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https://www.readbyqxmd.com/read/29344095/metachronous-metastasis-of-renal-cell-carcinoma-to-the-urinary-bladder-a-case-report
#1
Ruben De Groote, Alessandro Larcher, Marijn Goossens, De Raeve Hendrik, Van Der Steen Kris, Vincent De Coninck, Geert De Naeyer, Peter Schatteman, Frederiek D'Hondt, Alexandre Mottrie
We report a case of intravesical metastasis of a clear cell renal cell carcinoma. In renal cell carcinoma 16% of patients present with metastatic disease. Renal cell carcinoma can metastasize to nearly every organ, although metastatic spread to the urinary bladder is rare, with fewer than 70 described cases. The route and pattern of metastatic spread is not yet fully understood and different pathways are suggested. Gross haematuria is the presenting symptom in the majority of cases. These intravesical metastases may be synchronous or metachronous and can be solitary or part of polymetastatic disease...
January 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29343911/oncologic-outcomes-in-patients-with-nonurothelial-bladder-cancer
#2
Sanjay G Patel, Adam Benjamin Weiner, Kirk Keegan, Todd Morgan
Introduction: We aimed to evaluate the relative prognostic impact of the most common variant histologies on disease-specific survival (DSS) in patients undergoing radical cystectomy. Materials and Methods: The Surveillance, Epidemiology, and End Result database was used to identify patients who underwent radical cystectomy for bladder cancer from 1990 to 2007. Patients with urothelial cell carcinoma (UCC), squamous cell carcinoma (SCC), adenocarcinoma (AC), sarcoma, small cell carcinoma, signet ring carcinoma, and spindle cell carcinoma were included in the study...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29343302/does-previous-abdominal-surgery-adversely-affect-perioperative-and-oncologic-outcomes-of-laparoscopic-radical-cystectomy
#3
Xiaosong Wei, Jinjin Lu, Khurram Mutahir Siddiqui, Fan Li, Qianyuan Zhuang, Weimin Yang, Zhiquan Hu, Zhong Chen, Xiaodong Song, Shaogang Wang, Zhangqun Ye
BACKGROUND: Laparoscopic radical cystectomy (LRC) has been shown to have less estimated blood loss (EBL), transfusion rate, narcotic analgesic requirement, earlier return of bowel function, and shorter hospital stay. The aim of this study was to investigate the feasibility, peri-operative and oncologic outcomes of laparoscopic radical cystectomy (LRC) in patients with previous abdominal surgery (PAS). METHODS: We retrospectively reviewed 243 patients undergoing open radical cystectomy (ORC) or LRC with bilateral pelvic lymph node dissection and urinary diversion or cutaneous ureterostomy at a single center from January 2010 to December 2015...
January 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29342465/de-novo-bladder-urothelial-neoplasm-in-renal-transplant-recipients-a-retrospective-multicentered-study
#4
Anna Palazzetti, Andrea Bosio, Ettore Dalmasso, Paolo Destefanis, Fabrizio Fop, Francesca Pisano, Giuseppe Segoloni, Luigi Biancone, Alessandro Volpe, Antonia Di Domenico, Carlo Terrone, Samuele Iesari, Antonio Famulari, Paola Todeschini, Bruno Frea, Paolo Gontero
BACKGROUND AND OBJECTIVES: Renal transplant recipients (RTRs) have a 2- to 7-fold risk of developing a neoplasm compared to general population. Bladder urothelial neoplasms in this cohort has an incidence of 0.4-2%. Many reports describe a more aggressive behavior. The objective of this study is to describe oncologic characteristics of bladder urothelial neoplasms in RTRs and to evaluate its recurrence, progression, and survival rates. METHODS: A retrospective multicentered study was performed evaluating all de novo bladder urothelial neoplasms cases in RTRs from 1988 to 2014...
