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Todd Anderson

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https://www.readbyqxmd.com/read/28323823/clustering-of-cardiovascular-risk-factors-and-carotid-intima-media-thickness-the-use-imt-study
#1
Xin Wang, Geertje W Dalmeijer, Hester M den Ruijter, Todd J Anderson, Annie R Britton, Jacqueline Dekker, Gunnar Engström, Greg W Evans, Jacqueline de Graaf, Diederick E Grobbee, Bo Hedblad, Suzanne Holewijn, Ai Ikeda, Jussi Kauhanen, Kazuo Kitagawa, Akihiko Kitamura, Sudhir Kurl, Eva M Lonn, Matthias W Lorenz, Ellisiv B Mathiesen, Giel Nijpels, Shuhei Okazaki, Joseph F Polak, Jacqueline F Price, Christopher M Rembold, Maria Rosvall, Tatjana Rundek, Jukka T Salonen, Matthias Sitzer, Coen D A Stehouwer, Tomi-Pekka Tuomainen, Sanne A E Peters, Michiel L Bots
BACKGROUND: The relation of a single risk factor with atherosclerosis is established. Clinically we know of risk factor clustering within individuals. Yet, studies into the magnitude of the relation of risk factor clusters with atherosclerosis are limited. Here, we assessed that relation. METHODS: Individual participant data from 14 cohorts, involving 59,025 individuals were used in this cross-sectional analysis. We made 15 clusters of four risk factors (current smoking, overweight, elevated blood pressure, elevated total cholesterol)...
2017: PloS One
https://www.readbyqxmd.com/read/28316146/cover-image-volume-118-number-5-may-2017
#2
Lipsa Das, Todd A Anderson, Jaime M C Gard, Isis C Sroka, Stephanie R Strautman, Raymond B Nagle, Colm Morrissey, Beatrice S Knudsen, Anne E Cress
Cover: The cover image, by Anne E. Cress., is based on the Article Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells, DOI: 10.1002/jcb.25673.
May 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28279371/carotid-plaque-lipid-content-and-fibrous-cap-status-predict-systemic-cv-outcomes-the-mri-substudy-in-aim-high
#3
Jie Sun, Xue-Qiao Zhao, Niranjan Balu, Moni B Neradilek, Daniel A Isquith, Kiyofumi Yamada, Gádor Cantón, John R Crouse, Todd J Anderson, John Huston, Kevin O'Brien, Daniel S Hippe, Nayak L Polissar, Chun Yuan, Thomas S Hatsukami
OBJECTIVES: The aim of this study was to investigate whether and what carotid plaque characteristics predict systemic cardiovascular outcomes in patients with clinically established atherosclerotic disease. BACKGROUND: Advancements in atherosclerosis imaging have allowed assessment of various plaque characteristics, some of which are more directly linked to the pathogenesis of acute cardiovascular events compared to plaque burden. METHODS: As part of the event-driven clinical trial AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes), subjects with clinically established atherosclerotic disease underwent multicontrast carotid magnetic resonance imaging (MRI) to detect plaque tissue composition and high-risk features...
March 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28275196/mutating-the-cx3c-motif-in-the-g-protein-should-make-a-live-respiratory-syncytial-virus-vaccine-safer-and-more-effective
#4
S Boyoglu-Barnum, S O Todd, J Meng, T R Barnum, T Chirkova, L M Haynes, S J Jadhao, R A Tripp, A G Oomens, M L Moore, L J Anderson
Respiratory syncytial virus (RSV) belongs to the family Paramyxoviridae and is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is available. Through a CX3C chemokine motif ((182)CWAIC(186)) in the G protein, RSV binds to the corresponding chemokine receptor, CX3CR1. Since RSV binding to CX3CR1 contributes to disease pathogenesis, we investigated whether a mutation in the CX3C motif by insertion of an alanine A(186) within the CX3C motif to CX4C ((182)CWAIAC(187)), known to block binding to CX3CR1, might decrease disease...
March 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28204979/one-year-swallowing-outcomes-in-patients-treated-with-prophylactic-gabapentin-during-radiation-based-treatment-for-oropharyngeal-cancer
#5
Heather M Starmer, WuYang Yang, Christine G Gourin, Rachit Kumar, Bronwyn Jones, Todd McNutt, Sierra Cheng, Harry Quon
Recent investigations by our study team have demonstrated patients using gabapentin for pain management during chemoradiotherapy (CRT) do well maintaining swallowing during treatment with less need for narcotic pain medication, PEG dependence, weight loss, and short-term swallowing morbidity. The purpose of this investigation was to characterize the long-term swallowing function of these patients 1-year following treatment. Sequential patients receiving CRT for oropharyngeal cancer and concurrent gabapentin were evaluated 1-year following treatment for swallowing outcomes...
February 15, 2017: Dysphagia
https://www.readbyqxmd.com/read/28107724/effect-of-sole-or-combined-administration-of-nitrate-and-3-nitro-1-propionic-acid-on-fermentation-and-salmonella-survivability-in-alfalfa-fed-rumen-cultures-in-vitro
#6
Alejandro Castañeda Correa, Julian Trachsel, Heather K Allen, Agustin Corral-Luna, Hector Gutierrez-Bañuelos, Pedro Antonia Ochoa-Garcia, Oscar Ruiz-Barrera, Michael E Hume, Todd R Callaway, Roger B Harvey, Ross C Beier, Robin C Anderson, David J Nisbet
Ruminal methanogenesis is a digestive inefficiency resulting in the loss of dietary energy consumed by the host and contributing to environmental methane emission. Nitrate is being investigated as a feed supplement to reduce rumen methane emissions but safety and efficacy concerns persist. To assess potential synergies of co-administering sub-toxic amounts of nitrate and 3-nitro-1-propionate (NPA) on fermentation and Salmonella survivability with an alfalfa-based diet, ruminal microbes were cultured with additions of 8 or 16mM nitrate, 4 or 12mM NPA or their combinations...
April 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28056003/notes-from-the-field-botulism-outbreak-from-drinking-prison-made-illicit-alcohol-in-a-federal-correctional-facility-mississippi-june-2016
#7
Lindsey McCrickard, Mariel Marlow, Julie L Self, Louise Francois Watkins, Kevin Chatham-Stephens, Jannifer Anderson, Sheryl Hand, Kathryn Taylor, Jennifer Hanson, Keiundria Patrick, Carolina Luquez, Janet Dykes, Suzanne R Kalb, Kaitlin Hoyt, John R Barr, Todd Crawford, Anthony Chambers, Brian Douthit, Robert Cox, Matt Craig, John Spurzem, Joseph Doherty, Michael Allswede, Paul Byers, Thomas Dobbs
No abstract text is available yet for this article.
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28051805/%C3%A2-metastatic-lymphoepithelioma-like-hepatocellular-carcinoma-a-potential-diagnostic-pitfall-and-demonstration-of-pd-l1-expression
#8
Juan Putra, Todd A Anderson, Sasan Roayaie, Miho Maeda, Swan N Thung
No abstract text is available yet for this article.
January 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28049818/impact-of-short-chain-galactooligosaccharides-on-the-gut-microbiome-of-lactose-intolerant-individuals
#9
M Andrea Azcarate-Peril, Andrew J Ritter, Dennis Savaiano, Andrea Monteagudo-Mera, Carlton Anderson, Scott T Magness, Todd R Klaenhammer
Directed modulation of the colonic bacteria to metabolize lactose effectively is a potentially useful approach to improve lactose digestion and tolerance. A randomized, double-blind, multisite placebo-controlled trial conducted in human subjects demonstrated that administration of a highly purified (>95%) short-chain galactooligosaccharide (GOS), designated "RP-G28," significantly improved clinical outcomes for lactose digestion and tolerance. In these individuals, stool samples were collected pretreatment (day 0), after GOS treatment (day 36), and 30 d after GOS feeding stopped and consumption of dairy products was encouraged (day 66)...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28033606/correction-activating-receptor-signals-drive-receptor-diversity-in-developing-natural-killer-cells
#10
Jacquelyn Freund, Rebecca M May, Enjun Yang, Hongchuan Li, Matthew McCullen, Bin Zhang, Todd Lenvik, Frank Cichocki, Stephen K Anderson, Taku Kambayashi
[This corrects the article DOI: 10.1371/journal.pbio.1002526.].
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/28029183/temporal-monitoring-of-perfluorooctane-sulfonate-accumulation-in-aquatic-biota-downstream-of-historical-aqueous-film-forming-foam-use-areas
#11
Heather A Lanza, Rebecca S Cochran, Joseph F Mudge, Adric D Olson, Brett R Blackwell, Jonathan D Maul, Christopher J Salice, Todd A Anderson
Perfluoroalkyl substances (PFAS) have recently received increased research attention, particularly concerning aquatic organisms and in regions of exposure to aqueous film forming foams (AFFFs). Air Force bases historically applied AFFFs in the interest of fire training exercises and have since expressed concern for PFAS contamination in biota from water bodies surrounding former fire training areas. Six PFAS were monitored, including perfluorooctane sulfonate (PFOS), in aquatic species from 8 bayou locations at Barksdale Air Force Base in Bossier City, Louisiana (USA) over the course of 1 yr...
December 28, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27981236/a-phylogeny-based-global-nomenclature-system-and-automated-annotation-tool-for-h1-hemagglutinin-genes-from-swine-influenza-a-viruses
#12
Tavis K Anderson, Catherine A Macken, Nicola S Lewis, Richard H Scheuermann, Kristien Van Reeth, Ian H Brown, Sabrina L Swenson, Gaëlle Simon, Takehiko Saito, Yohannes Berhane, Janice Ciacci-Zanella, Ariel Pereda, C Todd Davis, Ruben O Donis, Richard J Webby, Amy L Vincent
The H1 subtype of influenza A viruses (IAVs) has been circulating in swine since the 1918 human influenza pandemic. Over time, and aided by further introductions from nonswine hosts, swine H1 viruses have diversified into three genetic lineages. Due to limited global data, these H1 lineages were named based on colloquial context, leading to a proliferation of inconsistent regional naming conventions. In this study, we propose rigorous phylogenetic criteria to establish a globally consistent nomenclature of swine H1 virus hemagglutinin (HA) evolution...
November 2016: MSphere
https://www.readbyqxmd.com/read/27943610/covalent-surface-modification-of-gallium-arsenide-photocathodes-for-water-splitting-in-highly-acidic-electrolyte
#13
Logan E Garner, K Xerxes Steirer, James L Young, Nicholas C Anderson, Elisa M Miller, Jonathan S Tinkham, Todd G Deutsch, Alan Sellinger, John A Turner, Nathan R Neale
Efficient water splitting using light as the only energy input requires stable semiconductor electrodes with favorable energetics for the water-oxidation and proton-reduction reactions. Strategies to tune electrode potentials using molecular dipoles adsorbed to the semiconductor surface have been pursued for decades but are often based on weak interactions and quickly react to desorb the molecule under conditions relevant to sustained photoelectrolysis. Here, we show that covalent attachment of fluorinated, aromatic molecules to p-GaAs(1 0 0) surfaces can be employed to tune the photocurrent onset potentials of p-GaAs(1 0 0) photocathodes and reduce the external energy required for water splitting...
December 12, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27908346/bringing-structure-to-the-art-of-lipid-lowering-therapy
#14
EDITORIAL
Todd J Anderson
No abstract text is available yet for this article.
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27905824/improved-survival-and-complete-response-rates-in-patients-with-advanced-melanoma-treated-with-concurrent-ipilimumab-and-radiotherapy-versus-ipilimumab-alone
#15
Kristian M Koller, Heath B Mackley, Jason Liu, Henry Wagner, Giampaolo Talamo, Todd D Schell, Colette Pameijer, Rogerio I Neves, Bryan Anderson, Kathleen M Kokolus, Carol A Mallon, Joseph J Drabick
There is a growing body of evidence supporting the synergistic roles of radiotherapy and immunotherapy in the treatment of malignancy. Published case studies of the abscopal effect have been reported with the use of ipilimumab and radiotherapy in metastatic melanoma, but evidence supporting the routine use of this combination of therapy is limited. We conducted a retrospective analysis to evaluate patients treated with ipilimumab for advanced melanoma at a single institution from May 2011 to June 2015. Patients were grouped into those who had received concurrent radiotherapy while on ipilimumab (Ipi-RT), and those who did not...
January 2, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27890521/financial-incentives-for-diabetes-prevention-in-a-medicaid-population-study-design-and-baseline-characteristics
#16
Jay Desai, Gretchen Taylor, Gabriela Vazquez-Benitez, Sara Vine, Julie Anderson, Joyce E Garrett, Todd Gilmer, Houa Vue-Her, Jeff Schiff, Sarah Rinn, Katelyn Engel, Amy Michael, Patrick J O'Connor
BACKGROUND: Medicaid beneficiaries at high risk for diabetes can benefit from the Diabetes Prevention Program (DPP) lifestyle intervention. The We Can Prevent Diabetes (WCPD) trial examined whether financial incentives are more effective than no financial incentives in sustaining participation in the DPP and increasing weight loss. Here we describe the study design and baseline characteristics. METHODS: The WCPD was a 3-arm group-randomized controlled trial. Medicaid beneficiaries were aged 18 to 74years, had prediabetes or gestational diabetes, and were overweight or obese...
