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https://www.readbyqxmd.com/read/29150702/high-pdl1-mrna-expression-predicts-better-survival-of-stage-pt1-non-muscle-invasive-bladder-cancer-nmibc-patients
#1
Johannes Breyer, Ralph M Wirtz, Wolfgang Otto, Philipp Erben, Thomas S Worst, Robert Stoehr, Markus Eckstein, Stefan Denzinger, Maximilian Burger, Arndt Hartmann
INTRODUCTION AND OBJECTIVES: Checkpoint inhibition has emerged as new therapeutic option in muscle-invasive bladder cancer. The objective of the present study was to evaluate the prognostic role of PD1 and PDL1 expression in non-muscle-invasive bladder cancer (NMIBC) and establish an objective measuring method using RNA quantification. MATERIALS AND METHODS: We retrospectively analyzed clinical data and formalin-fixed paraffin-embedded tissues (FFPE) of patients with stage pT1 NMIBC who underwent transurethral resection of the bladder...
November 17, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29147759/patterns-and-predictors-of-recurrence-after-open-radical-cystectomy-for-bladder-cancer-a-comprehensive-review-of-the-literature
#2
REVIEW
Andrea Mari, Riccardo Campi, Riccardo Tellini, Giorgio Gandaglia, Simone Albisinni, Mohammad Abufaraj, Georgios Hatzichristodoulou, Francesco Montorsi, Roland van Velthoven, Marco Carini, Andrea Minervini, Shahrokh F Shariat
PURPOSE: To review the currently available literature reporting the patterns of recurrence and their predictive factors after open radical cystectomy (RC) for bladder cancer. METHODS: A review of the literature was performed using the MEDLINE, Scopus and Web of Sciences databases from January 1997 to May 2017. The PRISMA guidelines were followed for the conduct of the study. RESULTS: Local recurrence rate ranges between 30 and 54%. Distant recurrence is not often standardized and is reported in up to 50% of cases...
November 16, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29147616/mrna-expression-levels-of-genes-involved-in-antitumor-immunity-identification-of-a-3-gene-signature-associated-with-prognosis-of-muscle-invasive-bladder-cancer
#3
Constance Le Goux, Sophie Vacher, Géraldine Pignot, Mathilde Sibony, Nicolas Barry Delongchamps, Benoit Terris, Eliane Piaggio, Marc Zerbib, Diane Damotte, Ivan Bieche
Immunotherapy for bladder cancer has given promising results. Here we aimed to evaluate the possible involvement and prognostic value of 33 genes involved in the immune response during bladder carcinogenesis. Expression levels were assessed by quantitative real-time RT-PCR in normal and tumor human bladder samples. Immunohistochemistry was performed to evaluate the protein expression of 2 genes and relation of the mRNA and protein levels was analyzed. Tumors were obtained from 154 patients (83 with muscle-invasive bladder cancer [MIBC] and 71 non-MIBC [NMIBC]) who underwent transurethral bladder resection or radical cystectomy between 2002 and 2006...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29144943/re-propensity-score-analysis-of-radical-cystectomy-versus-bladder-sparing-trimodal-therapy-in-the-setting-of-a-multidisciplinary-bladder-cancer-clinic
#4
https://www.readbyqxmd.com/read/29144901/re-quality-improvement-in-cystectomy-care-with-enhanced-recovery-quiccer-study
#5
David S Wang
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29140994/copy-number-gains-at-chr3p25-and-chr11p11-are-associated-with-lymph-node-involvement-and-survival-in-muscle-invasive-bladder-tumors
#6
Karla J Lindquist, Thomas Sanford, Terence W Friedlander, Pamela L Paris, Sima P Porten
Patients with muscle-invasive bladder cancer (MIBC) have poorer prognoses if cancer has metastasized to the lymph nodes. Genomic markers of lymph node involvement (LNI) would be useful for treatment planning, especially if measured at the biopsy stage, but large-scale studies of tumor tissue at any stage are needed to discover robust markers of LNI. We performed a genome-wide query of copy number alterations (CNA) in 237 MIBC surgical tumor specimens from patients in The Cancer Genome Atlas who had radical cystectomy and lymphadenectomy without neoadjuvant treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29140545/neobladder-vaginal-fistula-the-university-of-southern-california-experience
#7
Shilo Rosenberg, Gus Miranda, David A Ginsberg
AIMS: The use of orthotropic neobladder (ONB) construction in women has increased in popularity. With increasing numbers so have complications distinct to this procedure. Neobladder vaginal fistula (NVF) is a rare but challenging complication. We present our experience correcting this problem. METHODS: An IRB approved database of female patients with an ONB was retrospectively reviewed. Patients with a history of NVF were identified and charts reviewed. Our standard technique of radical cystectomy and orthotopic diversion in female patients includes interposition of omentum between the neobladder and anterior vaginal wall and sacrocolpopexy...