January 17, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29340094/can-urologists-introduce-the-concept-of-oligometastasis-for-metastatic-bladder-cancer-after-total-cystectomy
#5
Koichiro Ogihara, Eiji Kikuchi, Keitaro Watanabe, Ryohei Kufukihara, Yoshinori Yanai, Kimiharu Takamatsu, Kazuhiro Matsumoto, Satoshi Hara, Masafumi Oyama, Tetsuo Monma, Takeshi Masuda, Shintaro Hasegawa, Mototsugu Oya
We investigated whether the concept of oligometastasis may be introduced to the clinical management of metastatic bladder cancer patients. Our study population comprised 128 patients diagnosed with metastatic bladder cancer after total cystectomy at our 6 institutions between 2004 and 2014. We extracted independent predictors for identifying a favorable. Occurrence that fulfilled all 4 criteria which were independently associated with cancer-specific death was defined as oligometastasis: a solitary metastatic organ; number of metastatic lesions of 3 or less; the largest diameter of metastatic foci of 5cm or less; and no liver metastasis...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338914/prophylactic-antibiotics-following-radical-cystectomy-reduces-urinary-tract-infections-and-readmission-for-sepsis-from-a-urinary-source
#6
Ryan P Werntz, Ann Martinez-Acevedo, Hamed Amadi, Ryan Kopp, Jeffrey La Rochelle, Theresa Koppie, Christopher Amling, Kamran P Sajadi
INTRODUCTION: Urinary tract infections (UTI) and sepsis contribute significantly to the morbidity associated with cystectomy and urinary diversion in the first 30 days. We hypothesized that continuous antibiotic prophylaxis decreased UTIs in the first 30 days following radical cystectomy. METHODS: Patients with urothelial carcinoma of the bladder who underwent a radical cystectomy with urinary diversion for bladder cancer at Oregon Health and Science University from January 2014 to May 2015 were included in the study...
January 12, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29338913/discrepancies-in-staging-treatment-and-delays-to-treatment-may-explain-disparities-in-bladder-cancer-outcomes-an-update-from-the-national-cancer-data-base-2004-2013
#7
Adam B Weiner, Mary-Kate Keeter, Adarsh Manjunath, Joshua J Meeks
INTRODUCTION: We sought to characterize national disparities in the diagnosis of advanced stage bladder cancer. Among patients with advanced disease, we explored disparities in overall survival, treatment, and time to treatment. METHODS AND MATERIALS: We queried the National Cancer Data Base for patients diagnosed with bladder urothelial carcinoma. We used multivariable logistic regression to assess the association between covariates and diagnosis of advanced disease (AJCC stage III-IV)...
January 12, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29335609/prognostic-significance-of-halp-hemoglobin-albumin-lymphocyte-and-platelet-in-patients-with-bladder-cancer-after-radical-cystectomy
#8
Ding Peng, Cui-Jian Zhang, Yan-Qing Gong, Han Hao, Bao Guan, Xue-Song Li, Li-Qun Zhou
The outcome of bladder cancer after radical cystectomy is heterogeneous. We aim to evaluate the prognostic value of HALP (hemoglobin, albumin, lymphocyte and platelet) and explore novel prognostic indexes for patients with bladder cancer after radical cystectomy. In this retrospective study, 516 patients with bladder cancer after radical cystectomy were included. The median follow-up was 37 months (2 to 99 mo). Risk factors of decreased overall survival were older age, high TNM stage, high American Society of Anesthesiologists (ASA) grade and low HALP score...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334632/capillary-electrophoresis-mass-spectrometry-for-targeted-and-untargeted-analysis-of-the-sub-5%C3%A2-kda-urine-metabolome-of-patients-with-prostate-or-bladder-cancer-a-feasibility-study
#9
Matthew S MacLennan, Miranda G M Kok, Laiel Soliman, Alan So, Antonio Hurtado-Coll, David D Y Chen
Targeted and untargeted analyses of the sub-5 kDa urine metabolome of genitourinary cancer patients (prostate and/or bladder) were performed without chemical derivatization using capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS). For targeted analysis, endogenous levels of sarcosine and 5 other amino acid metabolites implicated in the progression of prostate cancer were quantified in four patients and in a pooled urine sample from healthy volunteers. An untargeted analysis (m/z 50 to 850) of patient urine was performed using the same CE-ESI-MS system identifying over 400 distinct molecular features per patient...
