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Metabolic OA

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https://www.readbyqxmd.com/read/29029746/liquid-chromatography-tandem-mass-spectrometric-determination-of-triterpenes-in-human-fluids-evaluation-of-markers-of-dietary-intake-of-olive-oil-and-metabolic-disposition-of-oleanolic-acid-and-maslinic-acid-in-humans
#1
Oscar J Pozo, Mitona Pujadas, Sarah Biel Gleeson, Maria Dolores Mesa-García, Antoni Pastor, Aristotelis Kotronoulas, Montserrat Fitó, Maria-Isabel Covas, José Ramón Fernández Navarro, Juan Antonio Espejo, Estefania Sanchez-Rodriguez, Rosa Marchal, Miguel Angel Calleja, Rafael de la Torre
Olive oil is rich in several minor components like maslinic (MA) and oleanolic (OA) acids which have cardioprotective, antitumor, and anti-inflammatory properties. In order to assess the health benefits in humans provided by the olive oil triterpenes (MA and OA), suitable analytical methods able to quantify the low concentrations expected in human fluids are required. In this study, the LC-MS/MS quantification of both OA and MA in plasma and urine has been evaluated. The plasmatic method is based on the direct determination of the analytes...
October 16, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28979900/comparison-of-the-effects-of-interleukin-1-on-equine-articular-cartilage-explants-and-cocultures-of-osteochondral-and-synovial-explants
#2
Christopher R Byron, Richard A Trahan
Osteoarthritis (OA) is a ubiquitous disease affecting many horses. The disease causes chronic pain and decreased performance for patients and great cost to owners for diagnosis and treatment. The most common treatments include systemic non-steroidal anti-inflammatory drugs and intra-articular injection of corticosteroids. There is excellent support for the palliative pain relief these treatments provide; however, they do not arrest progression and may in some instances hasten advancement of disease. Orthobiologic treatments have been investigated as potential OA treatments that may not only ameliorate pain but also prevent or reverse pathologic articular tissue changes...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28956662/leptin-alone-and-in-combination-with-interleukin-1-beta-induced-cartilage-degradation-potentially-inhibited-by-epa-and-dha
#3
Thanyaluck Phitak, Kanchanit Boonmaleerat, Peraphan Pothacharoen, Dumnoensun Pruksakorn, Prachya Kongtawelert
Osteoarthritis (OA) is the most common form of arthritis. Obesity has been believed to be an important risk factor for OA development and the progression of not only load-bearing joints, but low-load-bearing joints as well. Increased leptin has been the focus of a link between obesity and OA. In this study, the effects of pathological (100ng/ml) or supra-pathological (10μg/ml) concentrations of leptin alone or in combination with IL1β on cartilage metabolisms were studied in porcine cartilage explant. The involved mechanisms were examined in human articular chondrocytes (HACs)...
September 28, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28955780/pharmacological-treatment-with-diacerein-combined-with-mechanical-stimulation-affects-the-expression-of-growth-factors-in-human-chondrocytes
#4
Bibiane Steinecker-Frohnwieser, Heike Kaltenegger, Lukas Weigl, Anda Mann, Werner Kullich, Andreas Leithner, Birgit Lohberger
BACKGROUND: Osteoarthritis (OA) as the main chronic joint disease arises from a disturbed balance between anabolic and catabolic processes leading to destructions of articular cartilage of the joints. While mechanical stress can be disastrous for the metabolism of chondrocytes, mechanical stimulation at the physiological level is known to improve cell function. The disease modifying OA drug (DMOAD) diacerein functions as a slowly-acting drug in OA by exhibiting anti-inflammatory, anti-catabolic, and pro-anabolic properties on cartilage...
September 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28953990/metabolomics-as-a-promising-tool-for-early-osteoarthritis-diagnosis
#5
REVIEW
E B de Sousa, G C Dos Santos, M E L Duarte, V Moura, D P Aguiar
Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its pathogenesis. However, no biomarker has been identified to detect this disease at early stages or to track its development. Metabolomics is an emerging field and has the potential to detect many metabolites in a single spectrum using high resolution nuclear magnetic resonance (NMR) techniques or mass spectrometry (MS)...
