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Metabolic OA

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https://www.readbyqxmd.com/read/29662780/distinct-metabolic-programs-induced-by-tgf-%C3%AE-1-and-bmp2-in-human-articular-chondrocytes-with-osteoarthritis
#1
Cuicui Wang, Richard M Silverman, Jie Shen, Regis J O'Keefe
Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles. At the cellular and molecular level, osteoarthritis (OA) is characterised by alteration from a healthy homoeostatic state towards a catabolic state. Several molecular pathways, including transforming growth factor beta (TGF-β) and bone morphogenetic protein (BMP) signalling, have been identified as critical players in the pathogenesis and progression of OA...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29656143/quantitative-imaging-of-bone-cartilage-interactions-in-acl-injured-patients-with-pet-mri
#2
Feliks Kogan, Audrey P Fan, Uche Monu, Andrei Iagaru, Brian A Hargreaves, Garry E Gold
OBJECTIVE: To investigate changes in bone metabolism by PET, as well as spatial relationships between bone metabolism and MRI quantitative markers of early cartilage degradation, in ACL-reconstructed knees. DESIGN: Both knees of 15 participants with unilateral reconstructed ACL tears and unaffected contralateral knees were scanned using a simultaneous 3.0T PET-MRI system following injection of 18 F-sodium fluoride(18 F-NaF). The maximum pixel standardized uptake value(SUVmax ) in the subchondral bone and the average T2 relaxation time in cartilage were measured in each knee in 8 knee compartments...
April 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29644876/the-effects-of-well-rounded-exercise-program-on-systemic-biomarkers-related-to-cartilage-metabolism
#3
Masayuki Azukizawa, Hiromu Ito, Yosuke Hamamoto, Takayuki Fujii, Yugo Morita, Akinori Okahata, Takuya Tomizawa, Moritoshi Furu, Kohei Nishitani, Shinichi Kuriyama, Shinichiro Nakamura, Hiroyuki Yoshitomi, Toshiaki Nakatani, Tadao Tsuboyama, Masahide Hamaguchi, Shuichi Matsuda, Tadashi Yasuda
Nonsurgical treatment such as exercise is the preferred method for management of knee osteoarthritis (OA). A combination of aerobic, muscle strengthening, and flexibility exercises is recommended for older adults. However, effects of the exercise intervention on cartilage metabolism remain unclear. This study used biomarkers to investigate the effects of well-rounded exercise program on cartilage metabolism in 42 women (mean age: 59 years). Participants started a weekly supervised exercise program and continued for 12 weeks...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29629027/ethanol-extract-of-allium-fistulosum-inhibits-development-of-non-alcoholic-fatty-liver-disease
#4
Jin-Taek Hwang, Eun Ju Shin, Min-Yu Chung, Jae Ho Park, Sangwon Chung, Hyo-Kyoung Choi
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of ethanol extract of Allium fistulosum (EAF) on NAFLD and have suggested the possibility of using EAF as a natural product for application in the development of a treatment for NAFLD. MATERIALS/METHODS: The preventive effect on hepatic lipid accumulation was estimated by using an oleic acid (OA)-induced NAFLD model in vitro and a Western diet (high-fat high-sucrose; WD)-induced obese mouse model...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29604245/curcumin-protects-rabbit-articular-chondrocytes-against-sodium-nitroprusside-induced-apoptosis-in-vitro
#5
Ping Zhao, Jiafeng Cheng, Jiajin Geng, Min Yang, Yongqiang Zhang, Qiang Zhang, Yang Wang, Bin Lu
The preventive and therapeutic effects of curcumin on degeneration of articular (joint) cartilage diseases have rarely been investigated. In the present study, the protective effects of curcumin against sodium nitroprusside (SNP)-induced chondrocyte apoptosis were evaluated and the underlying molecular mechanisms were elucidated. Curcumin was used to as a co-treatment with SNP in chondrocytes, and changes occurring in the cells were observed and evaluated. It was shown using a cell counting kit-8 (CCK-8) assay that curcumin protected the viability of chondrocytes against SNP damage...