November 15, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29138560/biodistribution-of-gold-nanoparticles-in-bbn-induced-muscle-invasive-bladder-cancer-in-mice
#8
Henry M Smilowitz, Lauren J Tarmu, Mary Melinda Sanders, John A Taylor, Dharamainder Choudhary, Crystal Xue, Nathaniel A Dyment, Dan Sasso, Xiaomeng Deng, James F Hainfeld
Bladder-sparing options are being developed for muscle-invasive bladder cancer in place of radical cystectomy, including the combination of chemotherapy and radiation therapy. We reasoned that improving the radiotherapy component of chemoradiation could improve the control of locally advanced disease. Previously, we showed that gold nanoparticles (AuNPs) are potent enhancers of radiation therapy. We hypothesized that if AuNPs were to preferentially localize to bladder tumors, they may be used to enhance the radiation component of muscle-invasive bladder tumor therapy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29135138/-laparoscopic-radical-cystectomy-innovations-and-classics
#9
D V Perlin, I V Aleksandrov, V P Zipunnikov, M Popova
INTRODUCTION: Radical cystectomy remains the gold-standard treatment for muscle-invasive bladder cancer. To combine the advantages of minimally invasive interventions and the well-established open surgery, we attempted to reproduce as accurately as possible the technique of open radical cystectomy using a laparoscopic procedure. MATERIALS AND METHODS: The study comprised 35 patients (27 men and 8 women) with invasive bladder cancer who underwent laparoscopic radical cystectomy (LRC) between April 2013 and March 2016...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29131387/laparoscopic-mesh-repair-of-a-labial-hernia
#10
Philippe Grange, Fevzi Shakir, Ganesh Thiagamoorthy, George Araklitis, Dudley Robinson, Linda Cardozo
AIMS: To present a narrated video designed to demonstrate the steps involved in a laparoscopic mesh repair of a labial hernia. METHODS: This was in a 76-year-old woman who presented with a small bowel hernia in to her left labium majus. In 2014 she had a robotically assisted radical cystectomy for bladder cancer with anterior exenteration. She developed the hernia in February 2015 and initially a vaginal approach was attempted to repair the hernia (with layered non-absorbable sutures to close the fascia over the defect) at her local hospital, although this was unsuccessful...
November 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29128420/neoadjuvant-treatment-for-muscle-invasive-bladder-cancer-the-past-the-present-and-the-future
#11
REVIEW
Tom J N Hermans, Charlotte S Voskuilen, Michiel S van der Heijden, Bernd J Schmitz-Dräger, Wassim Kassouf, Roland Seiler, Ashish M Kamat, Petros Grivas, Anne E Kiltie, Peter C Black, Bas W G van Rhijn
BACKGROUND: Approximately half of patients who undergo radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) will succumb to metastatic disease. We summarize the evidence for neoadjuvant radiation (NAR), chemo (NAC), and immunotherapy (checkpoint inhibition) prior to RC for MIBC. MATERIALS AND METHODS: Data were obtained by a search of PubMed, ClinicalTrials.gov, and Cochrane databases for English language articles published from 1925 up to 2017. RESULTS: NAC usage has increased over the last decade, while NAR is rarely administered...
