keyword
https://read.qxmd.com/read/38485530/new-formulations-of-levothyroxine-in-the-treatment-of-hypothyroidism
#21
JOURNAL ARTICLE
Pedro Iglesias
No abstract text is available yet for this article.
March 13, 2024: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/38483545/tyrosine-kinase-inhibitor-induced-hypothyroidism-mechanism-and-clinical-implications
#22
REVIEW
Zhipeng Wang, Hongsen Wang, Chen Bu, Bosu Meng, Yuhui Mu, Shouhong Gao, Wansheng Chen, Xia Tao
INTRODUCTION: Since the first experimentally proven tyrosine kinase inhibitor (TKI) imatinib was introduced in the clinical setting, TKIs have attracted widespread attention because of their remarkable therapeutic effects and improvement of survival rates. TKIs are small-molecule, multi-target, anti-cancer agents that target different tyrosine kinases and block downstream signaling. ADVERSE REACTIONS AND CONCERNS: However, with in-depth research on TKI drugs, the adverse reactions-for example, thyroid dysfunction-have become a concern and thus have attracted the attention of numerous researchers...
March 14, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38482303/efficacy-of-a-levothyroxine-dosage-regimen-based-on-serum-thyrotropin-level-for-primary-hypothyroidism-an-open-label-dose-finding-study
#23
JOURNAL ARTICLE
Abilash Nair, Jayakumari Chellamma, Anjana Gopi, Chintha Sujatha, Soumya Sarayu, P K Jabbar
BACKGROUND: There are no guidelines on individualized initial levothyroxine dosage in primary hypothyroidism. This prospective observational study was done to assess whether a predetermined dose of levothyroxine based on Thyroid Stimulating Hormone (TSH) levels would be able to make the patient euthyroid during a period of six weeks and to find other factors which influence the levothyroxine requirement. MATERIALS AND METHODS: Newly diagnosed patients with primary hypothyroidism or those patients who were not on levothyroxine therapy were divided into TSH-based groups-Group 1, 5-9...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38481919/prevalence-and-awareness-of-carpal-tunnel-syndrome-among-adults-in-tabuk-city-of-saudi-arabia-a-cross-sectional-study
#24
JOURNAL ARTICLE
Hyder Mirghani, Areej A Aljohani, Abdulmajeed S Alharbi, Bandar S Alatawi, Fahad G Alanazi, Meshary D Alzahrani, Abdulaziz S AlJohani, Yasir M Alhusayni, Hassan A Alhwiti
Background Carpal Tunnel Syndrome (CTS) is a condition when the median nerve is entrapped and compressed within the wrist. It significantly affects the quality of life and work productivity of the affected individuals. Aim This study aimed to assess the prevalence of CTS and the risk factors associated with this condition among the general population in Tabuk City, Saudi Arabia, and to explore their knowledge of the causes, manifestations, and treatment options. Methods This cross-sectional study included male and female adult residents of Tabuk City aged 18 years and above who agreed to participate in the study...
February 2024: Curēus
https://read.qxmd.com/read/38476569/severe-pulmonary-hypertension-associated-with-hypothyroidism-and-mixed-aortic-valve-disease-a-case-report
#25
Thierno Hamidou Diallo, Frederick Nana Yeboah, Raynatou Djafarou Boubacar, Raid Faraj, Keltoum Boui-Issoui, Ely Sidi Sidi Mhamed, Hanaa El Ghiati, Ibrahima Dokal Diallo, Najat Mouine, Aatif Benyass
Pulmonary hypertension is a condition characterised by elevated pulmonary arterial pressures secondary to various aetiologies; the most common ones are left heart diseases. Similarly, an association between thyroid diseases and pulmonary hypertension has been reported in some cases, but the pathophysiological relationship has not been fully elucidated. Etiological investigation is an important step in the management of pulmonary hypertension and determines the appropriate treatment. In this report, we present a case of severe pulmonary hypertension in a 57-year-old woman, in which mixed aortic valve disease and hypothyroidism were involved...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38476426/factors-predicting-outcomes-of-endoscopic-endonasal-approach-in-craniopharyngioma-patients
#26
JOURNAL ARTICLE
Chin Taweesomboonyat, Raywat Noiphithak, Pree Nimmannitya, Sakchai Sae-Heng
OBJECTIVES: Endoscopic endonasal approach (EEA) is commonly used for resection of craniopharyngioma (CP). Treatment outcomes of EEA for CP were related to numerous factors; however, they have been evaluated in few studies. The objective of this study is to investigate factors associated with the outcomes of CP following this operation. MATERIALS AND METHODS: The records of patients with CP, who underwent EEA at our institution from January 2014 to June 2022, were retrospectively reviewed...
