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Metabolic OA

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https://www.readbyqxmd.com/read/28544753/no-association-between-metabolic-syndrome-and-radiographic-hand-osteoarthritis-data-from-the-framingham-study
#1
Mette P Strand, Tuhina Neogi, Jingbo Niu, David T Felson, Ida K Haugen
OBJECTIVE: To explore whether metabolic syndrome (MetS) and its components are associated with hand OA using longitudinal data from the Framingham study. METHODS: In our cross-sectional analyses we included 1089 persons (age 50-75 years), of whom 785 had 7-year longitudinal radiographs. Of these, 586 with no hand OA at baseline were included in analyses on hand OA incidence. We explored associations between and MetS and its components (central obesity, hypertension, diabetes, triglyceridemia, low high-density lipoprotein) and radiographic hand OA (defined as ≥2 interphalangeal joints with Kellgren-Lawrence grade≥2) using logistic regression analyses with adjustment for age, sex and body mass index (BMI)...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28544596/deletion-of-the-prostaglandin-d2-receptor-dp1-exacerbates-aging-associated-and-instability-induced-osteoarthritis
#2
Yassine Ouhaddi, Sarah-Salwa Nebbaki, Lauris Habouri, Hassan Afif, Bertrand Lussier, Mohit Kapoor, Shuh Narumiya, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi
OBJECTIVE: The D prostanoid receptor 1 (DP1), a receptor for prostaglandin D2 (PGD2 ), plays important roles in inflammation and cartilage metabolism. However, its role in the pathogenesis of osteoarthritis (OA) remains unknown. We undertook this study to explore the roles of DP1 in the development of OA and to evaluate the efficacy of a DP1 selective agonist in the treatment of OA. METHODS: We compared the development of aging-associated OA and destabilization of the medial meniscus (DMM)-induced OA in DP1-deficient (DP1-/-) and wild-type (WT) mice...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28534819/ginsenoside-rb2-alleviates-hepatic-lipid-accumulation-by-restoring-autophagy-via-induction-of-sirt1-and-activation-of-ampk
#3
Qi Huang, Ting Wang, Liu Yang, He-Yao Wang
Although Panax ginseng is a famous traditional Chinese medicine and has been widely used to treat a variety of metabolic diseases including hyperglycemia, hyperlipidemia, and hepatosteatosis, the effective mediators and molecular mechanisms remain largely unknown. In this study we found that ginsenoside Rb2, one of the major ginsenosides in Panax ginseng, was able to prevent hepatic lipid accumulation through autophagy induction both in vivo and in vitro. Treatment of male db/db mice with Rb2 significantly improved glucose tolerance, decreased hepatic lipid accumulation, and restored hepatic autophagy...
May 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28527806/endogenous-synthesis-of-milk-oleic-acid-in-dairy-ewes-in-vivo-measurement-using-13-c-labeled-stearic-acid
#4
P G Toral, P Frutos, D Carreño, G Hervás
The use of stable isotopes is a reliable and risk-free alternative to radioactive tracers for directly examining in vivo fatty acid (FA) metabolism. However, very limited information is available in ruminants, and none is available in sheep. Therefore, we conducted an experiment in dairy ewes to determine, for the first time in this species, the uptake, Δ(9)-desaturation, and secretion of (13)C-labeled stearic acid (SA) into milk with the aim of measuring in vivo endogenous synthesis of milk oleic acid (OA) and stearoyl-CoA desaturase activity...
May 17, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28498405/application-of-metabolomics-focus-on-the-quantification-of-organic-acids-in-healthy-adults
#5
Dimitris Tsoukalas, Athanasios Alegakis, Persefoni Fragkiadaki, Evangelos Papakonstantinou, Dragana Nikitovic, Aikaterini Karataraki, Alexander E Nosyrev, Emmanouel G Papadakis, Demetrios A Spandidos, Nikolaos Drakoulis, Aristides M Tsatsakis
Metabolomics, a 'budding' discipline, may accurately reflect a specific phenotype which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in science has been proposed as a tool for the evaluation of the effects of epigenetic factors, such as nutrition, environment, drug and lifestyle on phenotype. Urine, being sterile, is easy to obtain and as it contains metabolized or non‑metabolized products, is a favored study material in the field of metabolomics. Urine organic acids (OAs) reflect the activity of main metabolic pathways and have been used to assess health status, nutritional status, vitamin deficiencies and response to xenobiotics...
