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https://www.readbyqxmd.com/read/28437751/effects-of-picrotoxin-on-zebrafish-larvae-behaviors-a-comparison-study-with-ptz
#1
Xue Yang, Jia Lin, Xiaolan Peng, Qin Zhang, Yinglan Zhang, Ning Guo, Shuizhen Zhou, Qiang Li
Larval zebrafish (Danio rerio) have been suggested as a high-throughput experimental animal model for epilepsy-related genetic and developmental studies. The behavioral manifestations in response to the seizure-inducing drugs picrotoxin (PTX) (1, 5, 25, 125, or 625μM) or pentylenetetrazole (PTZ) (1, 2, 4, 8, or 16mM) under light-dark conditions were studied using zebrafish larvae at 5days post-fertilization (dpf). Two behavioral parameters, locomotor activity and thigmotaxis behavior, were analyzed. We conclude that high concentrations of PTX treatment increased locomotion and thigmotaxis in 5 dpf zebrafish larvae under continuous illumination and the locomotion of PTX-treated zebrafish was decreased under the dark condition...
April 21, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28437680/how-durable-is-the-effect-of-low-intensity-cbt-for-depression-and-anxiety-remission-and-relapse-in-a-longitudinal-cohort-study
#2
Shehzad Ali, Laura Rhodes, Omar Moreea, Dean McMillan, Simon Gilbody, Chris Leach, Mike Lucock, Wolfgang Lutz, Jaime Delgadillo
BACKGROUND: Depression and anxiety disorders are relapse-prone conditions, even after successful treatment with pharmacotherapy or psychotherapy. Cognitive behavioural therapy (CBT) is known to prevent relapse, but there is little evidence of the durability of remission after low intensity forms of CBT (LiCBT). METHOD: This study aimed to examine relapse rates 12 months after completing routinely-delivered LiCBT. A cohort of 439 LiCBT completers with remission of symptoms provided monthly depression (PHQ-9) and anxiety (GAD-7) measures during 12 months after treatment...
April 18, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28437668/genome-wide-association-study-of-treatment-response-to-venlafaxine-xr-in-generalized-anxiety-disorder
#3
Jeesun Jung, Elisabeth A Tawa, Christine Muench, Allison D Rosen, Karl Rickels, Falk W Lohoff
We conducted the first genome-wide association study (GWAS) in Generalized Anxiety Disorder (GAD) to identify potential predictors of venlafaxine XR treatment outcome. Ninety-eight European American patients participated in a venlafaxine XR clinical trial for GAD, with Hamilton Anxiety Scale (HAM-A) response/remission at 24 weeks as the primary outcome measure. All participants were genotyped with the Illumina PsychChip, and 266,820 common single nucleotide polymorphisms (SNPs) were analyzed. Although no SNPs reached genome-wide significance, 8 SNPs were marginally associated with treatment response/remission and HAM-A reduction at week 12 and 24 (p<0...
April 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28437171/psychological-benefits-of-yoga-for-female-inmates
#4
Yoika Danielly, Colin Silverthorne
Female inmates involved in the Yoga Prison Project at two correctional facilities in South Carolina served as subjects. Inmates were selected from those who applied to participate in a ten-week trauma-focused yoga program. To create control and experimental groups, inmates who requested to participate were randomly assigned to be in the class (Treatment Group, n = 33) or a waitlist (Control Group, n = 17). Inmates on the waitlist subsequently joined the next class, so all who applied and were eligible participated in a yoga class...
April 24, 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/28437147/comparison-of-two-types-of-meditation-on-patients-psychosocial-responses-during-radiation-therapy-for-head-and-neck-cancer
#5
Gisela Boxleitner, Shelley Jolie, Dana Shaffer, Nicholas Pasacreta, Mei Bai, Ruth McCorkle
OBJECTIVES: Radiation treatment for head and neck cancer introduces adaptive demands and subjects patients to significant and unique psychosocial challenges. There is growing evidence that meditation is useful in lessening anxiety and depression in cancer patients. This study compared the effects of two types of meditation training on the psychological responses of patients with head and neck cancer during radiation therapy. DESIGN: Randomized clinical trial. SETTING: Smilow Cancer Hospital at Yale New Haven...
