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Neurogenic inflammation

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https://www.readbyqxmd.com/read/28872725/dorsal-root-ganglion-field-stimulation-prevents-inflammation-and-joint-damage-in-a-rat-model-of-rheumatoid-arthritis
#1
Bin Pan, Zhiyong Zhang, Dongman Chao, Quinn H Hogan
OBJECTIVES: Electrical stimulation of the dorsal root ganglion (DRG), referred to here as ganglionic field stimulation (GFS), is effective in reducing clinical pain, probably by interrupting transmission of afferent impulse trains on sensory neurons as they pass through the DRG. We therefore tested whether efferent impulse trains conveyed by sensory neurons, which contribute to neurogenic inflammation, may also be interrupted by GFS. MATERIALS AND METHODS: Collagen-induced arthritis, a model of clinical rheumatoid arthritis, was initiated in rats concurrently with the insertion of an electrode for GFS at the fourth lumbar DRG...
September 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28862769/histamine-and-migraine
#2
Hsiangkuo Yuan, Stephen D Silberstein
BACKGROUND: Histamine is an ancient "tissue amine" preceding multicellular organisms. In the central nervous system (CNS), its fibers originate solely from the tuberomammillary nucleus and travel throughout the brain. It is mainly responsible for wakefulness, energy homeostasis, and memory consolidation. Recently, several studies suggest a potential role of histamine in migraine pathogenesis and management. METHODS: Narrative review of current literature regarding histamine and migraine...
September 1, 2017: Headache
https://www.readbyqxmd.com/read/28833574/the-effect-of-botulinum-neurotoxin-a-in-patients-with-plaque-psoriasis-an-exploratory-trial
#3
T Todberg, C Zachariae, A Bregnhøj, L Hedelund, K K Bonefeld, K Nielsen, L Iversen, L Skov
A few case stories have described patients with psoriasis who suffered from nerve injury which resulted in clearance of psoriasis (1, 2). Recently three reports have addressed a positive effect of botulinum neurotoxin A (BoNT-A) injections in patients with psoriasis (3-5). BoNT-A inhibits neuropeptide releasement and inflammatory cytokines(6), thus the hypothesis was that blocking neuromodulator could lower neurogenic inflammation resulting in improvement of psoriasis. This article is protected by copyright...
August 22, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28817088/the-role-of-neurogenic-inflammation-in-blood-brain-barrier-disruption-and-development-of-cerebral-oedema-following-acute-central-nervous-system-cns-injury
#4
REVIEW
Annabel J Sorby-Adams, Amanda M Marcoionni, Eden R Dempsey, Joshua A Woenig, Renée J Turner
Acute central nervous system (CNS) injury, encompassing traumatic brain injury (TBI) and stroke, accounts for a significant burden of morbidity and mortality worldwide, largely attributable to the development of cerebral oedema and elevated intracranial pressure (ICP). Despite this, clinical treatments are limited and new therapies are urgently required to improve patient outcomes and survival. Originally characterised in peripheral tissues, such as the skin and lungs as a neurally-elicited inflammatory process that contributes to increased microvascular permeability and tissue swelling, neurogenic inflammation has now been described in acute injury to the brain where it may play a key role in the secondary injury cascades that evolve following both TBI and stroke...
August 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28775014/brain-heart-interaction-cardiac-complications-after-stroke
#5
REVIEW
Zhili Chen, Poornima Venkat, Don Seyfried, Michael Chopp, Tao Yan, Jieli Chen
Neurocardiology is an emerging specialty that addresses the interaction between the brain and the heart, that is, the effects of cardiac injury on the brain and the effects of brain injury on the heart. This review article focuses on cardiac dysfunction in the setting of stroke such as ischemic stroke, brain hemorrhage, and subarachnoid hemorrhage. The majority of post-stroke deaths are attributed to neurological damage, and cardiovascular complications are the second leading cause of post-stroke mortality...
August 4, 2017: Circulation Research
https://www.readbyqxmd.com/read/28762564/capsaicin-induced-rapid-neutrophil-leukocyte-activation-in-the-rat-urinary-bladder-microcirculatory-bed
#6
Péter Járomi, Dénes Garab, Petra Hartmann, Dóra Bodnár, Sándor Nyíri, Péter Sántha, Mihály Boros, Gábor Jancsó, Andrea Szabó
AIMS: This study was initiated to investigate the involvement of neutrophil leukocyte activation in neurogenic inflammation, a process also involved in human urinary pathologies, elicited in the rat urinary bladder by the local administration of capsaicin, the archetypal TRPV1 agonist. The contribution of afferent nerves and sensory neuropeptides to leukocyte activation in the urinary bladder microcirculatory bed was examined. METHODS: Following a 15-min topical application of capsaicin (50 μM), leukocyte-endothelial interactions were examined for an observation period of 45 min with intravital microscopy...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28758554/neurogenic-obesity-and-systemic-inflammation-following-spinal-cord-injury-a-review
#7
Gary J Farkas, David R Gater
Content Spinal Cord Injury (SCI) results in physiological changes that markedly reduces whole-body metabolism, resulting in neurogenic obesity via adipose tissue accumulation. Adipose tissue has been implicated in the release of proinflammatory adipokines that lead to chronic, systemic inflammation, and evidence suggests these adipokines contribute to the pathogeneses of metabolic diseases that often accompany obesity. In this review, we propose the concept of neurogenic obesity through paralysis-induced adiposity as the primary source of systemic inflammation and metabolic dysfunction reported in chronic SCI...
