Wenhui Yu, Xianqing Lan, Jie Cai, Xueqing Wang, Xiaomei Liu, Xiangdong Ye, Qing Yang, Yanting Su, Bo Xu, Tielong Chen, Lingyun Li, Hui Sun
Acute liver failure (ALF) can be the consequence of various etiologies, which immune response plays a pivotal role in the pathogenesis. For the diversity of etiologies, more animal models are still needed in this field. Here, we developed a new acute liver injury mouse model induced by a fungal lectin AAGL (Agrocybe aegerita galectin). Intravenous injection of AAGL could induce the infiltration and activation of T, NKT and NK cells in liver and T cell played an important role in the pathogenesis. However, compared with the widely used concanavalin A model, AAGL model showed different immune mechanism...
October 29, 2019: Biochemical and Biophysical Research Communications