal-epithelial-cells-and-a-rat-model-of-5-fluorouracil-induced-mucositis
#15
Hanru Wang, Yoga D Jatmiko, Susan E P Bastian, Suzanne Mashtoub, Gordon S Howarth
Faecalibacterium prausnitzii (Fp) and Escherichia coli Nissle 1917 (EcN) are probiotics, which have been reported to ameliorate certain gastrointestinal disorders. We evaluated the effects of supernatants (SN) derived from Fp and EcN on 5-fluorouracil (5-FU)-treated intestinal cells and in a rat model of mucositis. In vitro: IEC-6, Caco-2, and T-84 cells were analyzed for viability and monolayer permeability. In vivo: Female dark agouti rats were gavaged with Fp or EcN SN and injected intraperitoneally with saline (control) or 5-FU to induce mucositis...
February 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28094541/intestinal-proportion-of-blautia-sp-is-associated-with-clinical-stage-and-histoprognostic-grade-in-patients-with-early-stage-breast-cancer
#16
Trang H Luu, Catherine Michel, Jean-Marie Bard, François Dravet, Hassan Nazih, Christine Bobin-Dubigeon
Improving knowledge about breast cancer etiology is crucial in order to propose prevention strategies for this pathology. Gut microbiota is involved in numerous physiopathological situations including cancers. Although its potential involvement in breast cancer through the alteration of the enterohepatic circulation of estrogens and/or the metabolism of phytoestrogens has been discussed for some time, it remains to be demonstrated. The present study seeks to strengthen this hypothesis by identifying possible links between the fecal microbiota composition and clinical characteristics in breast cancer patients...
February 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28045459/faecalibacterium-prausnitzii-from-microbiology-to-diagnostics-and-prognostics
#17
Mireia Lopez-Siles, Sylvia H Duncan, L Jesús Garcia-Gil, Margarita Martinez-Medina
There is an increasing interest in Faecalibacterium prausnitzii, one of the most abundant bacterial species found in the gut, given its potentially important role in promoting gut health. Although some studies have phenotypically characterized strains of this species, it remains a challenge to determine which factors have a key role in maintaining the abundance of this bacterium in the gut. Besides, phylogenetic analysis has shown that at least two different F. prausnitzii phylogroups can be found within this species and their distribution is different between healthy subjects and patients with gut disorders...
April 2017: ISME Journal
https://www.readbyqxmd.com/read/28039159/gut-microbiota-differs-between-children-with-inflammatory-bowel-disease-and-healthy-siblings-in-taxonomic-and-functional-composition-a-metagenomic-analysis
#18
Rebecca Luise Knoll, Kristoffer Forslund, Jens Roat Kultima, Claudius U Meyer, Ulrike Kullmer, Shinichi Sunagawa, Peer Bork, Stephan Gehring
Current treatment for pediatric IBD patients is often ineffective, with serious side effects. Manipulating the gut microbiota via fecal microbiota transplantation (FMT) is an emerging treatment approach but remains controversial. We aimed to assess the composition of the fecal microbiome through a comparison of pediatric IBD patients to their healthy siblings, evaluating risks and prospects for FMT in this setting. A Case-Control (Sibling) Study was conducted analyzing fecal samples of six children with Crohn's Disease (CD), six children with Ulcerative Colitis (UC) and 12 healthy siblings by metagenomic sequencing...
December 30, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28029051/adherence-to-a-mediterranean-diet-influences-the-fecal-metabolic-profile-of-microbial-derived-phenolics-in-a-spanish-cohort-of-middle-age-and-older-people
#19
Isabel Gutiérrez-Díaz, Tania Fernández-Navarro, Nuria Salazar, Begoña Bartolomé, M Victoria Moreno-Arribas, Enrique Juan de Andres-Galiana, Juan Luis Fernández-Martínez, Clara G de Los Reyes-Gavilán, Miguel Gueimonde, Sonia González
Despite the evidence regarding the influence of certain polyphenol food sources on the metabolic profile in feces, the association between the different phenolics provided by the diet and the fecal phenolic profile has not been elucidated. In this study, the composition of phenolic metabolites in fecal solutions was analyzed by UPLC-ESI-MS/MS in 74 volunteers. This fecal phenolic profile showed a high interindividual variation of the different compounds analyzed, phenylacetic and phenylpropionic acids being the major classes of phenolic metabolites excreted in feces...
January 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27883264/mucosa-associated-biohydrogenating-microbes-protect-the-simulated-colon-microbiome-from-stress-associated-with-high-concentrations-of-poly-unsaturated-fat
#20
Rosemarie De Weirdt, Emma Hernandez-Sanabria, Veerle Fievez, Eva Mees, Annelies Geirnaert, Florence Van Herreweghen, Ramiro Vilchez-Vargas, Pieter Van den Abbeele, Ruy Jauregui, Dietmar H Pieper, Bruno Vlaeminck, Tom Van de Wiele
Polyunsaturated fatty acids (PUFAs) may affect colon microbiome homeostasis by exerting (specific) antimicrobial effects and/or interfering with mucosal biofilm formation at the gut mucosal interface. We used standardized batch incubations and the Mucosal-Simulator of the Human Microbial Intestinal Ecosystem (M-SHIME) to show the in vitro luminal and mucosal effects of the main PUFA in the Western diet, linoleic acid (LA). High concentrations of LA were found to decrease butyrate production and Faecalibacterium prausnitzii numbers dependent on LA biohydrogenation to vaccenic acid (VA) and stearic acid (SA)...
November 24, 2016: Environmental Microbiology
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