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https://www.readbyqxmd.com/read/28742055/kinetic-validation-of-the-limax-test-during-10-000-intravenous-13c-methacetin-breath-tests
#1
Tom Moses Rubin, Karsten Heyne, Axel Luchterhand, Jan Bednarsch, Florian W Vondran, Georgios Polychronidis, Maciej Malinowski, Alen Nikolic, Hans-Michael Tautenhahn, Maximilian Jara, Tilo Wuensch, Martin Stockmann, Johan Friso Lock
The LiMAx test, a novel 13C-methacetin-breath-test, has proven clinical validity in determining the hepatic metabolic capacity. In contrast to prior 13C-methacetin-breath-test protocols, the LiMAx-test is performed by intravenous body-weight adjusted substrate administration. Furthermore, the DOB kinetics (Delta over Baseline of the time dependent exhaled 13CO2/12CO2-ratio) are measured online at bedside with a high time resolution in order to determine the DOB maximum. The aim of this study was to analyze the recorded DOB kinetics in a large population for further refinement of the test protocol...
July 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28711678/linezolid-in-liver-failure-exploring-the-value-of-the-maximal-liver-function-capacity-limax-test-in-a-pharmacokinetic-pilot-study
#2
Sebastian G Wicha, Otto R Frey, Anka C Roehr, Johann Pratschke, Martin Stockmann, Rawan Alraish, Tilo Wuensch, Magnus Kaffarnik
BACKGROUND: Patients in the intensive care unit frequently require antibiotic treatment. Liver impairment possesses substantial challenges for dose selection in these patients. The aim of the present pilot study was to assess the novel maximal liver function capacity (LiMAx test) in comparison to conventional liver function markers as covariates of drug clearance in liver failure using linezolid as model drug. METHODS: 28 patients with different degrees of liver failure were recruited and LiMAx test, plasma, dialysis and urine sampling was performed under linezolid steady-state therapy (600 mg BID)...
July 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28542386/correlation-between-plasma-endothelin-1-levels-and-severity-of-septic-liver-failure-quantified-by-maximal-liver-function-capacity-limax-test-a-prospective-study
#3
Magnus F Kaffarnik, Navid Ahmadi, Johan F Lock, Tilo Wuensch, Johann Pratschke, Martin Stockmann, Maciej Malinowski
AIM: To investigate the relationship between the degree of liver dysfunction, quantified by maximal liver function capacity (LiMAx test) and endothelin-1, TNF-α and IL-6 in septic surgical patients. METHODS: 28 septic patients (8 female, 20 male, age range 35-80y) were prospectively investigated on a surgical intensive care unit. Liver function, defined by LiMAx test, and measurements of plasma levels of endothelin-1, TNF-α and IL-6 were carried out within the first 24 hours after onset of septic symptoms, followed by day 2, 5 and 10...
2017: PloS One
https://www.readbyqxmd.com/read/28516292/limax-test-improves-diagnosis-of-chemotherapy-associated-liver-injury-before-resection-of-colorectal-liver-metastases
#4
Johan F Lock, Tilman Westphal, Tom Rubin, Maciej Malinowski, Antje Schulz, Maximilian Jara, Jan Bednarsch, Martin Stockmann
BACKGROUND: Chemotherapy of colorectal liver metastases (CLMs) prior to liver resection implies the risk of chemotherapy-associated liver injury, leading to increased postoperative morbidity and mortality OBJECTIVE: The aim of this study was to evaluate the LiMAx (liver maximum capacity) test for diagnosis of chemotherapy-associated liver injury. METHODS: This was a retrospective analysis of patients with CLMs, prior to liver resection. We performed preoperative assessment of liver function using biochemical parameters and the LiMAx test...
May 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28196354/effect-of-age-on-liver-function-in-patients-undergoing-partial-hepatectomy
#5
T M Lodewick, P H Alizai, R M van Dam, A A J Roeth, M Schmeding, C Heidenhain, A Andert, N Gassler, C H C Dejong, U P Neumann
BACKGROUND: Postresectional liver failure is the most frequent cause of fatal outcome following liver surgery. Diminished preoperative liver function in the elderly might contribute to this. Therefore, the aim of the present study was to evaluate preoperative liver function in patients <60 or >70 years of age scheduled for liver resection. METHODS: All consecutive patients aged <60 or >70 years who are about to undergo elective liver surgery between 2011 and 2013 and underwent the methacetin breath liver function test (LiMAx) preoperatively were included...
