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Neurogenic inflammation

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https://www.readbyqxmd.com/read/29306407/intracerebroventricular-injections-of-endotoxin-et-reduces-hippocampal-neurogenesis
#1
Farah Chamaa, Lynn Bitar, Batoul Darwish, Nayef E Saade, Wassim Abou-Kheir
Physio-pathological conditions such as neuroinflammation can modulate neurogenesis in the hippocampus. The aim of this study is to follow the time course of inflammation-induced effects on the neurogenic niche and the counter-effects of an anti-inflammatory drug. Rats received intracerebroventricular injections of lipopolysaccharide/endotoxin (ET) and intraperitoneal injections of 5'-bromo-2'-deoxyuridine, then perfused at different time intervals. At day 3, ET injection resulted in thermal hyperalgesia accompanied by a significant decrease in neurogenesis...
February 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29288742/the-research-of-the-possible-mechanism-and-the-treatment-for-capsaicin-induced-cough
#2
Li Zhang, Tieying Sun, Longteng Liu, Lifang Wang
Unexplained chronic cough (UCC) affects millions of patients worldwide. New therapeutic approaches to this condition are urgently needed, since current treatment options provide only symptomatic relief. Cough reflex hypersensitivity has been shown to play an important role in the pathogenesis of UCC. The transient receptor potential vanilloid type 1 (TRPV1) is present on peripheral terminals of airway sensory nerves and modulation of its activity represents a potential target for the pharmacological treatment of UCC...
December 27, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29285027/comparison-of-the-level-of-substance-p-and-neurokinin-a-in-gingival-crevicular-fluid-of-sound-and-symptomatic-carious-primary-teeth-by-elisa
#3
Alireza Heidari, Mehdi Shahrabi, Marzieh Salehi Shahrabi, Mehdi Ghandehari, Pegah Rahbar
Objectives: Pulpal inflammation is often associated with odontogenic pain. Dental pulp is abundantly innervated with sensory fibers encompassing neuropeptides. Neurokinin A (NKA) and substance P (SP) are important neuropeptides in the dental pulp that can cause neurogenic inflammation. Since no previous study has assessed dental pulp neuropeptides in children, this study aimed to compare the level of NKA and SP in gingival crevicular fluid (GCF) of sound and symptomatic carious primary teeth...
July 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29280518/a-new-tool-to-test-active-ingredient-using-acid-lactic-in-vitro-a-help-to-understand-cellular-mechanism-involved-in-stinging-test-an-example-using-a-bacterial-polysaccharide-fucogel%C3%A2
#4
Mehdi Sakka, Raphael Leschiera, Christelle Le Gall, Olivier Gouin, Killian L'herondelle, Paul Buscaglia, Olivier Mignen, Jean-Luc Philbé, Thibaut Saguet, Jean-Luc Carré, Laurent Misery, Nicolas Lebonvallet
The stinging test is an in vivo protocol that evaluates sensitive skin using lactic acid (LA). A soothing sensation of cosmetics or ingredients can be also appreciated through a decrease of stinging score. To predict the soothing sensation of a product before in vivo testing, we developed a model based on an LA test and substance P (SP) release using a co-culture of human keratinocytes and NGF-differentiated PC12 cells. A bacterial fucose-rich polysaccharide present in Fucogel® was evaluated as the soothing molecule in the in vivo stinging test and our in vitro model...
December 27, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29279348/international-union-of-basic-and-clinical-pharmacology-ciii-chemerin-receptors-cmklr1-chemerin1-and-gpr1-chemerin2-nomenclature-pharmacology-and-function
#5
Amanda J Kennedy, Anthony P Davenport
Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous ligand for a G protein-coupled receptor encoded by the gene CMKLR1 (also known as ChemR23), and as a consequence the receptor protein was renamed the chemerin receptor in 2013. Since then, chemerin has been identified as the endogenous ligand for a second G protein-coupled receptor, encoded by the gene GPR1 Therefore, the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification recommends that the official name of the receptor protein for chemokine-like receptor 1 (CMKLR1) is chemerin receptor 1, and G protein-coupled receptor 1 is chemerin receptor 2 to follow the convention of naming the receptor protein after the endogenous ligand...
