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Faecalibacterium prausnitzii

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https://www.readbyqxmd.com/read/29720977/-enterococcus-faecalis-ahg0090-is-a-genetically-tractable-bacterium-and-produces-a-secreted-peptidic-bioactive-that-suppresses-nuclear-factor-kappa-b-activation-in-human-gut-epithelial-cells
#1
Páraic Ó Cuív, Rabina Giri, Emily C Hoedt, Michael A McGuckin, Jakob Begun, Mark Morrison
Enterococcus faecalis is an early coloniser of the human infant gut and contributes to the development of intestinal immunity. To better understand the functional capacity of E. faecalis , we constructed a broad host range RP4 mobilizable vector, pEHR513112, that confers chloramphenicol resistance and used a metaparental mating approach to isolate E. faecalis AHG0090 from a fecal sample collected from a healthy human infant. We demonstrated that E. faecalis AHG0090 is genetically tractable and could be manipulated using traditional molecular microbiology approaches...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29719601/increased-gut-permeability-in-cancer-cachexia-mechanisms-and-clinical-relevance
#2
Laure B Bindels, Audrey M Neyrinck, Audrey Loumaye, Emilie Catry, Hannah Walgrave, Claire Cherbuy, Sophie Leclercq, Matthias Van Hul, Hubert Plovier, Barbara Pachikian, Luis G Bermúdez-Humarán, Philippe Langella, Patrice D Cani, Jean-Paul Thissen, Nathalie M Delzenne
Intestinal disorders often occur in cancer patients, in association with body weight loss, and this alteration is commonly attributed to the chemotherapy. Here, using a mouse model of cancer cachexia induced by ectopic transplantation of C26 cancer cells, we discovered a profound alteration in the gut functions (gut permeability, epithelial turnover, gut immunity, microbial dysbiosis) independently of any chemotherapy. These alterations occurred independently of anorexia and were driven by interleukin 6. Gut dysfunction was found to be resistant to treatments with an anti-inflammatory bacterium ( Faecalibacterium prausnitzii ) or with gut peptides involved in intestinal cell renewal (teduglutide, a glucagon-like peptide 2 analogue)...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29670191/fecal-microbiota-transplantation-reverses-antibiotic-and-chemotherapy-induced-gut-dysbiosis-in-mice
#3
Quentin Le Bastard, Tonya Ward, Dimitri Sidiropoulos, Benjamin M Hillmann, Chan Lan Chun, Michael J Sadowsky, Dan Knights, Emmanuel Montassier
Fecal microbiota transplantation (FMT) is now widely used to treat recurrent Clostridium difficile infection, but has been less studied as a means to restore microbiome diversity and composition following antibiotic or chemotherapy treatments. The purpose of our study was to assess the efficacy of FMT to reverse antibiotic- and chemotherapy-induced gut dysbiosis in a mouse model. C57BL/6J mice were treated with ampicillin for 1 week and/or received a single intraperitoneal injection of 5-Fluorouracil. Fresh stool was collected and analyzed using shotgun metagenomics and the Illumina sequencing platform...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663668/effect-of-cryopreservation-and-lyophilization-on-viability-and-growth-of-strict-anaerobic-human-gut-microbes
#4
Lea Bircher, Annelies Geirnaert, Frederik Hammes, Christophe Lacroix, Clarissa Schwab
Strict anaerobic gut microbes have been suggested as 'next-generation probiotics' for treating several intestinal disorders. The development of preservation techniques is of major importance for therapeutic application. This study investigated cryopreservation (-80°C) and lyophilization survival and storage stability (4°C for 3 months) of the strict anaerobic gut microbes Bacteroides thetaiotaomicron, Faecalibacterium prausnitzii, Roseburia intestinalis, Anaerostipes caccae, Eubacterium hallii and Blautia obeum...
April 17, 2018: Microbial Biotechnology
https://www.readbyqxmd.com/read/29615108/phages-infecting-faecalibacterium-prausnitzii-belong-to-novel-viral-genera-that-help-to-decipher-intestinal-viromes
#5
Jeffrey K Cornuault, Marie-Agnès Petit, Mahendra Mariadassou, Leandro Benevides, Elisabeth Moncaut, Philippe Langella, Harry Sokol, Marianne De Paepe
BACKGROUND: Viral metagenomic studies have suggested a role for bacteriophages in intestinal dysbiosis associated with several human diseases. However, interpretation of viral metagenomic studies is limited by the lack of knowledge of phages infecting major human gut commensal bacteria, such as Faecalibacterium prausnitzii, a bacterial symbiont repeatedly found depleted in inflammatory bowel disease (IBD) patients. In particular, no complete genomes of phages infecting F. prausnitzii are present in viral databases...