July 30, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28739972/recent-advances-in-neurogenic-hypertension-dietary-salt-obesity-and-inflammation
#8
REVIEW
Sean D Stocker, Brian J Kinsman, Alan F Sved
No abstract text is available yet for this article.
July 24, 2017: Hypertension
https://www.readbyqxmd.com/read/28738875/effects-of-fty720-on-brain-neurogenic-niches-in-vitro-and-after-kainic-acid-induced-injury
#9
Raffaela Cipriani, Juan Carlos Chara, Alfredo Rodríguez-Antigüedad, Carlos Matute
BACKGROUND: FTY720 (fingolimod, Gilenya™) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts several effects in the central nervous system (CNS), ranging from neuroprotection to reduction of neuroinflammation. However, the neurogenic and oligodendrogenic potential of FTY720 has been poorly investigated. In this study, we assessed the effect of FTY720 on the production of new neurons and oligodendrocytes from neural stem/precursor cells both in vitro and in vivo...
July 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28734722/guidelines-for-the-understanding-and-management-of-pain-in-chronic-pancreatitis
#10
REVIEW
Asbjørn M Drewes, Stefan A W Bouwense, Claudia M Campbell, Güralp O Ceyhan, Myriam Delhaye, Ihsan Ekin Demir, Pramod K Garg, Harry van Goor, Christopher Halloran, Shuiji Isaji, John P Neoptolemos, Søren S Olesen, Tonya Palermo, Pankaj Jay Pasricha, Andrea Sheel, Tooru Shimosegawa, Eva Szigethy, David C Whitcomb, Dhiraj Yadav
Abdominal pain is the foremost complication of chronic pancreatitis (CP). Pain can be related to recurrent or chronic inflammation, local complications or neurogenic mechanisms with corresponding changes in the nervous systems. Both pain intensity and the frequency of pain attacks have been shown to reduce quality of life in patients with CP. Assessment of pain follows the guidelines for other types of chronic pain, where the multidimensional nature of symptom presentation is taken into consideration. Quantitative sensory testing may be used to characterize pain, but is currently used in a research setting in advanced laboratories...
July 13, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28726232/-frequent-episodic-migraine-and-calcitonin-gene-related-peptide-influence-of-treatment-with-topiramate-and-zonisamide-on-levels-of-the-peptide
#11
D A Garcia-Estevez, M Pardo-Parrado, S Silvarrey-Rodriguez
INTRODUCTION: The pathophysiology of pain in migraine is related to the activation of the trigeminovascular system by releasing vasoactive neuropeptides, the most important of which is calcitonin gene-related peptide (CGRP), which causes a neurogenic inflammation in the leptomeningeal vessels. AIM: To study whether CGRP is increased in frequent episodic migraine and whether preventive treatment with topiramate or zonisamide modifies its levels. SUBJECTS AND METHODS: We studied 28 patients with episodic migraine with or without aura, in accordance with the International Headache Society criteria, with a frequency of 4-14 days/month...
August 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28707585/migraine-neurogenic-inflammation-drug-development-pharmacochemical-aspects
#12
Melinda Lukács, János Tajti, Ferenc Fülöp, József Toldi, Lars Edvinsson, László Vécsei
BACKGROUND: Migraine is a primary headache disorder. Despite numerous studies conducted with the aim to understand the pathophysiology of migraine, several aspects are still unclear. The trigeminovascular system plays a key role. Neurogenic inflammation is presumed to be an important factor in migraine pathophysiology, mediated by the activation of primary neurons, leading to the release of various pro-inflammatory neuropeptides and neurotransmitters such as Calcitonin Gene-Related Peptide (CGRP), substance P (SP), and vasoactive intestinal peptide (VIP)...
July 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28706720/endotype-driven-treatment-in-chronic-upper-airway-diseases
#13
REVIEW
Glynnis De Greve, Peter W Hellings, Wytske J Fokkens, Benoit Pugin, Brecht Steelant, Sven F Seys
Rhinitis and rhinosinusitis are the two major clinical entities of chronic upper airway disease. Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) affect respectively up to 10 and 30% of the total population, hence being associated with an important socio-economic burden. Different phenotypes of rhinitis and CRS have been described based on symptom severity and duration, atopy status, level of control, comorbidities and presence or absence of nasal polyps in CRS. The underlying pathophysiological mechanisms are diverse, with different, and sometimes overlapping, endotypes being recognized...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28690531/stem-cells-in-the-treatment-of-refractory-chronic-migraines
#14
Alexander Mauskop, Kenneth O Rothaus
BACKGROUND: Autologous adipose-derived stromal vascular fraction (SVF), which is rich in mesenchymal stromal cells, has been reported to be effective for the treatment of trigeminal neuropathic pain and chronic migraine and tension-type headaches. It is possible that stem cell activity targets neurogenic inflammation, which is a well-documented aspect of migraine pathogenesis. METHODS: Adult patients with severe migraine-related disability as measured by the Migraine Disability Assessment (MIDAS) score who failed botulinum toxin injections and at least 3 prophylactic drugs were included in this study...