March 28, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29588472/osteoarthritis-patterns-cardio-metabolic-risk-factors-and-risk-of-all-cause-mortality-20-years-follow-up-in-patients-after-hip-or-knee-replacement
#6
G Büchele, K P Günther, H Brenner, W Puhl, T Stürmer, D Rothenbacher, R E Brenner
Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. STUDY AIMS: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29587623/olive-leaf-extract-prevents-cartilage-degeneration-in-osteoarthritis-of-str-ort-mice
#7
Maruyama Takuma, Kamihama Haruka, Watanabe Mutsuto, Matsuo Toshiki, Matsuda Kenshiro, Tanaka Akane, Matsuda Hiroshi, Nomura Yoshihiro
The chondroprotective effect of olive leaf extract (OLE) on knee osteoarthritis (OA) was studied with STR/ort mice (n = 5). OLE was administrated with a dosage of 100 mg/kg for 8 weeks and the OA severity score of hind limb knee joints was then measured. The Mankin scores of the knee joints of the non-OA control group, OA control group and OLE-treated group were 3.50, 11.13 and 7.20, respectively. This suggests that oral OLE supplements help prevent cartilage degeneration in STR/ort mice. In vitro, the synthesis of high molecular weight hyaluronan in synovial cells (HIG-82) was increased by OLE stimulation...
March 27, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29578044/systemic-and-local-adipose-tissue-in-knee-osteoarthritis
#8
REVIEW
Jun Chang, Zetao Liao, Ming Lu, Tao Meng, Weiyu Han, Changhai Ding
Knee osteoarthritis (OA) is the most common joint disease. Body adipose tissue has been shown to be related to the development and progression of knee OA. Among systemic adipose tissues, subcutaneous adipose tissue is significantly and negatively associated with muscle mass and forces, and could be related to the presence and progression of knee OA. Visceral adipose tissue is associated with increased cartilage loss and production of pro-inflammatory cytokines. Intra-muscular adipose tissue is associated with knee osteoarthritic changes, but it remains controversial if inter-muscular adipose tissue has a role to play in the pathogenesis for knee OA...
March 22, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29565987/phospholipid-transfer-protein-pltp-exerts-a-direct-pro-inflammatory-effect-on-rheumatoid-arthritis-ra-fibroblasts-like-synoviocytes-fls-independently-of-its-lipid-transfer-activity
#9
Rachel Audo, Valérie Deckert, Claire I Daien, Hélène Che, Jamila Elhmioui, Stéphanie Lemaire, Jean-Paul Pais de Barros, Catherine Desrumaux, Bernard Combe, Michael Hahne, Laurent Lagrost, Jacques Morel
Rheumatoid arthritis (RA) is a chronic inflammatory rheumatic disease with modification of lipids profile and an increased risk of cardiovascular events related to inflammation. Plasma phospholipid transfer protein (PLTP) exerts a lipid transfer activity through its active form. PLTP can also bind to receptors such as ATP-binding cassette transporter A1 (ABCA1). In addition to its role in lipoprotein metabolism and atherosclerosis, the latest advances came in support of a complex role of PLTP in the regulation of the inflammatory response, both with pro-inflammatory or anti-inflammatory properties...
2018: PloS One
https://www.readbyqxmd.com/read/29550120/%C3%AE-lactalbumin-oleic-acid-complex-kills-tumor-cells-by-inducing-excess-energy-metabolism-but-inhibiting-mrna-expression-of-the-related-enzymes
#10
B Fang, M Zhang, K S Ge, H Z Xing, F Z Ren
Previous studies have demonstrated that the anti-tumor α-lactalbumin-oleic acid complex (α-LA-OA) may target the glycolysis of tumor cells. However, few data are available regarding the effects of α-LA-OA on energy metabolism. In this study, we measured glycolysis and mitochondrial functions in HeLa cells in response to α-LA-OA using the XF flux analyzer (Seahorse Bioscience, North Billerica, MA). The gene expression of enzymes involved in glycolysis, tricarboxylic acid cycle, electron transfer chain, and ATP synthesis were also evaluated...