April 3, 2018: Microbiome
https://www.readbyqxmd.com/read/29601608/in-vitro-co-cultures-of-human-gut-bacterial-species-as-predicted-from-co-occurrence-network-analysis
#6
Promi Das, Boyang Ji, Petia Kovatcheva-Datchary, Fredrik Bäckhed, Jens Nielsen
Network analysis of large metagenomic datasets generated by current sequencing technologies can reveal significant co-occurrence patterns between microbial species of a biological community. These patterns can be analyzed in terms of pairwise combinations between all species comprising a community. Here, we construct a co-occurrence network for abundant microbial species encompassing the three dominant phyla found in human gut. This was followed by an in vitro evaluation of the predicted microbe-microbe co-occurrences, where we chose species pairs Bifidobacterium adolescentis and Bacteroides thetaiotaomicron, as well as Faecalibacterium prausnitzii and Roseburia inulinivorans as model organisms for our study...
2018: PloS One
https://www.readbyqxmd.com/read/29572539/methodology-challenges-in-studying-human-gut-microbiota-effects-of-collection-storage-dna-extraction-and-next-generation-sequencing-technologies
#7
Marina Panek, Hana Čipčić Paljetak, Anja Barešić, Mihaela Perić, Mario Matijašić, Ivana Lojkić, Darija Vranešić Bender, Željko Krznarić, Donatella Verbanac
The information on microbiota composition in the human gastrointestinal tract predominantly originates from the analyses of human faeces by application of next generation sequencing (NGS). However, the detected composition of the faecal bacterial community can be affected by various factors including experimental design and procedures. This study evaluated the performance of different protocols for collection and storage of faecal samples (native and OMNIgene.GUT system) and bacterial DNA extraction (MP Biomedicals, QIAGEN and MO BIO kits), using two NGS platforms for 16S rRNA gene sequencing (Ilumina MiSeq and Ion Torrent PGM)...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29566907/action-and-function-of-faecalibacterium-prausnitzii-in-health-and-disease
#8
REVIEW
Carmen Veríssima Ferreira-Halder, Alessandra Valéria de Sousa Faria, Sheila Siqueira Andrade
Faecalibacterium prausnitzii, anaerobic bacteria, is one of the main components of gut microbiota and the most important butyrate-producing bacteria in the human colon. So far, this commensal bacterium has been considered as a bioindicator of human health, once when its population is altered (decreased), inflammatory processes are favored. Several reports in the literature highlighted that the amount of Faecalibacterium prausnitzii negatively correlates to the activity of inflammatory bowel disease and colorectal cancer...
December 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29559959/searching-for-the-bacterial-effector-the-example-of-the-multi-skilled-commensal-bacterium-faecalibacterium-prausnitzii
#9
Rebeca Martín, Luis G Bermúdez-Humarán, Philippe Langella
Faecalibacterium prausnitzii represents approximately 5% of the total fecal microbiota in healthy adults being one of the most abundant bacterium in the human intestinal microbiota of healthy adults. Furthermore, this bacterium has been proposed to be a sensor and a major actor of the human intestinal health because of its importance in the gut ecosystem. In this context, F. prausnitzii population levels have been found to be reduced in patients suffering from several syndromes and diseases such as inflammatory bowel diseases...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29491857/body-mass-index-and-sex-affect-diverse-microbial-niches-within-the-gut
#10
Francesca Borgo, Stefania Garbossa, Alessandra Riva, Marco Severgnini, Carmelo Luigiano, Albero Benetti, Antonio E Pontiroli, Giulia Morace, Elisa Borghi
Gut microbiota is considered a separate organ with endocrine capabilities, actively contributing to tissue homeostasis. It consists of at least two separate microbial populations, the lumen-associated (LAM) and the mucosa-associated microbiota (MAM). In the present study, we compared LAM and MAM, by collecting stools and sigmoid brush samples of forty adults without large-bowel symptoms, and through a 16S rRNA gene next-generation sequencing (NGS) approach. MAM sample analysis revealed enrichment in aerotolerant Proteobacteria , probably selected by a gradient of oxygen that decreases from tissue to lumen, and in Streptococcus and Clostridium spp...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29462405/gut-barrier-function-effects-of-antibiotic-growth-promoters-on-key-barrier-components-and-associations-with-growth-performance
#11
Leon J Broom
The gut barrier, comprising the microbiota and their products, mucus layers, host-derived antimicrobial compounds [e.g., host defense peptides (HDP), IgA], epithelium, and underlying immune tissues, performs the essential function of preventing the passage of harmful microorganisms and substances into the body, while enabling the acquisition of dietary nutrients. Antibiotic growth promoters (AGP) are widely accepted as the "gold standard" of performance-enhancing feed additives, which had become integral and valuable components of modern, efficient animal production, but are now being phased out in many parts of the world...
