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https://www.readbyqxmd.com/read/27914045/achievements-and-challenges-in-computational-protein-design
#1
Ilan Samish
Computational protein design (CPD), a yet evolving field, includes computer-aided engineering for partial or full de novo designs of proteins of interest. Designs are defined by a requested structure, function, or working environment. This chapter describes the birth and maturation of the field by presenting 101 CPD examples in a chronological order emphasizing achievements and pending challenges. Integrating these aspects presents the plethora of CPD approaches with the hope of providing a "CPD 101". These reflect on the broader structural bioinformatics and computational biophysics field and include: (1) integration of knowledge-based and energy-based methods, (2) hierarchical designated approach towards local, regional, and global motifs and the integration of high- and low-resolution design schemes that fit each such region, (3) systematic differential approaches towards different protein regions, (4) identification of key hot-spot residues and the relative effect of remote regions, (5) assessment of shape-complementarity, electrostatics and solvation effects, (6) integration of thermal plasticity and functional dynamics, (7) negative design, (8) systematic integration of experimental approaches, (9) objective cross-assessment of methods, and (10) successful ranking of potential designs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27909612/nonsurgical-treatment-options-in-peyronie-s-disease-2016-update
#2
REVIEW
Raidh A Talib, Mohammed Abdulkareem Ibrahim, Önder Cangüven
Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. In the last 5 years, commonly used oral medications left their places to intralesional therapies. Clostridium collagenase, which is the only Food and Drug Administration (FDA) approved treatment for PD, is now the most prescribed intralesional therapy in the last years...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27906117/carotid-artery-stenting-versus-no-stenting-assisting-thrombectomy-for-acute-ischaemic-stroke-protocol-for-a-systematic-review-of-randomised-clinical-trials-with-meta-analyses-and-trial-sequential-analyses
#3
Henrik Steglich-Arnholm, Markus Holtmannspötter, Christian Gluud, Derk Wolfgang Krieger
BACKGROUND: In patients with intracranial large vessel arterial occlusion, ipsilateral extracranial carotid artery occlusions or near-occlusions pose a significant hurdle in endovascular management of acute ischaemic stroke. Stenting of the carotid lesion may be beneficial in this situation to provide a stable access for introducing catheters through the carotid lesion into the intracranial vasculature and the target occlusion. Furthermore, carotid stenting may ensure ample blood flow for wash-out of clot material and reperfusion of the ischaemic penumbral tissue...
December 1, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27904831/orphan-drug-development-in-china-turning-challenges-into-opportunities
#4
Xiaowei Jin, Li Chen
Of over 7,000 known rare diseases, only 5% currently have an available treatment option worldwide. Moreover, the vast majority of rare disease patients in China have no access to treatment due to limited availability and the lack of appropriate infrastructure in China's healthcare system. Despite increased interest in orphan drug development, drug companies in China with active programs on drugs to treat rare diseases are still limited. Hence, there is a huge unmet need in China, with over 10 million patients suffering from rare diseases...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27904629/effect-of-various-kinds-of-beverages-on-stress-oxidative-f2-isoprostane-serum-lipid-and-blood-glucose-of-elite-taekwondo-players
#5
Zahra Maghsoudi, Ashfin Shiranian, Gholamreza Askai, Reza Ghaisvand
BACKGROUND: Athletes' recovery is important in improving their performance. Nutritional strategies can be effective in enhancing recovery rate. Choosing the best food items in appropriate intervals can play effective roles in resynthesis of fuels and recovery of muscle injury. Beverage micro and macronutrient content are helpful in fuel restoration. In this study, we assess the effects of various kinds of beverages on oxidative stress, muscle injury, and metabolic risk factors in taekwondo players...
September 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27900421/spectroscopic-sensors-for-in-line-bioprocess-monitoring-in-research-and-pharmaceutical-industrial-application
#6
REVIEW
Jens Claßen, Florian Aupert, Kenneth F Reardon, Dörte Solle, Thomas Scheper
The use of spectroscopic sensors for bioprocess monitoring is a powerful tool within the process analytical technology (PAT) initiative of the US Food and Drug Administration. Spectroscopic sensors enable the simultaneous real-time bioprocess monitoring of various critical process parameters including biological, chemical, and physical variables during the entire biotechnological production process. This potential can be realized through the combination of spectroscopic measurements (UV/Vis spectroscopy, IR spectroscopy, fluorescence spectroscopy, and Raman spectroscopy) with multivariate data analysis to obtain relevant process information out of an enormous amount of data...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27890976/study-frequency-of-hypertension-and-obesity-and-their-relationship-with-lifestyle-factors-nutritional-habits-physical-activity-cigarette-consumption-in-ardabil-city-physicians-2012-13
#7
Afshin Fathi, Saeid Sadeghieh Ahari, Firouz Amani, Mohammad Reza Nikneghad
BACKGROUND AND OBJECTIVE: Few studies have been done on lifestyle of Iranian physicians. As physicians have important role in health promotion, the main goal of the study was to assess the lifestyle of this influential group. MATERIALS AND METHODS: A cross-sectional descriptive study was conducted on lifestyle of all registered physicians of Ardabil hospitals, Iran, 2012-13. In this research, 225 physicians were selected, by using simple random sampling. Demographic and lifestyle data were obtained by self-report using standard questionnaires, physical activity by official Iranian short-version of the international physical activity questionnaire, and dietary intake by food frequency questionnaire...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27889495/health-status-physical-activity-and-orthorexia-nervosa-a-comparison-between-exercise-science-students-and-business-students
#8
Julia Malmborg, Ann Bremander, M Charlotte Olsson, Stefan Bergman
Orthorexia nervosa is described as an exaggerated fixation on healthy food. It is unclear whether students in health-oriented academic programs, highly focused on physical exercise, are more prone to develop orthorexia nervosa than students in other educational areas. The aim was to compare health status, physical activity, and frequency of orthorexia nervosa between university students enrolled in an exercise science program (n = 118) or a business program (n = 89). The students completed the Short Form-36 Health Survey (SF-36), the International Physical Activity Questionnaire (IPAQ), and ORTO-15, which defines orthorexia nervosa as a sensitive and obsessive behavior towards healthy nutrition...
