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akkermansia muciniphila

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https://www.readbyqxmd.com/read/28928206/microbial-metabolic-networks-at-the-mucus-layer-lead-to-diet-independent-butyrate-and-vitamin-b12-production-by-intestinal-symbionts
#1
Clara Belzer, Loo Wee Chia, Steven Aalvink, Bhawani Chamlagain, Vieno Piironen, Jan Knol, Willem M de Vos
Akkermansia muciniphila has evolved to specialize in the degradation and utilization of host mucus, which it may use as the sole source of carbon and nitrogen. Mucus degradation and fermentation by A. muciniphila are known to result in the liberation of oligosaccharides and subsequent production of acetate, which becomes directly available to microorganisms in the vicinity of the intestinal mucosa. Coculturing experiments of Amuciniphila with non-mucus-degrading butyrate-producing bacteria Anaerostipes caccae, Eubacterium hallii, and Faecalibacterium prausnitzii resulted in syntrophic growth and production of butyrate...
September 19, 2017: MBio
https://www.readbyqxmd.com/read/28893978/gut-bacteria-from-multiple-sclerosis-patients-modulate-human-t-cells-and-exacerbate-symptoms-in-mouse-models
#2
Egle Cekanaviciute, Bryan B Yoo, Tessel F Runia, Justine W Debelius, Sneha Singh, Charlotte A Nelson, Rachel Kanner, Yadira Bencosme, Yun Kyung Lee, Stephen L Hauser, Elizabeth Crabtree-Hartman, Ilana Katz Sand, Mar Gacias, Yungjiao Zhu, Patrizia Casaccia, Bruce A C Cree, Rob Knight, Sarkis K Mazmanian, Sergio E Baranzini
The gut microbiota regulates T cell functions throughout the body. We hypothesized that intestinal bacteria impact the pathogenesis of multiple sclerosis (MS), an autoimmune disorder of the CNS and thus analyzed the microbiomes of 71 MS patients not undergoing treatment and 71 healthy controls. Although no major shifts in microbial community structure were found, we identified specific bacterial taxa that were significantly associated with MS. Akkermansia muciniphila and Acinetobacter calcoaceticus, both increased in MS patients, induced proinflammatory responses in human peripheral blood mononuclear cells and in monocolonized mice...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28870194/a-yeast-fermentate-improves-gastrointestinal-discomfort-and-constipation-by-modulation-of-the-gut-microbiome-results-from-a-randomized-double-blind-placebo-controlled-pilot-trial
#3
RANDOMIZED CONTROLLED TRIAL
Iris Pinheiro, Larry Robinson, An Verhelst, Massimo Marzorati, Björn Winkens, Pieter Van den Abbeele, Sam Possemiers
BACKGROUND: Constipation and symptoms of gastrointestinal discomfort such as bloating are common among otherwise healthy individuals, but with significant impact on quality of life. Despite the recognized contribution of the gut microbiome to this pathology, little is known about which group(s) of microorganism(s) are playing a role. A previous study performed in vitro suggests that EpiCor® fermentate has prebiotic-like properties, being able to favorably modulate the composition of the gut microbiome...
September 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28835659/changes-in-the-intestinal-microbiota-following-the-administration-of-azithromycin-in-a-randomised-placebo-controlled-trial-among-infants-in-south-india
#4
Edward P K Parker, Ira Praharaj, Jacob John, Saravanakumar Puthupalayam Kaliappan, Beate Kampmann, Gagandeep Kang, Nicholas C Grassly
Macrolides are among the most widely prescribed antibiotics worldwide. However, their impact on the gut's bacterial microbiota remains uncertain. We characterised the intestinal microbiota in 6-11 month-old infants in India who received a 3-day course of azithromycin or placebo during a randomised trial of oral poliovirus vaccine immunogenicity (CTRI/2014/05/004588). In 60 infants per study arm, we sequenced the V4 region of the bacterial 16S rRNA gene in stool samples collected before and 12 days after finishing treatment...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28832994/c4b-gene-influences-intestinal-microbiota-through-complement-activation-in-patients-with-pediatric-onset-inflammatory-bowel-disease
#5
Eija Nissilä, Katri Korpela, A Inkeri Lokki, Riitta Paakkanen, Sakari Jokiranta, Willem de Vos, Marja-Liisa Lokki, Kaija-Leena Kolho, Seppo Meri
Complement C4 genes are linked to pediatric inflammatory bowel disease (PIBD), but the mechanisms have remained unclear. We examined the influence of C4B gene number on intestinal microbiota and in vitro serum complement activation by intestinal microbes in PIBD patients. Complement C4A and C4B gene numbers were determined by genomic RT-PCR from 64 patients with PIBD (Crohn's disease or ulcerative colitis). The severity of the disease course was determined from fecal calprotectin levels. Intestinal microbiota was assessed using the HITChip microarray...