September 21, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28940111/hyperuricemia-is-associated-with-increased-apo-ai-fractional-catabolic-rates-and-dysfunctional-hdl-in-new-zealand-rabbits
#6
Miriam Martínez-Ramírez, Cristóbal Flores-Castillo, L Gabriela Sánchez-Lozada, Rocío Bautista-Pérez, Elizabeth Carreón-Torres, José Manuel Fragoso, José Manuel Rodriguez-Pérez, Fernando E García-Arroyo, Victoria López-Olmos, María Luna-Luna, Gilberto Vargas-Alarcón, Martha Franco, Oscar Pérez-Méndez
The potential cause-effect relationship between uric acid plasma concentrations and HDL functionality remains elusive. Therefore, this study aimed to explore the effect of oxonic acid (OA)-induced hyperuricemia on the HDL size distribution, lipid content of HDL subclasses, and apo AI turnover, as well as HDL functionality in New Zealand white rabbits. Experimental animals received OA 750 mg/kg/day by oral gavage during 21 days. The HDL-apo AI fractional catabolic rate (FCR) was determined by exogenous labeling with (125)I, and HDL subclasses were determined by sequential ultracentrifugation and PAGE...
September 22, 2017: Lipids
https://www.readbyqxmd.com/read/28933742/vitamin-d-supplementation-improves-quality-of-life-and-physical-performance-in-osteoarthritis-patients
#7
Pacharee Manoy, Pongsak Yuktanandana, Aree Tanavalee, Wilai Anomasiri, Srihatach Ngarmukos, Thanathep Tanpowpong, Sittisak Honsawek
(1) Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D₂ supplementation on muscle strength and physical performance in knee OA patients; (2) Methods: One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D₂ (ergocalciferol) per week for six months...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28931493/homarus-gammarus-crustacea-decapoda-larvae-under-an-ocean-acidification-scenario-responses-across-different-levels-of-biological-organization
#8
Lénia D Rato, Sara C Novais, Marco F L Lemos, Luís M F Alves, Sérgio M Leandro
The present study evaluated the effects of exposure to different target pCO2 levels: control (C: 370μatm, pH = 8.15) and ocean acidification (OA: 710μatm, pH=7.85) on development and biochemical responses related with oxidative stress and energy metabolism during the crustacean Homarus gammarus (L.) larval development, integrating different levels of biological organization. After hatching in the laboratory, larvae from the same female brood were exposed to the described conditions from hatching until reaching Stage III (last larval stage - 11 days)...
September 17, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28926471/role-of-fat-soluble-vitamins-in-osteoarthritis-management
#9
Xiao-Yan Zheng, Jun Liang, Yu-Sheng Li, Min Tu
Osteoarthritis (OA) is a chronic degenerative joint disease, in which metabolic imbalance in bone is observed. The pathological mechanism of metabolic imbalance is not clear yet, but the nutritional factors, particularly the vitamins, might be intrinsic to the development and progression of OA. In this review article, we have explored databases such as PubMed, Scopus, and Google Scholar articles until the beginning of 2017 and reviewed the role of fat-soluble vitamins in pathological and therapeutic aspects of OA...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28912693/octopamine-underlies-the-counter-regulatory-response-to-a-glucose-deficit-in-honeybees-apis-mellifera
#10
Christina Buckemüller, Oliver Siehler, Josefine Göbel, Richard Zeumer, Anja Ölschläger, Dorothea Eisenhardt
An animal's internal state is a critical parameter required for adaptation to a given environment. An important aspect of an animal's internal state is the energy state that is adjusted to the needs of an animal by energy homeostasis. Glucose is one essential source of energy, especially for the brain. A shortage of glucose therefore triggers a complex response to restore the animal's glucose supply. This counter-regulatory response to a glucose deficit includes metabolic responses like the mobilization of glucose from internal glucose stores and behavioral responses like increased foraging and a rapid intake of food...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28905144/knee-osteoarthritis-and-associated-cardio-metabolic-clusters-in-a-tertiary-hospital-in-nigeria
#11
Abubakar Yerima, Olufemi Adelowo
Osteoarthritis (OA) of the knee is the most common type of arthritis all over the world. Obesity is the strongest modifiable risk factor and causes OA through a combination metabolic factors and mechanical loading. This study aimed to determine the frequency of metabolic syndrome (Mets) among patients with knee OA and its relationship with pain and functional status. This was a descriptive hospital-based cross-sectional study involving patients with knee OA. Pain was measured using a 0-10 numeric rating visual analog scale (VAS)...
