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Peanut Allergy

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https://www.readbyqxmd.com/read/28927819/effect-of-endotoxin-and-alum-adjuvant-vaccine-on-peanut-allergy
#1
Brandi T Johnson-Weaver, Susan McRitchie, Kelly A Mercier, Wimal Pathmasiri, Susan J Sumner, Cliburn Chan, Dori Germolec, Michael Kulis, A Wesley Burks, Herman F Staats
Environmental endotoxin and alum-adjuvanted vaccines did not influence peanut-allergy development in mice. Exposure to alum and CpG-adjuvanted vaccines indirectly reduced allergic disease severity. Fecal metabolites differentiated mice based on disease severity.
September 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28924447/passive-blood-anaphylaxis-subcutaneous-immunoglobulins-are-a-cause-of-ongoing-passive-anaphylactic-reaction
#2
Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda, Agnieszka Korzeniowska-Kowal
BACKGROUND: Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tests with commercially available immunoglobulins, but target antigens and responsible compounds of the tested immunoglobulins have not been strictly identified. CASE DESCRIPTION AND FINDINGS: Four adult patients with recently diagnosed common variable immunodeficiency qualified for standard subcutaneous immunoglobulin replacement therapy regimen...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28916221/reduced-risk-of-peanut-sensitization-following-exposure-through-breast-feeding-and-early-peanut-introduction
#3
Tracy J Pitt, Allan B Becker, Moira Chan-Yeung, Edmond S Chan, Wade T A Watson, Rishma Chooniedass, Meghan B Azad
BACKGROUND: Recent trials have shown that avoiding peanuts during infancy increases the risk of peanut allergy; however, these studies did not address maternal peanut consumption. OBJECTIVE: We sought to investigate the relationship between maternal peanut consumption while breast-feeding, timing of direct peanut introduction, and peanut sensitization at age 7 years. METHODS: Secondary analysis of a nested cohort within the 1995 Canadian Asthma Primary Prevention Study intervention study was performed...
August 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28914636/dietary-intervention-for-preventing-food-allergy-in-children
#4
Yichao Wang, Katrina J Allen, Jennifer J Koplin
PURPOSE OF REVIEW: In the past decade, food allergy has been increasingly recognized as an important public health issue. The role of maternal and infant diet in the development of food allergy has been a major focus of research throughout this period. Recently, research in this area has moved from observational studies to intervention trials, and the findings from these trials have started to influence infant feeding guidelines. In this article, we review recent studies of dietary interventions for preventing food allergy, summarize current knowledge and discuss future research directions...
September 13, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28906044/specific-ige-to-peanut-2s-albumin-ara-h-7-has-a-discriminative-ability-comparable-to-ara-h-2-and-6
#5
Mark A Blankestijn, Henny G Otten, Waltraud Suer, Alf Weimann, Edward F Knol, André C Knulst
BACKGROUND: Little is known on the clinical relevance of peanut 2S albumin Ara h 7. OBJECTIVE: To investigate the discriminative ability of Ara h 7 in peanut allergy and assess the role of cross-reactivity between Ara h 2, 6 and Ara h 7 isoforms. METHODS: Sensitization to recombinant peanut storage proteins Ara h 1, 2, 3, 6 and 7 was assessed using a line blot in sera from 40 peanut tolerant and 40 peanut allergic patients, based on food challenge outcome...
September 14, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28892729/immune-mechanisms-of-food-allergy-and-its-prevention-by-early-intervention
#6
REVIEW
Victor Turcanu, Helen A Brough, George Du Toit, Ru-Xin Foong, Tom Marrs, Alexandra F Santos, Gideon Lack
The environmental factors driving the increase in food allergies are unclear and possibly involve dual exposure to allergens, microbiome-driven effects or other mechanisms. Until they can be better understood, early intervention aiming at establishing oral tolerance provides an effective way to decrease the window-of-risk when children may develop allergic sensitisation to foods due to the absence of a protective immune response. Thus, the recent LEAP (Learning Early About Peanut allergy) and LEAP-On studies achieved a high level of peanut allergy prevention by early introduction of peanuts in the infants diet and conveyed more information regarding the evolution of IgE and IgG4 antibody responses to food antigens over time...
