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https://www.readbyqxmd.com/read/27272221/antioxidant-properties-and-gastroprotective-effects-of-2-ethylthio-benzohydrazones-on-ethanol-induced-acute-gastric-mucosal-lesions-in-rats
#1
Nafal Nazarbahjat, Farkaad A Kadir, Azhar Ariffin, Mahmood A Abdulla, Zanariah Abdullah, Wageeh A Yehye
A series of new 2-(ethylthio)benzohydrazone derivatives (1-6) were prepared and characterised by IR, 1H NMR, and 13C NMR spectroscopy and mass spectrometry. The newly prepared compounds were screened for their in vitro antioxidant activities using free radical scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Among them, most powerful antioxidant, compound 1 has been selected in order to illustrate anti-ulcer effect on ethanol-induced gastric mucosal lesions in rats...
2016: PloS One
https://www.readbyqxmd.com/read/25254513/use-of-humanised-rat-basophilic-leukaemia-cell-line-rs-atl8-for-the-assessment-of-allergenicity-of-schistosoma-mansoni-proteins
#2
Daniel Wan, Fernanda Ludolf, Daniel G W Alanine, Owen Stretton, Eman Ali Ali, Nafal Al-Barwary, Xiaowei Wang, Michael J Doenhoff, Adriano Mari, Colin M Fitzsimmons, David W Dunne, Ryosuke Nakamura, Guilherme C Oliveira, Marcos J C Alcocer, Franco H Falcone
BACKGROUND: Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE response in S. mansoni infection have been characterised. A better insight into the basic mechanisms of anti-parasite immunity could be gained from a genome-wide characterisation of such S. mansoni allergens. This would have repercussions on our understanding of allergy and the development of safe and efficacious vaccinations against helminthic parasites...
September 2014: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/25093989/new-thiosemicarbazides-and-1-2-4-triazolethiones-derived-from-2-ethylsulfanyl-benzohydrazide-as-potent-antioxidants
#3
Nafal Nazarbahjat, Nurdiana Nordin, Zanariah Abdullah, Mahmood Ameen Abdulla, Wageeh A Yehye, Siti Nadiah Abdul Halim, Chin Hui Kee, Azhar Ariffin
New thiosemicarbazide derivatives 2-6 were synthesised by reacting 2-(ethylsulfanyl)benzohydrazide with various aryl isothiocyanates. The cyclisation of compounds 2-6 under reflux conditions in a basic medium (aqueous NaOH, 4 N) yielded compounds 7-11 that contain a 1,2,4-triazole ring. All of the synthesised compounds were screened for their antioxidant activities. Compounds 2, 3, and 7 showed better radical scavenging in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, with IC50 values of 1.08, 0.22, and 0.74 µg/mL, respectively, compared to gallic acid (IC50, 1...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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