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akkermansia muciniphila

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https://www.readbyqxmd.com/read/29772753/dietary-polysaccharide-from-enteromorpha-clathrata-modulates-gut-microbiota-and-promotes-the-growth-of-akkermansia-muciniphila-bifidobacterium-spp-and-lactobacillus-spp
#1
Qingsen Shang, Ya Wang, Lin Pan, Qingfeng Niu, Chao Li, Hao Jiang, Chao Cai, Jiejie Hao, Guoyun Li, Guangli Yu
Recently, accumulating evidence has suggested that Enteromorpha clathrata polysaccharide (ECP) could contribute to the treatment of diseases. However, as a promising candidate for marine drug development, although ECP has been extensively studied, less consideration has been given to exploring its effect on gut microbiota. In this light, given the critical role of gut microbiota in health and disease, we investigated here the effect of ECP on gut microbiota using 16S rRNA high-throughput sequencing. As revealed by bioinformatic analyses, ECP considerably changed the structure of the gut microbiota and significantly promoted the growth of probiotic bacteria in C57BL/6J mice...
May 17, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29769268/pbdes-altered-gut-microbiome-and-bile-acid-homeostasis-in-male-c57bl-6-mice
#2
Cindy Yanfei Li, Joseph L Dempsey, Dongfang Wang, SooWan Lee, Kris M Weigel, Qiang Fei, Deepak Kumar Bhatt, Bhagwat Prasad, Daniel Raftery, Haiwei Gu, Julia Yue Cui
Polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants with well-characterized toxicities in host organs. Gut microbiome is increasingly recognized as an important regulator of xenobiotic biotransformation; however, little is known about its interactions with PBDEs. Primary bile acids (BAs) are metabolized by the gut microbiome into more lipophilic secondary BAs that may be absorbed and interact with certain host receptors. The goal of this study was to test our hypothesis that PBDEs cause dysbiosis and aberrant regulation of BA homeostasis...
May 16, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29754312/cloning-purification-and-biochemical-characterisation-of-a-gh35-beta-1-3-beta-1-6-galactosidase-from-the-mucin-degrading-gut-bacterium-akkermansia-muciniphila
#3
Bi-Shan Guo, Feng Zheng, Lucy Crouch, Zhi-Peng Cai, Meng Wang, David N Bolam, Li Liu, Josef Voglmeir
A putative GH35 β-galactosidase gene from the mucin-degrading bacterium Akkermansia muciniphila was successfully cloned and further investigated. The recombinant enzyme with the molecular mass of 74 kDa was purified to homogeneity and biochemically characterised. The optimum temperature of the enzyme was 42 °C, and the optimum pH was determined to be pH 3.5. The addition of sodium dodecyl sulphate (SDS) reduced the enzyme's activity significantly. The addition of Mg2+ -ions decreased the activity of the β-galactosidase, whereas other metal ions or EDTA showed no inhibitory effect...
May 12, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29737097/-quantitative-detection-of-akkermansia-muciniphila-in-fecal-samples-by-real-time-pcr
#4
Qian-Qian Qin, Ling Zhang, Guo-Qing Wang
OBJECTIVE: To develop a real-time fluorescence PCR assay for quantitative detection of Akkermansia muciniphila (A. muciniphila) in fecal samples,providing technical support for quantitative detection and deep research of A.muciniphila. METHODS: The quantitative detection method for A.muciniphila were established by using SYBR Green Ⅰ; The standard curve was made using A.muciniphila standards; The sensitivity,specificity,anti-interference and repeatability of this assay were analyzed; 30 human fecal samples were detected by the established method...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29734011/the-ability-of-human-intestinal-anaerobes-to-metabolize-different-oligosaccharides-novel-means-for-microbiota-modulation
#5
Riichi Ose, Katsuaki Hirano, Shintaro Maeno, Junichi Nakagawa, Seppo Salminen, Takumi Tochio, Akihito Endo
Prebiotic oligosaccharides are known to have significant impacts on gut microbiota and are thus widely used to program healthy microbiota composition and activity from infants to the elderly. Bifidobacteria and lactobacilli are among the major target microorganisms of oligosaccharides, but the metabolic properties of oligosaccharides in other predominant gut microbes have not been well characterized. In the present study, we demonstrated the metabolic properties of six oligosaccharides in 31 key gut anaerobes...