February 17, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28436999/clinical-practice-guidelines-on-the-evidence-based-use-of-integrative-therapies-during-and-after-breast-cancer-treatment
#6
REVIEW
Heather Greenlee, Melissa J DuPont-Reyes, Lynda G Balneaves, Linda E Carlson, Misha R Cohen, Gary Deng, Jillian A Johnson, Matthew Mumber, Dugald Seely, Suzanna M Zick, Lindsay M Boyce, Debu Tripathy
Answer questions and earn CME/CNE Patients with breast cancer commonly use complementary and integrative therapies as supportive care during cancer treatment and to manage treatment-related side effects. However, evidence supporting the use of such therapies in the oncology setting is limited. This report provides updated clinical practice guidelines from the Society for Integrative Oncology on the use of integrative therapies for specific clinical indications during and after breast cancer treatment, including anxiety/stress, depression/mood disorders, fatigue, quality of life/physical functioning, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep disturbance...
April 24, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28436756/the-role-of-attachment-style-in-interpersonal-psychotherapy-for-depressed-adolescents
#7
Meredith Gunlicks-Stoessel, Ana Westervelt, Kristina Reigstad, Laura Mufson, Susanne Lee
OBJECTIVE(S): This study examined changes in depressed adolescents' reports of attachment anxiety and avoidance with interpersonal psychotherapy (IPT-A), and the relationship between attachment style and change in depression with IPT-A. METHOD: Forty adolescents (aged 12-17) participated in a 16-week randomized clinical trial of 4 adaptive treatment strategies for adolescent depression that began with IPT-A and augmented treatment for insufficient responders (n = 22) by adding additional IPT-A sessions (n = 11) or the antidepressant medication, fluoxetine (n = 11)...
April 24, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28436695/the-impact-of-childhood-parental-quality-on-mental-health-outcomes-in-older-adults
#8
R A Burns, V Loh, J E Byles, H L Kendig
OBJECTIVE: Parental bonding is cited as a determinant of mental health outcomes in childhood, adolescence and early-mid adulthood. Examination of the long-term impact for older adults is limited. We therefore examine the long-term risk of perceived poor parental bonding on mental health across the lifespan and into early-old age. METHODS: Participants (N = 1255) were aged 60-64 years of age and drawn from the Australian Life Histories and Health study. Quality of parental bonding was assessed with the Parental Bonding Instrument (PBI)...
April 24, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28436583/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#9
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
April 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28436547/are-type-d-personality-and-depression-predictors-of-anxiety-and-posttraumatic-stress-symptoms-among-icd-patients
#10
EDITORIAL
Jessica Ford
The literature surrounding posttraumatic stress symptoms (PSS) and anxiety among patients living with implantable cardioverter defibrillators (ICD) is becoming increasingly sophisticated with evidence linking traumatic stress and anxiety to cardiovascular outcomes, examinations of psychosocial treatment of PSS and anxiety, and predictive modeling all contributing to a more nuanced understanding of the predictors, course, and treatment of PSS and anxiety among ICD patients. In this issue of PACE, Habibovic, Denollet, and Pedersen report secondary analyses from the WEBCARE trial data in which the author employed Latent Class Analysis (LCA) to identify trajectories of trauma and anxiety symptoms among patients implanted with ICDs across the 12-month post-implant period and examined associations between the identified trajectories and demographic, clinical, and psychological characteristics of the participants...
April 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28436445/cortical-thickness-and-subcortical-gray-matter-volume-in-pediatric-anxiety-disorders
#11
Andrea L Gold, Elizabeth R Steuber, Lauren K White, Jennifer Pacheco, Jessica F Sachs, David Pagliaccio, Erin Berman, Ellen Leibenluft, Daniel S Pine
Perturbations in the prefrontal cortex (PFC), hippocampus, and amygdala are implicated in the development of anxiety disorders. However, most structural neuroimaging studies of patients with anxiety disorders utilize adult samples, and the few studies in youths examine small samples, primarily with volume-based measures. This study tested the hypothesis that cortical thickness of PFC regions and gray matter volume of the hippocampus and amygdala differ between pediatric anxiety disorder patients and healthy volunteers (HVs)...