November 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29127452/accuracy-and-prognostic-value-of-variant-histology-and-lymphovascular-invasion-at-transurethral-resection-of-bladder
#12
Mohammad Abufaraj, Shahrokh F Shariat, Beat Foerster, Carmen Pozo, Marco Moschini, David D'Andrea, Romain Mathieu, Martin Susani, Anna K Czech, Pierre I Karakiewicz, Veronika Seebacher
OBJECTIVES: To evaluate the concordance rate of lymphovascular invasion (LVI) and variant histology (VH) of transurethral resection (TUR) with radical cystectomy (RC) specimens. Furthermore, to evaluate the value of LVI and VH at TUR for predicting non-organ confined (NOC) disease, lymph node metastasis, and survival outcomes. PATIENTS AND METHODS: Two hundred and sixty-eight patients who underwent TUR and subsequent RC were reviewed. Logistic regression analyses were performed to evaluate the association of LVI and VH with NOC and lymph node metastasis at RC...
November 11, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29126568/treatment-options-and-predictive-factors-for-recurrence-and-cancer-specific-mortality-in-bladder-cancer-after-renal-transplantation-a-multi-institutional-analysis
#13
O Rodriguez Faba, J Palou, H Vila Reyes, L Guirado, A Palazzetti, P Gontero, F Vigués, J Garcia-Olaverri, J M Fernández Gómez, J Olsburg, C Terrone, A Figueiredo, J Burgos, E Lledó, A Breda
OBJECTIVES: Bladder cancer (BC) in the transplanted population can represent a challenge owing to the immunosuppressed state of patients and the higher rate of comorbidities. The objective was to analyze the treatment of BC after renal transplant (RT), focusing on the mode of presentation, diagnosis, treatment options and predictive factors for recurrence. MATERIAL AND METHODS: We conducted an observational prospective study with a retrospective analysis of 88 patients with BC after RT at 10 European centers...
November 7, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29124853/intracorporeal-robotic-assisted-radical-cystectomy-together-with-an-enhanced-recovery-programme-improves-postoperative-outcomes-by-aggregating-marginal-gains
#14
Wei Shen Tan, Mae-Yen Tan, Benjamin W Lamb, Ashwin Sridhar, Anna Mohammed, Hilary Baker, Senthil Nathan, Timothy Briggs, Melanie Tan, John D Kelly
OBJECTIVE: To assess the cumulative effect of an enhanced recovery after surgery (ERAS) pathway and a minimally invasive RARC with intracorporeal urinary diversion (iRARC) in comparison to open radical cystectomy (ORC) on hospital length of stay (LOS) and perioperative outcomes. MATERIALS & METHODS: Between Feb 2009 and Oct 2017, 304 radical cystectomy cases were performed at a single institution (54 ORC, 250 RARC). Data were prospectively collected. We identified 45 consecutive ORC cases performed without ERAS before the commencement of the RARC programme (Cohort A), 50 consecutive iRARC cases performed without ERAS (Cohort B) and 40 iRARC cases with ERAS (Cohort C)...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29124346/live-surgery-highly-educational-or-harmful
#15
B Rocco, A A C Grasso, E De Lorenzis, J W Davis, C Abbou, A Breda, T Erdogru, R Gaston, I S Gill, E Liatsikos, B Oktay, J Palou, T Piéchaud, J U Stolzenburg, Y Sun, G Albo, H Villavicencio, X Zhang, V Disanto, P Emiliozzi, V Pansadoro
PURPOSE: Live surgery (LS) is considered a useful teaching opportunity. The benefits must be balanced with patient safety concerns. To evaluate the rate of complications of a series of urologic LS performed by experts during the Congress Challenge in Laparoscopy and Robotics (CILR). METHODS: We present a large, multi-institution, multi-surgeon database that derives from 12 CILR events, from 2004 to 2015 with a total of 224 cases. Radical prostatectomy (RP) was the most common procedure and a selection of complex cases was noted...