May 4, 2018: Anaerobe
https://www.readbyqxmd.com/read/29710384/resveratrol-prevents-the-development-of-hypertension-programmed-by-maternal-plus-post-weaning-high-fructose-consumption-through-modulation-of-oxidative-stress-nutrient-sensing-signals-and-gut-microbiota
#6
You-Lin Tain, Wei-Chia Lee, Kay L H Wu, Steve Leu, Julie Y H Chan
SCOPE: High-fructose (HF) intake, oxidative stress, nutrient-sensing signals, and gut microbiota dysbiosis are closely related to the development of hypertension. We investigated whether resveratrol can prevent hypertension induced by maternal plus post-weaning HF diets in adult offspring via the above-mentioned mechanisms. METHODS AND RESULTS: Female Sprague-Dawley rats received either a normal (ND) or 60% high-fructose (HF) diet during gestation and lactation...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29710029/gender-difference-and-dietary-supplemental-vitamin-b-6-impact-on-colon-luminal-environment
#7
Dwi Eva Nirmagustina, Yongshou Yang, Thanutchaporn Kumrungsee, Noriyuki Yanaka, Norihisa Kato
Colon diseases can be affected by several factors such as gender difference and dietary supplemental vitamin B6 (B6 ). The nutritional status of B6 is affected by gender difference, leading us to hypothesize that gender difference affects colon luminal environment, which is dependent on B6 status. To investigate this hypothesis, we fed male and female rats a diet containing 1 mg, 7 mg, or 35 mg pyridoxine HCl/kg diet for 6 wk. We found significantly higher fecal mucin levels in female rats compared to those in male rats...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29705028/food-microbiome-and-colorectal-cancer
#8
REVIEW
Lukas Niederreiter, Timon E Adolph, Herbert Tilg
You are what you eat. This adage has been confirmed by many studies demonstrating the high impact of nutrition on risk of cardiovascular diseases, many malignancies and other diseases. Dietary factors are of major relevance in the evolution of colorectal carcinoma. Various aspects are involved in colorectal carcinoma pathogenesis including genetics, lifestyle, age, chronic inflammation and others. It has only recently been recognized that the gut microbiota might reflect an important missing link in the interaction between diet and subsequent colorectal carcinoma development...
April 3, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29703936/ketogenic-diet-enhances-neurovascular-function-with-altered-gut-microbiome-in-young-healthy-mice
#9
David Ma, Amy C Wang, Ishita Parikh, Stefan J Green, Jared D Hoffman, George Chlipala, M Paul Murphy, Brent S Sokola, Björn Bauer, Anika M S Hartz, Ai-Ling Lin
Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB) function, plays a major role in determining cognitive capability. Recent studies suggest that neurovascular integrity could be regulated by the gut microbiome. The purpose of the study was to identify if ketogenic diet (KD) intervention would alter gut microbiome and enhance neurovascular functions, and thus reduce risk for neurodegeneration in young healthy mice (12-14 weeks old). Here we show that with 16 weeks of KD, mice had significant increases in CBF and P-glycoprotein transports on BBB to facilitate clearance of amyloid-beta, a hallmark of Alzheimer's disease (AD)...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29701959/prebiotic-mannan-oligosaccharides-augment-the-hypoglycemic-effects-of-metformin-in-correlation-with-modulating-gut-microbiota
#10
Jialin Zheng, Heng Li, Xiaojuan Zhang, Min Jiang, Chunqin Luo, Zhenming Lu, Zheng-Hong Xu, Jin-Song Shi
Type 2 diabetes (T2D) induced by obesity and high-fat diet is significantly associated with gut microbiota dysbacteriosis. Due to the first line clinical medicine of metformin has several intestinal drawbacks, combination usage of metformin with a prebiotic of konjac mannan-oligosaccharides (MOS) was conceived and implemented aiming to investigate whether there was some intestinal synergetic effects and how MOS would function. Composite treatment of metformin and MOS demonstrated synergistic effects on ameliorating insulin resistance and glucose tolerance, and repairing islet and hepatic histology...
