Read by QxMD icon Read

Metabolic OA

Mauro Maniscalco, Debora Paris, Dominique J Melck, Maria D'Amato, Anna Zedda, Matteo Sofia, Cristiana Stellato, Andrea Motta
BACKGROUND: Epidemiological and clinical evidence supports the existence of an obesity-related asthma phenotype. No distinct pathophysiological elements or specific biomarkers have been identified so far but increased oxidative stress has been reported. OBJECTIVE: We aimed at verifying whether metabolomics of exhaled breath condensate (EBC) from obese asthmatic (OA), lean asthmatic (LA) and obese non-asthmatic (ONA) patients could recognize specific, statistically validated biomarkers for a separate "asthma-obesity" respiratory metabolic phenotype, here defined as "metabotype"...
October 13, 2016: Journal of Allergy and Clinical Immunology
Saba Farnaghi, Indira Prasadam, Guangping Cai, Thor Friis, Zhibin Du, Ross Crawford, Xinzhan Mao, Yin Xiao
The contribution of metabolic factors on the severity of osteoarthritis (OA) is not fully appreciated. This study aimed to define the effects of hypercholesterolemia on the progression of OA. Apolipoprotein E-deficient (ApoE(-/-)) mice and diet-induced hypercholesterolemic (DIHC) rats were used to explore the effects of hypercholesterolemia on the progression of OA. Both models exhibited OA-like changes, characterized primarily by a loss of proteoglycans, collagen and aggrecan degradation, osteophyte formation, changes to subchondral bone architecture, and cartilage degradation...
October 13, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Julio Diaz-Perez, Sonia R Salvatore, Francisco J Schopfer, Bruce A Freeman, Louis D Falo
BACKGROUND: Reactions between nitric oxide (NO), nitrite (NO2(-) ), and unsaturated fatty acids give rise to electrophilic nitro-fatty acids (NO2 -FAs), such as nitro-oleic acid (OA-NO2 ) and nitro-linoleic acid (LNO2 ). Endogenous electrophilic fatty acids (EFAs) mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction reactions. Hence, there is considerable interest in employing NO2 -FAs and other EFAs for the prevention and treatment of inflammatory disorders...
October 8, 2016: Allergy
Olivier Malaise, Biserka Relic, Edith Charlier, Mustapha Zeddou, Sophie Neuville, Céline Deroyer, Philippe Gillet, Edouard Louis, Michel G Malaise, Dominique de Seny
BACKGROUND: Glucocorticoid-induced leucine zipper (GILZ) is a mediator of the anti-inflammatory activities of glucocorticoids. However, GILZ deletion does not impair the anti-inflammatory activities of exogenous glucocorticoids in mice arthritis models and GILZ could also mediate some glucocorticoid-related adverse events. Osteoarthritis (OA) is a metabolic disorder that is partly attributed to adipokines such as leptin, and we previously observed that glucocorticoids induced leptin secretion in OA synovial fibroblasts...
October 4, 2016: Arthritis Research & Therapy
Ingrid Möller, Myriam Gharbi, Helena Martinez Serrano, Marta Herrero Barbero, Josep Verges Milano, Yves Henrotin
BACKGROUND: The aim of this study was to investigate the effects of chondroitin sulfate (CS) on the serum levels of Coll2-1 in patients with knee OA. METHODS: Seventy two patients with unilateral symptomatic knee OA were involved in a post-authorization open-label study evaluating CS (800 mg/day). The primary outcome was the % relative change in serum Coll2-1 (sColl2-1). The secondary outcomes were the evaluation of pain (VAS) and function (Lequesne's Index). Responders and non-responders were classified according to OMERACT-OARSI recommendations...
October 6, 2016: BMC Musculoskeletal Disorders
William Lewis, Juan-Pablo Padilla-Martinez, Antonio Ortega-Martinez, Walfre Franco
A significant source of morbidity in the elderly population of the United States is osteoarthritis (OA), a disease caused by the breakdown and loss of articular cartilage. The exact causes of OA remain unknown, though biomechanical forces and biochemical alterations are important factors. There exists an unmet need for an imaging tool to identify early lesions of OA via metabolic, chemical or structural changes. Our work aims to characterize changes in the intensity of UV fluorescent bands associated with known structural proteins of cartilage...
