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Head neck

Roghayeh Mousavi-Khatir, Saeed Talebian, Nima Toosizadeh, Gholam Reaza Olyaei, Nader Maroufi
The highly complex proprioceptive system provides neuromuscular control of the mobile cervical spine. Static neck flexion can induce the elongation of posterior tissues and altered afferent input from the mechanoreceptors. The purpose of this study was to examine the effect of prolonged static neck flexion on neck proprioception and anticipatory postural adjustments. Thirty-eight healthy participants (20 females and 18 males) between the ages of 20-35 years with no history of neck, low back, and shoulder pain enrolled in this study...
April 24, 2018: Journal of Electromyography and Kinesiology
Xu Qian, Xiaobo Nie, Wenhao Yao, Konrad Klinghammer, Holger Sudhoff, Andreas M Kaufmann, Andreas E Albers
One of the greatest challenges in systemic treatment of head and neck squamous cell carcinoma (HNSCC) is a small tumor cell population, namely, cancer stem-like cells (CSC). CSC can regenerate and maintain a heterogenic tumor by their self-renewal capacity. Their potential ability to be more resistant to and survival after chemo- and radiation therapy was also identified. Further studies have shown that reactive oxygen species (ROS) contribute to this CSC-associated resistance. In this review, we focus on the current knowledge of HNSCC-CSC, with regard to ROS as a possible and novel therapeutic approach in targeting CSC...
June 20, 2018: Seminars in Cancer Biology
Kirsten L Moek, Rudolf S N Fehrmann, Bert van der Vegt, Elisabeth G E de Vries, Derk Jan A de Groot
Glypican 3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is overexpressed in ∼70% to 80% of hepatocellular carcinomas (HCCs), but uncommonly expressed in healthy tissues. This raised interest in GPC3 as drug target, and several GPC3-targeting drugs are in clinical development. We therefore predicted GPC3 protein overexpression across tumors and validated these predictions. Functional genomic mRNA profiling was applied to expression profiles of 18,055 patient-derived tumor samples to predict GPC3 overexpression at the protein level in 60 tumor types and subtypes using healthy tissues as reference...
June 20, 2018: American Journal of Pathology
Nicole L Lebo, Rebecca Griffiths, Stephen Hall, Jim Dimitroulakos, Stephanie Johnson-Obaseki
BACKGROUND: Preclinical and early-phase clinical studies have suggested an oncoprotective role of statins in head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to determine whether incidental statin use in patients with human papillomavirus (HPV)-negative HNSCC is predictive of improved oncologic outcomes. METHODS: A retrospective cohort study of 1194 patients from the Ontario Cancer Registry diagnosed with HNSCC from 2007 to 2012 was performed using linked databases from the Institute for Clinical Evaluative Sciences...
June 22, 2018: Head & Neck
Yasiru G Karunaratne, Dakshika A Gunaratne, Michael J Veness
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine tumor arising on the head and neck in 40%-50% of patients. Between 20% and 40% will harbor subclinical nodal metastasis. METHODS: Using search terms 'Merkel AND sentinel', MEDLINE, PUMED, and EMBASE databases were systematically reviewed for publications regarding sentinel lymph node biopsy (SLNB) in classification I and II MCC of the head and neck. RESULTS: Twenty-nine publications encompassing 136 patients were included...
June 22, 2018: Head & Neck
Benoît Morisod, Anne-Claude Guinchard, Philippe Gorphe, Valerie Schweizer, Kishore Sandu, Christian Simon
BACKGROUND: We report on the feasibility and functional outcome of transoral robotic (TORS) supracricoid partial laryngectomy (SCPL) with cricohyoidoepiglottopexy (CHEP). METHODS: Cadaveric studies and functional outcome at 3 years using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-H&N35), the Functional Outcome Swallowing Scale (FOSS), the Performance Status Scale for Head and Neck Cancer (PSS-HN), computerized voice analysis, and videotape recordings...
June 22, 2018: Head & Neck
Álvaro Jesús Bernal Martínez, Nieves Fernández Letamendi, Julio Delgado Martínez, Lucía Gómez-Escolar Larrañaga, Enara Reola Ramírez, Javier Puertas Peña
INTRODUCTION: It is unknown whether cervical lymphadenectomy as a treatment for cutaneous squamous cell carcinoma of the head and neck (cSCCh&n) increases survival in elderly patients. The aim of this study is to determine whether this procedure has an influence on the survival of these patients, and whether the Short-Form Charlson Comorbidity Index (CCI-SF) can be used as an alternative to age in the surgeon's estimation of elderly patient mortality. METHODS: The study population included all patients diagnosed with cSCCh&n consecutively treated between 2006 and 2011...