August 23, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28799667/coadministration-of-isomalto-oligosaccharides-augments-metabolic-health-benefits-of-cinnamaldehyde-in-high-fat-diet-fed-mice
#6
Dhirendra Pratap Singh, Pragyanshu Khare, Vandana Bijalwan, Ritesh Kumar Baboota, Jagdeep Singh, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
Bacteriostatic properties of a potential anti-obesity agent cinnamaldehyde (CMN) may present untoward effects on the resident gut microbiota. Here, we evaluated whether the combination of Isomalto-oligosaccharides (IMOs) with CMN prevents unwanted effects of CMN on gut microbiota and associated metabolic outcomes in HFD-fed mice. Male Swiss albino mice divided into four groups (n = 10), were fed on normal chow, or HFD (58% fat kcal), HFD + CMN (10 mg kg(-1) ) and HFD + CMN (10 mg kg(-1) ) + IMOs (1 g kg(-1) ) for 12 weeks...
August 11, 2017: BioFactors
https://www.readbyqxmd.com/read/28798745/commentary-dietary-polyphenols-promote-growth-of-the-gut-bacterium-akkermansia-muciniphila-and-attenuate-high-fat-diet-induced-metabolic-syndrome
#7
COMMENT
https://www.readbyqxmd.com/read/28741460/discovery-and-biochemical-characterization-of-udp-glucose-dehydrogenase-from-akkermansia-muciniphila
#8
Shuang Wei, Xiao-Yang Zhang, Yue Sun, Louis Patrick Conway, Li Liu
We report the discovery and characterization of a UDP-glucose dehydrogenase (AmUGD) from Akkermansia muciniphila, a bacterium originally isolated from human faeces in an anaerobic medium containing gastric mucin as the sole carbon source. The recombinant form of the protein was expressed in E. coli and the purified enzyme exhibited optimum levels of activity at 37°C and pH 9.0. While the enzyme is active in the absence of metal ions, the presence of Zn2+ ions results in markedly enhanced levels of catalysis...
July 24, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28740343/distinct-gut-microbiota-profiles-in-patients-with-primary-sclerosing-cholangitis-and-ulcerative-colitis
#9
Lukas Bajer, Miloslav Kverka, Martin Kostovcik, Peter Macinga, Jiri Dvorak, Zuzana Stehlikova, Jan Brezina, Pavel Wohl, Julius Spicak, Pavel Drastich
AIM: To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). METHODS: Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with (n = 32) or without (n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16S ribosomal RNA gene were sequenced on Illumina MiSeq platform to cover low taxonomic levels...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28726512/human-milk-oligosaccharide-categories-define-the-microbiota-composition-in-human-colostrum
#10
J Aakko, H Kumar, S Rautava, A Wise, C Autran, L Bode, E Isolauri, S Salminen
Human milk oligosaccharides (HMOs) are structurally diverse unconjugated glycans with a composition unique to each lactating mother. While HMOs have been shown to have an impact on the development of infant gut microbiota, it is not well known if HMOs also already affect milk microbial composition. To address this question, we analysed eleven colostrum samples for HMO content by high-pressure liquid chromatography and microbiota composition by quantitative PCR. Higher total HMO concentration was associated with higher counts of Bifidobacterium spp...
