Felix Oldhafer, Eva-Maria Wittauer, Oliver Beetz, Clara A Weigle, Lion Sieg, Hendrik Eismann, Peter Braubach, Michael Bock, Danny Jonigk, Kai Johanning, Florian Wolfgang Rudolf Vondran
BACKGROUND: Hepatocyte transplantation (HTx) is regarded as a potential treatment modality for various liver diseases including acute liver failure. We developed a preclinical pig model to evaluate if HTx could safely support recovery from liver function impairment after partial hepatectomy. METHODS: Pigs underwent partial hepatectomy with reduction of the liver volume by 50% to induce a transient but significant impairment of liver function. Thereafter, 2 protocols for HTx were evaluated and compared to a control group receiving liver resection only (group 1, n = 5)...
May 27, 2021: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes