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Miriam Brinkert

Miriam Brinkert, Patricia Rodrigues, Michael Rubens, Edward Nicol
False-negative results of coronary artery calcium score (CACS) are common due to small calcified lesions being missed using a 3-mm slice thickness, a threshold of 130 Hounsfield units (HU) and a minimum area of 1 mm(2) for defining a calcified plaque. In contrast, false-positive results of CACS, as verified by a lack of coronary artery calcifications in computed tomography coronary angiogram (CTCA), are extremely uncommon. We present a patient with a false-positive coronary calcium score who had normal coronary arteries in CTCA...
April 2016: Oxford Medical Case Reports
Nisha Arenja, Christian Mueller, Niklas F Ehl, Miriam Brinkert, Katharina Roost, Tobias Reichlin, Seoung Mann Sou, Thomas Hochgruber, Stefan Osswald, Michael J Zellweger
BACKGROUND: The phenomenon of silent myocardial infarction is poorly understood. METHODS: We aimed to evaluate the prevalence, extent, and independent predictors of silent myocardial infarction in 2 large independent cohorts of consecutive patients without a history of myocardial infarction referred for rest/stress myocardial perfusion single photon emission computed tomography. There were 1621 patients enrolled in the derivation cohort and 338 patients in the validation cohort...
June 2013: American Journal of Medicine
Angela Kohler, Stefano Muzzarelli, Gregor Leibundgut, Jan Müller-Brand, Miriam Brinkert, Michael J Zellweger
AIM: Sustained elevation of resting heart rate (RHR) is thought to promote the initiation and progression of coronary artery disease (CAD). The aim of this paper is to test the hypothesis whether elevated RHR correlates with the presence and the extent of CAD in patients evaluated for CAD. METHODS AND RESULTS: The association between RHR and CAD findings and myocardial perfusion SPECT (MPS) was tested in 1,465 patients. Patients with atrial fibrillation, pacemaker rhythm and treatment with negative chonotropic drugs were excluded...
August 13, 2012: Swiss Medical Weekly
Niklas F Ehl, Michael Kühne, Miriam Brinkert, Jan Müller-Brand, Michael J Zellweger
BACKGROUND: It is not clear whether diabetes reduces systolic left ventricular function (left ventricular ejection fraction, LVEF) irrespective of coronary artery disease (CAD). The aim of this study was to compare the LVEF between diabetic and non-diabetic patients with respect to the extent of CAD. METHODS AND RESULTS: Consecutive patients undergoing stress myocardial perfusion SPECT (MPS) were evaluated. MPS was interpreted using a 20-segment model with a five-point scale to define summed stress score (SSS), summed rest score, and summed difference score...
December 2011: European Journal of Endocrinology
Andreas Rohner, Miriam Brinkert, Nadine Kawel, Ronny R Buechel, Gregor Leibundgut, Leticia Grize, Michael Kühne, Jens Bremerich, Beat A Kaufmann, Michael J Zellweger, Peter Buser, Stefan Osswald, Michael Handke
AIMS: A novel real-time three-dimensional echocardiography (RT3DE) analysis tool specifically designed for evaluation of the left atrium enables comprehensive evaluation of left atrial (LA) size, global, and regional function using a dynamic 16-segment model. The aim of this study was the initial validation of this method using computed tomography (CT) as the method of reference. METHODS AND RESULTS: The study population consisted of 34 prospectively enrolled patients with clinical indication for pulmonary vein isolation...
July 2011: European Journal of Echocardiography
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