May 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29432061/atorvastatin-treatment-modulates-the-gut-microbiota-of-the-hypercholesterolemic-patients
#12
Tariq Jamal Khan, Youssri M Ahmed, Mazin A Zamzami, Aisha M Siddiqui, Imran Khan, Othman A S Baothman, Mohamed G Mehanna, Abudukadeer Kuerban, Mohammed Kaleemuddin, Muhammad Yasir
Hypercholesterolemia is one of the most important risk factors for development of cardiovascular diseases. The composition of gut microbiota (total microbes residing in the gut) impacts on cholesterol and lipid metabolism. On the contrary, alterations in gut microbiota in response to hypercholesterolemia or drug treatment with atorvastatin (a cholesterol-lowering agent) are rarely investigated. We performed 16S rDNA amplicon sequencing to evaluate the gut bacterial community of 15 untreated hypercholesterolemic patients (HP) and 27 atorvastatin-treated hypercholesterolemic patients (At-HP) and compared with 19 healthy subjects (HS)...
February 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29423216/dietary-proline-supplementation-alters-colonic-luminal-microbiota-and-bacterial-metabolite-composition-between-days-45-and-70-of-pregnancy-in-huanjiang-mini-pigs
#13
Yujiao Ji, Qiuping Guo, Yulong Yin, Francois Blachier, Xiangfeng Kong
Background: Pregnancy is associated with important changes in gut microbiota composition. Dietary factors may affect the diversity, composition, and metabolic activity of the intestinal microbiota. Among amino acids, proline is known to play important roles in protein metabolism and structure, cell differentiation, conceptus growth and development, and gut microbiota re-equilibration in case of dysbiosis. Results: Dietary supplementation with 1% proline decreased ( P  < 0...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29393195/fecal-microbiome-and-food-allergy-in-pediatric-atopic-dermatitis-a-cross-sectional-pilot-study
#14
Karin B Fieten, Joan E E Totté, Evgeni Levin, Marta Reyman, Yolanda Meijer, André Knulst, Frank Schuren, Suzanne G M A Pasmans
BACKGROUND: Exposure to microbes may be important in the development of atopic disease. Atopic diseases have been associated with specific characteristics of the intestinal microbiome. The link between intestinal microbiota and food allergy has rarely been studied, and the gold standard for diagnosing food allergy (double-blind placebo-controlled food challenge [DBPCFC]) has seldom been used. We aimed to distinguish fecal microbial signatures for food allergy in children with atopic dermatitis (AD)...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29385239/faecalibacterium-prausnitzii-and-a-prebiotic-protect-intestinal-health-in-a-mouse-model-of-antibiotic-and-clostridium-difficile-exposure
#15
Sanjoy Roychowdhury, Jennifer Cadnum, Bryan Glueck, Mark Obrenovich, Curtis Donskey, Gail A M Cresci
BACKGROUND: Clostridium difficile (CD) infection (CDI) increases patient morbidity, mortality and healthcare costs. Antibiotic treatment induces gut dysbiosis and is both a major risk factor for CD colonization and treatment of CDI. Probiotics have been trialed to support commensal gut microbiota and reduce CDI. This study investigated commensal microbe Faecalibacterium prausnitzii (FP) and a prebiotic, both known to yield butyrate and be anti-inflammatory and immunomodulatory, on CD colonization and gut integrity in mice...