April 24, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28436351/reactivity-to-unpredictable-threat-as-a-treatment-target-for-fear-based-anxiety-disorders
#12
S M Gorka, L Lieberman, H Klumpp, K L Kinney, A E Kennedy, O Ajilore, J Francis, J Duffecy, M G Craske, J Nathan, S Langenecker, S A Shankman, K L Phan
BACKGROUND: Heightened reactivity to unpredictable threat (U-threat) is a core individual difference factor underlying fear-based psychopathology. Little is known, however, about whether reactivity to U-threat is a stable marker of fear-based psychopathology or if it is malleable to treatment. The aim of the current study was to address this question by examining differences in reactivity to U-threat within patients before and after 12-weeks of selective serotonin reuptake inhibitors (SSRIs) or cognitive-behavioral therapy (CBT)...
April 24, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28435973/acclimatization-to-middle-altitude-hypoxia-protects-against-developmental-and-cognitive-deficits-caused-by-acute-fetal-hypoxia-in-mice
#13
Hui-Lang Liu, Yong-Mei Sun, Chuan-Yu Li, Hai-Chen Niu, Min Su, Jing-Kun Wang
Acute fetal hypoxia (AFH) can elicit postnatal motor deficits and cognitive impairments. To test whether lifelong acclimatization to middle altitude (MA) hypoxia has protective effects on the impairments caused by AFH, ICR mice bred at 1 900 m altitude for 6-7 generations were evaluated under AFH. On gestation day 9 (GD 9), 13 (GD 13) or 17 (GD 17), pregnant mice received a single exposure to acute hypoxia (7% O2, 6 h). Physiological and neurodevelopmental behaviors, motor function (open field), spatial learning and memory (Morris water maze), and anxiety level (elevated plus maze) were examined in the offspring from neonate to adulthood...
April 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28435819/psychological-disorders-among-iranian-infertile-couples-undergoing-assisted-reproductive-technology-art
#14
Mansoureh Karimzadeh, Nasser Salsabili, Firouzeh Akbari Asbagh, Robab Teymouri, Golamreza Pourmand, Tahereh Soleimanieh Naeini
BACKGROUND: Worldwide, infertility affects 10%-15% of couples and most of them seek medical help including Assisted Reproductive Technology (ART) treatments. Undergoing ART treatments create many physical and emotional burdens. This study examined the psychological consequences of infertility in Iranian infertile males and females as well as their spouses, unlike previous studies that examined mainly females with infertility. METHODS: Subjects in this descriptive analytical design were recruited from the IVF Department of Mirza Koochak Khan Hospital and the Rouyesh Infertility Treatment Center of Tehran, Iran between Aug 2014 and Sep 2015...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28435465/hypertension-cerebrovascular-impairment-and-cognitive-decline-in-aged-a%C3%AE-pp-ps1-mice
#15
Maximilian Wiesmann, Valerio Zerbi, Diane Jansen, Dieter Lütjohann, Andor Veltien, Arend Heerschap, Amanda J Kiliaan
Cardiovascular risk factors, especially hypertension, are also major risk factors for Alzheimer's disease (AD). To elucidate the underlying vascular origin of neurodegenerative processes in AD, we investigated the relation between systolic blood pressure (SBP) cerebral blood flow (CBF) and vasoreactivity with brain structure and function in a 16-18 months old double transgenic AβPPswe/PS1dE9 (AβPP/PS1) mouse model for AD. These aging AβPP/PS1 mice showed an increased SBP linked to a declined regional CBF...
