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Peanut Allergy

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https://www.readbyqxmd.com/read/29352591/potential-pitfalls-in-applying-screening-criteria-in-infants-at-risk-of-peanut-allergy
#1
Elissa M Abrams, Edmond S Chan
No abstract text is available yet for this article.
January 15, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29348584/quail-egg-homogenate-alleviates-food-allergy-induced-eosinophilic-esophagitis-like-disease-through-modulating-par-2-transduction-pathway-in-peanut-sensitized-mice
#2
Priscilia Lianto, Shiwen Han, Xinrui Li, Fredrick Onyango Ogutu, Yani Zhang, Zhuoyan Fan, Huilian Che
The present pharmacotherapy for eosinophilic esophagitis (EoE) fundamentally depend on inhaled corticosteroids. Despite the fact that oral intake of topical steroids can be successful in restricting EoE-related inflammation, there are concerns with respect to the long term utilization of steroids, especially in kids. In the current research, we assess the effect of quail egg, which is reportedly a known serine protease inhibitor, on symptomatology and immune responses in a peanut-sensitized mouse model of food allergy induced EoE...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342467/boiling-and-pressure-cooking-impact-on-ige-reactivity-of-soybean-allergens
#3
Beatriz Cabanillas, Carmen Cuadrado, Julia Rodriguez, Maria Carmen Dieguez, Jesus F Crespo, Natalija Novak
BACKGROUND: Soybean is one of the 8 foods that causes the most significant rate of food allergies in the USA and Europe. Thermal processing may impact on the allergenic potential of certain foods. We aimed to investigate modifications of the IgE-binding properties of soybean proteins due to processing methods that have been previously found to impact on the allergenicity of legumes such as peanut. METHODS: Soybean seeds were subjected to different thermal processing treatments...
January 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29339650/oral-immunotherapy-in-japanese-children-with-anaphylactic-peanut-allergy
#4
Ken-Ichi Nagakura, Sakura Sato, Noriyuki Yanagida, Makoto Nishino, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Reports on oral immunotherapy (OIT) for anaphylactic food allergy are lacking. We investigated the efficacy and safety of peanut OIT for anaphylactic patients. METHODS: We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline double-blind, placebo-controlled food challenge. After starting in-hospital OIT, participants gradually increased ingestion to 795 mg of peanut protein per day at home and then took a maintenance dose (795 mg) daily...
January 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29333846/-food-allergy-in-children-recommendations-for-diagnosis-and-treatment
#5
(no author information available yet)
Food allergy arises from a specific immune response induced by food exposure. It is the first cause of anaphylaxis in childhood. Its prevalence increased exponentially in western countries. The proteins most frequently involved in infants are cow's milk and hen's egg; and in adults, seafood. Peanuts have the same frequency in both groups. The clinical manifestations and methodology of study are directly related to the pathophysiology of the disease. Clinical history, skin prick test, patch test, and food oral challenge are essential to arrive at a correct diagnosis, that will avoid unnecessary exclusions or exposures that carry life risk...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29325868/canadian-genome-wide-association-study-and-meta-analysis-confirm-hla-as-a-risk-factor-for-peanut-allergy-independent-of-asthma
#6
Yuka Asai, Aida Eslami, C Dorien van Ginkel, Loubna Akhabir, Ming Wan, David Yin, George Ellis, Moshe Ben-Shoshan, Ingo Marenholz, David Martino, Manuel A Ferreira, Katrina Allen, Bruce Mazer, Hans de Groot, Nicolette W de Jong, Roy Gerth van Wijk, Anthony E J Dubois, Sarah Grosche, Sarah Ashley, Franz Rüschendorf, Birgit Kalb, Kirsten Beyer, Markus M Nöthen, Young-Ae Lee, Rick Chin, Steven Cheuk, Joshua Hoffman, Eric Jorgensen, John S Witte, Ronald B Melles, Xiumei Hong, Xiaobin Wang, Jennie Hui, Arthur W Bill Musk, Michael Hunter, Alan L James, Gerard H Koppelman, Andrew J Sandford, Ann E Clarke, Denise Daley
No abstract text is available yet for this article.
