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https://www.readbyqxmd.com/read/28823023/posttraumatic-stress-disorder-symptoms-and-white-matter-abnormalities-among-combat-exposed-veterans
#1
Kirstin Aschbacher, Synthia H Mellon, Owen M Wolkowitz, Clare Henn-Haase, Rachel Yehuda, Janine D Flory, Linda M Bierer, Duna Abu-Amara, Charles R Marmar, Susanne G Mueller
Posttraumatic stress disorder (PTSD) is associated with abnormalities in functional connectivity of a specific cortico-limbic network; however, less is known about white matter abnormalities providing structural connections for this network. This study investigated whether the diagnosis and symptoms of PTSD are associated with alterations in fractional anisotropy (FA), an index reflecting white matter organization, across six, a priori-defined tracts. White matter FA was quantified by diffusion tensor imaging using 3 T-MRI among 57 male, combat-exposed veterans with no history of moderate to severe head injuries or current alcohol dependence: 31 met criteria for PTSD and 26 were demographically comparable, combat-exposed controls without PTSD...
August 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28822262/evaluating-the-influence-of-at-risk-alcohol-use-on-factors-associated-with-smoking-cessation-combining-laboratory-and-ecological-momentary-assessment
#2
Joanna R Sells, Andrew J Waters, R Ross MacLean
OBJECTIVE: Most smokers want to quit but most cessation attempts end in failure. Alcohol consumption is associated with smoking behavior and relapse. We examined the associations between severity of drinking and psychological processes during a cessation attempt in the laboratory and during a quit attempt. METHODS: Smokers (N=209) enrolled in a smoking cessation study were followed from 2 weeks pre-quit through 4 weeks post-quit. Participants scoring 0-7 and 8-15 on the Alcohol Use Disorders Identification Test (AUDIT) were classified as low-risk and high-risk drinkers, respectively...
July 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28822049/potential-for-diagnosis-versus-therapy-monitoring-of-attention-deficit-hyperactivity-disorder-a-new-epigenetic-biomarker-interacting-with-both-genotype-and-auto-immunity
#3
Walter Adriani, Emilia Romano, Mariangela Pucci, Esterina Pascale, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Paolo Curatolo, Oleg Granstrem, Mauro Maccarrone, Giovanni Laviola, Claudio D'Addario
In view of the need for easily accessible biomarkers, we evaluated in ADHD children the epigenetic status of the 5'-untranslated region (UTR) in the SLC6A3 gene, coding for human dopamine transporter (DAT). We analysed buccal swabs and sera from 30 children who met DSM-IV-TR criteria for ADHD, assigned to treatment according to severity. Methylation levels at six-selected CpG sites (among which, a CGGCGGCGG and a CGCG motif), alone or in combination with serum titers in auto-antibodies against dopamine transporter (DAT aAbs), were analysed for correlation with CGAS scores (by clinicians) and Conners' scales (by parents), collected at recruitment and after 6 weeks...
August 18, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28821218/establishing-fidelity-of-occupational-performance-coaching
#4
Winnie Dunn, Lauren M Little, Ellen Pope, Anna Wallisch
As the call for evidence-based practices has risen, discussions about the fidelity of those practices have received increased attention. Although research suggests that Occupational Performance Coaching (OPC) is effective, a systematic evaluation of the fidelity of OPC is needed. The purpose of this study was to test fidelity of OPC intervention through study design, training, monitoring, and intervention receipt, and to offer the structure from this study as a guide for other programs of research and practice...
August 1, 2017: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/28821006/adherence-to-antiepileptic-drugs-in-children-and-adolescents-a-retrospective-study-in-primary-care-settings-in-germany
#5
Louis Jacob, Hajo M Hamer, Karel Kostev
OBJECTIVE: The goal of this study was to analyze adherence to antiepileptic drugs (AED) in children and adolescents treated in pediatric practices in Germany. METHODS: The present study included patients aged between 2 and 17years who were diagnosed with epilepsy (ICD-10: G40) and had received at least two prescriptions of AED between January 2006 and December 2015 in 243 pediatric practices in Germany. The medication possession ratio (MPR) was used to estimate adherence, and patients with a MPR greater than 80% were considered adherent...
August 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28820656/corrigendum-prestimulus-inhibition-of-saccades-in-adults-with-and-without-attention-deficit-hyperactivity-disorder-as-an-index-of-temporal-expectations
#6
(no author information available yet)
Original article: Dankner, Y., Shalev, L., Carrasco, J., & Yuval-Greenberg, S. (2017). Prestimulus inhibition of saccades in adults with and without attention-deficit/hyperactivity disorder as an index of temporal expectations. Psychological Science, 28, 835-850. doi:10.1177/0956797617694863.