January 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29260891/tnf-%C3%AE-antagonism-with-etanercept-enhances-penile-nos-expression-cavernosal-reactivity-and-testosterone-levels-in-aged-rats
#6
Tuğçe Demirtaş Şahin, Yusufhan Yazir, Tijen Utkan, Gulcin Gacar, Selenay Furat Rençber, Semil Selcen Gocmez
Erectile dysfunction (ED) has been reported to be associated with inflammation. This study investigated the effects of tumor necrosis factor alpha (TNF-α) inhibitor etanercept on penile neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) expressions, testosterone concentrations, neurogenic and endothelium-dependent relaxations of corpus cavernosum (CC), and circulating and cavernosal levels of inflammatory markers in aged rats. Animals were separated into control, aged, and etanercept-treated aged groups...
December 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29247491/the-roles-of-trpv1-trpa1-and-trpm8-channels-in-chemical-and-thermal-sensitivity-of-the-mouse-oral-mucosa
#7
Tatjana I Kichko, Winfried Neuhuber, Gerd Kobal, Peter W Reeh
Spices in food and beverages and compounds in tobacco smoke interact with sensory irritant receptors of the transient receptor potential (TRP) cation channel family. TRPV1 (vanilloid type 1), TRPA1 (ankyrin 1) and TRPM8 (melastatin 8) not only elicit action potential signaling through trigeminal nerves, eventually evoking pungent or cooling sensations, but by their calcium conductance they also stimulate the release of calcitonin gene-related peptide (CGRP). This is measured as an index of neuronal activation to elucidate the chemo- and thermosensory transduction in the isolated mouse buccal mucosa of wildtypes and pertinent knockouts...
December 15, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29227562/crosstalk-between-substance-p-and-calcitonin-gene-related-peptide-during-heterotopic-ossification-in-murine-achilles-tendon
#8
Ceren Tuzmen, Kostas Verdelis, Lee Weiss, Phil Campbell
Heterotopic ossification (HO) is abnormal bone formation within soft tissue, usually predisposed by neurogenic or musculoskeletal trauma. Inflammation resulting from trauma is considered to be the main trigger for HO by eliciting changes within the injury site, including elevation of bone morphogenetic proteins (BMPs). Recent research, however, has also associated changes in sensory neuropeptide expression with HO. Substance P (SP) and calcitonin gene-related peptide (CGRP) are two of those neuropeptides that have been implicated with various aspects of HO, including regulation of inflammation and BMP signaling...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29226878/asic1a-contributes-to-the-symptom-of-pain-in-a-rat-model-of-chronic-prostatitis
#9
Song Fan, Zong-Yao Hao, Li Zhang, Jun Zhou, Yi-Fei Zhang, Shen Tai, Xian-Sheng Zhang, Chao-Zhao Liang
This study aims to validate our hypothesis that acid-sensing ion channels (ASICs) may contribute to the symptom of pain in patients with chronic prostatitis (CP). We first established a CP rat model, then isolated the L5-S2 spinal dorsal horn neurons for further studies. ASIC1a was knocked down and its effects on the expression of neurogenic inflammation-related factors in the dorsal horn neurons of rat spinal cord were evaluated. The effect of ASIC1a on the Ca2+ ion concentration in the dorsal horn neurons of rat spinal cord was measured by the intracellular calcium ([Ca2+]i) intensity...
December 8, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29205096/anatomical-and-functional-changes-to-the-colonic-neuromuscular-compartment-after-experimental-spinal-cord-injury
#10
Amanda White, Gregory M Holmes
A profound reduction in colorectal transit time accompanies spinal cord injury (SCI), yet the colonic alterations after SCI have yet to be fully understood. The loss of descending supraspinal input to lumbosacral neural circuits innervating the colon is recognized as one causal mechanism. However, remodeling of the colonic enteric nervous system/smooth muscle junction in response to inflammation is recognized as one factor leading to colonic dysmotility in other pathophysiological models. We investigated the alterations to the neuromuscular junction in rats with experimental high-thoracic (T3) SCI...
