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https://www.readbyqxmd.com/read/29453570/molecular-mechanisms-and-signaling-pathways-involved-in-the-nutritional-support-of-spermatogenesis-by-sertoli-cells
#1
Luís Crisóstomo, Marco G Alves, Agostina Gorga, Mário Sousa, María F Riera, María N Galardo, Silvina B Meroni, Pedro F Oliveira
Sertoli cells play a central role in spermatogenesis. They maintain the blood-testis barrier, an essential feature of seminiferous tubules which creates the proper environment for the occurrence of the spermatogenesis. However, this confinement renders germ cells almost exclusively dependent on Sertoli cells' nursing function and support. Throughout spermatogenesis, differentiating sperm cells become more specialized, and their biochemical machinery is insufficient to meet their metabolic demands. Although the needs are not the same at all differentiation stages, Sertoli cells are able to satisfy their needs...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29451419/physical-exercise-nutrition-and-hormones-three-pillars-to-fight-sarcopenia
#2
Paolo Sgrò, Massimiliano Sansone, Andrea Sansone, Stefania Sabatini, Paolo Borrione, Francesco Romanelli, Luigi Di Luigi
BACKGROUND: Sarcopenia is a pathophysiological condition diffused in elderly people; it represents a social issue due to the longer life expectancy and the growing aging population. It affects negatively quality of life and it represents a risk factor for other pathologies, such as diabetes, cardiovascular disease, and obesity. No silver bullet exists to hinder sarcopenia, but it may be counteracted by physical exercise, nutrition, and a proper endocrine milieu. Indeed, we aim to analyze the scientific literature to give to clinician effective advices to counteract sarcopenia...
February 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29450958/use-of-physician-recommended-non-pharmacological-strategies-for-hypertension-control-among-hypertensive-patients
#3
Xuefeng Liu, James Brian Byrd, Carlos J Rodriguez
This study aims to evaluate the 4 non-pharmacological strategies adopted by patients for hypertension control and patient characteristics that affect the choice of strategies. Four thousand hypertensive patients aged ≥18 years were selected from the National Health and Nutrition Examination Survey. Odds ratios of the choice of strategies were analyzed using weighted logistic models. Clinical recommendations of non-pharmacological strategies for hypertension control were relatively low. More exercise was the least frequent strategy used for hypertension control...
February 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29447091/obesity-in-pregnancy-a-comparison-of-four-national-guidelines
#4
Dana Vitner, Kristin Harris, Cynthia Maxwell, M D Farine
BACKGROUND: Obesity in pregnancy has become one of the most important challenges in obstetrical care given its prevalence and potential adverse impact on both mother and fetus. The primary objective of this descriptive review is to identify common themes and distinctions within the current recommendations for maternal obesity in the most updated version of four published national guidelines. METHODS: We reviewed the following guidelines for obesity in pregnancy: American College of Obstetricians and Gynecologists (ACOG) 2015, Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG) 2013, Royal College of Obstetrics and Gynecology (RCOG) 2010, and Society of Obstetrics and Gynecologists of Canada (SOGC) 2010...
February 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29437902/maternal-resveratrol-consumption-and-its-programming-effects-on-metabolic-health-in-offspring-mechanisms-and-potential-implications
#5
Sheng Zheng, Qianyun Feng, Jing Cheng, Jia Zheng
A growing body of evidence has clearly demonstrated that maternal nutrition can strongly determine the susceptibility to the development of metabolic diseases in offspring. With the increasing prevalence of maternal overweight, obesity, and gestational diabetes mellitus, it yields enormous burden for individual and public health. Interventions during pregnancy have been proven to be challenging, with limited efficacy and low compliance. Resveratrol, as a natural polyphenolic compound, has a wide-range of beneficial properties, including potent anti-obesogenic, anti-atherosclerotic, and anti-diabetic effects...