August 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28820639/impulsive-aggressive-behavior-triggered-by-headaches-in-a-child-with-severe-attention-deficit-hyperactivity-disorder
#7
Thomas C Yang, Maxwell J Luber, Barbara J Coffey
No abstract text is available yet for this article.
August 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28820232/recognizing-and-managing-adrenal-disorders-in-the-emergency-department
#8
Amy Cutright, Stephen Ducey, Claudia L. Barthold
Primary and secondary adrenal insufficiency are underrecognized conditions among emergency department patients, affecting an estimated 10% to 20% of critically ill patients. The signs and symptoms of cortisol deficit can be nonspecific and wide-ranging, and identification and swift treatment with stress-dosing of hydrocortisone is vital to avoid life-threatening adrenal crisis. Laboratory evaluation focuses on identification of electrolyte abnormalities typical of adrenal insufficiency, and while additional testing may depend on the type and severity of symptoms, it should not delay corticosteroid replacement...
September 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28820054/qsar-modeling-of-histamine-h3r-antagonists-inverse-agonists-as-future-drugs-for-neurodegenerative-diseases
#9
Michelle Fidelis Corrêa, João Paulo Dos Santos Fernandes
Histamine H3 receptor (H3R) is associated with several neuropsychological diseases. It is predominantly expressed in the central nervous system as presynaptic receptor, especially in regions associated with cognition and behavior, and is responsible for modulate the synthesis and release of histamine and other neurotransmitters such as acetylcholine, dopamine and serotonin. Therefore, H3R is an important target involved in several CNS disorders, such as narcolepsy, attention deficit hyperactivity disorder and schizophrenia...
August 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28819875/pathways-from-birth-weight-to-adhd-symptoms-through-fluid-reasoning-in-youth-with-or-without-intellectual-disability
#10
Julia E Morgan, Steve S Lee, Sandra K Loo, Joshua W Yuhan, Bruce L Baker
Although individual differences in fluid reasoning reliably mediate predictions of attention-deficit/hyperactivity disorder (ADHD) symptoms from birth weight in youth with typical cognitive development (TD), it is unknown if this indirect effect operates similarly in the development of ADHD symptoms secondary to intellectual disability (ID). Thus, we evaluated mediation by fluid reasoning in a longitudinal sample of 163 youth (45% female) with (n = 52) or without (n = 111) ID who were followed prospectively from age 5 to age 13...
August 18, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28818658/cue-dependent-inhibition-in-posttraumatic-stress-disorder-and-attention-deficit-hyperactivity-disorder
#11
Zachary W Adams, Michael Meinzer, Howard Mandel, Joshua Voltin, Blaine Caughron, Floyd R Sallee, Mark Hamner, Zhewu Wang
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are common among military veterans, but the comorbidity of these two psychiatric disorders remains largely unstudied. Evaluating response inhibition and cue-dependent learning as behavioral and neurocognitive mechanisms underlying ADHD/PTSD can inform etiological models and development of tailored interventions. METHOD: A cued go/no-go task evaluated response inhibition in 160 adult males...
August 9, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28818274/the-affection-of-the-disturbance-of-the-hydrodynamics-of-blood-in-case-of-stress-on-pathological-increase-of-level-of-low-density-lipoproteins-in-blood-the-formation-of-cylindrical-plaques-and-their-participation-in-the-development-of-acute-ischemic-disorders
#12
S E Rusanov
In this article is given the new insight about the affection of stress on the increase of level of low density lipoproteins (LDL) in the blood, which is connected with the disturbance of hydrodynamics in the bloodstream, the attention was paid to the cylindrical cholesterol plaque, and it's classification. The disturbance of hydrodynamics of blood under the stress leads to the formation of a cylindrical cholesterol plaque, which repeats the contour of the vessel, and leads to the ischemic disorders of the heart and brain...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28818147/attention-deficit-hyperactivity-disorder-and-fatal-accidents-in-aviation-medicine
#13
Tanja Laukkala, Robert Bor, Bruce Budowle, Antti Sajantila, Pooshan Navathe, Markku Sainio, Alpo Vuorio
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with symptoms of inattention and/or hyperactivity-impulsivity that interfere with functioning and/or development. ADHD occurs in about 2.5% of adults. ADHD can be an excluding medical condition among pilots due to the risk of attentional degradation and therefore impact on flight safety. Diagnosis of ADHD is complex, which complicates aeromedical assessment. This study highlights fatal accident cases among pilots with ADHD and discusses protocols to detect its presence to help to assess its importance to flight safety...
September 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28817953/the-evidence-base-for-interventions-targeting-individuals-with-work-related-ptsd-a-systematic-review-and-recommendations
#14
Iris Torchalla, Verena Strehlau
The purpose of this study was to summarize the evidence base for interventions targeting individuals with work-related posttraumatic stress disorder (PTSD), to make recommendations for clinicians and administrative decision makers involved in their rehabilitation, and to guide future research in this area. Particular attention was given to studies that were conducted in naturalistic clinical settings or in a workers' compensation claim context. Electronic searches of Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, PsycINFO, CINAHL, PILOTS, and EMBASE identified 11 articles...
