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Musaffe Tuna, Christopher I Amos
Approximately 18% of all human cancers have a viral etiology, and human papillomavirus (HPV) has been identified as one of the most prevalent viruses that plays causative role in nearly all cervical cancers and, in addition, in subset of head and neck, anal, penile and vulvar cancers. The recent introduction of next generation sequencing (NGS) and other 'omics' approaches have resulted in comprehensive knowledge on the pathogenesis of HPV-driven tumors. Specifically, these approaches have provided detailed information on genomic HPV integration sites, disrupted genes and pathways, and common and distinct genetic and epigenetic alterations in different human HPV-associated cancers...
October 23, 2016: Oncotarget
Katharina Koppe, Klaus Rothermund
BACKGROUND AND OBJECTIVES: Previous studies have demonstrated that clinging to unattainable goals is linked to the onset of depression. The present study investigated whether symptoms of a clinical depression are adaptive in that they facilitate disengagement from unattainable goals. METHODS: A group of depressive inpatients (n = 40) was compared to a non-depressive control group (n = 38) in regard to how much time they spent on unsolvable anagrams, while controlling for group differences in the time spent on solvable anagrams...
October 18, 2016: Journal of Behavior Therapy and Experimental Psychiatry
Dror Alishekevitz, Svetlana Gingis-Velitski, Orit Kaidar-Person, Lilach Gutter-Kapon, Sandra D Scherer, Ziv Raviv, Emmanuelle Merquiol, Yael Ben-Nun, Valeria Miller, Chen Rachman-Tzemah, Michael Timaner, Yelena Mumblat, Neta Ilan, David Loven, Dov Hershkovitz, Ronit Satchi-Fainaro, Galia Blum, Jonathan P Sleeman, Israel Vlodavsky, Yuval Shaked
While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting tumor re-growth and/or metastases, thus limiting therapeutic efficacy. Here, we show that vascular endothelial growth factor receptor 3 (VEGFR3)-expressing macrophages infiltrating chemotherapy-treated tumors play a significant role in metastasis. They do so in part by inducing lymphangiogenesis as a result of cathepsin release, leading to VEGF-C upregulation by heparanase...
October 25, 2016: Cell Reports
David S Wald, Jonathan P Bestwick, Joan K Morris, Ken Whyte, Lucy Jenkins, Nicholas J Wald
Background Child-parent screening for familial hypercholesterolemia has been proposed to identify persons at high risk for inherited premature cardiovascular disease. We assessed the efficacy and feasibility of such screening in primary care practice. Methods We obtained capillary blood samples to measure cholesterol levels and to test for familial hypercholesterolemia mutations in 10,095 children 1 to 2 years of age during routine immunization visits. Children were considered to have positive screening results for familial hypercholesterolemia if their cholesterol level was elevated and they had either a familial hypercholesterolemia mutation or a repeat elevated cholesterol level 3 months later...
October 27, 2016: New England Journal of Medicine
Kelly Walker, Megan Arbour, Justin Waryold
Graduate medical, nursing, and midwifery curricula often have limited amounts of time to focus on issues related to cultural competency in clinical practice, and respectful sexual and reproductive health care for all individuals in particular. Respectful health care that addresses sexual and reproductive concerns is a right for everyone, including those who self-identify as lesbian, gay, bisexual, or transgender (LGBT). LGBT persons have unique reproductive health care needs as well as increased risks for poor health outcomes...
October 26, 2016: Journal of Midwifery & Women's Health
Nancy W Selix, Stefan Rowniak
INTRODUCTION: Transgender individuals have unique health care needs and experience health disparities. There is an increased need for transgender health care services and primary care for this underserved population. However, provision of appropriate health care services for transgender persons requires cultural competency and skill on the part of the health care provider, and providers need specific skills to address the needs of this population. METHODS: A review of the literature was performed by accessing CINAHL, PsycINFO, and PubMed databases...
October 26, 2016: Journal of Midwifery & Women's Health
Georgios N Panagopoulos, Panayiotis D Megaloikonomos, Andreas F Mavrogenis
Peripheral nerve injury can have a potentially devastating impact on a patient's quality of life, resulting in severe disability with substantial social and personal cost. Refined microsurgical techniques, advances in peripheral nerve topography, and a better understanding of the pathophysiology and molecular basis of nerve injury have all led to a decisive leap forward in the field of translational neurophysiology. Nerve repair, nerve grafting, and nerve transfers have improved significantly with consistently better functional outcomes...