2024: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38470079/evaluation-of-efficacy-and-safety-of-vitiligo-treatment-with-micro-needling-combined-with-n-acetylcysteine-and-micro-needling-alone-a-double-blinded-randomized-controlled-clinical-trial
#27
JOURNAL ARTICLE
Najmolsadat Atefi, Elham Ziaeifar, Farnoosh Seirafianpour, Afsaneh Sadeghzadeh-Bazargan, Nazila Ghoreishi Amin, Samaneh Mozafarpoor, Abolfazl Abouie, Mohammad Amin Jafari, Azadeh Goodarzi
INTRODUCTION: Vitiligo is a skin pigmentation disorder caused by the selective degradation of melanocytes. This study investigates the therapeutic effects of microneedling with and without N-acetylcysteine (NAC) in patients with persistent and limited vitiligo. METHOD: This research employed a clinical trial design with double-blind randomization. Individuals affected by vitiligo and seeking treatment at Rasool Akram Medical Complex were divided into two separate treatment groups...
March 12, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38465761/pediatric-psoriasis-associated-with-van-wyk-grumbach-syndrome-a-case-report
#28
JOURNAL ARTICLE
Asma Marzouk, Rania Mezzi, Saida Zelfani, Nour Jelaila, Saad Ayeb, Asma Bouaziz
INTRODUCTION: Psoriasis is a common chronic inflammatory condition, often beginning in childhood in approximately one-third of cases. It can be associated with various other autoimmune diseases such as rheumatoid arthritis, celiac disease, and thyroid disorders. However, its co-occurrence with Van Wyk Grumbach syndrome has not been described in the pediatric population. This syndrome, resulting from untreated hypothyroidism, is characterized by early puberty and ovarian cysts. OBSERVATION: A 15-year-old adolescent with a diagnosis of psoriasis since the age of 9 presented with chronic constipation and headaches...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38465442/ectopic-lingual-thyroid-with-subclinical-hypothyroidism-in-children
#29
Se Jin An, Min Hyung Cho, Young Suk Shim, Hae Sang Lee, Jin Soon Hwang
OBJECTIVES: Lingual thyroid is a rare condition that affects approximately 1 in 100,000 individuals. Although it is usually detected in the pediatric population through newborn screening tests or evaluation of congenital hypothyroidism, there are cases in which it remains undetected until adulthood or until symptoms arise because of glandular enlargement. The possible symptoms of lingual thyroid include foreign body sensation in the throat, dysphagia, dyspnea, and hemorrhage. Several cases of lingual thyroid are asymptomatic and accompanied by subclinical hypothyroidism...
March 12, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38463080/myasthenic-crisis-induced-takotsubo-cardiomyopathy-a-case-report
#30
Janak Khadka, Pravesh Bhattarai, Apsara Adhikari, Rajat Acharya, Parash Rayamajhi
INTRODUCTION AND IMPORTANCE: Myasthenic crisis (MC) is characterized by severe weakness in the bulbar and respiratory muscles. Takotsubo cardiomyopathy (TC) is a rare clinical entity mainly associated with postmenopausal women. We report a case of both these conditions in a premenopausal woman. CASE PRESENTATION: A 31-year-old woman with hypothyroidism presented with dyspnea. Bedside echocardiography in the ICU revealed an apical ballooning with an ejection fraction of 25%, and she was treated with losartan, furosemide, and spironolactone...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38462996/use-of-thyroid-hormones-in-hypothyroid-and-euthyroid-patients-a-survey-of-members-of-the-endocrine-society-of-australia
#31
JOURNAL ARTICLE
Nicole Lafontaine, Suzanne J Brown, Petros Perros, Enrico Papini, Endre V Nagy, Roberto Attanasio, Laszlo Hegedüs, John P Walsh
OBJECTIVE: Hypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients. DESIGN AND PARTICIPANTS: Members of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire...