August 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28817952/professional-socialization-a-grounded-theory-of-the-clinical-reasoning-processes-that-rns-and-lpns-use-to-recognize-delirium
#15
Mohamed El Hussein, Sandra Hirst, Joseph Osuji
Delirium is an acute disorder of attention and cognition. It affects half of older adults in acute care settings and is a cause of increasing mortality and costs. Registered nurses (RNs) and licensed practical nurses (LPNs) frequently fail to recognize delirium. The goals of this research were to identify the reasoning processes that RNs and LPNs use to recognize delirium, to compare their reasoning processes, and to generate a theory that explains their clinical reasoning processes. Theoretical sampling was employed to elicit data from 28 participants using grounded theory methodology...
August 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28817578/deliberate-self-harm-behavior-among-young-violent-offenders
#16
Natalie Laporte, Andrejs Ozolins, Sofie Westling, Åsa Westrin, Eva Billstedt, Björn Hofvander, Märta Wallinius
Deliberate self-harm behavior (DSH) can have profound effects on a person's quality of life, and challenges the health care system. Even though DSH has been associated with aggressive interpersonal behaviors, the knowledge on DSH in persons exhibiting such behaviors is scarce. This study aims to (1) specify the prevalence and character of DSH, (2) identify clinical, neurocognitive, psychosocial, and criminological characteristics associated with DSH, and (3) determine predictors of DSH among young violent offenders...
2017: PloS One
https://www.readbyqxmd.com/read/28817309/weight-height-and-body-mass-index-in-patients-with-attention-deficit-hyperactivity-disorder-treated-with-methylphenidate
#17
Azucena Díez-Suárez, María Vallejo-Valdivielso, Juan J Marín-Méndez, Pilar de Castro-Manglano, César A Soutullo
OBJECTIVE: To describe the methylphenidate (MPH) effects on weight, height, and body mass index (BMI) in a Spanish sample diagnosed with attention-deficit/hyperactivity disorder (ADHD). METHODS: Patients (6-18 years) diagnosed with ADHD treated at our Unit with MPH in the last 10 years were included in an observational longitudinal study. Weight, height, and BMI Z scores were measured at baseline and at last follow-up. RESULTS: Three hundred forty-two patients (mean [standard deviation] age: 10...
August 17, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28816913/influence-of-written-informed-consent-for-methylphenidate-on-medicine-persistence-rates-in-children-with-attention-deficit-hyperactivity-disorder
#18
Kristian Naenen-Hernani, Antonio Palazón-Bru, Francisco Colomina-Climent, Vicente F Gil-Guillén
OBJECTIVE: To assess the influence of written informed consent on nonpersistence with methylphenidate treatment in children with attention-deficit hyperactivity disorder (ADHD). METHODS: We undertook a cohort study including 141 children with ADHD who started treatment with methylphenidate, with a follow-up of 6 months. The main outcome variable was nonpersistence, defined as discontinuation of treatment by the patient. Two groups were analyzed with and without written informed consent...
August 9, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28816912/distance-learning-adhd-quality-improvement-in-primary-care-a-cluster-randomized-trial
#19
Alexander G Fiks, Stephanie L Mayne, Jeremy J Michel, Jeffrey Miller, Manju Abraham, Andrew Suh, Abbas F Jawad, James P Guevara, Robert W Grundmeier, Nathan J Blum, Thomas J Power
OBJECTIVE: To evaluate a distance-learning, quality improvement intervention to improve pediatric primary care provider use of attention-deficit/hyperactivity disorder (ADHD) rating scales. METHODS: Primary care practices were cluster randomized to a 3-part distance-learning, quality improvement intervention (web-based education, collaborative consultation with ADHD experts, and performance feedback reports/calls), qualifying for Maintenance of Certification (MOC) Part IV credit, or wait-list control...
August 9, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28816910/acceptability-of-group-visits-for-attention-deficit-hyperactivity-disorder-in-pediatric-clinics
#20
Nerissa S Bauer, Nina Azer, Paula D Sullivan, Dorota Szczepaniak, Sarah M Stelzner, Stephen M Downs, Aaron E Carroll
OBJECTIVE: Children with attention-deficit hyperactivity disorder (ADHD) have ongoing needs that impair home and school functioning. Group visit models are a promising way to deliver timely parenting support but family and provider acceptance has not previously been examined. The objective was to describe the acceptability of ADHD group visits in busy pediatric clinics based on caregivers, child participants and facilitators. METHODS: Data were analyzed from school-age children and caregivers who participated in one of two 12-month long randomized controlled studies of the ADHD group visit model from 2012 to 2013 or 2014 to 2015...
August 11, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
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