June 19, 2018: Cirugía Española
Müberra Pehlivan, Melek Kezban Gurbuz, Cemal Cingi, Baki Adapinar, A Nevbahar Değirmenci, F Mustafa Acikalin, Mehmet Özgür Pinarbaşli, Ertugrul Colak
INTRODUCTION: Ultrasonography is the easiest non-invasive method to diagnose lymph node metastases in patients with head and neck cancer. However, since CT scans are often preferred in the evaluation of primary tumours of these patients, information about lymphatic metastases may also available in these patients. Therefore, ultrasound is not routinely employed in the evaluation of these patients. However, elastography technique, a recent development in ultrasound technology, could make use of ultrasonography in these patients even more widespread, even though it is still not widely used today...
February 16, 2018: Brazilian Journal of Otorhinolaryngology
Jeremy D P Hoisak, Todd Pawlicki
Optical surface imaging is a nonradiographic, noninvasive technology for continuous localization of patients during radiation therapy. Surface-guided radiation therapy (SGRT) has been applied to many treatment sites including breast, intracranial, head and neck, and extremities. SGRT enables a reduction of initial setup variability, provides verification of immobilization continuously during treatment including at noncoplanar linac gantry angles, and provides dynamic surface information for use in gated and breath-hold treatment techniques, all of which can permit reductions in the margins required to account for target localization uncertainty...
June 2018: Seminars in Radiation Oncology
Vivek Verma, J Isabelle Choi, Amit Sawant, Rao P Gullapalli, Wengen Chen, Abass Alavi, Charles B Simone
Molecular and functional imaging is increasingly being used to guide radiotherapy (RT) management and target delineation. This review summarizes existing data in several disease sites of various functional imaging modalities, chiefly positron emission tomography/computed tomography (PET/CT), with respect to RT target definition and management. For gliomas, differentiation between postoperative changes and viable tumor is discussed, as well as focal dose escalation and reirradiation. Head and neck neoplasms may also benefit from precise PET/CT-based target delineation, especially for cancers of unknown primary; focal dose escalation is also described...
June 2018: Seminars in Radiation Oncology
Hoi-Lam Ngan, Lan Wang, Kwok-Wai Lo, Vivian Wai Yan Lui
: Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequencing (WES) clearly reveal critical roles of: (1) inflammation via NF-kB activation, (2) survival via PI3K aberrations, and perhaps (3) immune evasion via MHC loss in these cancers as summarized in this review...
June 21, 2018: Cancers
Carmen Segrelles, David Contreras, Elena M Navarro, Carmen Gutiérrez-Muñoz, Ramón García-Escudero, Jesús M Paramio, Corina Lorz
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and although new therapeutic approaches have been recently evaluated, overall patient survival is still poor. Thus, new effective and selective clinical treatments are urgently needed. An analysis of data from large-scale, high-throughput drug screening cell line projects identified Bosutinib, a Src/Abl inhibitor that is currently used for the treatment of chronic myelogenous leukemia, as a candidate drug to treat HNSCC...
June 21, 2018: International Journal of Molecular Sciences
Judith M Graber, Connie T Chuang, Carolyn L Ward, Kathleen Black, Iris G Udasin
OBJECTIVE: To report on cases of head and neck cancer (HNC) among World Trade Center (WTC) responders participating in the WTC Health Program and seen at Rutgers WTC Center of Clinical Excellence. METHODS: Medical records were abstracted by two clinical reviewers and discrepancies resolved. Cases were defined as WTC responders diagnosed with HNC between 9/12/2005 and 12/31/2016. RESULTS: Sixteen HNC patients met the case definition, most (13) arrived at the WTC location on 9/11 or within the following 2 days and half worked in law enforcement during the 9/1 response...