April 27, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29692798/the-presence-of-genotoxic-and-or-pro-inflammatory-bacterial-genes-in-gut-metagenomic-databases-and-their-possible-link-with-inflammatory-bowel-diseases
#11
Abiel Roche-Lima, Kelvin Carrasquillo-Carrión, Ramón Gómez-Moreno, Juan M Cruz, Dayanara M Velázquez-Morales, Igor B Rogozin, Abel Baerga-Ortiz
Background: The human gut microbiota is a dynamic community of microorganisms that mediate important biochemical processes. Differences in the gut microbial composition have been associated with inflammatory bowel diseases (IBD) and other intestinal disorders. In this study, we quantified and compared the frequencies of eight genotoxic and/or pro-inflammatory bacterial genes found in metagenomic Whole Genome Sequences (mWGSs) of samples from individuals with IBD vs. a cohort of healthy human subjects. Methods: The eight selected gene sequences were clbN, clbB, cif, cnf-1, usp, tcpC from Escherichia coli, gelE from Enterococcus faecalis and murB from Akkermansia muciniphila ...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29686654/high-fat-diet-induces-dysbiosis-of-gastric-microbiota-prior-to-gut-microbiota-in-association-with-metabolic-disorders-in-mice
#12
Cong He, Dandan Cheng, Chao Peng, Yanshu Li, Yin Zhu, Nonghua Lu
Accumulating evidence suggests that high-fat diet (HFD) induced metabolic disorders are associated with dysbiosis of gut microbiota. However, no study has explored the effect of HFD on the gastric microbiota. This study established the HFD animal model to determine the impact of HFD on the gastric microbiota and its relationship with the alterations of gut microbiota. A total of 40 male C57BL/6 mice were randomly allocated to receive a standard chow diet (CD) or HFD for 12 weeks (12CD group and 12HFD group) and 24 weeks (24CD group and 24HFD group) ( n = 10 mice per group)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29668928/akkermansia-muciniphila-can-reduce-the-damage-of-gluco-lipotoxicity-oxidative-stress-and-inflammation-and-normalize-intestine-microbiota-in-streptozotocin-induced-diabetic-rats
#13
Ling Zhang, Qianqian Qin, Manni Liu, Xiangling Zhang, Fang He, Guoqing Wang
This study aimed to investigate how Akkermansia muciniphila can implicate type 2 diabetes mellitus and the mechanisms underlying the effects Akkermansia muciniphila on type 2 diabetes mellitus. Normal and streptozotocin-induced diabetic Sprague-Dawley rats were orally administered with Akkermansia muciniphila and solvent. After four weeks of treatment, diabetic rats orally administered with live or pasteurized Akkermansia muciniphila exhibited significant increase in the blood concentration of high-density lipoprotein, and decrease in the hepatic glycogen, serum plasminogen activator inhibitor-1, tumor necrosis factor-α, lipopolysaccharide, malondialdehyde, and total glucagon-like peptide-1...
April 16, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29667480/the-human-gut-microbiota-metabolism-and-perspective-in-obesity
#14
Aline Corado Gomes, Christian Hoffmann, João Felipe Mota
The gut microbiota has been recognized as an important factor in the development of metabolic diseases such as obesity and is considered an endocrine organ involved in the maintenance of energy homeostasis and host immunity. Dysbiosis can change the functioning of the intestinal barrier and the gut-associated lymphoid tissues (GALT) by allowing the passage of structural components of bacteria, such as lipopolysaccharides (LPS), which activate inflammatory pathways that may contribute to the development of insulin resistance...
April 18, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29620942/food-withdrawal-alters-the-gut-microbiota-and-metabolome-in-mice
#15
Xiaojiao Zheng, Kejun Zhou, Yunjing Zhang, Xiaolong Han, Aihua Zhao, Jiajian Liu, Chun Qu, Kun Ge, Fengjie Huang, Brenda Hernandez, Herbert Yu, Jun Panee, Tianlu Chen, Weiping Jia, Wei Jia
Food withdrawal as a health-enhancing measure has beneficial effects on aging, disease prevention, and treatment. However, the cellular and molecular mechanisms involving gut microbial changes and metabolic consequences resulting from food withdrawal have yet to be elucidated. In this study, we subjected lean and obese mice to a dietary intervention that consisted of a 4-d complete food withdrawal and an 8-d 50% food withdrawal, and we studied changes in cecal microbiome and host serum metabolome. The abundance of potentially pathogenic Proteobacteria was decreased and Akkermansia muciniphila was elevated by food withdrawal in mice fed a high-fat diet (HFD)...