January 31, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29382366/age-and-fecal-microbial-strain-specific-differences-in-patients-with-spondyloarthritis
#16
Matthew L Stoll, Pamela F Weiss, Jennifer E Weiss, Peter A Nigrovic, Barbara S Edelheit, S Lou Bridges, Maria I Danila, Charles H Spencer, Marilynn G Punaro, Kenneth Schikler, Andreas Reiff, Ranjit Kumar, Randy Q Cron, Casey D Morrow, Elliot J Lefkowitz
BACKGROUND: Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA). In particular, diminished fecal abundance of Faecalibacterium prausnitzii and abnormalities in both directions in the abundance of the Bacteroides genus have been identified. METHODS: We obtained fecal specimens from 30 children with treatment-naïve enthesitis-related arthritis (ERA) and 19 healthy controls, as well as specimens from 11 adult patients with longstanding SpA and 10 adult healthy controls...
January 30, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29362454/nonalcoholic-fatty-liver-disease-is-associated-with-dysbiosis-independent-of-body-mass-index-and-insulin-resistance
#17
Hannah E Da Silva, Anastasia Teterina, Elena M Comelli, Amel Taibi, Bianca M Arendt, Sandra E Fischer, Wendy Lou, Johane P Allard
This study aimed to determine if there is an association between dysbiosis and nonalcoholic fatty liver disease (NAFLD) independent of obesity and insulin resistance (IR). This is a prospective cross-sectional study assessing the intestinal microbiome (IM) of 39 adults with biopsy-proven NAFLD (15 simple steatosis [SS]; 24 nonalcoholic steatohepatitis [NASH]) and 28 healthy controls (HC). IM composition (llumina MiSeq Platform) in NAFLD patients compared to HC were identified by two statistical methods (Metastats, Wilcoxon)...
January 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29361151/chemoprevention-of-colorectal-cancer-by-black-raspberry-anthocyanins-involved-the-modulation-of-gut-microbiota-and-sfrp2-demethylation
#18
Lili Chen, Bowen Jiang, Chunge Zhong, Jun Guo, Lihao Zhang, Teng Mu, Qiuhua Zhang, Xiuli Bi
Freeze-dried black raspberry (BRB) powder is considered as a potential cancer chemopreventive agent. In this study, we fed azoxymethane (AOM)/dextran sodium sulfate (DSS)-treated C57BL/6J mice with a diet containing BRB anthocyanins for 12 weeks, and this led to a reduction in colon carcinogenesis. These animals had consistently lower tumor multiplicity compared with AOM/DSS-treated mice not receiving BRB anthocyanins. In AOM/DSS-treated mice, the number of pathogenic bacteria, including Desulfovibrio sp. and Enterococcus spp...
March 8, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29342270/whole-genome-analysis-reveals-the-evolution-and-transmission-of-an-mdr-dh-nap11-106-clostridium-difficile-clone-in-a-paediatric-hospital
#19
Larry K Kociolek, Egon A Ozer, Dale N Gerding, David W Hecht, Sameer J Patel, Alan R Hauser
Background: Clostridium difficile strain DH/NAP11/106, a relatively antibiotic-susceptible strain, is now the most common cause of C. difficile infection (CDI) among adults in the USA. Objectives: To identify mechanisms underlying the evolution and transmission of an MDR DH/NAP11/106 clone. Methods: WGS (Illumina MiSeq), restriction endonuclease analysis (REA) and antibiotic susceptibility testing were performed on 134 C. difficile isolates collected from paediatric patients with CDI over a 2 year period...
January 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29330424/metagenomic-and-metabolomic-analyses-unveil-dysbiosis-of-gut-microbiota-in-chronic-heart-failure-patients
#20
Xiao Cui, Lei Ye, Jing Li, Ling Jin, Wenjie Wang, Shuangyue Li, Minghui Bao, Shouling Wu, Lifeng Li, Bin Geng, Xin Zhou, Jian Zhang, Jun Cai
Previous studies suggested a possible gut microbiota dysbiosis in chronic heart failure (CHF). However, direct evidence was lacking. In this study, we investigated the composition and metabolic patterns of gut microbiota in CHF patients to provide direct evidence and comprehensive understanding of gut microbiota dysbiosis in CHF. We enrolled 53 CHF patients and 41 controls. Metagenomic analyses of faecal samples and metabolomic analyses of faecal and plasma samples were then performed. We found that the composition of gut microbiota in CHF was significantly different from controls...
January 12, 2018: Scientific Reports
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