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ischemic stroke cancer

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https://www.readbyqxmd.com/read/29894733/modeling-the-impact-of-changes-in-tobacco-use-on-individual-disease-risks
#1
S Djurdjevic, Z Sponsiello-Wang, P N Lee, J S Fry, R Weitkunat, F Lüdicke, G Baker
Reduced Risk Products (RRPs) do not burn tobacco and produce lower levels of toxicants than in cigarette smoke. The long-term effects of using RRPs on health are difficult to assess in a pre-market setting and a modeling approach is required to quantify harm reduction. The Population Health Impact Model (Weitkunat et al., 2015) follows a hypothetical population of individuals over time, creating their tobacco use histories and, based on these, estimating relative and absolute risks of lung cancer, ischemic heart disease, stroke and chronic obstructive pulmonary disease...
June 9, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29889889/adipose-tissue-content-of-alpha-linolenic-acid-and-the-risk-of-ischemic-stroke-and-ischemic-stroke-subtypes-a-danish-case-cohort-study
#2
Christian Sørensen Bork, Stine Krogh Venø, Søren Lundbye-Christensen, Marianne Uhre Jakobsen, Anne Tjønneland, Philip C Calder, Kim Overvad, Erik Berg Schmidt
BACKGROUND: The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA) may reduce the risk of cardiovascular disease. OBJECTIVE: We have investigated associations between the content of ALA in adipose tissue and the risk of ischemic stroke and its subtypes. METHODS: Incident cases of ischemic stroke among participants enrolled into the Danish Diet, Cancer and Health cohort (n = 57,053) were identified by linkage with the Danish National Patient Register...
2018: PloS One
https://www.readbyqxmd.com/read/29889460/evaluation-of-ischemic-stroke-patients-with-systemic-cancer
#3
Ufuk Emre, Taskin Gunes, Irem Pinar, Furuzan Kokturk, Esengul Liman, Orhan Yağiz
Background and purpose: In cancer patients, an ischemic stroke can be seen as both a direct effect of cancer and a complication of treatment. This condition can negatively affect the follow-up and treatment of these patients. For this research, we aimed to evaluate the clinical features, stroke types and etiological features of ischemic stroke patients with histories of cancer or found to have cancer during the aetiological investigation. Methods: We retrospectively evaluated 100 patients (57 males, 43 females) who were hospitalized with acute stroke and determined to have the presence of cancer or a cancer history during the aetiological investigation between 2011 and 2016...
May 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29886721/self-rated-health-status-and-risk-of-incident-stroke-in-0-5-million-chinese-adults-the-china-kadoorie-biobank-study
#4
Wenhong Dong, Xiong-Fei Pan, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li
BACKGROUND AND PURPOSE: Self-rated health (SRH) is a consistent and strong predictor of all-cause and cardiovascular mortality in various populations. However, the associations between SRH measures and risk of first-ever or recurrent stroke were rarely explored. We thus aim to prospectively investigate the associations between SRH measures and risk of total and subtypes of stroke in Chinese population. METHODS: A total of 494,113 participants from the China Kadoorie Biobank without prior heart diseases or cancer (486,541 without stroke and 7,572 with stroke) were followed from baseline (2004 to 2008) until December 31, 2013...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29886671/-sole-angioplasty-with-tiny-balloon-for-high-risk-complex-symptomatic-intracranial-atherosclerotic-stenosis
#5
P Qi, J J Wang, L J Wang, J Lu, S Hu, X M Yang, K P Chen, H F Wang, D M Wang
Objective: To explore the safety and short-term efficacy of sole angioplasty with tiny balloon for symptomatic intracranial atherosclerotic stenosis (ICAS) patients with complex lesions refractory. Methods: Consecutive 11 patients with complex ICAS lesions treated by sole angioplasty with tiny balloon (diameter≤2 mm) from September 2016 to November 2017 at Department of Neurosurgery, Beijing Hospital were retrospectively reviewed. Patients' demographics, lesions characteristics, procedures, complications, and clinical and imaging follow-up data were collected...
June 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29883549/upregulated-long-non-coding-rna-snhg1-promotes-the-angiogenesis-of-brain-microvascular-endothelial-cells-after-oxygen-glucose-deprivation-treatment-by-targeting-mir-199a
#6
Zhengfeng Wang, Ruihua Wang, Kai Wang, Xianzhi Liu
Angiogenesis after ischemic stroke have important clinical significance, which stimulates endogenous recovery mechanisms and improves the neurological outcome. Enhancing angiogenesis may facilitate the function recovery from ischemic stroke. Recent studies have shown that aberrant expression of long non-coding RNAs (lncRNAs) is related to angiogenesis after ischemic stroke. Snhg1, a cancer-related lncRNA, has been reported to be upregulated after stroke. However, little is known about its role in stroke. In this study, we performed in vitro experiments to investigate the effects of Snhg1 on cell survival and angiogenesis and molecular mechanism in ischemic stroke...