November 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28898260/hyperglycemia-related-advanced-glycation-end-products-is-associated-with-the-altered-phosphatidylcholine-metabolism-in-osteoarthritis-patients-with-diabetes
#12
Weidong Zhang, Edward W Randell, Guang Sun, Sergei Likhodii, Ming Liu, Andrew Furey, Guangju Zhai
To test whether type 2 diabetic patients have an elevated level of advanced glycation end-products (AGEs) and responsible for altered phosphatidylcholine metabolism, which we recently found to be associated with osteoarthritis (OA) and diabetes mellitus (DM), synovial fluid (SF) and plasma samples were collected from OA patients with and without DM. Hyperglycemia-related AGEs including methylglyoxal (MG), free methylglyoxal-derived hydroimidazolone (MG-H1), and protein bound N-(Carboxymethyl)lysine (CML) and N-(Carboxyethyl)lysine (CEL) levels were measured in both SF and plasma samples using liquid chromatography coupled tandem mass spectrometry methodology...
2017: PloS One
https://www.readbyqxmd.com/read/28893232/plasminogen-activator-inhibitor-1-deficiency-enhances-subchondral-osteopenia-after-induction-of-osteoarthritis-in-mice
#13
Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi, Hiroshi Kaji
BACKGROUND: Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to bone metabolism, its role in OA remains unknown. We therefore investigated the roles of PAI-1 in the subchondral bone in OA model mice. METHODS: Wild type (WT) and PAI-1-deficient (KO) mice were ovariectomized (OVX), and then destabilization of the medial meniscus (DMM) surgery was performed...
September 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28888901/oral-administration-of-undenatured-native-chicken-type-ii-collagen-uc-ii-diminished-deterioration-of-articular-cartilage-in-a-rat-model-of-osteoarthritis-oa
#14
C M Bagi, E R Berryman, S Teo, N E Lane
OBJECTIVE: The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA). METHODS: Twenty male rats were subjected to partial medial meniscectomy tear (PMMT) surgery to induce OA. Immediately after the surgery 10 rats received vehicle and another 10 rats oral daily dose of UC-II at 0.66 mg/kg for a period of 8 weeks. In addition 10 naïve rats were used as an intact control and another 10 rats received sham surgery...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28882805/suppressor-of-cytokine-signaling-3-socs3-is-related-to-pro-inflammatory-cytokine-production-and-triglyceride-deposition-in-turbot-scophthalmus-maximus
#15
Peng Tan, Mo Peng, Dongwu Liu, Huarong Guo, Kangsen Mai, Rui Nian, Benoit Macq, Qinghui Ai
Turbot (Scophthalmus maximus) is an economically important fish that is farmed by aquaculture for human consumption. Aquacultured turbot are commonly fed a high-lipid diet; however, this diet causes excessive lipid deposition and the overexpression of pro-inflammatory cytokines. Studies in mammals have indicated that a relationship exists between pro-inflammatory cytokine overexpression and altered lipid metabolism through the activation of suppressor of cytokine signaling 3 (SOCS3). In this study, we investigated the relationship between SOCS3 and triglyceride (TG) deposition and mechanism of SOCS3 activation in farmed turbot fed high-lipid diet (HLD)...