January 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29333514/what-is-the-fate-of-artificial-urinary-sphincters-among-men-undergoing-repetitive-bladder-cancer-treatment
#10
S Mitchell Heiner, Boyd R Viers, Marcelino E Rivera, Brian J Linder, Daniel S Elliott
Purpose: Functional characteristics and durability of the artificial urinary sphincter (AUS) among patients who develop bladder cancer has been poorly characterized. We sought to evaluate AUS outcomes among patients subsequently diagnosed with bladder cancer, in order to describe device survivability when subject to diagnostic and therapeutic procedures such as cystoscopy, transurethral resection, and cystectomy. Materials and Methods: We retrospectively reviewed 1,803 male patients treated with AUS surgery at a single institution between 1983-2014...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29329898/-prognostic-of-older-age-for-patients-with-invasive-muscle-bladder-cancer-and-treated-by-radical-cystectomy
#11
Y Dehayni, M Tetou, Y Khdach, A Janane, M Alami, A Ameur
INTRODUCTION: Bladder tumor is a disease of older persons, but can also occur in young adults, because certainly an influence of environmental factors and a change of lifestyle. The aim of our retrospective analysis is to assess and evaluate the extent of the prognostic impact of age on the carcinological prognosis of invasive-muscle-bladder cancer treated by total cystotomy. METHODS: To evaluate the association of patient age with pathological characteristics and recurrence-free and disease survival, we retrospectively reviewed 345 patients with invasive bladder cancer between January 2000 and January 2015...
January 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29329894/neoadjuvant-dose-dense-mvac-versus-gc-in-patients-with-ct3-4an0m0-bladder-cancer-treated-with-radical-cystectomy
#12
Homayoun Zargar, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Trinity J Bivalacqua, Philippe E Spiess, Peter C Black, Wassim Kassouf
BACKGROUND: Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC. METHODS: We retrospectively reviewed records of patients with urothelial cancer who received NAC and underwent cystectomy at 20 contributing institutions from 2000-2015...
January 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29322799/predictors-and-prognostic-implications-of-clinical-decisions-in-patients-with-primary-high-risk-non-muscle-invasive-bladder-cancer-results-of-a-cross-country-retrospective-study
#13
S Poletajew, R Biernacki, P Buraczynski, J Chojnacki, S Czarniecki, D Gajewska, T Pohaba, J Sondka-Migdalska, M Skrzypczyk, T Suchojad, D Wojtkowiak, B Zaforemski, L Zapala, A Zemla, P Radziszewski
Adjuvant diagnostic and therapeutic procedures are available to reduce the risk of recurrence or progression in patients with high-risk non-muscle-invasive bladder cancer (NMIBC). However, their indications and efficacy remain a matter of debate. The aim of this study was to analyze therapeutic decisions in patients with primary high-risk NMIBC and to analyze the adherence to clinical guidelines in this field.545 consecutive patients, aged a median of 70.3 years, diagnosed with primary high-risk NMIBC in thirteen urological institutions, were enrolled into this retrospective study...
2018: Neoplasma
https://www.readbyqxmd.com/read/29319917/nerve-sparing-cystectomy-has-a-beneficial-impact-on-urinary-continence-after-othotopic-bladder-substitution-which-becomes-even-more-apparent-over-time
#14
Marc A Furrer, Urs E Studer, Tobias Gross, Fiona C Burkhard, George N Thalmann, Daniel P Nguyen
OBJECTIVES: To analyse urinary continence in long-term survivors after cystectomy and orthotopic bladder substitute according to attempted nerve-sparing status. MATERIALS AND METHODS: We analysed 180 consecutive patients treated at our department between 1985 and 2007 who underwent cystectomy with orthotopic bladder substitution, and survived ≥10 years post-cystectomy. We stratified patients by attempted nerve-sparing status and evaluated continence outcomes using descriptive statistics and Cox proportional hazards regression models...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29316106/robotic-assisted-radical-cystectomy-with-intracorporeal-urinary-diversion-versus-open-early-australian-experience
#15
Ken Chow, Homayoun Zargar, Niall M Corcoran, Anthony J Costello, Justin S Peters, Philip Dundee
BACKGROUND: The aim of this study was to describe our initial Australian single surgeon experience with robotic-assisted radical cystectomy (RARC) and intracorporeal urinary diversion (ICUD) and to compare the outcomes with open radical cystectomy (ORC). METHODS: Between January 2014 and June 2016, consecutive patients diagnosed with muscle invasive and high-risk non-muscle invasive bladder cancer undergoing radical cystectomy were included. Treatment modalities included either RARC with ICUD or ORC...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29316041/bilateral-tubo-ovarian-abscesses-presenting-with-huge-pelvic-mass-after-repeated-intrauterine-inseminations-in-a-woman-with-severe-endometriosis
#16
Patsama Vichinsartvichai
A 32-year-old woman consulted for an evaluation of pelvic pain following intrauterine insemination (IUI). Vaginal and abdominal sonography, septic workup were performed and laparoscopic surgery was scheduled after failure to respond to a course of antibiotics. During laparoscopic surgery, bilateral tubo-ovarian abscesses arising on the endometriotic cysts of both ovaries were identified with a vast amount of brownish peritoneal fluid under the adhesion of the greater omentum. Bilateral ovarian cystectomy, right salpingectomy and lysis adhesion were performed...