September 8, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28890356/multicenter-prevalence-of-anaphylaxis-in-clinic-based-oral-food-challenges
#7
Kwei Akuete, Danielle Guffey, Ryan B Israelsen, John M Broyles, Lori Jo Higgins, Todd D Green, David R Naimi, Andrew J MacGinnitie, Girish Vitalpur, Charles G Minard, Carla M Davis
BACKGROUND: Although previous single-center studies report the rate of anaphylaxis for oral food challenges (OFCs) as 9% to 11%, little is known regarding the epidemiology of clinical OFCs across multiple centers in the United States. OBJECTIVE: To examine the epidemiology, symptoms, and treatment of clinical low-risk OFCs in the nonresearch setting. METHODS: Data were obtained from 2008 to 2013 through a physician survey in 5 food allergy centers geographically distributed across the United States...
September 1, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28890022/lymphoproliferative-responses-to-dendritic-cell-presentation-of-sensitizing-allergens-in-atopic-children-with-multiple-allergies
#8
Tim H Scott-Taylor, Stefan-Claudiu Axinia, Stephan Strobel
BACKGROUND: Peripheral blood mononuclear cells (PBMCs) proliferate inconsistently, rendering current lymphoproliferation assays unreliable in diagnosis. OBJECTIVE: To investigate the utility and nature of proliferation responses in allergy by comparison of the standard lymphoproliferation with a new dendritic cell (DC) stimulated assay. METHODS: Monocyte-derived DCs were pulsed with allergens and incubated with autologous T cells for 7 days...
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28885749/paediatric-food-induced-anaphylaxis-hospital-presentations-in-new-zealand
#9
Sophie Speakman, Bridget Kool, Jan Sinclair, Penny Fitzharris
AIM: Globally, rates of paediatric food-induced anaphylaxis (FIA) are increasing. Little data is available regarding the epidemiology of FIA among New Zealand (NZ) children. This study investigated the incidence of paediatric (0-14 years) FIA hospital presentations in NZ over a 10-year period. METHODS: Ministry of Health public hospital discharge data from 2006 to 2015 were analysed using FIA-related International Classification of Diseases codes (T78.0 - anaphylactic shock due to adverse food reaction and T78...
September 8, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28881055/individual-healthcare-plan-for-allergic-children%C3%A2-at-school-lessons-from-a-2015-2016-school-year-survey
#10
Guillaume Pouessel, Stépanie Lejeune, Marie-Pierre Dupond, Annie Renard, Camille Fallot, Antoine Deschildre
The Individual Healthcare Plan (IHP) was implemented in schools in France in 2003 to improve management of allergic children. Our objectives were to assess the practical aspects of IHP (excluding asthma) and allergic reactions occurring at school. METHODS: Prospective study conducted in the North Department (France) during the 2015/2016 school-year. Two questionnaires were developed: one for the school doctors (n=67) and one for the school principals (n=2372). RESULTS: Data from 336 (25%) of the 1325 IHPs (0...
September 7, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28865877/oral-immunotherapy-for-food-allergy
#11
REVIEW
Deborah M Hussey Freeland, Monali Manohar, Sandra Andorf, Benjamin D Hobson, Wenming Zhang, Kari C Nadeau
Food allergy is a pathological, potentially deadly cascade of immune responses to molecules or molecular fragments that are normally innocuous when encountered in foods, such as milk, egg, or peanut. As the incidence and prevalence of food allergy rise, the standard of care is poised to advance beyond food allergen avoidance coupled with injectable epinephrine treatment of allergen-induced systemic reactions. Recent studies provide evidence that oral immunotherapy may effectively redirect the atopic immune responses of food allergy patients as they ingest small but gradually increasing allergen doses over many months, eliciting safer immune responses to these antigens...
August 30, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28842925/polyphenol-rich-pomegranate-juice-reduces-ige-binding-to-cashew-nut-allergens
#12
Yichen Li, Christopher P Mattison
BACKGROUND: Food allergy negatively impacts quality of life and can be life-threatening. Cashew nuts can cause severe reactions in very small amounts, and they are included in a group of foods most commonly responsible for causing food allergy. Polyphenols and polyphenol rich juices have been demonstrated to complex with peanut allergens. Here, the interaction between cashew nut allergens and polyphenol rich juices is evaluated biochemically and immunologically. RESULTS: Various juices, including pomegranate (POM), blueberry (BB), and concord grape (CG) juices, were evaluated for polyphenol content and formation of polyphenol-cashew allergen complexes...
August 26, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28836701/bsaci-guideline-for-the-diagnosis-and-management-of-peanut-and-tree-nut-allergy
#13
G Stiefel, K Anagnostou, R J Boyle, N Brathwaite, P Ewan, A T Fox, P Huber, D Luyt, S J Till, C Venter, A T Clark
Peanut nut and tree nut allergy are characterised by IgE mediated reactions to nut proteins. Nut allergy is a global disease. Limited epidemiological data suggest varying prevalence in different geographical areas. Primary nut allergy affects over 2% of children and 0.5% of adults in the UK. Infants with severe eczema and/or egg allergy have a higher risk of peanut allergy. Primary nut allergy presents most commonly in the first five years of life, often after the first known ingestion with typical rapid onset IgE-mediated symptoms...