December 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29197625/chemical-warfare-agents-classes-and-targets
#11
Michael Schwenk
Synthetic toxic chemicals (toxicants) and biological poisons (toxins) have been developed as chemical warfare agents in the last century. At the time of their initial consideration as chemical weapon, only restricted knowledge existed about their mechanisms of action. There exist two different types of acute toxic action: nonspecific cytotoxic mechanisms with multiple chemo-biological interactions versus specific mechanisms that tend to have just a single or a few target biomolecules. TRPV1- and TRPA-receptors are often involved as chemosensors that induce neurogenic inflammation...
November 29, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29191767/capsaicin-the-primary-constituent-of-pepper-sprays-and-its-pharmacological-effects-on-mammalian-ocular-tissues
#12
REVIEW
Harshita Krishnatreyya, Hemanga Hazarika, Achintya Saha, Pronobesh Chattopadhyay
Capsaicin is the principal constituent of Oleoresin capsicum, or Pepper spray, as it is commonly known. Pepper sprays are frequently used in riot control situations and have been used for many years to deal with uncontrolled civil demonstrations and disturbances by defence organizations all over the world. Although capsaicin is noted for its irritant and inflammatory properties but the ocular profile of capsaicin has not been specifically studied and interpreted. The present review analyses the mammalian opthalmological profile of capsaicin and its pharmacological and toxicological manifestations including capsaicin induced corneal changes, neurogenic inflammation, neuroprotective influences on Retinal ganglion cells (RGCs), depletion of neuropeptide content in sensory nerve terminals, etc...
November 27, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29187212/roles-of-bronchopulmonary-c-fibers-in-airway-hyperresponsiveness-and-airway-remodeling-induced-by-house-dust-mite
#13
Zhimei Yang, Jianguo Zhuang, Lei Zhao, Xiuping Gao, Zhengxiu Luo, Enmei Liu, Fadi Xu, Zhou Fu
BACKGROUND: Asthma is characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and airway remodeling. While exposure of house dust mites (HDM) is a common cause of asthma, the pathogenesis of the HDM-induced asthma is not fully understood. Bronchopulmonary C-fibers (PCFs) contribute to the neurogenic inflammation, viral infection induced-persistent AHR, and ovalbumin induced collagen deposition largely via releasing neuropeptides, such as substance P (SP). However, PCF roles in the pathogenesis of the HDM-induced asthma remain unexplored...
November 29, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29168468/strontium-chloride-hexahydrate-as-a-candidate-molecule-for-long-term-treatment-of-allergic-rhinitis
#14
Emine Elif Altuntas, Nergiz Hacer Turgut, Kasım Durmuş, Ömer Tamer Doǧan, Melih Akyol
BACKGROUND & OBJECTIVES: Neurogenic inflammation plays a role in the pathophysiology of allergic rhinitis (AR). Strontium salts are highly effective in reducing the sensory irritation. This study was aimed to investigate the efficacy of strontium chloride (SC) on AR symptoms based on the duration of SC use before the symptoms begin. METHODS: Wistar albino rats (n=18) were randomly divided into three groups: Group 1, received 1μg mometasone furoate (MF); Group 2, three per cent SC; and Group 3 received five per cent SC (2 μl/site)...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29155703/modeling-amyloid-%C3%AE-42-toxicity-and-neurodegeneration-in-adult-zebrafish-brain
#15
Prabesh Bhattarai, Alvin Kuriakose Thomas, Mehmet Ilyas Cosacak, Christos Papadimitriou, Violeta Mashkaryan, Yixin Zhang, Caghan Kizil
Alzheimer's disease (AD) is a debilitating neurodegenerative disease in which accumulation of toxic amyloid-β42 (Aβ42) peptides leads to synaptic degeneration, inflammation, neuronal death, and learning deficits. Humans cannot regenerate lost neurons in the case of AD in part due to impaired proliferative capacity of the neural stem/progenitor cells (NSPCs) and reduced neurogenesis. Therefore, efficient regenerative therapies should also enhance the proliferation and neurogenic capacity of NSPCs. Zebrafish (Danio rerio) is a regenerative organism, and we can learn the basic molecular programs with which we could design therapeutic approaches to tackle AD...