May 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28685843/oxidative-stress-management-in-the-hair-follicle-could-targeting-nrf2-counter-age-related-hair-disorders-and-beyond
#15
REVIEW
Laura Jadkauskaite, Pierre A Coulombe, Matthias Schäfer, Albena T Dinkova-Kostova, Ralf Paus, Iain S Haslam
Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition...
August 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28670360/pain-and-the-pathogenesis-of-biceps-tendinopathy
#16
REVIEW
Elise B Raney, Finosh G Thankam, Matthew F Dilisio, Devendra K Agrawal
Biceps tendinopathy is a relatively common ailment that typically presents as pain, tenderness, and weakness in the tendon of the long head of the biceps brachii. Though it is often associated with degenerative processes of the rotator cuff and the joint, this is not always the case, thus, the etiology remains considerably unknown. There has been recent interest in elucidating the pathogenesis of tendinopathy, since it can be an agent of chronic pain, and is difficult to manage. The purpose of this article is to critically evaluate relevant published research that reflects the current understanding of pain and how it relates to biceps tendinopathy...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28622417/the-anti-migraine-component-of-butterbur-extracts-isopetasin-desensitizes-peptidergic-nociceptors-by-acting-on-trpa1-cation-channel
#17
Silvia Benemei, Francesco De Logu, Simone Li Puma, Ilaria Maddalena Marone, Elisabetta Coppi, Filippo Ugolini, Wolfgang Liedtke, Federica Pollastro, Giovanni Appendino, Pierangelo Geppetti, Serena Materazzi, Romina Nassini
BACKGROUND AND PURPOSE: The mechanism of the anti-migraine action of extracts of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses relevant to migraine. EXPERIMENTAL APPROACH: Single-cell calcium imaging and patch-clamp recordings in human and rodent TRPA1-expressing cells, neurogenic motor responses in rodent isolated urinary bladder, release of CGRP from mouse spinal cord in vitro and facial rubbing in mice and meningeal blood flow in rats were examined...
September 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28620644/topical-application-of-mesenchymal-stromal-cells-ameliorated-liver-parenchyma-damage-after-ischemia-reperfusion-injury-in-an-animal-model
#18
Ping Kuen Lam, Charing Ching Ning Chong, Anthony Wing Ip Lo, Anthony Wing Hung Chan, Cindy See Wai Tong, Don Wai Ching Chin, Kenneth Hoi Kin Wong, Richard Kwong Wai Choy, Andrew Kai-Yip Fung, Yi Xiang Wang, Ka Fai To, Paul Bo San Lai
BACKGROUND: Ischemia-reperfusion injury (IRI) is commonly encountered after liver surgery. This study evaluated the hepatoprotective effects of topically applied adipose-derived mesenchymal stromal cells (ADMSCs) on hepatic IRI in a rat model. METHODS: ADMSCs from transgenic green fluorescent protein Sprague-Dawley rats were topically applied to the liver surface of Sprague-Dawley rats after hepatic IRI and fixed in position by fibrin glue (group A, n = 24). An equivalent amount of ADMSCs were administered through the portal (group B, n = 24) or tail vein (group C, n = 24)...
June 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28614189/dose-response-study-of-topical-allyl-isothiocyanate-mustard-oil-as-a-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation
#19
Hjalte H Andersen, Silvia Lo Vecchio, Parisa Gazerani, Lars Arendt-Nielsen
Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, and 90%) and vehicle (paraffin) were applied for 5 minutes to 3 × 3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed...
September 2017: Pain
https://www.readbyqxmd.com/read/28553881/the-relationship-between-levels-of-plasma-soluble-urokinase-plasminogen-activator-receptor-supar-and-presence-of-migraine-attack-and-aura
#20
Nigar Yılmaz, Mustafa Yılmaz, Burcu Sirin, Sureyya Yılmaztekin, Gülnihal Kutlu
Migraine is one of the most common types of pain associated with sterile inflammatory conditions. Soluble urokinase plasminogen activator receptor (suPAR) is a potential novel inflammatory marker. We aim to determine the association between serum values of suPAR, procalcitonin, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP) and migraine disease characteristics. The study involved a total of 60 migraine patients (33 patients in the interictal period, 27 patients in the attack period) and 30 healthy individuals...
October 2017: Journal of Receptor and Signal Transduction Research
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