June 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28825657/nut-allergy-in-two-different-areas-of-spain-differences-in-clinical-and-molecular-pattern
#14
Elisa Haroun-Díaz, Julián Azofra, Eloína González-Mancebo, Manuel de Las Heras, Carlos Pastor-Vargas, Vanesa Esteban, Mayte Villalba, Araceli Díaz-Perales, Javier Cuesta-Herranz
INTRODUCTION: Different clinical and molecular patterns of food allergy have been reported in different areas of the world. The aim of the study is to evaluate differences in allergen patterns among nut-allergic patients in two different areas of Spain. MATERIAL AND METHODS: A total of 77 patients with nut allergy from two different regions of Spain (Madrid and Asturias) were evaluated. RESULTS: Hazelnut, peanut, and walnut were the three most frequent nuts eliciting allergy in both regions, but in a different order...
August 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28821489/peanut-immunotherapy-provides-long-lasting-suppression-of-allergy-finds-study
#15
Susan Mayor
No abstract text is available yet for this article.
August 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28802077/helicobacter-pylori-and-its-secreted-immunomodulator-vaca-protect-against-anaphylaxis-in-experimental-models-of-food-allergy
#16
A Kyburz, S Urban, A Altobelli, S Floess, J Huehn, T L Cover, A Müller
BACKGROUND: Food allergy is an increasingly common health problem in Western populations. Epidemiological studies have suggested both positive and negative associations between food allergy and infection with the gastric bacterium Helicobacter pylori. OBJECTIVE: The objective of this work was to investigate whether experimental infection with H. pylori, or prophylactic treatment with H. pylori-derived immunomodulatory molecules, affects the onset and severity of food allergy, either positively or negatively...
August 12, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28800361/identification-of-a-common-ara-h-3-epitope-recognized-by-both-the-capture-and-the-detection-monoclonal-antibodies-in-an-elisa-detection-kit
#17
Lipei Zhao, Liang Zhao, Buchang Zhang, Jason M Robotham, Kenneth H Roux, Hengli Tang
Allergy to peanuts has become a common and severe problem, especially in westernized countries. In this study, we evaluated the target and epitope specificity of the capture and detection mouse monoclonal antibodies (mAbs) used in a commercial peanut allergen detection platform. We first identified the target of these antibodies as Ara h 3 and then used an overlapping peptide array of Ara h 3 to determine the antibody-binding epitopes. Further amino acids critical for the binding via alanine substitutions at individual amino acid residues within the epitope were mapped...
2017: PloS One
https://www.readbyqxmd.com/read/28795292/relevance-of-lipophilic-allergens-in-food-allergy-diagnosis
#18
REVIEW
Uta Jappe, Christian Schwager
PURPOSE OF REVIEW: The purpose of this review is to provide available data on a new class of allergens, the oleosins, and their diagnostic value. There is evidence that allergen extracts used for in vivo as well as in vitro diagnostic tests do not contain oleosins because these proteins are lipophilic and nearly insoluble in saline or aqueous solutions. So far, only oleosins of peanut, sesame and hazelnut have been registered as allergens. Reports on IgE-binding tests performed with oleosins of different species with sera from allergic patients show that IgE specific for oleosins are associated with severe allergic reactions which is why they should be part of the diagnostic tests in the future...
August 9, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28792732/integrated-magneto-chemical-sensor-for-on-site-food-allergen-detection
#19
Hsing-Ying Lin, Chen-Han Huang, Jongmin Park, Divya Pathania, Cesar M Castro, Alessio Fasano, Ralph Weissleder, Hakho Lee
Adverse food reactions, including food allergies, food sensitivities, and autoimmune reaction (e.g., celiac disease) affect 5-15% of the population and remain a considerable public health problem requiring stringent food avoidance and epinephrine availability for emergency events. Avoiding problematic foods is practically difficult, given current reliance on prepared foods and out-of-home meals. In response, we developed a portable, point-of-use detection technology, termed integrated exogenous antigen testing (iEAT)...
August 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28762705/peanut-allergy-prevention-guidelines-from-the-niaid
#20
Lisa Hauk
No abstract text is available yet for this article.
July 15, 2017: American Family Physician
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