October 25, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29141824/inhibition-of-neurogenesis-in-a-case-of-marburg-variant-multiple-sclerosis
#16
Celia Oreja-Guevara, Ulises Gómez-Pinedo, Julia García-López, Rafael Sánchez-Sánchez, Roberto Valverde-Moyano, Alberto Rabano-Gutierrez, Jordi A Matías-Guiu, Ines González-Suárez, Jorge Matías-Guiu
INTRODUCTION: Neural stem cells (NSC) are located essentially in the subventricular zone (SVZ), subgranular zone (SGZ), and along the central canal of the spinal cord. These cells can proliferate in vitro and differentiate into neurons, oligodendrocytes, and astroglia, thus contributing to repair in multiple sclerosis (MS). We conducted a pathological study to analyse neurogenic response in a patient with Marburg variant MS. METHODS: We present the case of a 27-year-old immunocompetent patient with Marburg variant MS, a fulminant form of the disease...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29134730/role-of-central-versus-peripheral-opioid-system-in-antinociceptive-and-anti-inflammatory-effect-of-botulinum-toxin-type-a-in-trigeminal-region
#17
V Drinovac Vlah, B Filipović, L Bach-Rojecky, Z Lacković
BACKGROUND: Although botulinum toxin type A (BT-A) is approved for chronic migraine treatment, its site and mechanism of action are still elusive. Recently our group discovered that suppression of CGRP release from dural nerve endings might account for antimigraine action of pericranially injected BT-A. We demonstrated that central antinociceptive effect of BT-A in sciatic region involves endogenous opioid system as well. Here we investigated possible interaction of BT-A with endogenous opioid system within the trigeminal region...
November 13, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29132068/secretoneurin-and-pe-11-immunoreactivity-in-the-human-dental-pulp
#18
René Steiner, Reiner Fischer-Colbrie, Athanasia Bletsa, Johannes Laimer, Josef Troger
OBJECTIVE: To explore whether there are differences in the concentration of the secretogranin II-derived peptide secretoneurin and the chromogranin B-derived peptide PE-11 between the healthy and inflamed human dental pulps. Furthermore, colocalization studies with calcitonin gene-related peptide were performed to confirm the sensory origin of the peptidergic nerves in the dental pulp. DESIGN: The concentrations of secretoneurin and PE-11 were determined by highly sensitive radioimmunoassays in extracts of dental pulps, the molecular form of secretoneurin immunoreactivities by RP-HPLC with subsequent radioimmunoassay and colocalization studies with calcitonin gene-related peptide were performed by double immunofluorescence...
November 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29123119/acupuncture-points-can-be-identified-as-cutaneous-neurogenic-inflammatory-spots
#19
Do-Hee Kim, Yeonhee Ryu, Dae Hyun Hahm, Boo Yong Sohn, Insop Shim, O Sang Kwon, Suchan Chang, Young Seob Gwak, Min Sun Kim, Jae Hyo Kim, Bong Hyo Lee, Eun Young Jang, Rongjie Zhao, Jin Mo Chung, Chae Ha Yang, Hee Young Kim
Acupuncture, a traditional medical procedure practised for over 2000 years in Asia, stimulates specific but poorly defined sites called acupoints. To date, no unique anatomical acupoint structures have been found. However, noxious sensory signals from visceral organs produce hypersensitive spots on the skin (neurogenic spots), caused by cutaneous neurogenic inflammation, in the dermatome that overlaps with visceral afferent innervations. Here, we show that an acupoint is one form of neurogenic inflammation on the skin...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122628/a-novel-curcumin-derivative-for-the-treatment-of-diabetic-neuropathy
#20
Daniel J Daugherty, Alexandra Marquez, Nigel A Calcutt, David Schubert
Neuropathy is a common complication of long-term diabetes. Proposed mechanisms of neuronal damage caused by diabetes that are downstream of hyperglycemia and/or loss of insulin signaling include ischemic hypoxia, inflammation and loss of neurotrophic support. The curcumin derivative J147 is a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy...
November 6, 2017: Neuropharmacology
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