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https://www.readbyqxmd.com/read/29671285/effect-of-non-vitamin-k-antagonist-oral-anticoagulants-in-atrial-fibrillation-patients-with-newly-diagnosed-cancer
#1
Kyu Kim, Yong Joon Lee, Tae Hoon Kim, Jae Sun Uhm, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung
BACKGROUND AND OBJECTIVES: There are limited data on the use of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with cancer. We aimed to assess the efficacy and safety of NOACs in AF patients with cancer in this study. METHODS: In 2,568 consecutive non-valvular AF patients with newly diagnosed cancer, we analyzed ischemic stroke/systemic embolism (SE), major bleeding, and all-cause death. Based on propensity score matching, 388 matched pairs were included in the NOAC and warfarin groups...
February 26, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29666603/long-term-factors-associated-with-falls-and-fractures-poststroke
#2
Emma J Foster, Raphae S Barlas, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, John F Potter, Phyo K Myint
Background: Risk factors for poststroke falls and fractures remain poorly understood. This study aimed to evaluate which factors increased risk of these events after stroke. Methods: Data from 7,267 hospitalized stroke patients were acquired from the Norfolk and Norwich University Hospital Stroke Register from 2003-2015. The impacts of multiple patient level and stroke characteristics and comorbidities on post-discharge falls and fractures were assessed. Univariate and multivariable models were constructed, adjusting for multiple confounders, using binary logistic regression for short-term analysis (up to 1-year post-discharge) and Cox-proportional hazard models for longer term analysis (1-3, 3-5, and 0-10 years follow-up)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29628482/relationship-between-long-interspersed-nuclear-element-1-dna-methylation-in-leukocytes-and-dyslipidemia-in-the-japanese-general-population
#3
Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Yuri Murase, Koji Ohashi, Hiroaki Ishikawa, Mari Kondo, Takashi Inoue, Shuji Hashimoto, Nobuyuki Hamajima, Koji Suzuki
AIM: Aberrant global DNA methylation is involved in the development of several diseases, including cardiovascular disease (CVD). We investigated whether the methylation of long interspersed nuclear element-1 (LINE-1) in leukocytes is associated with dyslipidemia, a major risk factor for CVD, in the Japanese general population. METHODS: We conducted a cross-sectional study consisting of 420 Japanese subjects (187 men and 233 women) without a clinical history of cancer, stroke, or ischemic heart disease...
April 7, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29619341/right-carotid-cutaneous-fistula-and-right-carotid-pseudoaneurysm-formation-secondary-to-a-chronically-infected-polyethylene-terephthalate-patch
#4
W T Hillman Terzian, Samuel Schadt, Sharvil U Sheth
Carotid endarterectomy (CEA) remains the treatment for significant carotid stenosis and stroke prevention. Approximately 100,000 CEAs are performed in the United States every year. Randomized trials have demonstrated an advantage of patch carotid angioplasty over primary closure. Complications from patches include thrombosis, transient ischemic attack, stroke, restenosis, pseudoaneurysm (PA), and infection. PA after CEA is rare, with a reported average of 0.37% of cases. We describe an unusual case of PA after polyethylene terephthalate (PTFE) patching for CEA...
January 2018: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29610261/association-of-cancer-cell-type-and-extracellular-vesicles-with-coagulopathy-in-patients-with-lung-cancer-and-stroke
#5
Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang
BACKGROUND AND PURPOSE: Coagulopathy is an important cause of stroke in cancer patients. However, underlying mechanisms and clinical factors related to coagulopathy remain unclear. We hypothesized that certain characteristics of cancer affect coagulopathy in patients with lung cancer and ischemic stroke. METHODS: Consecutive patients with active lung cancer and acute ischemic stroke were prospectively studied. Volume and pattern of acute brain infarcts and plasma levels of circulating tumor extracellular vesicles (EVs) were measured using flow cytometry...