September 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28878633/the-role-of-monoaminergic-neurotransmission-for-metabolic-control-in-the-fruit-fly-drosophila-melanogaster
#16
Yong Li, Lasse Tiedemann, Jakob von Frieling, Stella Nolte, Samar El-Kholy, Flora Stephano, Christoph Gelhaus, Iris Bruchhaus, Christine Fink, Thomas Roeder
Hormones control various metabolic traits comprising fat deposition or starvation resistance. Here we show that two invertebrate neurohormones, octopamine (OA) and tyramine (TA) as well as their associated receptors, had a major impact on these metabolic traits. Animals devoid of the monoamine OA develop a severe obesity phenotype. Using flies defective in the expression of receptors for OA and TA, we aimed to decipher the contributions of single receptors for these metabolic phenotypes. Whereas those animals impaired in octß1r, octß2r and tar1 share the obesity phenotype of OA-deficient (tβh-deficient) animals, the octß1r, octß2r deficient flies showed reduced insulin release, which is opposed to the situation found in tβh-deficient animals...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28877688/effects-of-hyaluronic-acid-combined-with-anti-inflammatory-drugs-compared-with-hyaluronic-acid-alone-in-clinical-trials-and-experiments-in-osteoarthritis-a-systematic-review-and-meta-analysis
#17
Thippaporn Euppayo, Veerasak Punyapornwithaya, Siriwadee Chomdej, Siriwan Ongchai, Korakot Nganvongpanit
BACKGROUND: The objectives are to compare the efficacy of intra-articular hyaluronic acid (IA-HA) alone and in combination with anti-inflammatory drugs (IA-HA + AI), corticosteroids (CS) or non-steroidal anti-inflammatory drugs (NSAIDs) in clinical trials and in vivo and in vitro studies of osteoarthritis (OA). METHODS: Data in the BIOSIS, CINAHL, Cochrane Library, EMBASE and Medline databases were collected and analyzed. Random effects models were used to compute the effect size (ES) of the mean difference in pain reduction scores from baseline and the relative risk (RR) of adverse events...
September 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28875826/current-treatment-options-for-osteoarthritis
#18
Sevdalina Lambova, Walter Hermann, Ulf Müller-Ladner
BACKGROUND: Osteoarthritis (ОА) is the most common joint disease and a leading cause for impaired function and disability with significant treatment costs and socio-economic burden. Despite recent achievements in the knowledge on disease pathogenesis, the treatment is still a challenge and contrary to inflammatory joint diseases, no disease-modifying drugs are currently available for OA. OBJECTIVE: Different response in different localizations of the disease further complicates the therapeutic choice...
August 29, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28862360/mechanically-stimulated-biomarkers-signal-cartilage-changes-over-5-years-consistent-with-disease-progression-in-medial-knee-osteoarthritis-patients
#19
Constance R Chu, Shikha Sheth, Jennifer C Erhart-Hledik, Bao Do, Matthew R Titchenal, Thomas P Andriacchi
Using serum biomarkers to assess osteoarthritis (OA) disease state and risks of progression remain challenging. This study tested the hypothesis that changes to serum biomarkers in response to a mechanical stimulus in patients with medial knee OA signal cartilage thickness changes five years later. Specifically, serum concentrations of a collagen degradation marker (C1,2C) and a chondroitin sulfate synthesis marker (CS846) were measured 0.5 and 5.5 hours after a 30-minute walk in 16 patients. Regional cartilage thickness changes measured from magnetic resonance images obtained at study entry and at 5-year follow-up were tested for correlations with baseline biomarker changes after mechanical stimulus, and for differences between groups stratified based on whether biomarker levels increased or decreased...
September 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28862289/lipid-droplet-formation-in-hela-cervical-cancer-cells-depends-on-cell-density-and-the-concentration-of-exogenous-unsaturated-fatty-acids
#20
Ema Guštin, Eva Jarc, Ana Kump, Toni Petan
Cytosolic lipid droplets (LDs) store excess fatty acids (FAs) in the form of neutral lipids and prevent starvation-induced cancer cell death. Here we studied the ability of mono- and polyunsaturated FAs to affect LD formation and survival in HeLa cervical cancer cells. We found that the LD content in HeLa cells increases with cell density, but it decreases in MDA-MB-231 breast cancer cells. Exogenously-added unsaturated FAs, including oleic (OA), linoleic (LA), arachidonic (AA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) displayed a similar ability to alter LD formation in HeLa cells...
September 2017: Acta Chimica Slovenica
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