October 25, 2016: Orthopedics
Mary K Donnelly, Karan S Kverno, Anne E Belcher, Lindsay R Ledebur, Linda D Gerson
BACKGROUND: Online graduate courses provide opportunities for faculty to use technology and digital applications to enhance student learning and learning environments. In nursing education, as we become increasingly dependent on technology, it is important to ensure that both faculty and students add digital literacy to their repertoire of knowledge and skills. VoiceThread(©), one type of Web-based digital application tool, allows students and faculty to verbally communicate and collaborate asynchronously...
November 1, 2016: Journal of Nursing Education
Anahi Guedes de Mello
Anthropology has increasingly questioned the hegemony of biomedical knowledge in ethical review processes of social research projects prevailing in Brazil, which was governed until 2012 by the Human Research Ethics Committee of each institution under the auspices of the National Research Ethics Commission (CONEP). This was mandated through Resolution No. 196/1996 prevailing in 2012 when this field research was conducted. The scope of this study is to recount and reflect upon the barriers to obtaining approval in 2012 for my master's research project from the Human Research Ethics Committee of the Federal University of Santa Catarina (CEP/UFSC) in Florianopolis...
October 2016: Ciência & Saúde Coletiva
Manoel Antonio Dos Santos, Maria Laura de Paula Lopes Pereira-Martins
The tasks of caregiving for children with disabilities involve contextual life stressors. The study aimed to investigate the coping strategies used by parents of children with intellectual disabilities (ID). The search included articles published between 2001 and 2015 on the PubMed, LILACS and PsycINFO databases, using the following key words: intellectual disability, coping, parents, caregivers, family. Thirteen articles were selected, the majority of which adopt a cross-sectional, comparative and quantitative approach...
October 2016: Ciência & Saúde Coletiva
Bruna Rafaela de Batista, Márcia Duarte, Fabiana Cia
The presence of a disabled person causes transformations in the family that demand a redefinition of the role of each member. Siblings, like all other members, experience frustration, acceptance, guilt and adaptation. In this respect, an attempt was made to; (a) analyze the interaction between a sibling with standard development and a sibling with Down syndrome; (b) identify what information and reaction the siblings with standard development have regarding the diagnosis of Down syndrome; (c) verify whether or not there were changes in the family context and also changes in their own lives after the birth of the sibling with Down syndrome...
October 2016: Ciência & Saúde Coletiva
Nilson do Rosário Costa, Miguel Abud Marcelino, Cristina Maria Rabelais Duarte, Deborah Uhr
The article analyzes the social protection policy for people with disabilities in Brazil. It describes the patterns of demand and eligibility for Continued Benefit of Social Assistance (Benefício de Prestação Continuada - BPC) in the 1996-2014 period. The article argues that BPC is a direct result of the social pact achieved by the Brazilian Federal Constitution of 1988. BPC is a social assistance benefit consisting in an unconditional and monthly transference of the equivalent of a minimum wage, to poor people with deficiency and elders with more than 65 years...
October 2016: Ciência & Saúde Coletiva
Nádia Xavier Moreira, Ludmila Fontenele Cavalcanti, Rodriane de Oliveira Souza
This is a qualitative study based on in-depth interviews, with the aim of analyzing the meanings associated with a social phenomenon, specifically disabilities in the military field. A total of 22 people were interviewed, 3 managers and 19 Brazilian Navy professionals responsible for coordinating, standardizing, enforcing and overseeing the Special Care Program (Programa de Assistência Especial) in Rio de Janeiro. Data was processed using the Interpretation of Meaning Approach, based on the concept of disablement and military habitus...
October 2016: Ciência & Saúde Coletiva
Éverton Luís Pereira, Livia Barbosa
This article derives from a study conducted on the validation of the Brazilian Functionality Index (IF-BrA) applied to the granting of retirement benefits to disabled persons. The retirement of persons with disabilities is regulated by Complementary Law 142 of May 8, 2013. The aim is to discuss how the individuals involved in application of the instrument perceive the concept of disability and the possible implications for ensuring the right to retirement. Eleven agencies of the National Social Security Institute (INSS) were visited and 16 physicians, 16 social workers and 40 persons with disabilities were interviewed...