March 14, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29550110/is-abnormal-glucose-tolerance-or-diabetes-a-risk-factor-for-knee-hip-or-hand-osteoarthritis-a-systematic-review
#11
REVIEW
Luke P Dawson, Jessica L Fairley, Michelle C Papandony, Sultana Monira Hussain, Flavia M Cicuttini, Anita E Wluka
OBJECTIVE: Diabetes (DM) and osteoarthritis (OA) are two common co-existing chronic conditions. However, whether this is due to shared risk factors or may differ between joints is unclear. We performed a systematic review to determine whether abnormal glucose metabolism is a risk factor for knee, hip and hand OA, separately, independent of age and obesity. METHODS: A systematic search of Ovid Medline and EMBASE was performed from inception until October 2016 to identify studies relating glucose metabolism to osteoarthritis-related outcomes...
February 21, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29549054/knocking-out-or-pharmaceutical-inhibition-of-fatty-acid-binding-protein-4-fabp4-alleviates-osteoarthritis-induced-by-high-fat-diet-in-mice
#12
Chaofan Zhang, Kwong Yuen Chiu, Boris Pok Man Chan, Teng Li, Chunyi Wen, Aimin Xu, Chun Hoi Yan
OBJECTIVES: Adipokines play roles in the pathogenesis of osteoarthritis (OA). Fatty acid binding protein 4 (FABP4) is a novel adipokine that is closely associated with obesity and metabolic diseases. The aim of this study was to discover the potential role of FABP4 in OA. METHODS: Seventy-two FABP4 knockout mice (KO) in C57BL/6N background and wild-type littermates (WT) (male, 6-week-old) were fed with a high-fat diet (HFD, 60% calorie) or standard diet (STD, 11...
March 13, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29547792/intersegmental-kinematics-coordination-in-unilateral-peripheral-and-central-origin-effect-on-gait-mechanism
#13
Laura Wallard, Sophie Boulet, Olivier Cornu, Jean-Emile Dubuc, Philippe Mahaudens, Didier Postlethwaite, Maïté Van Cauter, Christine Detrembleur
BACKGROUND: The gait mechanism requires an efficient intersegmental coordination in order to ensure the displacement of the body while simultaneously maintaining the postural stability. However, intersegmental coordination may be disrupted by neurological or orthopaedic involvement, this increasing the metabolic cost associated with excessive or prolonged muscle co-contraction. RESEARCH QUESTION: Our aim was to evaluate and to understand how hip OA affects lower limbs coordination during gait by using the kinematic segmental covariation law method and predict the energy expenditure...
March 7, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29547667/comparison-of-secretome-from-osteoblasts-derived-from-sclerotic-versus-non-sclerotic-subchondral-bone-in-oa-a-pilot-study
#14
Christelle Sanchez, Gabriel Mazzucchelli, Cécile Lambert, Fanny Comblain, Edwin DePauw, Yves Henrotin
OBJECTIVE: Osteoarthritis (OA) is characterized by cartilage degradation but also by other joint tissues modifications like subchondral bone sclerosis. In this study, we used a proteomic approach to compare secretome of osteoblast isolated from sclerotic (SC) or non sclerotic (NSC) area of OA subchondral bone. DESIGN: Secretome was analyzed using differential quantitative and relative label free analysis on nanoUPLC G2 HDMS system. mRNA of the more differentially secreted proteins were quantified by RT-PCR in cell culture from 5 other patients...
2018: PloS One
https://www.readbyqxmd.com/read/29542003/scutellaria-baicalensis-regulates-ffa-metabolism-to-ameliorate-nafld-through-the-ampk-mediated-srebp-signaling-pathway
#15
Qian Chen, Mengyang Liu, Haiyang Yu, Jian Li, Sijian Wang, Yi Zhang, Feng Qiu, Tao Wang
Scutellaria baicalensis has been reported to improve the lipid metabolism of high-fat diet-induced liver dysfunction, but direct evidence is rare. This study aimed to explore the effects and mechanisms of S. baicalensis and its major constituent baicalin on hepatic lipotoxicity. KK-Ay mice and orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) rats were used to evaluate lipid metabolism regulatory effects. Sodium oleate-induced triglyceride-accumulated HepG2 cells were used for the mechanism study, pretreated with or without compound C or STO-609 or transfected with liver kinase B1 (LKB1) siRNA...