February 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29433770/acid-folic-and-pregnancy-a-mandatory-supplementation
#6
Morgane Valentin, Perrine Coste Mazeau, Michel Zerah, Pierre François Ceccaldi, Alexandra Benachi, Dominique Luton
Neural tube defects (NTD) occur in 0.5 to 2 per 1000 pregnancies with various handicaps for the affected child. It is now well established that folic acid deficiency (absolute or relative) is a predisposing factor to this type of malformation. Several randomized controlled trials showed that high-dose folic acid (4mg) is an essential factor for prevention of neural tube defects recurrence and significantly prevents the first occurrence of neural tube defects with a lower dose (0.4mg). Other etiologies can favor the occurrence of NTD such as MTHFR polymorphism, some antiepileptic therapies, obesity and pregestational mellitus diabetes...
February 9, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29429278/-the-relationship-between-gut-microbiota-and-diet-and-nutrition-related-diseases
#7
M Q Wang, Y Li, C H Sun
The human gastro-intestinal tract is not only the habitat of gut microbiota, but also the main place that the body gets available nutrients. Therefore, the gut microbiota of human can be inseparable associated with the human nutrition. The common technologies used among gut microbiota research included metageonomic, metatranscriptomics, metaproteomics, and metabolomics. The research of gut microbiota based on above omics methods confirmed that diets were the main factors influencing the composition and expression of gut microbiota...
February 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29428452/association-between-dietary-glycemic-index-and-knee-osteoarthritis-the-korean-national-health-and-nutrition-examination-survey-2010-2012
#8
Min Wook So, Sunggun Lee, Seong-Ho Kim
BACKGROUND: Obesity and metabolic abnormalities are important risk factors for knee osteoarthritis (KOA). Recent epidemiologic studies have found that a high glycemic index (GI) and glycemic load (GL) diet are associated with a higher risk for metabolic complications and cardiovascular mortality. OBJECTIVE: We aimed to examine the association between dietary GI, dietary GL, and KOA among Korean adults. DESIGN: This was a cross-sectional study that analyzed data obtained from the Korean National Health and Nutrition Examination Survey 2010-2012...
February 7, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29417495/effectiveness-and-safety-of-a-novel-care-model-for-the-management-of-type-2-diabetes-at-1%C3%A2-year-an-open-label-non-randomized-controlled-study
#9
Sarah J Hallberg, Amy L McKenzie, Paul T Williams, Nasir H Bhanpuri, Anne L Peters, Wayne W Campbell, Tamara L Hazbun, Brittanie M Volk, James P McCarter, Stephen D Phinney, Jeff S Volek
INTRODUCTION: Carbohydrate restriction markedly improves glycemic control in patients with type 2 diabetes (T2D) but necessitates prompt medication changes. Therefore, we assessed the effectiveness and safety of a novel care model providing continuous remote care with medication management based on biometric feedback combined with the metabolic approach of nutritional ketosis for T2D management. METHODS: We conducted an open-label, non-randomized, controlled, before-and-after 1-year study of this continuous care intervention (CCI) and usual care (UC)...
February 7, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29417450/zebrafish-as-a-model-for-toxicological-perturbation-of-yolk-and-nutrition-in-the-early-embryo
#10
REVIEW
Karilyn E Sant, Alicia R Timme-Laragy
PURPOSE OF REVIEW: Developmental toxicity assessments often focus on structural outcomes and overlook subtle metabolic differences which occur during the early embryonic period. Deviant embryonic nutrition can result in later-life disease, including diabetes, obesity, and cardiovascular disease. Prior to placenta-mediated nutrient exchange, the human embryo requires maternally supplied nutritional substrates for growth, called yolk. Here, we compare the biology of the human and zebrafish yolk and review examples of toxicant-mediated perturbation of yolk defects, composition, and utilization...