November 23, 2016: Appetite
https://www.readbyqxmd.com/read/27888425/an-overview-on-common-aspects-influencing-the-dissipation-pattern-of-pesticides-a-review
#9
Waziha Farha, A M Abd El-Aty, Md Musfiqur Rahman, Ho-Chul Shin, Jae-Han Shim
The common aspects and processes influencing dissipation kinetics of pesticides are determinants of their fate in the environment. Nowadays, with increasing population, the demand for food and fodder crops has also increased. With the development in science and technology, the methods of controlling pests may improve, but the major role played by the environment cannot be altered, i.e. the environmental factors, climatic conditions, and geology of areas under cultivation. Plants play a crucial role in the dissipation kinetics, as they may vary in species and characteristics...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27885680/effect-of-high-hydrostatic-pressure-on-the-enzymatic-hydrolysis-of-bovine-serum-albumin
#10
Serena De Maria, Giovanna Ferrari, Paola Maresca
BACKGROUND: The extent of the enzymatic proteolysis mainly depends on the accessibility of the peptide bonds, which stabilize the protein structure. High Hydrostatic Pressure (HHP) process is able to induce, at certain operating conditions, protein displacement, thus suggesting that this technology can be used to modify protein resistance to the enzymatic attack. This work aims at investigating the mechanism of the enzymatic hydrolysis assisted by HHP performed at different processing conditions (pressure level, treatment time)...
November 24, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27885294/infant-and-young-child-feeding-practices-among-mothers-at-chapagaun-vdc
#11
D Basnet
BACKGROUND: Since childhood under nutrition and mortality are high in Nepal, promotion of infant and young child feeding practices among children is most critical intervention,which contributes to improved nutrition, health and development of children ultimately having impact on child survival. The objective of the study was to identify infant and young child feeding practices. METHODS: A descriptive cross-sectional study was carried out among mothers visiting Chapagaun Primary Health Care and Resource Centre (PHCRC) with child aged 6-23 months between January1-14, 2016...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27885080/importance-of-engaging-in-dialogue-with-the-population-after-a-nuclear-accident
#12
Hans Vanmarcke
Human behaviour is primarily driven by perceptions and this is particularly important in the aftermath of a nuclear accident. One of the main lessons we can draw from the Chernobyl and Fukushima accidents is that once the acute phase of the accident is over, it is important to engage in dialogue with the affected population. Science-based government measures, imposed from above, give rise to much opposition. Examples of this are the aversion of having to live in a contaminated territory, the reluctance of consumers to buy even slightly contaminated food and the opposition of most evacuees to return to their old homes...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27884295/research-techniques-made-simple-workflow-for-searching-databases-to-reduce-evidence-selection-bias%C3%A2-in%C3%A2-systematic-reviews
#13
Laurence Le Cleach, Elizabeth Doney, Kenneth A Katz, Hywel C Williams, Ludovic Trinquart
Clinical trials and basic science studies without statistically significant results are less likely to be published than studies with statistically significant results. Systematic reviews and meta-analyses that omit unpublished data are at high risk of distorted conclusions. Here, we describe methods to search beyond bibliographical databases to reduce evidence selection bias in systematic reviews. Unpublished studies may be identified by searching conference proceedings. Moreover, clinical trial registries-databases of planned and ongoing trials-and regulatory agency websites such as the European Medicine Agency (EMA) and the United States Food and Drug Administration (FDA) may provide summaries of efficacy and safety data...
December 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27881142/ethnoagroforestry-integration-of-biocultural-diversity-for-food-sovereignty-in-mexico
#14
Ana Isabel Moreno-Calles, Alejandro Casas, Alexis Daniela Rivero-Romero, Yessica Angélica Romero-Bautista, Selene Rangel-Landa, Roberto Alexander Fisher-Ortíz, Fernando Alvarado-Ramos, Mariana Vallejo-Ramos, Dídac Santos-Fita
BACKGROUND: Documenting the spectrum of ecosystem management, the roles of forestry and agricultural biodiversity, TEK, and human culture for food sovereignty, are all priority challenges for contemporary science and society. Ethnoagroforestry is a research approach that provides a theoretical framework integrating socio-ecological disciplines and TEK. We analyze in this study general types of Agroforestry Systems of México, in which peasants, small agriculturalist, and indigenous people are the main drivers of AFS and planning of landscape diversity use...