November 9, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29124240/lymph-node-yield-in-node-negative-patients-predicts-cancer-specific-survival-following-radical-cystectomy-for-transitional-cell-carcinoma
#16
Jack Crozier, Nathan Papa, Marlon Perera, Michael Stewart, Jeremy Goad, Shomik Sengupta, Damien Bolton, Nathan Lawrentschuk
Purpose: To determine the oncological implications of increased nodal dissection in node-negative bladder cancer during radical cystectomy in a contemporary Australian series. Materials and Methods: We performed a multicenter retrospective study, including more than 40 surgeons across 5 sites over a 10-year period. We identified 353 patients with primary bladder cancer undergoing radical cystectomy. Extent of lymphadenectomy was defined as follows; limited pelvic lymph node dissection (PLND) (perivesical, pelvic, and obturator), standard PLND (internal and external iliac) and extended PLND (common iliac)...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29123922/robotic-management-of-a-duplicated-ureter-during-intracoporeal-urinary-diversion-following-robotic-cystectomy
#17
Abdullah Erdem Canda, Erem Asil, Erdem Koc, Mustafa Aldemir, Arslan Ardicoglu, Ali Fuat Atmaca
No abstract text is available yet for this article.
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29122621/simple-operating-room-bundle-reduces-superficial-surgical-site-infections-after-major-urologic-surgery
#18
Sarah C Vij, Ganesh Kartha, Venkatesh Krishnamurthi, Michelle Ponziano, Howard B Goldman
OBJECTIVE: To reduce our superficial surgical site infection rate (sSSI) following major urologic surgery by implementing a simple operating room bundle. METHODS: A simple operating room bundle was applied to all major urologic cases (cystectomy, nephrectomy and prostatectomy) at a single tertiary referral center. The bundle included allowing skin prep to dry appropriately, changing gloves prior to skin closure, irrigating the wound prior to skin closure and using a new separate sterile closing instrument set for skin closure...
November 6, 2017: Urology
https://www.readbyqxmd.com/read/29122377/the-role-of-surgery-in-metastatic-bladder-cancer-a-systematic-review
#19
REVIEW
Mohammad Abufaraj, Guido Dalbagni, Siamak Daneshmand, Simon Horenblas, Ashish M Kamat, Ryu Kanzaki, Alexandre R Zlotta, Shahrokh F Shariat
CONTEXT: The role of surgery in metastatic bladder cancer (BCa) is unclear. OBJECTIVE: In this collaborative review article, we reviewed the contemporary literature on the surgical management of metastatic BCa and factors associated with outcomes to support the development of clinical guidelines as well as informed clinical decision-making. EVIDENCE ACQUISITION: A systematic search of English language literature using PubMed-Medline and Scopus from 1999 to 2016 was performed...
November 6, 2017: European Urology
https://www.readbyqxmd.com/read/29116491/prognostic-and-predictive-value-of-o-6-methylguanine-methyltransferase-for-chemotherapy-in-patients-with-muscle-invasive-bladder-cancer
#20
Junyu Zhang, Yu Zhu, Yiwei Wang, Qiang Fu, Huyang Xie, Zheng Liu, Hangcheng Fu, Yifan Cao, Jiejie Xu, Bo Dai
PURPOSE: DNA repair genes are potential biomarkers for chemotherapy in muscle-invasive bladder cancer (MIBC). O(6)-methylguanine methyltransferase (MGMT) is involved in DNA repair and is found to affect the efficacy of platinum-based chemotherapy. However, the prognostic or predictive value of MGMT expression in chemotherapy for MIBC is unknown. MATERIALS AND METHODS: Immunohistochemical staining for MGMT was performed in paraffin-embedded tumor tissue of high-grade MIBC patients who underwent cystectomy in two independent cohorts [n = 74 for Fudan University Shanghai Cancer Center (FUSCC) cohort and n = 115 for Zhongshan Hospital (ZS) cohort]...
November 7, 2017: Annals of Surgical Oncology
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