August 24, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28724546/high-protein-diet-promotes-sensitivity-to-cholecystokinin-and-shifts-the-cecal-microbiome-without-altering-brain-inflammation-in-diet-induced-obesity-in-rats
#11
Lixin Wang, Jonathan P Jacobs, Venu Lagishetty, Pu-Qing Yuan, Shuping Vincent Wu, Mulugeta Million, Joseph R Reeve, Joseph R Pisegna, Yvette Taché
High protein diet (HPD) curtails obesity and/or fat mass but it is unknown whether it reverses neuroinflammation, altered glucose levels, cholecystokinin (CCK) sensitivity and gut microbiome in rats fed a Western diet (WD)-induced obesity (DIO). Male rats fed a WD (high fat and sugar) for 12 weeks were switched to a HPD for 6 weeks. Body composition, food intake, meal pattern, sensitivity to intraperitoneal CCK-8S, blood glucose, brain signaling, and cecal microbiota were assessed. Compared to normal diet, WD increased body weight (9...
July 19, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28713349/the-gut-microbiota-of-healthy-chilean-subjects-reveals-a-high-abundance-of-the-phylum-verrucomicrobia
#12
Sayaka Fujio-Vejar, Yessenia Vasquez, Pamela Morales, Fabien Magne, Patricia Vera-Wolf, Juan A Ugalde, Paola Navarrete, Martin Gotteland
The gut microbiota is currently recognized as an important factor regulating the homeostasis of the gastrointestinal tract and influencing the energetic metabolism of the host as well as its immune and central nervous systems. Determining the gut microbiota composition of healthy subjects is therefore necessary to establish a baseline allowing the detection of microbiota alterations in pathologic conditions. Accordingly, the aim of this study was to characterize the gut microbiota of healthy Chilean subjects using 16S rRNA gene sequencing...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28705785/determination-of-certain-bacterial-groups-in-gut-microbiota-and-endotoxin-levels-in-patients-with-nonalcoholic-steatohepatitis
#13
Ceren Özkul, Meltem Yalınay, Tarkan Karakan, Güldal Yılmaz
BACKGROUND/AIMS: In recent years, the role of the gut microbiota has emerged in several diseases. Herein we aimed to determine the fecal microbiota, endotoxin levels, and inflammation markers in patients with nonalcoholic steatohepatitis (NASH) and healthy controls. MATERIALS AND METHODS: A total of 46 NASH patients and 38 healthy controls were included. NASH patients were diagnosed according to the steatosis, activity, and fibrosis score/fatty liver inhibition of progression algorithm...
July 13, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28687644/genome-scale-model-and-omics-analysis-of-metabolic-capacities-of-akkermansia-muciniphila-reveal-a-preferential-mucin-degrading-lifestyle
#14
Noora Ottman, Mark Davids, Maria Suarez-Diez, Sjef Boeren, Peter J Schaap, Vitor A P Martins Dos Santos, Hauke Smidt, Clara Belzer, Willem M de Vos
The composition and activity of the microbiota in the human gastrointestinal tract are primarily shaped by nutrients derived from either food or the host. Bacteria colonizing the mucus layer have evolved to use mucin as a carbon and energy source. One of the members of the mucosa-associated microbiota is Akkermansia muciniphila, which is capable of producing an extensive repertoire of mucin-degrading enzymes. To further study the substrate utilization abilities of A. muciniphila, we constructed a genome-scale metabolic model to test amino acid auxotrophy, vitamin biosynthesis, and sugar-degrading capacities...