2017: Digestive Surgery
https://www.readbyqxmd.com/read/27497918/length-of-the-memory-retention-period-depends-on-the-extent-of-protein-synthesis-in-the-terrestrial-slug-limax
#6
Yuko Suenaga, Ryota Matsuo
The terrestrial slug Limax can form an odor-aversion memory by the single simultaneous presentation of a food odor and an aversive stimulus. We have previously demonstrated that the long-term retention of this memory was impaired by a high-dose injection of a protein synthesis inhibitor 30min prior to the conditioning. However, the onset of amnesia was delayed if the dose of the inhibitor was reduced or a less potent protein synthesis inhibitor was used. We thus speculated that the persistence of memory depends on the amount of newly synthesized protein following learning...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27293483/monitoring-of-liver-function-in-a-73-year-old-patient-undergoing-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-case-report-applying-the-novel-liver-maximum-function-capacity-test
#7
Felix Oldhafer, Kristina I Ringe, Kai Timrott, Moritz Kleine, Wolf Ramackers, Sebastian Cammann, Mark D Jäger, Juergen Klempnauer, Hueseyin Bektas, Florian W R Vondran
BACKGROUND: The two-stage liver resection combining in situ liver transection with portal vein ligation, also referred to as ALPPS (Associating Liver Partition and Portal vein ligation for Staged hepatectomy), has been described as a promising method to increase the resectability of liver tumors. However, one of the most important issues regarding the safety of this procedure is the optimal timing of the second stage at the point of sufficient hypertrophy of the future liver remnant. The recently developed liver maximum function capacity test (LiMAx) can be applied to monitor the liver function postoperatively and hence could be a useful tool for decision-making regarding the timing of the second stage of ALPPS...
2016: Patient Safety in Surgery
https://www.readbyqxmd.com/read/27274881/application-of-the-liver-maximum-function-capacity-test-in-acute-liver-failure-a-helpful-tool-for-decision-making-in-liver-transplantation
#8
Florian Wolfgang Rudolf Vondran, Carsten Schumacher, Kai Johanning, Björn Hartleben, Wolfgang Knitsch, Olaf Wiesner, Elmar Jaeckel, Michael Peter Manns, Juergen Klempnauer, Hueseyin Bektas, Frank Lehner
Background. Despite aggressive intensive medical management acute liver failure (ALF) may require high-urgency liver transplantation (LTx). Available prognostic scores do not apply for all patients; reliable tools to identify individuals in need of LTx are highly required. The liver maximum function capacity test (LiMAx) might represent an appropriate option. Referring to a case of ALF after Amanita phalloides-intoxication the potential of the LiMAx-test in this setting is discussed. Presentation of Case. LiMAx was performed in a 27-year-old patient prior to and after high-urgency LTx...
2016: Case Reports in Transplantation
https://www.readbyqxmd.com/read/27164934/regeneration-of-liver-function-capacity-after-partial-liver-resection-is-impaired-in-case-of-postoperative-bile-leakage
#9
Jan Bednarsch, Elisabeth Blüthner, Maciej Malinowski, Daniel Seehofer, Johann Pratschke, Martin Stockmann
BACKGROUND: Postoperative bile leakage (PBL) is a major surgical complication after partial liver resection resulting in increased perioperative morbidity and mortality. Previous experimental studies have shown an adverse effect on functional liver regeneration, but there are still no data available concerning these effects in humans. MATERIALS AND METHODS: A retrospective matched pair analysis was carried out comparing the postoperative course of 51 patients with PBL to 51 patients without PBL...
September 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/26721255/preliminary-study-on-liver-function-changes-after-trisectionectomy-with-versus-without-prior-portal-vein-embolization
#10
COMPARATIVE STUDY
Maciej Malinowski, Johan Friso Lock, Daniel Seehofer, Bernhard Gebauer, Antje Schulz, Lina Demirel, Jan Bednarsch, Victoria Stary, Peter Neuhaus, Martin Stockmann
PURPOSE: Post-hepatectomy liver failure (PHLF) is the major risk factor for mortality after hepatectomy. Preoperative planning of the future liver remnant volume reduces PHLF rates; however, future liver remnant function (FLR-F) might have an even stronger predictive value. In this preliminary study, we used a new method to calculate FLR-F by the LiMAx test and computer tomography-assisted volumetric-analysis to visualize liver function changes after portal vein embolization (PVE) before extended hepatectomy...
