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https://www.readbyqxmd.com/read/27901032/from-the-past-to-future-from-energy-expenditure-to-energy-intake-to-energy-expenditure
#1
REVIEW
M J Müller, C Geisler
Although most recent research on energy balance focusses on energy intake (EI) there is still need to think about both sides of the energy balance. Current research on energy expenditure (EE) relates to metabolic adaptation to negative energy balance, mitochondrial metabolism associated with aging, obesity and type 2 diabetes mellitus, the role of EE in hunger and appetite control, non-shivering thermogenesis and brown adipose tissue activity, cellular bioenergetics as a target of obesity treatment and the evolutionary and ecological determinants of EE in humans and other primates...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27899816/bariatric-surgery-for-obesity-and-metabolic-disorders-state-of-the-art
#2
REVIEW
Ninh T Nguyen, J Esteban Varela
Obesity is one of the most important public health conditions worldwide. Bariatric surgery for severe obesity is an effective treatment that results in the improvement and remission of many obesity-related comorbidities, as well as providing sustained weight loss and improvement in quality of life. Contemporary bariatric operations include Roux-en-Y gastric bypass, sleeve gastrectomy, adjustable gastric band and the duodenal switch. The vast majority of these procedures are now performed using laparoscopic technique, the main advantages of which include rapid recovery, the reduction of postoperative pain and the reduction of wound-related complications, compared with open surgery...
November 30, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27895819/nutrition-insulin-resistance-and-dysfunctional-adipose-tissue-determine-the-different-components-of-metabolic-syndrome
#3
REVIEW
Juan Antonio Paniagua
Obesity is an excessive accumulation of body fat that may be harmful to health. Today, obesity is a major public health problem, affecting in greater or lesser proportion all demographic groups. Obesity is estimated by body mass index (BMI) in a clinical setting, but BMI reports neither body composition nor the location of excess body fat. Deaths from cardiovascular diseases, cancer and diabetes accounted for approximately 65% of all deaths, and adiposity and mainly abdominal adiposity are associated with all these disorders...
November 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27891602/cannabimimetic-phytochemicals-in-the-diet-an-evolutionary-link-to-food-selection-and-metabolic-stress-adaptation
#4
REVIEW
Jürg Gertsch
The endocannabinoid system (ECS) is a major lipid signaling network that plays important pro-homeostatic (allostatic) roles not only in the nervous system but in peripheral organs. Increasing evidence points towards a dietary component in the modulation of the ECS. Cannabinoid receptors in hominids co-evolved with diet and the ECS constitutes a feedback loop for food selection and energy metabolism. Here it is postulated that the mismatch of ancient lipid genes of hunter-gatheres and pastoralists with the high carbohydrate diet introduced by agriculture could be compensated via dietary modulation of the ECS...
November 27, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27886704/position-of-the-academy-of-nutrition-and-dietetics-vegetarian-diets
#5
Vesanto Melina, Winston Craig, Susan Levin
It is the position of the Academy of Nutrition and Dietetics that appropriately planned vegetarian, including vegan, diets are healthful, nutritionally adequate, and may provide health benefits for the prevention and treatment of certain diseases. These diets are appropriate for all stages of the life cycle, including pregnancy, lactation, infancy, childhood, adolescence, older adulthood, and for athletes. Plant-based diets are more environmentally sustainable than diets rich in animal products because they use fewer natural resources and are associated with much less environmental damage...
December 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27884961/therapeutic-silencing-of-fat-specific-protein-27-improves-glycemic-control-in-mouse-models-of-obesity-and-insulin-resistance
#6
Cédric Langhi, Noemí Arias, Ananthi Rajamoorthi, Jeannine Basta, Richard G Lee, Ángel Baldán
Obesity is a component of the metabolic syndrome, mechanistically linked to diabetes, fatty liver disease, and cardiovascular disease. Proteins that regulate the metabolic fate of intracellular lipid droplets are potential therapeutic candidates to treat obesity and its related consequences. CIDEC (cell death-inducing DFFA-like effector C), also known in mice as Fsp27 (fat-specific protein 27), is a lipid droplet-associated protein that prevents lipid mobilization and promotes intracellular lipid storage. The consequences of complete loss of FSP27 on hepatic metabolism and on insulin resistance are controversial, as both healthy and deleterious lipodystrophic phenotypes have been reported in Fsp27-/- mice...