February 7, 2018: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29417016/risk-factor-of-type-2-diabetes-mellitus-among-adolescents-from-rural-area-of-india
#11
Shilpa Gaidhane, Wani Mittal, Nazli Khatib, Quazi Syed Zahiruddin, Pramita A Muntode, Abhay Gaidhane
Context: Health system is likely to encounter more adolescents with Type 2 diabetes mellitus (T2DM) as a consequence of obesity and sedentary lifestyle. Intervention at various stages of the life cycle is needed as cumulative effect of risk factors accumulated from fetal life to adult increases risk of noncommunicable disease. Aims: The aim of this study was to find out awareness regarding T2DM and distribution of risk factor for T2DM in adolescents from the rural areas of Wardha district, India...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29415895/intracellular-localization-of-diacylglycerols-and-sphingolipids-influences-insulin-sensitivity-and-mitochondrial-function-in-human-skeletal-muscle
#12
Leigh Perreault, Sean A Newsom, Allison Strauss, Anna Kerege, Darcy E Kahn, Kathleen A Harrison, Janet K Snell-Bergeon, Travis Nemkov, Angelo D'Alessandro, Matthew R Jackman, Paul S MacLean, Bryan C Bergman
BACKGROUND: Accumulation of diacylglycerol (DAG) and sphingolipids is thought to promote skeletal muscle insulin resistance by altering cellular signaling specific to their location. However,the subcellular localization of bioactive lipids in human skeletal muscle is largely unknown. METHODS: We evaluated subcellular localization of skeletal muscle DAGs and sphingolipids in lean individuals (n = 15), endurance-trained athletes (n = 16), and obese men and women with (n = 12) and without type 2 diabetes (n = 15)...
February 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29412146/predictive-factors-for-birth-weight-of-newborns-of-mothers-with-gestational-diabetes-mellitus
#13
Sara de Oliveira Corrêa da Silva, Cláudia Saunders, Lenita Zajdenverg, Luciana Novaes Moreira, Sonaly Petronilho Heidelmann, Ariane Cristine Dos Santos Pereira, Patricia de Carvalho Padilha
AIMS: To evaluate the predictive factors of birth weight (BW) of newborns of women with gestational diabetes mellitus (GDM). METHODS: A cross-sectional study was performed among pregnant women with GDM treated in a public maternity unit, Brazil. We selected 283 pregnant women, with nutritional follow-up initiated till the 28th gestational week, singleton pregnancy, without chronic diseases and with birth weight information of the newborns. The predictive factors of BW were identified by multivariate linear regression...
February 2, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29404514/serine-threonine-protein-kinase-25-antisense-oligonucleotide-treatment-reverses-glucose-intolerance-insulin-resistance-and-nonalcoholic-fatty-liver-disease-in-mice
#14
Esther Nuñez-Durán, Mariam Aghajan, Manoj Amrutkar, Silva Sütt, Emmelie Cansby, Sheri L Booten, Andrew Watt, Marcus Ståhlman, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Jan Borén, Hanns-Ulrich Marschall, Margit Mahlapuu
Nonalcoholic fatty liver disease (NAFLD) contributes to the pathogenesis of type 2 diabetes and cardiovascular disease, and patients with nonalcoholic steatohepatitis (NASH) are also at risk of developing cirrhosis, liver failure, and hepatocellular carcinoma. To date, no specific therapy exists for NAFLD/NASH, which has been recognized as one of the major unmet medical needs of the twenty-first century. We recently identified serine/threonine protein kinase (STK)25 as a critical regulator of energy homeostasis and NAFLD progression...
January 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29393863/risk-factors-for-obesity-and-overfat-among-primary-school-children-in-mashonaland-west-province-zimbabwe
#15
George Kambondo, Benn Sartorius
Associated childhood obesity risk factors are not well established in developing countries such as Zimbabwe and this information is essential for tailored intervention development. This study aimed to identify prominent risk factors for overweight/obese and overfat/obese among primary school children of Mashonaland West Province in Zimbabwe. A school-based cross-sectional study was conducted using multi-stage random cluster sampling approach (30 × 30). Bivariate and multivariable logistic regression was employed and identified the risk factors for overweight/obese and overfat/obese...