September 2016: Surgery Today
https://www.readbyqxmd.com/read/26527580/-13-c-breath-tests-are-feasible-in-patients-with-extracorporeal-membrane-oxygenation-devices
#11
Jan Bednarsch, Mario Menk, Maciej Malinowski, Steffen Weber-Carstens, Johann Pratschke, Martin Stockmann
Temporary extracorporeal membrane oxygenation (ECMO) has been established as an essential part of therapy in patients with pulmonary or cardiac failure. As physiological gaseous exchange is artificially altered in this patient group, it is debatable whether a (13) C-breath test can be carried out. In this proof of technical feasibility report, we assess the viability of the (13) C-breath test LiMAx (maximum liver function capacity) in patients on ECMO therapy. All breath probes for the test device were obtained directly via the membrane oxygenator...
July 2016: Artificial Organs
https://www.readbyqxmd.com/read/26507639/effects-of-oxaliplatin-based-chemotherapy-on-liver-function-an-analysis-of-impact-and-functional-recovery-using-the-limax-test
#12
Maximilian Jara, Jan Bednarsch, Maciej Malinowski, Johann Pratschke, Martin Stockmann
PURPOSE: Chemotherapy-associated liver injury of patients undergoing therapy for colorectal liver metastases stimulates concerns on surgical safety. No common guidelines for the optimal timing of liver surgery after the application of systemic chemotherapy (chemotherapy-free interval) have been established and effects on individual liver function remain unexplored. METHODS: Maximum liver function capacity (LiMAx) and indocyanine green plasma disappearance rate (ICG-PDR) were measured in 20 patients with colorectal cancer receiving adjuvant oxaliplatin-based chemotherapy (OBC) prior to the first and after the last treatment course as well as 4 and 8 weeks thereafter...
February 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/26230140/imaging-based-liver-function-tests-past-present-and-future
#13
REVIEW
D Geisel, L Lüdemann, B Hamm, T Denecke
UNLABELLED: Preoperative assessment of liver function and prediction of postoperative functional reserve are important in patients scheduled for liver resection. While determination of absolute liver function currently mostly relies on laboratory tests and clinical scores, postoperative remnant liver function is estimated volumetrically using imaging data obtained with computed tomography (CT) or magnetic resonance imaging (MRI). Accurate estimation of hepatic function is also relevant for intensive care patients, oncologic patients, and patients with diffuse liver disease...
October 2015: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/25965488/chitosan-isoniazid-conjugates-synthesis-evaluation-of-tuberculostatic-activity-biodegradability-and-toxicity
#14
Alexander S Berezin, Yury A Skorik
Novel water-soluble chitosan-isoniazid conjugates were synthesized by two methods: (1) the carbodiimide method using isoniazid (INH) and N-(2-carboxyethyl)chitosan (CEC), and (2) the reaction between INH and N-(3-chloro-2-hydroxypropyl)chitosan (CHPC). The solubility of the conjugates under physiological conditions was enhanced by phosphorylation. Method (1) is preferable in terms of obtaining conjugates with a high content of active substance; depending on reaction conditions, the degree of substitution in the INH-CEC conjugates varies from 0...
August 20, 2015: Carbohydrate Polymers
https://www.readbyqxmd.com/read/25889706/noninvasive-diagnosis-of-chemotherapy-induced-liver-injury-by-limax-test-two-case-reports-and-a-review-of-the-literature
#15
REVIEW
Jan Bednarsch, Maximilian Jara, Johan Friso Lock, Maciej Malinowski, Johann Pratschke, Martin Stockmann
BACKGROUND: Chemotherapy-induced liver injury is a well-known phenomenon after neoadjuvant therapy of liver metastasis and contributes to postoperative morbidity and mortality. Still there is no suitable test available to reliably determine functional impairment and hepatic regeneration after chemotherapy. CASE PRESENTATION: We report two cases of caucasian patients who underwent repeated liver function assessments using LiMAx (maximum liver function capacity), Indocyanine plasma disappearance rate and biochemical liver function parameters in the course of adjuvant oxaliplatin-based chemotherapy...