October 2016: Ciência & Saúde Coletiva
Wederson Santos
This article discusses the main advances and challenges for understanding and evaluating disability as a restriction for social participation. This new understanding has its origins in the 2006 WHO International Classification of Functioning, Disability, and Health - ICF, the 2001 UN Convention on the Rights of Persons with Disabilities, and more recently, the July 2015 Brazilian Inclusion of People with Disabilities Act (IPDA), also known as the Statute on Persons with Disabilities. The change in the understanding of disability from a merely biomedical perspective, to an understanding that is based on oppression and social inequality reinforces the idea that disability is not an individual attribute, but the result of a society that is not prepared for human diversity...
October 2016: Ciência & Saúde Coletiva
Charles Dalcanale Tesser, Armando Henrique Norman
This article contends that the distinction between clinical care (illness) and prevention of future disease is essential to the practice of quaternary prevention. The authors argue that the ongoing entanglement of clinical care and prevention transforms healthy into "sick" people through changes in disease classification criteria and/or cut-off points for defining high-risk states. This diverts health care resources away from those in need of care and increases the risk of iatrogenic harm in healthy people...
October 20, 2016: Cadernos de Saúde Pública
Erica Mayumi Guskuma, Aline Alves Dos Santos Dullius, Mônica La Salette da Costa Godinho, Maria Silvana Totti Costa, Fábio de Souza Terra
Objective: report the experience of international academic mobility in Ireland through the program Science Without Borders during undergraduate education in nursing. Method: a report of experience presented in chronological order, with a descriptive nature. Results: the opportunity to know and be able to discuss questions regarding health and nursing in Ireland allowed the review of concepts and a more reflective perspective regarding nursing practices...
September 2016: Revista Brasileira de Enfermagem
Sheila Mara Pedrosa, Mary Lopes Reis, Daniela Tavares Gontijo, Sheila Araújo Teles, Marcelo Medeiros
Objective: the objective of this study was to understand the meaning of the harmful use of crack by people undergoing addiction treatment. Method: qualitative approach of social research on strategic modality was used. Field observation, preparation of field diary and focus groups, and data analysis through the method of interpreting meaning were carried out. Results: the results contributed to the construction of three thematic categories: "The discovery of crack and other drugs" that describes the experimentation with crack and other drugs; "The pain of the pleasure", key category that describes the moments after crack experimentation and that, many times, turns into addiction, which leads the person into a cycle of short periods of attempts at abstinence, relapse, and relentless consumption; and "Return to normal life"...
September 2016: Revista Brasileira de Enfermagem
Álvaro Francisco Lopes de Sousa, Artur Acelino Francisco Luz Nunes Queiroz, Layze Braz de Oliveira, Maria Eliete Batista Moura, Odinéa Maria Amorim Batista, Denise de Andrade
Objective: to understand the biosecurity social representations by primary care nursing professionals and analyze how they articulate with quality of care. Methods: exploratory and qualitative research based on social representation theory. The study participants were 36 nursing workers from primary health care in a state capital in the Northeast region of Brazil. The data were analyzed by descending hierarchical classification. Results: five classes were obtained: occupational accidents suffered by professionals; occupational exposure to biological agents; biosecurity management in primary health care; the importance of personal protective equipment; and infection control and biosecurity...
September 2016: Revista Brasileira de Enfermagem
Jorge Barros, Susana Morales, Orietta Echávarri, Arnol García, Jaime Ortega, Takeshi Asahi, Claudia Moya, Ronit Fischman, María P Maino, Catalina Núñez
Objective: To analyze suicidal behavior and build a predictive model for suicide risk using data mining (DM) analysis. Methods: A study of 707 Chilean mental health patients (with and without suicide risk) was carried out across three healthcare centers in the Metropolitan Region of Santiago, Chile. Three hundred forty-three variables were studied using five questionnaires. DM and machine-learning tools were used via the support vector machine technique. Results: The model selected 22 variables that, depending on the circumstances in which they all occur, define whether a person belongs in a suicide risk zone (accuracy = 0...
October 20, 2016: Revista Brasileira de Psiquiatria
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