November 24, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27884128/a-randomised-controlled-demonstration-trial-of-multifaceted-nutritional-intervention-and-or-probiotics-the-healthy-mums-and-babies-humba-trial
#7
Karaponi Okesene-Gafa, Minglan Li, Rennae S Taylor, John M D Thompson, Caroline A Crowther, Christopher J D McKinlay, Lesley M E McCowan
BACKGROUND: Maternal obesity is associated with adverse pregnancy outcomes and has lifelong negative implications for offspring health. The Institute of Medicine recommends limited gestational weight gain (GWG) in obese women for optimal maternal and infant outcomes. However, there is a gap regarding an effective and sustainable intervention strategy to achieve this goal. The aim of the healthy mums and babies (HUMBA) demonstration trial is to assess whether a multifaceted nutritional intervention and/or an oral probiotic treatment in obese pregnant women can reduce excessive GWG and optimise pregnancy outcomes...
November 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27882862/milk-and-dairy-products-good-or-bad-for-human-health-an-assessment-of-the-totality-of-scientific-evidence
#8
REVIEW
Tanja Kongerslev Thorning, Anne Raben, Tine Tholstrup, Sabita S Soedamah-Muthu, Ian Givens, Arne Astrup
BACKGROUND: There is scepticism about health effects of dairy products in the public, which is reflected in an increasing intake of plant-based drinks, for example, from soy, rice, almond, or oat. OBJECTIVE: This review aimed to assess the scientific evidence mainly from meta-analyses of observational studies and randomised controlled trials, on dairy intake and risk of obesity, type 2 diabetes, cardiovascular disease, osteoporosis, cancer, and all-cause mortality...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27881521/is-famine-exposure-during-developmental-life-in-rural-bangladesh-associated-with-a-metabolic-and-epigenetic-signature-in-young-adulthood-a-historical-cohort-study
#9
S Finer, M S Iqbal, R Lowe, B W Ogunkolade, S Pervin, C Mathews, M Smart, D S Alam, G A Hitman
OBJECTIVES: Famine exposure in utero can 'programme' an individual towards type 2 diabetes and obesity in later life. We sought to identify, (1) whether Bangladeshis exposed to famine during developmental life are programmed towards diabetes and obesity, (2) whether this programming was specific to gestational or postnatal exposure windows and (3) whether epigenetic differences were associated with famine exposure. DESIGN: A historical cohort study was performed as part of a wider cross-sectional survey...
November 23, 2016: BMJ Open
https://www.readbyqxmd.com/read/27874274/differential-association-between-sarcopenia-and-metabolic-phenotype-in-korean-young-and-older-adults-with-and-without-obesity
#10
You-Cheol Hwang, In-Jin Cho, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
OBJECTIVE: To determine whether sarcopenia was associated with metabolic phenotype in subjects with and without obesity. METHODS: A total of 6,021 participants (2,592 men, 3,429 women) aged 30 to 93 years were assessed using data from the 2009 Korea National Health and Nutrition Examination Survey. Sarcopenia was defined as appendicular skeletal muscle mass divided by weight (%) that is <1 SD below the sex-specific mean for young adults. Metabolically unhealthy was defined as ≥2 components of metabolic syndrome or the presence of hypertension, diabetes, or cardiovascular disease...
November 22, 2016: Obesity
https://www.readbyqxmd.com/read/27874179/association-between-chewing-difficulty-and-symptoms-of-depression-in-adults-results-from-the-korea-national-health-and-nutrition-examination-survey
#11
Hye-Sun Shin, Yong-Soon Ahn, Do-Seon Lim
OBJECTIVES: To assess the association between chewing difficulty and symptoms of depression in a representative sample of the Korean population. DESIGN: Cross-sectional. SETTING: Korea National Health and Nutrition Examination Survey (KNHANES). PARTICIPANTS: KNHANES participants (N = 5,158). MEASUREMENTS: Chewing difficulty was assessed according to the self-reported presence of chewing problems using a structured questionnaire...