April 2, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29596481/neck-dissection-does-not-increases-the-risk-of-stroke-in-thyroid-cancer-a-national-cohort-study
#6
Bumjung Park, Chanyang Min, Hyo Geun Choi
OBJECTIVES: The purpose of this study is to evaluate the risk of stroke (hemorrhagic or ischemic) after neck dissection in thyroid cancer patients in Korea using national cohort data. METHODS: Using the national cohort study from the Korean Health Insurance Review and Assessment Service, patients with neck dissection for thyroid cancer (1,041) and control participants (4,164) were selected and matched 1:4 (age, gender, income, and region of residence). The Chi-square test, Fischer's exact test, and the Cox-proportional hazard model were used...
2018: PloS One
https://www.readbyqxmd.com/read/29584626/characterization-of-fine-particulate-matter-and-associated-health-burden-in-nanjing
#7
Dongyang Nie, Mindong Chen, Yun Wu, Xinlei Ge, Jianlin Hu, Kai Zhang, Pengxiang Ge
Particulate matter (PM) air pollution has become a serious environmental problem in Nanjing and poses great health risks to local residents. In this study, characteristics of particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5 ) over Nanjing were analyzed using hourly and daily averaged PM2.5 concentrations and meteorological parameters collected from nine national monitoring sites during the period of March 2014 to February 2017. Then, the integrated exposure-response (IER) model was applied to assess premature mortality, years of life lost (YLL) attributable to PM2...
March 27, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29580034/risk-factors-biomarkers-etiology-outcome-and-prognosis-of-ischemic-stroke-in-cancer-patients
#8
Mine Hayriye Sorgun, Muge Kuzu, Inci Sule Ozer, Volkan Yilmaz, Cagrı Ulukan, Hafize Cotur Levent, Sabiha Tezcan, Sefer Rzayev, Anwar Rawandi, Batuhan Bakırarar, Canan Togay Isikay
Introduction: Cerebrovascular disease is the second most common complication in individuals with tumours. The aim of this study was to investigate risk factors, biomarkers, etiology and prognosis of ischemic stroke in cancer patients (ISCPs). Methods: The medical records of 619 consecutive patients who were admitted with acute ischemic stroke from January 2012 to November 2014 were retrospectively evaluated. The patients were divided into two groups (group 1, patients with an active cancer prior to the onset of ischemic stroke; group 2, patients without an active cancer history)...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29575995/large-vessel-arteriopathy-after-cranial-radiation-therapy-in-pediatric-brain-tumor-survivors
#9
Matthew Nordstrom, Erin Felton, Katherine Sear, Benita Tamrazi, Joseph Torkildson, Karen Gauvain, Daphne A Haas-Kogan, Josephine Chen, Benedict Del Buono, Anuradha Banerjee, David Samuel, David Saloner, Bing Tian, Erika Roddy, Christopher Hess, Heather Fullerton, Sabine Mueller
Among childhood cancer survivors, increased stroke risk after cranial radiation therapy may be caused by radiation-induced arteriopathy, but limited data exist to support this hypothesis. Herein, we assess the timing and presence of cerebral arteriopathy identified by magnetic resonance angiography (MRA) after cranial radiation therapy in childhood brain tumor survivors. In a cohort of 115 pediatric brain tumor survivors, we performed chart abstraction and prospective annual follow-up to assess the presence of large vessel cerebral arteriopathy by MRA...
April 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29563017/predictors-of-adverse-outcome-in-patients-with-myocardial-infarction-with-non-obstructive-coronary-artery-minoca-disease
#10
A M Nordenskjöld, T Baron, K M Eggers, T Jernberg, B Lindahl
BACKGROUND: Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCAs) is an increasingly recognized entity. No previous study has evaluated predictors for new major adverse cardiacvascular events (MACEs) and death in patients with MINOCA. METHODS: We conducted an observational study of MINOCA patients recorded between July 2003 and June 2013 and followed until December 2013 for outcome events. Out of 199,163 MI admissions, 9092 consecutive unique patients with MINOCA were identified...