April 5, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29599513/akkermansia-muciniphila-is-permissive-to-arthritis-in-the-k-bxn-mouse-model-of-arthritis
#16
Matthew L Stoll, M Kathy Pierce, Jordan A Watkins, Mingce Zhang, Pamela F Weiss, Jennifer E Weiss, Charles O Elson, Randy Q Cron, Ranjit Kumar, Casey D Morrow, Trenton R Schoeb
Studies have identified abnormalities in the microbiota of patients with arthritis. To evaluate the pathogenicity of human microbiota, we performed fecal microbial transplantation from children with spondyloarthritis and controls to germ-free KRN/B6xNOD mice. Ankle swelling was equivalent in those that received patient vs. control microbiota. Principal coordinates analysis revealed incomplete uptake of the human microbiota with over-representation of two genera (Bacteroides and Akkermansia) among the transplanted mice...
March 24, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29572539/methodology-challenges-in-studying-human-gut-microbiota-effects-of-collection-storage-dna-extraction-and-next-generation-sequencing-technologies
#17
Marina Panek, Hana Čipčić Paljetak, Anja Barešić, Mihaela Perić, Mario Matijašić, Ivana Lojkić, Darija Vranešić Bender, Željko Krznarić, Donatella Verbanac
The information on microbiota composition in the human gastrointestinal tract predominantly originates from the analyses of human faeces by application of next generation sequencing (NGS). However, the detected composition of the faecal bacterial community can be affected by various factors including experimental design and procedures. This study evaluated the performance of different protocols for collection and storage of faecal samples (native and OMNIgene.GUT system) and bacterial DNA extraction (MP Biomedicals, QIAGEN and MO BIO kits), using two NGS platforms for 16S rRNA gene sequencing (Ilumina MiSeq and Ion Torrent PGM)...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29571008/grape-proanthocyanidin-induced-intestinal-bloom-of-akkermansia-muciniphila-is-dependent-on-its-baseline-abundance-and-precedes-activation-of-host-genes-related-to-metabolic-health
#18
Li Zhang, Rachel N Carmody, Hetal M Kalariya, Rocio M Duran, Kristin Moskal, Alexander Poulev, Peter Kuhn, Kevin M Tveter, Peter J Turnbaugh, Ilya Raskin, Diana E Roopchand
We previously showed that C57BL/6J mice fed high-fat diet (HFD) supplemented with 1% grape polyphenols (GP) for 12 weeks developed a bloom of Akkermansia muciniphila with attenuated metabolic syndrome symptoms. Here we investigated early timing of GP-induced effects and the responsible class of grape polyphenols. Mice were fed HFD, low-fat diet (LFD) or formulations supplemented with GP (HFD-GP, LFD-GP) for 14 days. Mice fed HFD-GP, but not LFD-GP, showed improved oral glucose tolerance compared to controls...
February 15, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29566906/action-and-function-of-akkermansia-muciniphila-in-microbiome-ecology-health-and-disease
#19
REVIEW
Noora Ottman, Sharon Y Geerlings, Steven Aalvink, Willem M de Vos, Clara Belzer
The discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine where it triggers both host metabolic and immune responses. A. muciniphila is particularly effective in increasing mucus thickness and increasing gut barrier function. As a result host metabolic markers ameliorate. The mechanism of host regulation is thought to involve the outer membrane composition, including the type IV pili of A...
December 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29473096/influence-of-gemcitabine-chemotherapy-on-the-microbiota-of-pancreatic-cancer-xenografted-mice
#20
Concetta Panebianco, Kaarel Adamberg, Madis Jaagura, Massimiliano Copetti, Andrea Fontana, Signe Adamberg, Kaia Kolk, Raivo Vilu, Angelo Andriulli, Valerio Pazienza
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-related death. We aimed to evaluate whether gemcitabine treatment shapes the gut microbiota in a model of PDAC xenografted mice. MATERIALS AND METHODS: Pancreatic cancer xenograft mice were subjected to gemcitabine injection once per week for 3 weeks to assess the tumor volume as compared to control mice injected with normal saline solution. The composition of fecal microbiota, the activation of NF-kB pathway in cancer tissues and the serum metabolomics were further analyzed...
April 2018: Cancer Chemotherapy and Pharmacology
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