June 8, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29876857/ambient-air-pollution-of-particles-and-gas-pollutants-and-the-predicted-health-risks-from-long-term-exposure-to-pm-2-5-in-zhejiang-province-china
#7
Yuanchen Chen, Lu Zang, Wei Du, Da Xu, Guofeng Shen, Quan Zhang, Qiaoli Zou, Jinyuan Chen, Meirong Zhao, Defei Yao
In recent years, ambient air has been severely contaminated by particulate matters (PMs) and some gas pollutants (nitrogen dioxide (NO2 ) and sulfur dioxide (SO2 )) in China, and many studies have demonstrated that exposure to these pollutants can induce great adverse impacts on human health. The concentrations of the pollutants were much higher in winter than those in summer, and the average concentrations in this studied area were lower than those in northern China. In the comparison between high-resolution emission inventory and spatial distribution of PM2...
June 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29869055/pyruvate-kinase-m2-increases-angiogenesis-neurogenesis-and-functional-recovery-mediated-by-upregulation-of-stat3-and-focal-adhesion-kinase-activities-after-ischemic-stroke-in-adult-mice
#8
Dongdong Chen, Ling Wei, Zhi-Ren Liu, Jenny J Yang, Xiaohuan Gu, Zheng Z Wei, Li-Ping Z Liu, Shan Ping Yu
Ischemic stroke remains a serious threat to human life. Generation of neuronal and vascular cells is an endogenous regenerative mechanism in the adult brain, which may contribute to tissue repair after stroke. However, the regenerative activity is typically insufficient for significant therapeutic effects after brain injuries. Pyruvate kinase isoform M2 (PKM2) is a key regulator for energy metabolism. PKM2 also has nonmetabolic roles involving regulations of gene expression, cell proliferation, and migration in cancer cells as well as noncancerous cells...
June 4, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29866752/risk-of-ischemic-and-hemorrhagic-strokes-in-occult-and-manifest-cancers
#9
Klaus Kaae Andersen, Tom Skyhøj Olsen
BACKGROUND AND PURPOSE: Manifest cancer is associated with increased risk of stroke. The risk of stroke in people with occult cancer in comparison to the risk in the background population without cancer has not been investigated. Smoking is a risk factor for both cancer and stroke, but the role of smoking for the risk of stroke in cancer has not been investigated. METHODS: We identified all incident cases of cancer in Denmark 2003 to 2012 (n=264.376) from the Danish Cancer Registry...
June 4, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29807000/arterial-ischemic-events-are-a-major-complication-in-cancer-patients-with-venous-thromboembolism
#10
Benjamin Brenner, Behnood Bikdeli, Inna Tzoran, Olga Madridano, Raquel López-Reyes, José María Suriñach, Ángeles Blanco-Molina, Antonella Tufano, Juan José López Núñez, Javier Trujillo-Santos, Manuel Monreal
BACKGROUND: Venous thromboembolism is common in patients with malignancies, affecting up to 10% of this patient population. The association between arterial ischemic events and venous thromboembolism has been also established. However, the influence of arterial ischemic events on outcomes in cancer patients with venous thromboembolism has not been fully determined. METHODS: The current study analyzed clinical characteristics, time-course, risk factors, incidence and severity of venous thromboembolism recurrences, arterial ischemic events and major bleeding in 5,717 patients with active cancer and venous thromboembolism recruited into RIETE (multi-center prospective registry of patients with objectively confirmed venous thromboembolism)...
May 25, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29806794/the-history-of-natural-progesterone-the-never-ending-story
#11
P Piette
The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium...
May 28, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29799416/an-update-on-physical-health-and-economic-consequences-of-overweight-and-obesity
#12
REVIEW
Dinh-Toi Chu, Nguyen Thi Minh Nguyet, Thien Chu Dinh, Nguyen Vu Thai Lien, Khanh-Hoang Nguyen, Vo Truong Nhu Ngoc, Yang Tao, Le Hoang Son, Duc-Hau Le, Vu Bich Nga, Adam Jurgoński, Quoc-Hung Tran, Pham Van Tu, Van-Huy Pham
Overweight and obesity (OW and OB) have been on the increase globally and posed health risks to the world's population of all ages, including pre-born babies, children, adolescents, adults and elderly people, via their comorbid conditions. Excellent examples of comorbidities associated with obesity include cancer, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM). In this article, we aimed to review and update scientific evidence regarding the relationships between obesity and its common physical health consequences, including CVD, T2DM, hypertension, ischemic stroke, cancer, dyslipidemia and reproductive disorders...
May 5, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29798981/-microrna-in-ischemic-stroke
#13
K A Aitbaev, I T Murkamilov, V V Fomin, J A Murkamilova, F A Yusupov
Today, stroke is the third most common pathology after cardiovascular disease and cancer, as well as the leading cause of disability in the world. Although some progress has been made in the field of primary and secondary stroke prevention over the past few decades, a deeper knowledge of the pathophysiology of the disease is needed to significantly improve diagnosis and therapy. MicroRNA (miRNA) is an important, recently identified class of posttranscriptional regulators of gene expression. MiRNA can be used as a tool for therapeutic interventions...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29793661/dietary-magnesium-and-chronic-disease
#14
REVIEW
Forrest H Nielsen
Although official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement. This moderate or marginal (subclinical) deficient Mg intake generally is asymptomatic. Animal studies, however, indicate that moderate or subclinical Mg deficiency primes phagocytic cells for the release of proinflammatory cytokines leading to chronic inflammatory and oxidative stress. Human studies have found that dietary Mg is inversely related to serum or plasma C-reactive protein (CRP)...