November 23, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27846344/effect-of-evolocumab-on-progression-of-coronary-disease-in-statin-treated-patients-the-glagov-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Stephen J Nicholls, Rishi Puri, Todd Anderson, Christie M Ballantyne, Leslie Cho, John J P Kastelein, Wolfgang Koenig, Ransi Somaratne, Helina Kassahun, Jingyuan Yang, Scott M Wasserman, Robert Scott, Imre Ungi, Jakub Podolec, Antonius Oude Ophuis, Jan H Cornel, Marilyn Borgman, Danielle M Brennan, Steven E Nissen
Importance: Reducing levels of low-density lipoprotein cholesterol (LDL-C) with intensive statin therapy reduces progression of coronary atherosclerosis in proportion to achieved LDL-C levels. Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors produce incremental LDL-C lowering in statin-treated patients; however, the effects of these drugs on coronary atherosclerosis have not been evaluated. Objective: To determine the effects of PCSK9 inhibition with evolocumab on progression of coronary atherosclerosis in statin-treated patients...
December 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27816246/clinical-trial-on-the-effects-of-a-free-access-acidified-milk-replacer-feeding-program-on-the-health-and-growth-of-dairy-replacement-heifers-and-veal-calves
#18
C G Todd, K E Leslie, S T Millman, V Bielmann, N G Anderson, J M Sargeant, T J DeVries
The objectives of this study were to evaluate the effects of free-access acidified milk replacer feeding on the pre- and postweaning health of dairy and veal calves. Individually housed calves were systematically assigned at birth to 1 of 2 feeding programs: free-access feeding (ad libitum) of acidified milk replacer (ACD, n=249) or traditional restricted feeding (3L fed twice daily) of milk replacer (RES, n=249). Calves were fed milk replacer containing 24% crude protein and 18% fat. Acidified milk replacer was prepared to a target pH between 4...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27811173/an-allosteric-potentiator-of-the-dopamine-d1-receptor-increases-locomotor-activity-in-human-d1-knock-in-mice-without-causing-stereotypy-or-tachyphylaxis
#19
Kjell A Svensson, Beverly A Heinz, John M Schaus, James P Beck, Junliang Hao, Joseph H Krushinski, Matthew R Reinhard, Michael P Cohen, Sarah L Hellman, Brian G Getman, Xushan Wang, Michelle M Menezes, Deanna L Maren, Julie F Falcone, Wesley H Anderson, Rebecca A Wright, S Michelle Morin, Kelly L Knopp, Benjamin L Adams, Borys Rogovoy, Ilya Okun, Todd M Suter, Michael A Statnick, Donald R Gehlert, David L Nelson, Virginia L Lucaites, Renee Emkey, Neil W DeLapp, Todd R Wiernicki, Jeffrey W Cramer, Charles R Yang, Robert F Bruns
Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one]. In human embryonic kidney 293 (HEK293) cells expressing the human D1 receptor, DETQ induced a 21-fold leftward shift in the cAMP response to dopamine, with a Kb of 26 nM...
January 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27798629/a-viral-strategy-for-targeting-and-manipulating-interneurons-across-vertebrate-species
#20
Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Joshua S Grimley, Anne-Rachel Krostag, Ajamete Kaykas, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wilson, Georg Kosche, Illya Kruglikov, Tomasz Rusielewicz, Vibhakar C Kotak, Todd M Mowery, Stewart A Anderson, Edward M Callaway, Jeremy S Dasen, David Fitzpatrick, Valentina Fossati, Michael A Long, Scott Noggle, John H Reynolds, Dan H Sanes, Bernardo Rudy, Guoping Feng, Gord Fishell
A fundamental impediment to understanding the brain is the availability of inexpensive and robust methods for targeting and manipulating specific neuronal populations. The need to overcome this barrier is pressing because there are considerable anatomical, physiological, cognitive and behavioral differences between mice and higher mammalian species in which it is difficult to specifically target and manipulate genetically defined functional cell types. In particular, it is unclear the degree to which insights from mouse models can shed light on the neural mechanisms that mediate cognitive functions in higher species, including humans...
December 2016: Nature Neuroscience
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