March 26, 2015: BMC Research Notes
https://www.readbyqxmd.com/read/25869925/functional-liver-recovery-after-bariatric-surgery-a-prospective-cohort-study-with-the-limax-test
#16
Patrick H Alizai, Janica Wendl, Anjali A Roeth, Christian D Klink, Tom Luedde, Inga Steinhoff, Ulf P Neumann, Maximilian Schmeding, Florian Ulmer
BACKGROUND: Bariatric surgery provides long-term weight loss and improvement of obesity-associated diseases such as nonalcoholic steatohepatitis (NASH). Histologic improvement of NASH has been reported in some studies after bariatric surgery. This study was designed to assess the liver function in obese patients as well as its recovery after bariatric surgery with a noninvasive test method. METHODS: In a prospective cohort study from October 2011 to May 2014, morbidly obese individuals receiving bariatric surgery were investigated for functional liver recovery (n = 34)...
November 2015: Obesity Surgery
https://www.readbyqxmd.com/read/25263095/prognostic-value-of-enzymatic-liver-function-for-the-estimation-of-short-term-survival-of-liver-transplant-candidates-a-prospective-study-with-the-limax-test
#17
Maximilian Jara, Maciej Malinowski, Katja Lüttgert, Eckart Schott, Peter Neuhaus, Martin Stockmann
LiMAx has been recently proposed as a new quantitative liver function test. Thus, we aimed to evaluate the diagnostic ability of LiMAx to assess short-term survival in liver transplant candidates and compare its performance to the model for end-stage liver disease (MELD) and indocyanine green plasma disappearance rate (ICG-PDR). Liver function of 167 chronic liver failure patients without hepatocellular carcinoma was prospectively investigated when they were evaluated for liver transplantation. Primary study endpoints were liver-related death within 6 months of follow-up...
January 2015: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/25178675/effect-of-delayed-cni-based-immunosuppression-with-advagraf%C3%A2-on-liver-function-after-meld-based-liver-transplantation-imutect
#18
Susanne Richter, Georg Polychronidis, Daniel N Gotthardt, Philipp Houben, Thomas Giese, Anja Sander, Colette Dörr-Harim, Markus K Diener, Peter Schemmer
BACKGROUND: MELD-based allocation for liver transplantation follows the "sickest-patient-first" strategy. The latter patients present with both, decreased immune competence and poor kidney function which is further impaired by immunosuppressants. METHODS/DESIGN: In this prospective observational study, 50 patients with de novo low-dose standard Advagraf®-based immunosuppression consisting of Advagraf®, Mycophenolat-mofetil and Corticosteroids after liver transplantation will be evaluated...
September 1, 2014: BMC Surgery
https://www.readbyqxmd.com/read/25150081/reliable-assessment-of-liver-function-using-limax
#19
COMPARATIVE STUDY
Maximilian Jara, Jan Bednarsch, Erika Valle, Johan Friso Lock, Maciej Malinowski, Antje Schulz, Daniel Seehofer, Tobias Jung, Martin Stockmann
BACKGROUND: (13)C-liver function breath tests can facilitate the assessment of hepatic function in-vivo and may help surgeons to identify candidates for safe liver surgery. However, their acceptance into clinical practice is dependent on evaluation of technical efficacy and repeatability. The aims of this study were to evaluate the within-subject repeatability of the LiMAx (maximum liver function capacity) test in healthy individuals and in surgical patients to determine liver function in the perioperative workup...
January 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/24993690/enzymatic-liver-function-capacity-correlates-with-disease-severity-of-patients-with-liver-cirrhosis-a-study-with-the-limax-test
#20
Maciej Malinowski, Maximilian Jara, Katja Lüttgert, James Orr, Johan Friso Lock, Eckart Schott, Martin Stockmann
BACKGROUND: Assessment and quantification of actual liver function is crucial in patients with chronic liver disease to monitor disease progression and predict individual prognosis. Mathematical models, such as model for end-stage liver disease, are used for risk stratification of patients with chronic liver disease but do not include parameters that reflect the actual functional state of the liver. AIM: We aimed to evaluate the potential of a (13)C-based liver function test as a stratification tool by comparison with other liver function tests and clinical parameters in a large sample of healthy controls and cirrhotic patients...
December 2014: Digestive Diseases and Sciences
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