March 14, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29558659/cancer-associated-ischemic-stroke-a-retrospective-multicentre-cohort-study
#11
Stefano Grazioli, Maurizio Paciaroni, Giancarlo Agnelli, Monica Acciarresi, Andrea Alberti, Cataldo D'Amore, Valeria Caso, Michele Venti, Luigina Guasti, Walter Ageno, Alessandro Squizzato
BACKGROUND: The association between stroke and cancer is well-known but insufficiently investigated. Aim of this multicentre retrospective cohort study was to estimate the prevalence of cancer-associated ischemic stroke, describe clinical outcomes in patients with cancer-associated ischemic stroke and investigate independent factors associated with active cancer. METHODS: Consecutive adult patients admitted for acute ischemic stroke were included. Included patients were admitted in the Stroke Unit of the Hospital of Perugia, Italy, from March 2005 to March 2015, and in a medical unit of the Hospital of Varese, Italy, from January 2010 till December 2011...
March 15, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29547637/temporal-changes-in-the-neutrophil-to-lymphocyte-ratio-and-the-neurological-progression-in-cryptogenic-stroke-with-active-cancer
#12
Ki-Woong Nam, Tae Jung Kim, Chi Kyung Kim, Heejung Mo, Han-Yeong Jeong, Min Kyoung Kang, Moon-Ku Han, Sang-Bae Ko, Byung-Woo Yoon
BACKGROUND: Ischemic stroke patients with active cancer frequently experience early neurological deterioration (END); however, the predictors of END are not well studied. The neutrophil to lymphocyte ratio (NLR) has recently been described as a predictor of poor outcomes in cancer and stroke. However, its role in cancer-related stroke has not been addressed. AIM: We aimed to evaluate the association between the NLR and END in cancer-related stroke patients. METHODS: We included 85 cryptogenic stroke patients with active cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29534728/long-non-coding-rna-miat-in-development-and-disease-a-new-player-in-an-old-game
#13
REVIEW
Cheng Sun, Lining Huang, Zhenglong Li, Kaiming Leng, Yi Xu, Xingming Jiang, Yunfu Cui
BACKGROUND: Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression of disease. Myocardial infarction associated transcript (MIAT), which was recently found to demonstrate aberrant expression in various diseases, such as myocardial infarction, schizophrenia, ischemic stroke, diabetic complications, age-related cataract and cancers, is a novel disease-related lncRNA...
March 13, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29525076/characterization-of-patients-with-embolic-strokes-of-undetermined-source-in-the-navigate-esus-randomized-trial
#14
Scott E Kasner, Pablo Lavados, Mukul Sharma, Yongjun Wang, Yilong Wang, Antoni Dávalos, Nikolay Shamalov, Luis Cunha, Arne Lindgren, Robert Mikulik, Antonio Arauz, Wilfried Lang, Anna Czlonkowska, Jens Eckstein, Rubens Gagliardi, Pierre Amarenco, Sebastián F Ameriso, Turgut Tatlisumak, Roland Veltkamp, Graeme J Hankey, Danilo S Toni, Daniel Bereczki, Shinichiro Uchiyama, George Ntaios, Byung-Woo Yoon, Raf Brouns, M M DeVries Basson, Matthias Endres, Keith Muir, Natan Bornstein, Serefnur Ozturk, Martin O'Donnell, Hardi Mundl, Calin Pater, Jeffrey Weitz, W Frank Peacock, Balakumar Swaminathan, Bodo Kirsch, Scott D Berkowitz, Gary Peters, Guillaume Pare, Ellison Themeles, Ashkan Shoamanesh, Stuart J Connolly, Robert G Hart
BACKGROUND: The New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial vs. ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial is a randomized phase-III trial comparing rivaroxaban versus aspirin in patients with recent ESUS. AIMS: We aimed to describe the baseline characteristics of this large ESUS cohort to explore relationships among key subgroups. METHODS: We enrolled 7213 patients at 459 sites in 31 countries...