May 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28492349/a-novel-compressive-stress-based-osteoarthritis-like-chondrocyte-system
#6
In-Chi Young, Sung-Ting Chuang, Amit Gefen, Wei-Ting Kuo, Chun-Ting Yang, Chia-Hsien Hsu, Feng-Huei Lin
Mechanical stress damage and insufficient self-repair can contribute to osteoarthritis (OA) in the affected joint. As the effects of stress on chondrocyte metabolism can regulate cartilage homeostasis, the specific stress-response condition is therefore a key to the generation of an OA disease model. We aimed to produce a specific stress- and cell-based OA model after evaluating the metabolic responses of chondrocytes in response to a series of static and cyclic compression stressors. A static load exceeding 40 psi initiated extracellular matrix (ECM) degradation through a decrease in the sulphated-glycosaminoglycan (GAG) content, upregulation of catabolic matrix metalloproteinase (MMP)-13 encoding gene expression, and downregulation of the ECM-related aggrecan and type II collagen encoding genes within 24 h...
May 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28492150/selective-screening-for-organic-acidurias-and-amino-acidopathies-in-pakistani-children
#7
Noreen Abbas Sherazi, Aysha Habib Khan, Lena Jafri, Azeema Jamil, Nasir Ali Khan, Bushra Afroze
OBJECTIVE: To determine the frequency of organic acidurais (OA) and amino acidopathies (AA) in selected high-risk patients screened in two years. STUDY DESIGN: Retrospective Observational study. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital (AKUH), Karachi, from January 2013 to December 2014. METHODOLOGY: Patients with OA and AA were included in the study and patients with IMDs other than OA and AA were excluded...
April 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28490838/adipokine-contribution-to-the-pathogenesis-of-osteoarthritis
#8
REVIEW
Daniel Azamar-Llamas, Gabriela Hernández-Molina, Bárbara Ramos-Ávalos, Janette Furuzawa-Carballeda
Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28476673/soluble-adenylyl-cyclase-mediates-mitochondrial-pathway-of-apoptosis-and-atp-metabolism-in-oyster-crassostrea-gigas-exposed-to-elevated-co2
#9
Xiudan Wang, Mengqiang Wang, Jiachao Xu, Zhihao Jia, Zhaoqun Liu, Lingling Wang, Linsheng Song
Ocean acidification (OA) has deleterious impacts on immune response and energy homeostasis status of Mollusca. In the present study, the apoptosis ratio of hemocytes and the adenosine triphosphate (ATP) allocation in gill tissues were determined after Pacific oysters Crassostrea gigas were exposed to elevated CO2 environment (pH = 7.50) for 16 days.The apoptosis ratio in CO2 exposure group (35.2%) was significantly higher (p < 0.05) than that in the control group, and the increased apoptosis ratio induced by elevated CO2 could be significantly inhibited (p < 0...