March 11, 2024: Clinical Endocrinology
https://read.qxmd.com/read/38459620/megalencephaly-secondary-to-a-novel-germline-missense-variant-p-asp322tyr-in-akt3-associated-with-growth-hormone-deficiency-and-central-hypothyroidism-a-case-report
#32
E Renard, C Bonnet, M Di Patrizio, E Schmitt, A C Madkaud, C Chabot, M Kuchenbuch, L Lambert
Germline gain of function variations in the AKT3 gene cause brain overgrowth syndrome with megalencephaly and diffuse bilateral cortical malformations. Here we report a child with megalencephaly, who is a carrier of a novel heterozygous missense variant in the AKT3 gene NM_005465.7:c.964G>T,p.Asp322Tyr. The phenotype of this patient is associated with pituitary deficiencies diagnosed at 2 years of age: growth hormone (GH) deficiency responsible for growth delay and central hypothyroidism. After 6 months of GH treatment, intracranial hypertension was noted, confirmed by the observation of papilledema and increased intracranial pressure, requiring the initiation of acetazolamide treatment and the discontinuation of GH treatment...
March 8, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38459507/sarcoid-like-reaction-and-hypothyroidism-induced-by-pd-1-inhibitor-treatment-in-metastatic-renal-cell-carcinoma-a-case-report-and-literature-review
#33
JOURNAL ARTICLE
Oadi N Shrateh, Yazan Abugharbieh, Yousef Abu Asbeh, Hani Hour, Iyad Awad, Sami Bannoura
BACKGROUND: Pembrolizumab is among the approved treatments for a variety of cancer types, including clear cell renal cell carcinoma (ccRCC). It has contributed to enhancing the prognosis of renal cell carcinoma. However, it is essential to be aware of the numerous potential immune-related side effects associated with its use. CASE PRESENTATION: A 69-year-old patient with a history of metastatic renal cell carcinoma has been undergoing treatment with Pembrolizumab, an immune checkpoint inhibitor...
March 8, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38455622/normal-intellectual-ability-and-hyperprolactinemia-as-unique-clinical-manifestations-of-congenital-hypothyroidism-a-case-report-and-review-of-hypotheses
#34
JOURNAL ARTICLE
Putri O Zulfa, Maulina Debbyousha, Krishna W Sucipto, Agustia S Ekadamayanti, Sarah Firdausa, Hendra Zufry
Congenital hypothyroidism is the deficiency of thyroid hormone in infants and hyperprolactinemia is frequently observed. Previously reported cases typically involve intellectual disability, highlighting this particular unique case report to the first reported patient demonstrating normal intellectual ability despite experiencing growth and gonad dysfunction. This study aims to present a case and review medical hypotheses related to the patient's condition. A 19-year-old female presented with a chief complaint of irregular menstruation for up to 40 days or not occurring at all...