November 22, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27871259/prevalence-and-determinants-of-diabetes-among-older-adults-in-ghana
#12
Samwel Maina Gatimu, Benson Williesham Milimo, Miguel San Sebastian
BACKGROUND: Diabetes is one of the leading non-communicable diseases in Africa, contributing to the increasing disease burden among the old adults. Thus, the aim of this study was to determine the prevalence and determinants of diabetes among adults aged 50 years and above in Ghana. METHODS: A cross sectional study based on data collected from Study of Ageing and Adult Health (SAGE) Wave 1 from 2007 to 2008. Data was collected from 5565 respondents of whom 4135 were aged 50+ years identified using a multistage stratified clusters design...
November 21, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27864335/effects-of-maternal-obesity-on-placental-function-and-fetal-development
#13
Kristy R Howell, Theresa Powell
Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders, preterm birth and caesarian section. Children born to obese mothers are at increased risk of obesity and metabolic disease and are susceptible to develop neuropsychiatric and cognitive disorders. Changes in placental function not only play a critical role in the development of pregnancy complications but may also be involved in linking maternal obesity to long-term health risks in the infant...
November 18, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27864073/eating-behaviour-of-university-students-in-germany-dietary-intake-barriers-to-healthy-eating-and-changes-in-eating-behaviour-since-the-time-of-matriculation
#14
Jennifer Hilger, Adrian Loerbroks, Katharina Diehl
A healthy diet plays a key role in preventing obesity and non-communicable diseases such as type 2 diabetes. This is true for all age groups, including young adults. While unhealthy eating habits among young adults, in particular university students, have been identified in former studies, this group has been neglected in existing health promotion strategies. Our aim was to explore baseline dietary intake, common barriers to healthy eating, and changes in eating behaviour among university students since the time of matriculation...
November 15, 2016: Appetite
https://www.readbyqxmd.com/read/27860374/chemoprevention-of-obesity-by-dietary-natural-compounds-targeting-mitochondrial-regulation
#15
REVIEW
Ching-Shu Lai, Jia-Ching Wu, Chi-Tang Ho, Min-Hsiung Pan
Mitochondria are center stage in the control of energy homeostasis in many organs and tissue including adipose tissue. Recently, abundant evidences from experimental studies have clearly supported the strong correlation between mitochondrial dysfunction in adipocytes and obesity. Various physiological conditions, such as excessive nutrition, genetic factors, hypoxia and toxins disrupt mitochondrial function by impairing mitochondrial biogenesis, dynamics and oxidative capacity. Mitochondrial dysfunction in adipocytes could have impact on differentiation, adipogenesis, insulin sensitivity and with the significant alteration in their metabolic function, which ultimately results in obesity and type 2 diabetes...
November 16, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27855143/trends-in-obesity-among-participants-aged-2-4-years-in-the-special-supplemental-nutrition-program-for-women-infants-and-children-united-states-2000-2014
#16
Liping Pan, David S Freedman, Andrea J Sharma, Karen Castellanos-Brown, Sohyun Park, Ray B Smith, Heidi M Blanck
Childhood obesity is associated with negative health consequences in childhood (1) that continue into adulthood (2), putting adults at risk for type 2 diabetes, cardiovascular disease, and certain cancers (1). Obesity disproportionately affects children from low-income families (3). Through a collaboration with the United States Department of Agriculture (USDA), CDC has begun to use data from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) Participants and Program Characteristics (WIC PC) to replace the Pediatric Nutrition Surveillance System (PedNSS) (4,5) for obesity surveillance among young children from low-income families...