2017: Theranostics
https://www.readbyqxmd.com/read/28435216/pain-perception-description-after-advanced-surface-ablation
#16
Eva M Sobas, Sebastián Videla, Amanda Vázquez, Itziar Fernández, Miguel J Maldonado, José-Carlos Pastor
PURPOSE: The objective of this study was to characterize the evolution of ocular pain after advanced surface ablation (ASA) to improve strategies in postoperative pain management. METHODS: This was a multicenter, prospective, descriptive, cohort study. The inclusion criteria were healthy individuals ≥18 years old receiving bilateral alcohol-assisted surface ablation with epithelial removal. Pain intensity was evaluated with the visual analog scale (VAS) and the numeric pain rating scale before and after surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28434623/does-unilateral-insular-resection-disturb-personality-a-study-with-epileptic-patients
#17
Benjamin Hébert-Seropian, Olivier Boucher, Carole Sénéchal, Isabelle Rouleau, Alain Bouthillier, Franco Lepore, Dang Khoa Nguyen
The insula is now regarded as a potential site of epileptogenesis in drug-resistant epilepsy, and the advent of microsurgical techniques has allowed insular cortectomy to become a treatment of choice when the insular cortex is involved in the seizure focus. However, considering the evidence of an insular role in socio-emotional processing, it remains unknown whether these cortical resections disturb personality and social behavior as experienced in daily life. We examined such changes in a group of patients (n=19) who underwent epilepsy surgery involving partial or complete resection of the insula, and compared them to a group of patients who underwent standard temporal lobe epilepsy (TLE) surgery (n=19) as a lesion-control group...
April 20, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28434095/patient-reported-outcomes-in-cancer-survivors-a-population-wide-cross-sectional-study
#18
Michael Jefford, Andrew C Ward, Karolina Lisy, Karen Lacey, Jon D Emery, Adam W Glaser, Hannah Cross, Mei Krishnasamy, Sue-Anne McLachlan, Jim Bishop
PURPOSE: There is a lack of robust population-based data regarding the lived experience of cancer survivors. This study assessed the quality of life (QoL) of survivors of breast, colorectal, or prostate cancer, non-Hodgkin lymphoma or melanoma 1, 3 and 5 years post-diagnosis. Associations between various demographic and disease-related factors and QoL were assessed. METHODS: A cross-sectional postal survey was undertaken. Eligible participants were identified from a population-based cancer registry...
April 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28434091/continued-bullying-victimization-in-adolescents-maladaptive-schemas-as-a-mediational-mechanism
#19
Esther Calvete, Liria Fernández-González, Joaquín M González-Cabrera, Manuel Gámez-Guadix
Bullying victimization in adolescence is a significant social problem that can become persistent over time for some victims. However, there is an overall paucity of research examining the factors that contribute to continued bullying victimization. Schema therapy proposes a model that can help us understand why bullying victimization can be persistent for some victims. This study examines the role of maladaptive schemas, the key concept in schema therapy, as a mechanism of continued bullying victimization. The hypothesis was that maladaptive schemas of rejection mediate the predictive association between victimization in both the family and at school and future bullying victimization...
April 22, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28433854/comorbidity-age-of-onset-and-suicidality-in-obsessive-compulsive-disorder-ocd-an-international-collaboration
#20
V Brakoulias, V Starcevic, A Belloch, C Brown, Y A Ferrao, L F Fontenelle, C Lochner, D Marazziti, H Matsunaga, E C Miguel, Ycj Reddy, M C do Rosario, R G Shavitt, A Shyam Sundar, D J Stein, A R Torres, K Viswasam
OBJECTIVES: To collate data from multiple obsessive-compulsive disorder (OCD) treatment centers across seven countries and five continents, and to report findings in relation to OCD comorbidity, age of onset of OCD and comorbid disorders, and suicidality, in a large clinical and ethnically diverse sample, with the aim of investigating cultural variation and the utility of the psychiatric diagnostic classification of obsessive-compulsive and related disorders. METHODS: Researchers in the field of OCD were invited to contribute summary statistics on current and lifetime psychiatric comorbidity, age of onset of OCD and comorbid disorders and suicidality in their patients with OCD...
April 12, 2017: Comprehensive Psychiatry
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