January 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29319184/diagnostic-accuracy-risk-assessment-and-cost-effectiveness-of-component-resolved-diagnostics-for-food-allergy-a-systematic-review
#7
REVIEW
Javier Flores Kim, Nicola McCleary, Bright I Nwaru, Andrew Stoddart, Aziz Sheikh
BACKGROUND: Component-resolved diagnostics (CRD) are promising tools for diagnosing food allergy, offering the potential to determine specific phenotypes and to develop patient-tailored risk profiles. Nevertheless, the diagnostic accuracy of these tests varies across studies; thus, their clinical utility remains unclear. Therefore, we synthesized the evidence from studies investigating the diagnostic accuracy, risk assessment ability, and cost-effectiveness of CRD for food allergy. METHODS: We systematically searched 10 electronic databases and four clinical trial registries for studies published January 2000-February 2017...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29315922/the-use-of-omalizumab-in-allergen-immunotherapy
#8
Jennifer A Dantzer, Robert A Wood
Although omalizumab (anti-IgE) is currently only approved for the treatment of asthma and chronic idiopathic urticaria, it has also been studied as an off-label treatment for numerous allergic conditions, including use as an adjunct to allergen immunotherapy in the treatment of allergic rhinitis, asthma, venom hypersensitivity, and food allergy. We conducted a review of publications involving the use of omalizumab with allergen immunotherapy, by searching PubMed with key search terms of "omalizumab" and "immunotherapy...
January 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29315919/prevalence-and-longitudinal-trends-of-food-allergy-during-childhood-and-adolescence-results-of-the-isle-of-wight-birth-cohort-study
#9
D Venkataraman, M Erlewyn-Lajeunesse, R J Kurukulaaratchy, S Potter, G Roberts, S Matthews, S Hasan Arshad
BACKGROUND: The prevalence and time trends of food allergy change during childhood depending on the age of the child and the type of food. OBJECTIVE: To study prevalence and longitudinal trends in food allergy from birth to 18 years in an unselected birth cohort in the Isle of Wight. METHOD: Information on food allergy was collected at ages 1, 2, 4, 10 and 18 years from the Isle of Wight Birth Cohort (n = 1456). Skin prick testing (SPT) was performed at the age of 1 and 2 years in symptomatic children...
January 8, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29289463/the-importance-of-reducing-risk-in-peanut-allergy-current-and-future-therapies
#10
Wayne G Shreffler, Joe L Baumert, Benjamin C Remington, Stef J Koppelman, Chitra Dinakar, David M Fleischer, Edwin Kim, Stephen A Tilles, Jonathan M Spergel
No abstract text is available yet for this article.
December 28, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29284183/predicting-reactivity-threshold-in-children-with-anaphylaxis-to-peanut
#11
Tonje Reier-Nilsen, Merethe Melbye Michelsen, Karin C Lødrup Carlsen, Kai-Håkon Carlsen, Petter Mowinckel, Unni C Nygaard, Ellen Namork, Magnus P Borres, Geir Håland
BACKGROUND: Peanut allergy necessitates dietary restrictions, preferably individualised by determining reactivity threshold through an oral food challenge (OFC). However, risk of systemic reactions often precludes OFC in children with severe peanut allergy. OBJECTIVE: We aimed to determine if clinical and/or immunological characteristics were associated with reactivity threshold in children with anaphylaxis to peanut and secondarily, to investigate if these characteristics were associated with severity of the allergic reaction during OFC...
December 28, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29273132/preliminary-psychometric-analyses-and-clinical-performance-of-a-caregiver-self-efficacy-scale-for-food-allergy-self-management
#12
Matthew Greenhawt, Audrey DunnGalvin
BACKGROUND: Food allergy health-related quality of life has been defined, but self-efficacy is poorly described. OBJECTIVE: To examine the preliminary reliability, validity, and clinical performance of a novel food allergy self-efficacy index. METHODS: An 8-item Food Allergy Self-Efficacy Questionnaire (FASEQ) was adapted for food allergy-related themes and coadministered with the Food Allergy Quality of Life Parental Burden (FAQL-PB) index to caregivers self-reporting a food allergic child (group A) and those with children followed up at a food allergy referral center clinic (group B)...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29249131/medicinal-bioactivites-and-allergenic-properties-of-pumpkin-seeds-review-upon-a-pediatric-food-anaphylaxis-case-report
#13
C Chatain, I Pin, P Pralong, J P Jacquier, M T Leccia
Food allergy to pumpkin seed is considered very rare, and only some isolated case reports have so far been published. We report here a case of food anaphylaxis to pumpkin seed in an eight-year-old boy, who tolerated all other edible seeds, peanut and tree nuts, as well as pulp of different kinds of pumpkins and other fruits of the Cucurbitaceae family. From this observation, a review of the botanical, historical, medicinal and allergenic aspects of pumpkin and its seeds is proposed. With the advent of diets rich in omega-3 and omega-6 polyunsaturated fatty acids, edible seeds like pumpkin seed have been incorporated in the modern diet...