November 18, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27853041/prevalence-and-risk-factors-of-hypertension-and-diabetes-in-the-katkari-tribe-of-coastal-maharashtra
#17
M G Deo, P V Pawar, S R Kanetkar, S V Kakade
BACKGROUND AND OBJECTIVES: Urban and rural India are both going through health epidemiological transition and will soon face huge burden of noncommunicable diseases (NCDs). Information on the status of NCDs in tribals is limited. Although the prevalence of hypertension in scheduled tribes (STs) has been studied in several states by the National Nutrition Monitoring Bureau, tribe-specific data are very scanty. The objective of this study was to generate data on the status of hypertension and diabetes, the two objectively measurable NCDs in Katkaris, the dominant ST in the Raigad district of coastal Maharashtra...
November 16, 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27837039/low-risk-for-local-and-systemic-complications-after-primary-repair-of-1626-achilles-tendon-ruptures
#18
Nicholas Rensing, Brian R Waterman, Rachel M Frank, Kenneth A Heida, Justin D Orr
INTRODUCTION: Historically, Achilles tendon repairs and other surgeries about the hindfoot have demonstrated a significantly higher rate of wound healing complications and surgical site morbidity. The purpose of this study was to evaluate the comprehensive complication profile and risk factors for adverse short-term, clinical outcomes after primary repair of Achilles tendon ruptures. METHODS: Between the years 2005 and 2014, all cases of primary Achilles tendon repair (Current Procedural Terminology code 27650) entered into the National Surgical Quality Improvement Project (NSQIP) database were extracted for analysis...
November 10, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27834300/the-surmetagit-study-design-and-rationale-for-a-prospective-pan-omics-examination-of-the-gastrointestinal-response-to-roux-en-y-gastric-bypass-surgery
#19
Priscila Sala, Giliane Belarmino, Natasha Mendonça Machado, Camila Siqueira Cardinelli, Karina Al Assal, Mariane Marques Silva, Danielle Cristina Fonseca, Robson Kiyoshi Ishida, Marco Aurélio Santo, Eduardo Guimarães Hourneaux de Moura, Paulo Sakai, Ismael Francisco Mota Siqueira Guarda, Ismael Dale Cotrim Guerreiro da Silva, Agatha Sacramento Rodrigues, Carlos Alberto de Bragança Pereira, Steven Heymsfield, Joel Doré, Raquel Susana Matos de Miranda Torrinhas, Daniel Giannella-Neto, Dan Linetzky Waitzberg
OBJECTIVE: To describe the protocol of the SURgically induced Metabolic effects on the Human GastroIntestinal Tract (SURMetaGIT) study, a clinical pan-omics study exploring the gastrointestinal tract as a central organ driving remission of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGB). The main points considered in the study's design and challenges faced in its application are detailed. METHODS: This observational, longitudinal, prospective study involved collection of gastrointestinal biopsy specimens, faeces, urine, and blood from 25 obese women with T2DM who were candidates for RYGB (20 patients for omics assessment and 5 for omics validation)...
November 10, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27832763/a-comparison-of-intestinal-microbiota-in-a-population-of-low-risk-infants-exposed-and-not-exposed-to-intrapartum-antibiotics-the-baby-microbiota-of-the-intestine-cohort-study-protocol
#20
Julia Simioni, Eileen K Hutton, Elizabeth Gunn, Alison C Holloway, Jennifer C Stearns, Helen McDonald, Andrea Mousseau, Jonathan D Schertzer, Elyanne M Ratcliffe, Lehana Thabane, Michael G Surette, Katherine M Morrison
BACKGROUND: The intestinal microbiota influences metabolic, nutritional, and immunologic processes and has been associated with a broad range of adverse health outcomes including asthma, obesity and Type 2 diabetes. Early life exposures may alter the course of gut microbial colonization leading to differences in metabolic and immune regulation throughout life. Although approximately 50 % of low-risk full-term infants born in Canada are exposed to intrapartum antibiotics, little is known about the influence of this common prophylactic treatment on the developing neonatal intestinal microbiota...
November 10, 2016: BMC Pediatrics
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