March 7, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29520943/pre-admission-treatment-with-beta-blockers-in-hypertensive-patients-with-acute-stroke-and-3-month-outcome-data-from-a-national-stroke-registry
#15
Yoav Eizenberg, Ehud Grossman, David Tanne, Silvia Koton
The impact of beta-blockers (BB) treatment on stroke outcome is unclear. We used data from a prospective national stroke registry to assess the associations between use of BB and poor outcome 3 months after stroke. Using the National Acute Stroke Israeli (NASIS) registry, we identified 1126 patients with ischemic stroke and intracerebral hemorrhage with pre-stroke hypertension treatment, who were followed for 3-months. Functional outcome and mortality at 3-month were compared by use of BB, adjusting for demographics and clinical factors...
March 9, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29509282/medicare-part-d-use-of-older-medicare-beneficiaries-admitted-to-hospice
#16
Patrick M Zueger, Holly M Holmes, Gregory S Calip, Dima M Qato, A Simon Pickard, Todd A Lee
OBJECTIVES: To describe medications that older hospice beneficiaries receive through Medicare Part D and assess patterns in Part D use for individuals admitted to hospice for cancer and noncancer causes. DESIGN: Descriptive cohort analysis using the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database. SETTING: U.S. hospice programs PARTICIPANTS: Part D-enrolled Medicare beneficiaries aged 66 and older who were admitted to hospice and died while under hospice care between January 1, 2008, and December 31, 2013 (N = 88,957)...
March 6, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29507614/molecular-magnetic-resonance-imaging-of-endothelial-activation-in-the-central-nervous-system
#17
REVIEW
Maxime Gauberti, Antoine P Fournier, Fabian Docagne, Denis Vivien, Sara Martinez de Lizarrondo
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), P-Selectin and E-Selectin...
2018: Theranostics
https://www.readbyqxmd.com/read/29495200/-family-history-and-risk-of-coronary-heart-disease
#18
J H Si, R R Meng, C Q Yu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, Z M Chen, J Lyu, L M Li
Objective: To evaluate the association of family history with risk of major coronary events (MCE) and ischemic heart disease (IHD). Methods: After excluding participants with heart disease, stroke or cancer at baseline survey, a total of 485 784 participants from the China Kadoorie Biobank, who had no missing data on critical variables, were included in the analysis. Cox regression analysis was used to estimate the hazard ratios ( HR ) and 95% CI . Subgroup analyses were performed according to the baseline characteristics...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29484138/impact-of-atrial-fibrillation-on-the-development-of-ischemic-stroke-among-cancer-patients-classified-by-cha-2-ds-2-vasc-score-a-nationwide-cohort-study
#19
Wei-Syun Hu, Cheng-Li Lin
Purpose: The current study aimed to explore the impact of atrial fibrillation (AF) on risk of ischemic stroke among cancer patients classified by CHA2 DS2 -VASc score. Methods: Study participants were identified from Registry for Catastrophic Illness Patient Database. All cancer patients whether they had comorbid AF or not were divided into 4 groups according to their CHA2 DS2 -VASc score-a score of 0-1, 2-3, 4-5 and >5. Competing risk analysis was used to evaluate the subhazard ratios (SHRs) and 95% confidence intervals (CIs) of incident ischemic stroke between cancer patients with and without AF according to their CHA2 DS2 -VASc score...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29477017/long-term-trends-and-health-impact-of-pm-2-5-and-o-3-in-tehran-iran-2006-2015
#20
Sasan Faridi, Mansour Shamsipour, Michal Krzyzanowski, Nino Künzli, Heresh Amini, Faramarz Azimi, Mazen Malkawi, Fatemeh Momeniha, Akbar Gholampour, Mohammad Sadegh Hassanvand, Kazem Naddafi
The main objectives of this study were (1) investigation of the temporal variations of ambient fine particulate matter (PM2.5 ) and ground level ozone (O3 ) concentrations in Tehran megacity, the capital and most populous city in Iran, over a 10-year period from 2006 to 2015, and (2) estimation of their long-term health effects including all-cause and cause-specific mortality. For the first goal, the data of PM2.5 and O3 concentrations, measured at 21 regulatory monitoring network stations in Tehran, were obtained and the temporal trends were investigated...
February 21, 2018: Environment International
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