December 2023: Narra J
https://read.qxmd.com/read/38449850/analysis-of-dose-tsh-response-effect-of-levothyroxine-soft-gel-formulation
#35
JOURNAL ARTICLE
Pierpaolo Trimboli, Tommaso Piticchio, Zeno Dadda, Ilaria Stramazzo, Elena Gamarra, Lorenzo Ruinelli, Camilla Virili
BACKGROUND: Hypothyroidism is treated with daily levothyroxine (LT4). In recent years, soft gel caps of LT4 (LT4-C) have been commercialized, and their performance has been optimized. Since guidelines recommend dose LT4 according to the tablet preparation efficacy, the present study was undertaken to obtain data about the daily requirement, normalized per body weight, of LT4-C. METHODS: Patients undergoing LT4-C after total thyroidectomy and radioiodine treatment for differentiated thyroid carcinoma were selected...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38440934/blood-pressure-in-hyperthyroid-cats-before-and-after-radioiodine-treatment
#36
JOURNAL ARTICLE
Lisa Stammeleer, Pilar Xifra, Sara I Serrano, Mark Rishniw, Sylvie Daminet, Mark E Peterson
BACKGROUND: Hyperthyroid cats commonly have systemic hypertension, with a reported prevalence of 7% to 48%. Although hypertension might be expected to resolve once treatment restores euthyroidism, it can persist or only first develop after treatment. OBJECTIVES: To determine the proportion of hyperthyroid cats with hypertension (systolic blood pressure [SBP] ≥160 mm Hg), persistence or first development of hypertension after successful radioiodine treatment, and correlation of post-treatment hypertension with azotemia or hypothyroidism...
March 5, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38440556/advances-in-lingual-thyroid-management-using-coblation-technology-a-case-series-study
#37
JOURNAL ARTICLE
Divya Nayani, Sampath Kumar Singh, K V N Durga Prasad, Rahul Kumar Rahul Pitale Ashok
Lingual thyroid is a rare, abnormal ectopic thyroid tissue seen at the base of the tongue. It is a rare embryological anomaly caused by the failure of the descendence of the thyroid gland from the foramen caecum to its normal prelaryngeal area. The main aim of our study is to discuss recent advancements in the management of lingual thyroid using coblation technology. We are discussing the prospective study of 12 lingual thyroid cases that came to the government ENT hospital, Koti, in Hyderabad, from July 2016 to July 2023...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38440229/the-clinical-outcome-of-pembrolizumab-for-patients-with-recurrent-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck-a-single-center-real-world-study-in-china
#38
JOURNAL ARTICLE
Zongyu Fan, Rongrong Hui, Houyu Ju, Yunteng Wu, Xuhui Ma, Hao Song, Yang Liu, Mengyu Rui, Xinrong Geng, Minqi Zhao, Yingye Xin, Dongliang Wei, Guoxin Ren
BACKGROUND: The KEYNOTE-048 and KEYNOTE-040 study have demonstrated the efficacy of pembrolizumab in recurrent or metastatic squamous cell carcinoma of the head and neck (R/M HNSCC), we conducted this real-world study to investigate the efficacy of pembrolizumab in patients with R/M HNSCC. METHODS: This is a single-center retrospective study conducted in the Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Shanghai, China)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38440203/a-multifaceted-approach-to-seizure-management-in-a-patient-with-down-syndrome-obstructive-sleep-apnea-and-hypothyroidism-a-case-report
#39
Takafumi Uchi, Shingo Konno, Hideo Kihara, Hideki Sugimoto
In this case study, a 16-year-old male with Down syndrome (DS) faced persistent nocturnal seizures despite anti-seizure medications and treatment for concurrent hypothyroidism. Obstructive sleep apnea (OSA), a common issue in patients with Down syndrome, was revealed as a trigger of the seizures. The implementation of continuous positive airway pressure (CPAP) therapy along with medication adjustments led to a significant decrease in seizure frequency, highlighting the importance of a comprehensive approach to seizure management in patients with complex medical conditions...
March 2024: Curēus
https://read.qxmd.com/read/38439728/sars-cov-2-infection-in-pemphigus-vulgaris-two-weeks-after-rituximab-therapy-with-total-recovery-a-case-report
#40
JOURNAL ARTICLE
Lili Róbert, Anikó Kovács, Miklós Sárdy, Melinda Fábián
The mortality risk factors for Corona Virus Disease-19 (COVID-19) infection (caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)) include advanced age, male sex, certain comorbidities, and immunosuppression (1). Pemphigus vulgaris is a rare mucocutaneous autoimmune disease with autoantibodies against desmosomal desmoglein-1 and desmoglein-3, resulting in acantholysis and blister formation. This epithelial barrier defect increases susceptibility to infections, which may lead to relapses (2)...
December 2023: Acta Dermatovenerologica Croatica: ADC
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