November 23, 2016: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/27880835/built-environment-selected-risk-factors-and-major-cardiovascular-disease-outcomes-a-systematic-review
#15
Pasmore Malambo, Andre P Kengne, Anniza De Villiers, Estelle V Lambert, Thandi Puoane
INTRODUCTION: Built environment attributes have been linked to cardiovascular disease (CVD) risk. Therefore, identifying built environment attributes that are associated with CVD risk is relevant for facilitating effective public health interventions. OBJECTIVE: To conduct a systematic review of literature to examine the influence of built environmental attributes on CVD risks. DATA SOURCE: Multiple database searches including Science direct, CINAHL, Masterfile Premier, EBSCO and manual scan of reference lists were conducted...
2016: PloS One
https://www.readbyqxmd.com/read/27879501/introducing-allergenic-food-into-infants-diets-systematic-review
#16
Katelin Larson, Jessica McLaughlin, Mallory Stonehouse, Brittany Young, Kristin Haglund
PURPOSE: The purpose of this evidence-based review was to explore the association between timing of introduction of potentially allergenic foods to infants and development of food allergies. METHODS: CINAHL, Medline, PubMed, Science Direct, and Web of Science were searched using the terms solid food, complementary food, or infant feeding combined with allergy or hypersensitivity for articles published in English in 2000 or later. Inclusion criteria were 1) primary research articles with 2) a focus on association between introduction of complementary foods including potentially allergenic foods into diets of infants less than 12 months of age and development of food allergies...
November 22, 2016: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/27871944/predictors-of-food-decision-making-a-systematic-interdisciplinary-mapping-sim-review
#17
Claudia Symmank, Robert Mai, Stefan Hoffmann, F Marijn Stok, Britta Renner, Nanna Lien, Harald Rohm
The number of publications on consumer food decision making and its predictors and correlates has been steadily increasing over the last three decades. Given that different scientific disciplines illuminate this topic from different perspectives, it is necessary to develop an interdisciplinary overview. The aim of this study is to conduct a systematic interdisciplinary mapping (SIM) review by using rapid review techniques to explore the state-of-the-art, and to identify hot topics and research gaps in this field...
November 18, 2016: Appetite
https://www.readbyqxmd.com/read/27869667/metabolomics-a-powerful-tool-for-agricultural-research
#18
REVIEW
He Tian, Sin Man Lam, Guanghou Shui
Metabolomics, which is based mainly on nuclear magnetic resonance (NMR), gas-chromatography (GC) or liquid-chromatography (LC) coupled to mass spectrometry (MS) analytical technologies to systematically acquire the qualitative and quantitative information of low-molecular-mass endogenous metabolites, provides a direct snapshot of the physiological condition in biological samples. As complements to transcriptomics and proteomics, it has played pivotal roles in agricultural and food science research. In this review, we discuss the capacities of NMR, GC/LC-MS in the acquisition of plant metabolome, and address the potential promise and diverse applications of metabolomics, particularly lipidomics, to investigate the responses of Arabidopsis thaliana, a primary plant model for agricultural research, to environmental stressors including heat, freezing, drought, and salinity...
November 17, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27867503/the-croprotect-project-and-wider-opportunities-to-improve-farm-productivity-through-web-based-knowledge-exchange
#19
REVIEW
Toby J A Bruce
A key global 21st century challenge is to maximize agricultural production while minimizing use of resources such as land, water, and energy to meet rising demand for produce. To meet this challenge, while also adapting to climate change, agriculture will have to become more knowledge intensive and deploy smarter farming techniques. The intention of this study was to: (1) Highlight the opportunity for web-based knowledge exchange to increase farm productivity and thus contribute to achieving food and energy security, (2) Give some examples of online farming information services such as the "CROPROTECT" tool I am developing in the UK, the CABI "Plantwise" Knowledge Bank and the IRRI "Rice Doctor," and (3) Consider lessons learnt so far...
May 2016: Food and energy security
https://www.readbyqxmd.com/read/27864207/clinical-and-regulatory-considerations-in-pharmacogenetic-testing
#20
Robert N Schuck, Elizabeth Marek, Hobart Rogers, Michael Pacanowski
PURPOSE: Both regulatory science and clinical practice rely on best available scientific data to guide decision-making. However, changes in clinical practice may be driven by numerous other factors such as cost. In this review, we reexamine noteworthy examples where pharmacogenetic testing information was added to drug labeling to explore how the available evidence, potential public health impact, and predictive utility of each pharmacogenetic biomarker impacts clinical uptake. SUMMARY: Advances in the field of pharmacogenetics have led to new discoveries about the genetic basis for variability in drug response...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
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