June 21, 2018: Journal of Occupational and Environmental Medicine
Zhiping Hu, Xiaoling Zhou, Weiwei Duan, Wenge Lei, Min Zhang, Lingxia Zeng
BACKGROUND: Maintenance of good functional status and improvement of quality of life (QOL) in patients with head and neck cancer help to determine the efficacy of anticancer therapies. OBJECTIVE: The aims of this study were to describe the profile of QOL changing over time and evaluate the correlation between anxiety, pain severity, and shoulder and neck function with QOL in patients. METHODS: A prospective cohort study was conducted. Quality of life, neck and shoulder function, anxiety, and pain were assessed at the time of presurgery, 1 week, and 3 and 6 months postsurgery...
June 22, 2018: Cancer Nursing
An-Wei Chen, Shao-Hua Liu, Ying-Ying Huang, Tao Wang
BACKGROUND: Foam sclerotherapy is an effective treatment strategy for venous malformations (VMs). Stability is one of the characteristics of sclerosant foams that determine the sclerosing power. OBJECTIVE: To evaluate the clinical outcomes of sclerotherapy with prolonged half-life of hyaluronic acid (HA)-polidocanol (POL) foam for treating head and neck VMs. MATERIALS AND METHODS: Seventy patients with head and neck VMs were enrolled between October 2013 and January 2015 in Qilu Hospital Shandong University...
June 21, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Chun-Wen Su, Ming-Hsien Chien, Chiao-Wen Lin, Mu-Kuan Chen, Jyh-Ming Chow, Chun-Yi Chuang, Chia-Hsuan Chou, Yu-Cheng Liu, Shun-Fa Yang
Oral cancer is a major head and neck cancer that is reported to be causally associated with genetic factors and environmental carcinogens. Endothelial nitric oxide synthase (eNOS) was reported to modulate carcinogenesis and progression through nitric oxide (NO) production. Genetic polymorphisms in the eNOS gene can regulate its transcription and further mediate NO production. The purpose of this study was to explore the influences of eNOS gene polymorphisms combined with environmental carcinogens on the predisposition for oral cancer...
June 19, 2018: Nitric Oxide: Biology and Chemistry
Stephanie F Polites, Bentley B Rodrigue, Carol Chute, Adrienne Hammill, Roshni Dasgupta
BACKGROUND: There has been a paradigm shift from steroids to propranolol for the pharmacologic treatment of infantile hemangiomas (IH); however, the outcomes for ulcerated IH are not well studied. The purpose of this study was to compare the efficacy of steroids and propranolol specifically for ulcerated IH. METHODS: A retrospective review was conducted on patients with ulcerated IH treated with propranolol or steroids at a single tertiary care institution between 2007 and 2014...
June 22, 2018: Pediatric Blood & Cancer
James C H Chow, Kwok Hung Au, Oscar W K Mang, Ka Man Cheung, Roger K C Ngan
AIM: Second primary tumor (SPT) is a serious late complication after definitive radiotherapy for nasopharyngeal carcinoma (NPC). We evaluated the incidence, pattern, risk factors and survival impact of SPT in NPC patients following definitive intensity-modulated radiotherapy (IMRT). METHODS: A retrospective review of 780 consecutive IMRT-treated NPC patients between February 2003 and September 2011 was conducted. Cumulative SPT incidence and overall survival after SPT diagnosis were estimated...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Aiwen Yu, Yu Wang, Yue Bian, Lisha Chen, Junfu Guo, Wei Shen, Danqi Chen, Shanshan Liu, Xiuju Sun
It has been shown that nuclear expression of S100A4 is significantly correlated with increased metastasis and reduced survival in patients with gastric cancer and many other cancers. However, the factors which could influence the nuclear contents of S100A4 in cancer cells are not clear. It has also been reported that Interleukin-1β (IL-1β) promotes the nuclear translocation of S100A4 in chondrocytes. Previous studies have shown that IL-1β promotes the stemness of colon cancer cells, and S100A4 is also involved in maintaining cancer-initiating cells in head and neck cancers...
June 22, 2018: Journal of Cellular Biochemistry
Alexandra E Quimby, Diana Khalil, Stephanie Johnson-Obaseki
OBJECTIVE: Controversy exists regarding the surgical management of cutaneous melanoma and the optimal timing of reconstruction. One approach to ensuring an oncologically sound outcome is a two-stage procedure, with reconstruction delayed for negative permanent section margins. Alternatively, a single-stage excision with immediate reconstruction is advantageous because it limits both resource use and patient morbidity from multiple procedures. We sought to examine available published data on the oncologic outcomes associated with immediate versus delayed reconstruction of cutaneous melanoma in the head and neck region...
June 22, 2018: Laryngoscope
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