September 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28668239/association-of-altered-gut-microbiota-composition-with-chronic-urticaria
#15
Edris Nabizadeh, Nima Hosseini Jazani, Morteza Bagheri, Shahram Shahabi
BACKGROUND: An altered gut microbiota composition has recently been linked to some types of allergies. OBJECTIVE: To compare the relative amounts of Akkermansia muciniphila, Clostridium leptum, Faecalibacterium prausnitzii, and Enterobacteriaceae as members of gut microbiota among patients with chronic urticaria (CU) and healthy controls. METHODS: A total of 20 patients with CU and 20 healthy individuals matched by age and sex participated in the study...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28630461/antrodia-cinnamomea-reduces-obesity-and-modulates-the-gut-microbiota-in-high-fat-diet-fed-mice
#16
C-J Chang, C-C Lu, C-S Lin, J Martel, Y-F Ko, D M Ojcius, T-R Wu, Y-H Tsai, T-S Yeh, J-J Lu, H-C Lai, J D Young
BACKGROUND: Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD). METHODS: Male C57BL/6J mice were fed a HFD for eight weeks to induce obesity and chronic inflammation...
June 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28629947/temporal-microbiota-changes-of-high-protein-diet-intake-in-a-rat-model
#17
Chunlong Mu, Yuxiang Yang, Zhen Luo, Weiyun Zhu
Alterations of specific microbes serve as important indicators that link gut health with specific diet intake. Although a six-week high-protein diet (45% protein) upregulates the pro-inflammatory response and oxidative stress in colon of rats, the dynamic alteration of gut microbiota remains unclear. To dissect temporal changes of microbiota, dynamic analyses of fecal microbiota were conducted using a rat model. Adult rats were fed a normal-protein diet or an HPD for 6 weeks, and feces collected at different weeks were used for microbiota and metabolite analysis...
June 17, 2017: Anaerobe
https://www.readbyqxmd.com/read/28591587/nlrp6-protects-il10-mice-from-colitis-by-limiting-colonization-of-akkermansia-muciniphila
#18
Sergey S Seregin, Natasha Golovchenko, Bryan Schaf, Jiachen Chen, Nicholas A Pudlo, Jonathan Mitchell, Nielson T Baxter, Lili Zhao, Patrick D Schloss, Eric C Martens, Kathryn A Eaton, Grace Y Chen
No abstract text is available yet for this article.
June 6, 2017: Cell Reports
https://www.readbyqxmd.com/read/28550049/recovery-of-ethanol-induced-akkermansia-muciniphila-depletion-ameliorates-alcoholic-liver-disease
#19
Christoph Grander, Timon E Adolph, Verena Wieser, Patrick Lowe, Laura Wrzosek, Benedek Gyongyosi, Doyle V Ward, Felix Grabherr, Romana R Gerner, Alexandra Pfister, Barbara Enrich, Dragos Ciocan, Sophie Macheiner, Lisa Mayr, Matthias Drach, Patrizia Moser, Alexander R Moschen, Gabriel Perlemuter, Gyongyi Szabo, Anne Marie Cassard, Herbert Tilg
OBJECTIVE: Alcoholic liver disease (ALD) is a global health problem with limited therapeutic options. Intestinal barrier integrity and the microbiota modulate susceptibility to ALD. Akkermansia muciniphila, a Gram-negative intestinal commensal, promotes barrier function partly by enhancing mucus production. The aim of this study was to investigate microbial alterations in ALD and to define the impact of A. muciniphila administration on the course of ALD. DESIGN: The intestinal microbiota was analysed in an unbiased approach by 16S ribosomal DNA (rDNA) sequencing in a Lieber-DeCarli ALD mouse model, and faecal A...
May 26, 2017: Gut
https://www.readbyqxmd.com/read/28530168/microbe-profile-akkermansia-muciniphila-a-conserved-intestinal-symbiont-that-acts-as-the-gatekeeper-of-our-mucosa
#20
Willem M de Vos
Akkermansia muciniphila is an abundant inhabitant of the intestinal tract of humans and many other animals. It is the sole intestinal representative of the verrucomicrobia in human stools and depleted in adults suffering from obesity, diabetes and several other diseases. A. muciniphila degrades intestinal mucin into mainly propionic and acetic acid, and lives in symbiosis with its host, marked by signalling to immune and metabolic pathways, priming trophic chains and likely providing competitive exclusion at the host-microbe interface...
May 22, 2017: Microbiology
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