May 2, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28469628/physiological-and-biochemical-analyses-shed-light-on-the-response-of-sargassum-vulgare-to-ocean-acidification-at-different-time-scales
#10
Amit Kumar, Hamada AbdElgawad, Immacolata Castellano, Maurizio Lorenti, Massimo Delledonne, Gerrit T S Beemster, Han Asard, Maria Cristina Buia, Anna Palumbo
Studies regarding macroalgal responses to ocean acidification (OA) are mostly limited to short-term experiments in controlled conditions, which hamper the possibility to scale up the observations to long-term effects in the natural environment. To gain a broader perspective, we utilized volcanic CO2 vents as a "natural laboratory" to study OA effects on Sargassum vulgare at different time scales. We measured photosynthetic rates, oxidative stress levels, antioxidant contents, antioxidant enzyme activities, and activities of oxidative metabolic enzymes in S...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28461019/polar-and-apolar-extra-virgin-olive-oil-and-leaf-extracts-as-a-promising-anti-inflammatory-natural-treatment-for-osteoarthritis
#11
Houda Nsir, Marta Anna Szychlinska, Venera Cardile, Adriana Carol Eleonora Graziano, Rosanna Avola, Hanen Esafi, Alessandra Bendini, Mokhtar Zarouk, Carla Loreto, Venerando Rapisarda, Paola Castrogiovanni, Giuseppe Musumeci
Osteoarthritis (OA) is a common joint disease with important socio-economic impact. Looking for a novel natural treatment represents an important challenge and a public health objective. A wide range of previous studies highlighted the antioxidant and anti-inflammatory properties especially of phenolic compounds present in olive oil. Therefore, the aim of this study was to investigate the anti-inflammatory activity of Tunisian Extra Virgin Olive Oil (EVOO) extracts in an in vitro OA model. To this aim we evaluated the polar and apolar olive oil fractions and olive leaf extract...
April 28, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28460910/organic-acids-in-kakadu-plum-terminalia-ferdinandiana-the-good-ellagic-the-bad-oxalic-and-the-uncertain-ascorbic
#12
David J Williams, David Edwards, Sharon Pun, Mridusmita Chaliha, Brian Burren, Ujang Tinggi, Yasmina Sultanbawa
The phenolic ellagic acid (EA) is receiving increasing attention for its nutritional and pharmacological potential as an antioxidant and antimicrobial agent. The Australian native Kakadu plum (Terminalia ferdinandiana) fruit is an abundant source of this phytochemical. The fruit also contains large amounts of vitamin C (mainly as ascorbic acid, AA) and possibly the undesirable oxalic acid (OA). Regular consumption of high oxalate foods poses a variety of health risks in humans including interference with calcium absorption and kidney stone formation...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28451795/distribution-of-osteoarthritis-in-a-norwegian-population-based-cohort-associations-to-risk-factor-profiles-and-health-related-quality-of-life
#13
Guro Økelsrud Lombnæs, Karin Magnusson, Nina Østerås, Lars Nordsletten, May Arna Risberg, Kåre Birger Hagen
The objective of the study was to examine the hand-, knee- and hip osteoarthritis (OA) distribution, risk factor profiles and health-related quality of life (HRQoL) in a population-based OA cohort. Persons with self-reported OA responded to questionnaires and attended a clinical examination (N = 606). We analyzed cross-sectional associations to risk factor profiles and HRQoL dimensions (Short Form 36) in four mutually exclusive groups based on fulfillment of The American College of Rheumatology criteria: no OA (NOA), monoarticular upper extremity (hand) OA (MOAupper-ex...
April 27, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28450214/omics-analysis-of-human-bone-to-identify-genes-and-molecular-networks-regulating-skeletal-remodeling-in-health-and-disease
#14
REVIEW
Sjur Reppe, Harish K Datta, Kaare M Gautvik
The skeleton is a metabolically active organ throughout life where specific bone cell activity and paracrine/endocrine factors regulate its morphogenesis and remodeling. In recent years, an increasing number of reports have used multi-omics technologies to characterize subsets of bone biological molecular networks. The skeleton is affected by primary and secondary disease, lifestyle and many drugs. Therefore, to obtain relevant and reliable data from well characterized patient and control cohorts are vital...