October 7, 2016: Journal of Biophotonics
Olga Katsara, Mukundan Attur, Rachel Ruoff, Steven B Abramson, Victoria Kolupaeva
Objectives Degeneration of articular cartilage is central to OA pathology; however, the molecular mechanisms leading to these irreversible changes are still poorly understood. Here, we investigated how changes in the chondrocyte translational apparatus may contribute to the pathology of OA. Methods Normal and OA human knee cartilage was used to analyze the activity of different components of the translational machinery. Chondrocytes isolated from lesional and non-lesional areas of OA cartilage were used to estimate relative rate of protein synthesis by metabolic labeling...
October 1, 2016: Arthritis & Rheumatology
Leela J Chakravarti, Michael D Jarrold, Emma M Gibbin, Felix Christen, Gloria Massamba-N'Siala, Pierre U Blier, Piero Calosi
Human-assisted, trans-generational exposure to ocean warming and acidification has been proposed as a conservation and/or restoration tool to produce resilient offspring. To improve our understanding of the need for and the efficacy of this approach, we characterized life-history and physiological responses in offspring of the marine polychaete Ophryotrocha labronica exposed to predicted ocean warming (OW: + 3°C), ocean acidification (OA: pH -0.5) and their combination (OWA: + 3°C, pH -0.5), following the exposure of their parents to either control conditions (within-generational exposure) or the same conditions (trans-generational exposure)...
October 2016: Evolutionary Applications
T Shen, O Alvarez-Garcia, Y Li, M Olmer, M K Lotz
OBJECTIVES: Aging is an important osteoarthritis (OA) risk factor and compromised stress defense responses may mediate this risk. The Sestrins (Sesn) promote cell survival under stress conditions and regulate AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signaling. This study examined Sesn expression in normal and OA cartilage and functions of Sesn in chondrocytes. METHODS: Sesn expression in human and mouse normal and OA cartilage was analyzed by quantitative polymerase chain reaction (PCR) and immunohistochemistry...
September 29, 2016: Osteoarthritis and Cartilage
Yang Tan, Yunpeng Wu, Qubo Ni, Yu Deng, Jing Li, Linlong Wang, Lang Shen, Yansong Liu, Jacques Magdalou, Hui Wang, Liaobin Chen
Epidemiological data show that osteoarthritis (OA) is significantly associated with lower birth weight, and that OA may be a type of fetal-originated adult disease. The present study aimed to investigate the prenatal food-restriction (PFR) effect on the quality of articular cartilage in female offspring to explore the underlying mechanisms of fetal-originated OA. Maternal rats were fed a restricted diet from gestational day (GD) 11 to 20 to induce intra-uterine growth retardation. Female fetuses and female adult offspring fed a post-weaning high-fat diet were killed at GD20 and postnatal week 24, respectively...
September 29, 2016: British Journal of Nutrition
Wafa Haj Hamad, Marwa Maraoui, Mouna Sghir, Mohamed Guedria, Wafa Said, Saida Jerbi, Wassia Kessomtini
OBJECTIVE: The aim of our study was firstly to determine the frequency and the characteristics of metabolic syndrome in patients with knee osteoarthritis and secondly to assess the functional consequences of this combination. MATERIAL/PATIENTS AND METHODS: This is a prospective study including patients with knee OA referred to the department of physical medicine of Mahdia. In all patients, we sought the clinical and biological criteria for metabolic syndrome (according to NCEP - ATP III) and determined the radiological grade of knee OA according to Kellgren and Lawrence (KL)...
September 2016: Annals of Physical and Rehabilitation Medicine
Li-Li Gong, Guang-Run Li, Wen Zhang, He Liu, Ya-Li Lv, Fei-Fei Han, Zi-Rui Wan, Ming-Biao Shi, Li-Hong Liu
Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of metabolic syndrome, and its incidence is rapidly increasing. However, there is a lack of appropriate drugs for the therapy of NAFLD. In the present article, we aimed to elucidate the protective effects and mechanisms of Akebia saponin D (ASD) against NAFLD on ob/ob mice and BRL cells. ASD significantly decreased hepatic steatosis and heptocyte apoptosis in ob/ob mice. Furthermore, ASD significantly activated the autophagic flux assessed by decreased the expression of LC3-II, p62 accumulation of autophagosomes...