February 2, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29393817/relationship-between-paraoxonase-1-and-butyrylcholinesterase-activities-and-nutritional-status-in-mexican-children
#16
Rocío Ramírez-Jiménez, María Fernanda Martínez-Salazar, Damianys Almenares-López, Leticia Yáñez-Estrada, Antonio Monroy-Noyola
BACKGROUND: The enzymes butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are the primary bioscavenging enzymes in serum and exhibit antioxidant and anti-inflammatory activities. PON1 has been associated with diseases caused by high oxidative stress, whereas BuChE appears to be involved in the pathophysiology of the metabolic syndrome and related disorders. It has been suggested that children from rural communities in Mexico may have a predisposition to develop obesity or type 2 diabetes during adolescence or adulthood...
February 2, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29389511/position-of-the-academy-of-nutrition-and-dietetics-the-role-of-medical-nutrition-therapy-and-registered-dietitian-nutritionists-in-the-prevention-and-treatment-of-prediabetes-and-type-2-diabetes
#17
Kathaleen Briggs Early, Kathleen Stanley
It is the position of the Academy of Nutrition and Dietetics that for adults with prediabetes or type 2 diabetes, medical nutrition therapy (MNT) provided by registered dietitian nutritionists (RDNs) is effective in improving medical outcomes and quality of life, and is cost-effective. MNT provided by RDNs is also successful and essential to preventing progression of prediabetes and obesity to type 2 diabetes. It is essential that MNT provided by RDNs be integrated into health care systems and public health programs and be adequately reimbursed...
February 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29385791/the-influence-of-patients-nutritional-status-on-the-prevalence-course-and-treatment-outcomes-of-lower-limb-ischemia-an-overview-of-current-evidence
#18
Marta Spychalska-Zwolińska, Tomasz Zwoliński, Marzena Anaszewicz, Jacek Budzyński
INTRODUCTION: The association of lower limb ischemia (LLI) with disturbances in nutritional status, in respect to over- or undernutrition, is still uncertain. The aim of this study was to present the current state of knowledge on this issue. EVIDENCE ACQUISITION: Systematic review of papers published between 2006 and 2018. EVIDENCE SYNTHESIS: The literature shows inconclusive evidence regarding the impact of nutritional status on the risk, course, prognosis and outcomes of conservative and invasive treatment of LLI...
January 31, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29383535/time-spent-outdoors-activity-levels-and-chronic-disease-among-american-adults
#19
Kirsten M M Beyer, Aniko Szabo, Kelly Hoormann, Melinda Stolley
Chronic diseases-including cancer, cardiovascular diseases, and metabolic conditions such as diabetes and obesity-account for over 60% of overall global mortality. Sedentary time increases the risk for chronic disease incidence and mortality, while moderate to vigorous physical activity is known to decrease risk. Most Americans spend at least half of their time sedentary, with a trend toward increasingly sedentary lifestyles, and few Americans achieve recommended levels of physical activity. Time spent outdoors has been associated with reduced sedentary time and increased physical activity among children/youth and the elderly, but few population-based studies have examined this relationship among working age adults who may face greater constraints on active, outdoor time...
January 30, 2018: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29380304/nutritional-programming-effects-on-development-of-metabolic-disorders-in-later-life
#20
Thomas Prates Ong, Paul C Guest
Developmental programming resulting from maternal malnutrition can lead to an increased risk of metabolic disorders such as obesity, insulin resistance, type 2 diabetes and cardiovascular disorders in the offspring in later life. Furthermore, many conditions linked with developmental programming are also known to be associated with the aging process. This review summarizes the available evidence about the molecular mechanisms underlying these effects, with the potential to identify novel areas of therapeutic intervention...
2018: Methods in Molecular Biology
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