April 24, 2017: Bone
https://www.readbyqxmd.com/read/28428621/osteoarthritis-metabolic-syndrome-and-risk-of-knee-oa
#15
Sarah Onuora
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28418007/saturated-fatty-acids-induce-development-of-both-metabolic-syndrome-and-osteoarthritis-in-rats
#16
Sunderajhan Sekar, Siti Raihanah Shafie, Indira Prasadam, Ross Crawford, Sunil K Panchal, Lindsay Brown, Yin Xiao
The predominant saturated fatty acids (SFA) in human diets are lauric acid (LA, C12:0), myristic acid (MA, C14:0), palmitic acid (PA, C16:0) and stearic acid (SA, C18:0). The aim of this study was to investigate whether diets containing individual SFA together with excess simple carbohydrates induce osteoarthritis (OA)-like changes in knee joints and signs of metabolic syndrome in rats. Rats were given either a corn starch diet or a diet composed of simple carbohydrates together with 20% LA, MA, PA, SA or beef tallow for 16 weeks...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28414453/global-proteome-profiling-of-a-marine-copepod-and-the-mitigating-effect-of-ocean-acidification-on-mercury-toxicity-after-multigenerational-exposure
#17
Minghua Wang, Jae-Seong Lee, Yan Li
Previously, we found that ocean acidification (OA) mitigates mercury (Hg) toxicity to marine copepod Tigriopus japonicus under multigenerational exposure (four generations, F0-F3). To determine the response mechanisms of T. japonicus against long-term exposure to OA and Hg pollution, we investigated the proteome of F3 copepods after multigenerational exposure to four conditions: pCO2 400 μatm + control; pCO2 1000 μatm + control; pCO2 400 μatm +1.0 μg/L Hg; and pCO2 1000 μatm +1.0 μg/L Hg. Functional enrichment analysis indicated that OA enhanced the copepod's energy production mainly by increasing protein assimilation and proteolysis as a compensatory strategy, which explained its physiological resilience to reduced pH...
April 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28414161/metabolism-of-okadaic-acid-by-nadph-dependent-enzymes-present-in-human-or-rat-liver-s9-fractions-results-in-different-toxic-effects
#18
Franziska Kolrep, Kathleen Rein, Alfonso Lampen, Stefanie Hessel-Pras
The lipophilic marine biotoxin okadaic acid (OA) represents a natural contaminant produced by algae accumulating in seafood. Acute intoxications result in diarrhetic shellfish poisoning causing symptoms like nausea, vomiting and abdominal cramps. OA was preincubated with liver enzymes present in S9 fractions from humans, rats and rats pretreated with enzyme inducers in the presence or absence of the cofactor NADPH to investigate hepatic metabolism. Cytotoxicity was examined in HepG2 cells and metabolites of OA were determined by LC-MS/MS...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28413518/effect-of-n-acetylglucosamine-administration-on-cartilage-metabolism-and-safety-in-healthy-subjects-without-symptoms-of-arthritis-a-case-report
#19
Daiki Kubomura, Tomoya Ueno, Masanori Yamada, Akihito Tomonaga, Isao Nagaoka
N-acetylglucosamine (GlcNAc) is a widely accepted treatment for osteoarthritis (OA); however, its effect on healthy individuals is poorly understood. To evaluate the effect of GlcNAc administration on healthy subjects that do not exhibit symptoms of arthritis, the present randomized, double-blind, placebo-controlled study was performed. In the present study, 68 male and female Japanese participants, without symptomatic and radiographic evidence of OA, were enrolled and randomly allocated to receive placebo or GlcNAc (500 or 1,000 mg/day) for 16 weeks...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28410667/comparative-effects-of-high-oleic-acid-vs-high-mixed-saturated-fatty-acid-obesogenic-diets-upon-pufa-metabolism-in-mice
#20
COMPARATIVE STUDY
Matthew J Picklo, Joseph Idso, Drew R Seeger, Harold M Aukema, Eric J Murphy
Emerging evidence indicates that the fatty acid composition of obesogenic diets influences physiologic outcomes. There are scant data regarding how the content of non-essential fatty acids like monounsaturated fatty acids (MUFA) and saturated fatty acids (SFAs) impact the metabolism of polyunsaturated fatty acids (PUFAs). In this work, we tested the hypothesis that obesogenic diets enriched in oleic acid (OA; 18:1n-9) reduce polyunsaturated fatty acid (PUFA) levels vs an obesogenic diet enriched in SFAs. Adult male mice were fed for eight weeks either (1) a control 16% fat energy (en) diet with 5...
April 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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