May 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29792090/procedural-and-clinical-outcomes-of-endovascular-recanalization-therapy-in-patients-with-cancer-related-stroke
#15
Seunguk Jung, Cheolkyu Jung, Jae Hyoung Kim, Byung Se Choi, Yun Jung Bae, Leonard Sunwoo, Ho Geol Woo, Jun Young Chang, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae
Objective Embolism due to coagulopathy might be the main pathomechanism underlying cancer-related stroke (CRS). CRS patients with a large artery occlusion could be candidates for endovascular recanalization therapy (ERT), although its procedural and clinical outcomes are not well known. This study aimed to investigate the procedural and clinical outcomes of ERT in CRS patients and the characteristics associated with outcomes compared with those of conventional stroke patients. Methods A registry of consecutive acute ischemic stroke patients who underwent ERT between January 2011 and October 2015 was retrospectively reviewed...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29779882/antithrombotic-therapy-strategy-for-cancer-associated-ischemic-stroke-a-case-series-of-26-patients
#16
Hiroyuki Naito, Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Hiroki Ueno, Kazuhide Ochi, Hirofumi Maruyama
BACKGROUND: The risk of complications from thromboembolism is increased for patients with malignancy. Cancer-associated stroke is also a serious issue with regard to the management of patients with cancer because stroke incidence often causes disabilities that affect daily life and cancer treatment strategy. METHODS: Between March 2011 and September 2017, 328 patients with acute ischemic stroke were registered to our hospital. RESULTS: Of these patients, 26 (7...
May 17, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29776431/validation-of-verbal-autopsy-methods-using-hospital-medical-records-a-case-study-in-vietnam
#17
Hong Thi Tran, Hoa Phuong Nguyen, Sue M Walker, Peter S Hill, Chalapati Rao
BACKGROUND: Information on causes of death (COD) is crucial for measuring the health outcomes of populations and progress towards the Sustainable Development Goals. In many countries such as Vietnam where the civil registration and vital statistics (CRVS) system is dysfunctional, information on vital events will continue to rely on verbal autopsy (VA) methods. This study assesses the validity of VA methods used in Vietnam, and provides recommendations on methods for implementing VA validation studies in Vietnam...
May 18, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29767732/dietary-intake-of-alpha-linolenic-acid-is-not-appreciably-associated-with-the-risk-of-ischemic-stroke-among-middle-aged-danish-men-and-women
#18
Christian S Bork, Stine K Venø, Søren Lundbye-Christensen, Marianne U Jakobsen, Anne Tjønneland, Erik B Schmidt, Kim Overvad
Background: Intake of the plant-derived omega-3 (n-3) fatty acid alpha-linolenic acid (ALA) may reduce the risk of ischemic stroke. Objective: We have investigated the associations between dietary intake of ALA and the risk of ischemic stroke and ischemic stroke subtypes. Methods: This was a follow-up study. A total of 57,053 participants aged 50-64 y were enrolled into the Danish Diet, Cancer and Health cohort between 1993 and 1997. Intake of ALA was assessed by a validated semiquantitative food frequency questionnaire...
May 15, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29762085/association-between-comorbid-cancer-and-outcomes-among-admissions-for-acute-ischemic-stroke-receiving-systemic-thrombolysis
#19
Erin R Weeda, Nicole Bohm
Background The impact of cancer on outcomes was not assessed in major trials of systemic thrombolysis in acute ischemic stroke. Aims To evaluate the association between comorbid cancer and hospital outcomes among patients receiving systemic thrombolysis for the treatment of acute ischemic stroke. Methods The 2013 and 2014 United States National Inpatient Sample was used to identify adult patients hospitalized for acute ischemic stroke who received systemic thrombolysis. Identified admissions were stratified into two cohorts based on the presence or absence of comorbid cancer...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29730064/risk-of-radiation-vasculopathy-and-stroke-in-pediatric-patients-treated-with-proton-therapy-for-brain-and-skull-base-tumors
#20
Matthew D Hall, Julie A Bradley, Ronny L Rotondo, Ricardo Hanel, Chetan Shah, Christopher G Morris, Philipp R Aldana, Daniel J Indelicato
PURPOSE: To estimate the rate of and identify risk factors for vasculopathy after proton therapy in pediatric patients with central nervous system and skull base tumors. METHODS AND MATERIALS: Between 2006 and 2015, 644 pediatric patients with central nervous system and skull base tumors were treated with proton therapy at a single institution. The 3 most common histologies were craniopharyngioma (n = 135), ependymoma (n = 135), and low-grade glioma (n = 131)...
March 29, 2018: International Journal of Radiation Oncology, Biology, Physics
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