March 14, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29533007/oxaloacetate-induces-apoptosis-in-hepg2-cells-via-inhibition-of-glycolysis
#16
Ye Kuang, Xiaoyun Han, Mu Xu, Qing Yang
Most cancer cells perform glycolysis despite having sufficient oxygen. The specific metabolic pathways of cancer cells have become the focus of cancer treatment. Recently, accumulating evidence indicates oxidative phosphorylation (OXPHOS) and glycolysis can be regulated with each other. Thus, we suggest that the glycolysis of cancer cells is inhibited by restoring or improving OXPHOS in cancer cells. In our study, we found that oxaloacetate (OA) induced apoptosis in HepG2 cells in vivo and in vitro. Meanwhile, we found that OA induced a decrease in the energy metabolism of HepG2 cells...
March 13, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29525610/arctigenin-protects-against-steatosis-in-wrl68-hepatocytes-through-activation-of-phosphoinositide-3-kinase-protein-kinase-b-and-amp-activated-protein-kinase-pathways
#17
Kung-Yen Chen, Jui-An Lin, Han-Yun Yao, An-Chih Hsu, Yu-Ting Tai, Jui-Tai Chen, Mao-Chih Hsieh, Tang-Long Shen, Ren-Yi Hsu, Hong-Tan Wu, Guey Horng Wang, Bing-Ying Ho, Yu-Pei Chen
Arctigenin (ATG), a lignin extracted from Arctium lappa (L.), exerts antioxidant and anti-inflammatory effects. We hypothesized that ATG exerts a protective effect on hepatocytes by preventing nonalcoholic fatty liver disease (NAFLD) progression associated with lipid oxidation-associated lipotoxicity and inflammation. We established an in vitro NAFLD cell model by using normal WRL68 hepatocytes to investigate oleic acid (OA) accumulation and the potential bioactive role of ATG. The results revealed that ATG inhibited OA-induced lipid accumulation, lipid peroxidation, and inflammation in WRL68 hepatocytes, as determined using Oil Red O staining, thiobarbituric acid reactive substance assay, and inflammation antibody array assays...
February 11, 2018: Nutrition Research
https://www.readbyqxmd.com/read/29494586/an-evolutionary-learning-and-network-approach-to-identifying-key-metabolites-for-osteoarthritis
#18
Ting Hu, Karoliina Oksanen, Weidong Zhang, Ed Randell, Andrew Furey, Guang Sun, Guangju Zhai
Metabolomics studies use quantitative analyses of metabolites from body fluids or tissues in order to investigate a sequence of cellular processes and biological systems in response to genetic and environmental influences. This promises an immense potential for a better understanding of the pathogenesis of complex diseases. Most conventional metabolomics analysis methods exam one metabolite at a time and may overlook the synergistic effect of combining multiple metabolites. In this article, we proposed a new bioinformatics framework that infers the non-linear synergy among multiple metabolites using a symbolic model and subsequently, identify key metabolites using network analysis...
March 1, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29483877/participation-of-arachidonic-acid-metabolism-in-the-aortic-aneurysm-formation-in-patients-with-marfan-syndrome
#19
María E Soto, Verónica Guarner-Lans, Karla Y Herrera-Morales, Israel Pérez-Torres
Marfan syndrome (MFS) is a pleiotropic genetic disease involving the cardiovascular system where a fibrillin-1 mutation is present. This mutation is associated with accelerated activation of transforming growth factor β (TGFβ1) which contributes to the formation of aneurysms in the root of the aorta. There is an imbalance in the synthesis of thromboxane A2 (TXA2 ) and prostacyclin, that is a consequence of a differential protein expression of the isoforms of cyclooxygenases (COXs), suggesting an alteration of arachidonic acid (AA) metabolism...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29470404/oleanolic-acid-exerts-osteoprotective-effects-and-modulates-vitamin-d-metabolism
#20
Sisi Cao, Xiao-Li Dong, Ming-Xian Ho, Wen-Xuan Yu, Ka-Chun Wong, Xin-Sheng Yao, Man-Sau Wong
Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)₂D₃ and renal CYP27B1 mRNA expression in mature C57BL/6 ovariectomised (OVX) mice. OA also improved bone properties, Ca balance, and exerted modulatory effects on renal CYP27B1 and CYP24A1 expressions in aged normal female Sprague-Dawley rats...
February 22, 2018: Nutrients
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