November 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29248387/the-prevalence-of-food-sensitization-appears-not-to-have-changed-between-2-melbourne-cohorts-of-high-risk-infants-recruited-15-years-apart
#14
Rachel L Peters, Jennifer J Koplin, Katrina J Allen, Adrian J Lowe, Caroline J Lodge, Mimi L K Tang, Melissa Wake, Anne-Louise Ponsonby, Bircan Erbas, Michael J Abramson, David Hill, Lyle C Gurrin, Shyamali C Dharmage
BACKGROUND: Although food allergy has probably risen over recent decades, recent reports suggest that the prevalence of food sensitization in the general population has not changed. However, this has not been analyzed in infants at high risk of food allergy. OBJECTIVE: The objective of this study was to compare the prevalence of food sensitization in high-risk infants from 2 cohorts recruited 15 years apart in the same region. METHODS: This study includes 620 high-risk infants with a family history of allergy (Melbourne Atopy Cohort Study [MACS]) born 1990-1994, and a subgroup of high-risk infants from the population-based HealthNuts study (n = 3,661/5,276), born 2006-2010...
December 13, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29247716/airway-exposure-initiates-peanut-allergy-by-involving-the-il-1-pathway-and-t-follicular-helper-cells-in-mice
#15
Joseph J Dolence, Takao Kobayashi, Koji Iijima, James Krempski, Li Y Drake, Alexander L Dent, Hirohito Kita
BACKGROUND: Little is currently known regarding the immunological mechanism(s) that initiate peanut allergy. Notably, peanut proteins have been detected in house dust, and their levels correlate with peanut allergy prevalence. OBJECTIVE: This study aimed to develop a new mouse model for peanut allergy and to investigate the immunological mechanisms involved in peanut allergen sensitization. METHODS: To mimic environmental exposure, naïve mice were exposed to peanut flour by inhalation for up to 4 weeks...
December 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29247574/ige-promotes-type-2-innate-lymphoid-cells-in-murine-food-allergy
#16
Oliver T Burton, Jaciel Medina Tamayo, Amanda J Stranks, Samuel Miller, Kyle J Koleoglou, Ellen O Weinberg, Hans C Oettgen
BACKGROUND: Mast cells serve an important sentinel function at mucosal barriers and have been implicated as key early inducers of Type 2 immune responses in food allergy. The generation of Th2 and IgE following food allergen ingestion is inhibited in the absence of mast cells. Group 2 innate lymphoid cells are also thought to play an important early role in nascent allergic responses. OBJECTIVE: To test whether IgE-mediated mast cell activation promotes intestinal ILC2 responses following ingestion of food allergens and whether ILC2 amplify food allergy...
December 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29246346/peanut-allergy-an-epidemiologic-analysis-of-a-large-database
#17
Frederick E Leickly, Kirsten M Kloepfer, James E Slaven, Girish Vitalpur
OBJECTIVE: To confirm new observations on peanut allergy and answer current concerns that families and healthcare providers have about peanut allergy. STUDY DESIGN: Children who presented with a story of peanut allergy or peanut sensitization were asked to participate in a registry, which allowed an analysis focused on questions that a food allergy support group had about children with peanut allergy or sensitization. RESULTS: A total of 1070 children were entered into the registry over 5 years...
January 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29240247/do-we-still-need-oral-food-challenges-for-the-diagnosis-of-food-allergy
#18
REVIEW
Philippe A Eigenmann
Food challenges are standard in the diagnosis in patients suspected of being allergic to food. However, their role is regularly questioned due to the time required to perform them, and to their cost and the inherent risk of severe reactions. Food challenges have been challenged by recent advances defining threshold values for food-specific IgE helping to predict the probability of having symptoms to the suspected food. Also, identification of major allergens to various highly allergenic foods such as peanuts or tree nuts have contributed to an increased accuracy of IgE testing...
December 14, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29238902/dietary-therapy-for-eosinophilic-esophagitis-elimination-and-reintroduction
#19
REVIEW
Kara L Kliewer, Alison M Cassin, Carina Venter
Eosinophilic esophagitis (EoE) is a food antigen-mediated disorder of the esophagus characterized by eosinophil predominant inflammation and symptoms of esophageal dysfunction. Dietary antigen elimination induces clinical and histological remission in patients with EoE. The most restrictive of elimination diets (the elemental diet) removes all possible food antigens while empiric elimination diets remove all (or a subset) of food antigens most commonly reported to cause esophageal eosinophilia and food allergies (milk, egg, wheat, soy, peanuts, tree nuts, fish, or legumes)...
December 14, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29233462/recent-advancement-to-prevent-the-development-of-allergy-and-allergic-diseases-and-therapeutic-strategy-in-the-perspective-of-barrier-dysfunction
#20
REVIEW
Osamu Natsume, Yukihiro Ohya
Therapeutic strategy in late 20th century to prevent allergic diseases was derived from a conceptual framework of allergens elimination which was as same as that of coping with them after their onset. Manifold trials were implemented; however, most of them failed to verify the effectiveness of their preventive measures. Recent advancement of epidemiological studies and cutaneous biology revealed epidermal barrier dysfunction plays a major role of allergen sensitization and development of atopic dermatitis which ignites the inception of allergy march...
December 7, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
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