September 26, 2016: Journal of Pharmacology and Experimental Therapeutics
Lin Wang, Guiting Lin, Yung-Chin Lee, Amanda B Reed-Maldonado, Melissa T Sanford, Guifang Wang, Huixi Li, Lia Banie, Zhengcheng Xin, Tom F Lue
OBJECTIVE: To study and compare the function and structure of the urethral sphincter in female Zucker lean (ZL) and Zucker fatty (ZF) rats and to assess the viability of ZF fats as a model for female obesity-associated stress urinary incontinence (SUI). MATERIALS AND METHODS: Two study arms were created: a ZL arm including 16-week-old female ZL rats (ZUC-Lepr(fa) 186; n = 12) and a ZF arm including 16-week-old female ZF rats (ZUC-Lepr(fa) 185; n = 12). I.p. insulin tolerance testing was carried out before functional study...
October 5, 2016: BJU International
T Shinohara, T Izawa, A Mino-Oka, H Mori, A Iwasa, T Inubushi, Y Yamaguchi, E Tanaka
This study aimed to examine hyaluronan (HA) metabolism in relation to the onset and progression of temporomandibular joint osteoarthritis (TMJ-OA) induced by mechanical overloading. Two-month-old and 6-month-old C57BL/6N mice were divided into experimental and untreated control groups (n = 5/group). A sliding plate was attached to the maxillary incisors of the experimental mice for 10 days to overload the condylar cartilage in TMJ. In experimental group, profound cartilage degradation was detected in haematoxylin-eosin, Safranin-O-Fast Green-stained sections...
September 14, 2016: Journal of Oral Rehabilitation
Christoph Bauer, Eugenia Niculescu-Morzsa, Vivek Jeyakumar, Daniela Kern, Stephan S Späth, Stefan Nehrer
BACKGROUND: Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the low viscosity of the synovial fluid. High-molecular-weight hyaluronic acid (HA) can be used to increase the viscosity and also reduce inflammatory processes. The purpose was to establish an in vitro inflammation model and to evaluate the effects of high-molecular-weight HA in a co-cultivation inflammation model of osteoarthritic chondrocytes and M1 macrophages...
2016: Journal of Inflammation
YanYan Guo, YuanJun Deng, XiaoQing Li, Yong Ning, XuePing Lin, ShuiMing Guo, MeiXue Chen, Min Han
Vascular endothelial cells can survive under hypoxic and inflammatory conditions by alterations of the cellular energy metabolism. In addition to high rates of glycolysis, glutaminolysis is another important way of providing the required energy to support cellular sprouting in such situations. However, the exact mechanism in which endothelial cells upregulate glutaminolysis remains unclear. Here we demonstrated that protein phosphatase 2A (PP2A)-mediated Raf-MEK-ERK signaling was involved in glutaminolysis in endothelial cells...
2016: PloS One
Yusheng Li, Wei Luo, Zhenhan Deng, Guanghua Lei
Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA...
2016: Mediators of Inflammation
Ronald K June, Ru Liu-Bryan, Fanxing Long, Timothy M Griffin
Obesity and associated metabolic diseases collectively referred to as the metabolic syndrome increase the risk of skeletal and synovial joint diseases, including osteoarthritis (OA). The relationship between obesity and musculoskeletal diseases is complex, involving biomechanical, dietary, genetic, inflammatory, and metabolic factors. Recent findings illustrate how changes in cellular metabolism and metabolic signaling pathways alter skeletal development, remodeling, and homeostasis, especially in response to biomechanical and inflammatory stressors...
September 8, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Abhishek Abhishek, Michael Doherty
Calcium pyrophosphate crystal deposition (CPPD) associates with ageing, osteoarthritis (OA), uncommon metabolic diseases, mutations and polymorphisms in the ankylosis human gene (ANKH). CPPD is frequently polyarticular, occurs due to a generalised articular predisposition, and the association between CPPD and OA is joint specific, for example CPPD associates with knee OA, but not with hip OA. Other recently identified associations include knee malalignment (knee CC), low cortical BMD and soft-tissue calcification...
July 2016: Clinical and Experimental Rheumatology
Antonio B Ward, Mary B Dail, Janice E Chambers
Organochlorine compounds (OC), such as the legacy insecticides, were widespread environmental contaminants. OC including dichlorodiphenyldichloroethylene (DDE), a metabolite of the insecticide DDT, have an epidemiological association with type 2 diabetes mellitus (T2D) and may play a role in risk factors that contribute to T2D such as dyslipidemia. The liver, a potential target for DDE, plays a role in dyslipidemia. The in vitro effect of DDE on hepatocyte lipid metabolism and secretion was investigated using McArdle-RH7777 (McA) rodent hepatoma liver cells...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"