January 5, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29313114/bladder-cancer-local-staging-multiparametric-mri-performance-following-transurethral-resection
#17
Christian B van der Pol, Atul B Shinagare, Sree Harsha Tirumani, Mark A Preston, Mark G Vangel, Stuart G Silverman
PURPOSE: To evaluate the performance of multiparametric MRI (mpMRI) for the local staging of bladder cancer following transurethral resection of bladder tumor. METHODS: This Institutional Review Board-approved, retrospective study identified 45 patients with pathology-proven bladder cancer who underwent transurethral resection followed by mpMRI between August 2011 and October 2016. Two radiologists reviewed each MRI independently and assigned T and N stage. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for the presence of muscle invasion (T2 or higher), peri-vesical invasion (T3 or higher), and regional nodal disease compared to findings at cystectomy as the reference standard...
January 9, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29305945/urosymphyseal-fistulas-resulting-from-endoscopic-treatment-of-radiation-induced-posterior-urethral-strictures
#18
Daniel D Shapiro, David C Goodspeed, Wade Bushman
Objective To describe the inciting events leading to urosymphyseal fistulas (UF) and pubic osteomyelitis (PO) in patients who had radiation induced urethral strictures. Materials and Methods We retrospectively reviewed patients who underwent simultaneous pubic debridement, simple cystectomy and urinary diversion for refractory UF and PO from 2014-2016. We investigated inciting events leading to UF as well as patient presenting symptoms, diagnosis, management, and outcomes. Results Five patients were identified over a two-year period...
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29305710/ecto-5-nucleotidase-cd73-contributes-to-the-radiosensitivity-of-t24-human-bladder-cancer-cell-line
#19
Fabrícia Dietrich, Fabrício Figueiró, Eduardo Cremonese Filippi-Chiela, Angélica Regina Cappellari, Liliana Rockenbach, Alain Tremblay, Patrícia Boni de Paula, Rafael Roesler, Aroldo Braga Filho, Jean Sévigny, Fernanda Bueno Morrone, Ana Maria Oliveira Battastini
PURPOSE: Trimodal therapy is a reasonable bladder-preserving option to radical cystectomy. However, many tumors are radioresistive. In this sense, the identification of new prognostic and predictive biomarkers that allow the selection of patients with better responses to radiation therapy would improve outcomes. With the aim of using ecto-5'-nucleotidase/CD73 as a predictive biomarker, the role of this enzyme in the context of radiotherapy in T24 human bladder cancer cell line was investigated...
January 5, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29305205/associations-between-travel-distance-hospital-volume-and-outcomes-following-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#20
Leilei Xia, Benjamin L Taylor, Ronac Mamtani, John P Christodouleas, Thomas J Guzzo
OBJECTIVE: To explore the associations between travel distance, hospital volume, and outcomes following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) METHODS: The 2006 to 2013 National Cancer Database (NCDB) was queried to identify patients with MIBC who underwent RC. Multivariable regressions alternately including travel distance, hospital volume, and both in the models were used. Travel distances and hospital volumes were categorized by quartiles. Outcomes of interest were overall survival and quality-of-care indicators...
January 2, 2018: Urology
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