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https://www.readbyqxmd.com/read/28545164/loss-of-appendicular-muscle-mass-in-haemodialysis-patients-is-associated-with-increased-self-reported-depression-anxiety-and-lower-general-health-scores
#1
Helen Alston, Aine Burns, Andrew Davenport
AIMS: Depressive symptoms are commonly reported by haemodialysis (HD) patients. Previous reports have suggested an association between depression and nutritional status. To investigate this, we measured muscle mass in HD patients screened for depression. METHODS: The Beck Depression Inventory-II (BDI-II), Hospital Anxiety and Depression Scale (HADS) were used to screen for depression, and quality of life assessed by the short form 36 (SF36), and measured appendicular lean mass (ALM) post-dialysis with segmental bioimpedance...
May 25, 2017: Nephrology
https://www.readbyqxmd.com/read/28545069/behavioral-alterations-are-associated-with-vitamin-b12-deficiency-in-the-transcobalamin-receptor-cd320-ko-mouse
#2
Kaveri Arora, Jeffrey M Sequeira, Alejandro I Hernández, Juan M Alarcon, Edward V Quadros
Vitamin B12 (cobalamin) deficiency is prevalent worldwide and causes megaloblastic anemia and neurologic deficits. While the anemia can be treated, the neurologic deficits can become refractive to treatment as the disease progresses. Therefore, timely intervention is critical for a favorable outcome. Moreover, the metabolic basis for the neuro-pathologic changes and the role of cobalamin deficiency in the pathology still remains unexplained. Using a transcobalamin receptor / CD320 knockout mouse that lacks the receptor for cellular uptake of transcobalamin bound cobalamin, we aimed to determine whether cobalamin deficiency in the central nervous system produced functional neurologic deficits in the mouse that would parallel those observed in humans...
2017: PloS One
https://www.readbyqxmd.com/read/28545063/financial-distress-in-patients-with-advanced-cancer
#3
Cécile Barbaret, Christelle Brosse, Wadih Rhondali, Murielle Ruer, Léa Monsarrat, Patrick Michaud, Anne Marie Schott, Marvin Delgado-Guay, Eduardo Bruera, Stéphane Sanchez, Marilène Filbet
PURPOSE: We examined the frequency and severity of financial distress (FD) and its association with quality of life (QOL) and symptoms among patients with advanced cancer in France. DESIGN: In this cross-sectional study, 143 patients with advanced cancer were enrolled. QOL was assessed using the Functional Assessment of Cancer General (FACT-G) and symptoms assessed using Edmonton Assessment System (ESAS) and Hospital Anxiety and Depression Scale (HADS). FD was assessed using a self-rated numeric scale from 0 to 10...
2017: PloS One
https://www.readbyqxmd.com/read/28544581/a-comparison-of-the-pharmacokinetics-of-methylphenidate-extended-release-orally-disintegrating-tablets-with-a-reference-extended-release-formulation-of-methylphenidate-in-healthy-adults
#4
Ann Childress, Jeffrey G Stark, Russ McMahen, Dorothy Engelking, Carolyn Sikes
Extended-release (ER) methylphenidate (MPH) is a first-line treatment for attention-deficit/hyperactivity disorder. A methylphenidate extended-release orally disintegrating tablet (MPH XR-ODT) has recently been developed. This was a randomized, open-label, 3-period, 3-treatment study comparing the bioavailability and absorption of 2 MPH XR-ODT formulations with an MPH ER reference medication. Here we report the 2 treatments comparing the commercial MPH XR-ODT formulation and reference medication. Following a ≥10-hour fast, 42 healthy adults received 60 mg of reference medication or MPH XR-ODT (2 × 30 mg)...
May 25, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28544343/levels-of-anxiety-in-parents-in-the-24-h-before-and-after-their-child-s-surgery-a-descriptive-study
#5
Laura Pomicino, Elena Maccacari, Sara Buchini
AIMS AND OBJECTIVES: To: a. investigate pre and post-operative anxiety levels in parents of surgical patients; b. identify factors that affect parental anxiety; c. analyze assistance provided and overall parental satisfaction in order to assess if and how this aspect can impact their anxiety level. BACKGROUND: Surgery as an event generates anxiety in children and their parents. Children who are anxious before surgery are likely to develop more postoperative psychological and physiological complications than those who are not...
May 25, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28544085/e-tc-development-and-pilot-testing-of-a-web-based-intervention-to-reduce-anxiety-and-depression-in-survivors-of-testicular-cancer
#6
L E Heiniger, A B Smith, I Olver, P Grimison, B Klein, A Wootten, J-A M Abbott, M A Price, M McJannett, B Tran, M R Stockler, H Gurney, P N Butow
e-TC is an online intervention designed to address common psychosocial concerns of testicular cancer survivors. It aims to reduce anxiety, depression and fear of cancer recurrence by providing evidence-based information and psychological intervention. This paper details the development and pilot testing of e-TC. During pilot testing, 25 men (with varying psychological profiles) who had completed treatment for testicular cancer, 6 months to 5 years ago (which had not recurred), used e-TC over a 10-week period and provided quantitative and qualitative feedback on the feasibility and acceptability of the programme...
May 22, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28544024/contribution-of-perceived-cognitive-functioning-to-quality-of-life-in-service-members-and-veterans-with-posttraumatic-stress-disorder
#7
Noah D Silverberg, Magdalena Wojtowicz, Eric Bui, Rebecca Wershba, Ross Zafonte, Lauren M Laifer, Naomi M Simon, Grant L Iverson
Perceived cognitive impairment is a core clinical feature of posttraumatic stress disorder (PTSD) and may be an important determinant of quality of life (QOL) in those who suffer from this disorder. Using a clinical data repository, we evaluated this hypothesis in a cross-sectional sample of U.S. military service members and veterans who served after September 11, 2001, and were seeking mental health treatment at a tertiary outpatient clinic. A consecutive series of 117 patients with a clinical diagnosis of PTSD completed a battery of questionnaires at intake, including the PTSD Checklist (Weathers, Litz, Herman, Huska, & Keane, 1993), a 4-item Cognitive Symptom subscale of the Neurobehavioral Symptom Inventory (Cicerone & Kalmar, 1995), the Depression Anxiety Stress Scale-21 (Lovibond & Lovibond, 1995), and the Quality of Life Enjoyment and Satisfaction Questionnaire (Endicott, Nee, Harrison, & Blumenthal, 1993)...
May 19, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28542911/changes-in-patient-quality-of-life-during-oral-immunotherapy-for-food-allergy
#8
Na'ama Epstein Rigbi, Michael R Goldberg, Michael B Levy, Liat Nachshon, Keren Golobov, Arnon Elizur
BACKGROUND: Quality of life is (QOL) impaired in patients with food allergy and improves following oral immunotherapy (OIT). However, the treatment itself is prolonged and demanding. We examined changes in patient QOL during OIT for food allergy. METHODS: The FAQLQ-PF was administered to children aged 4-12 years undergoing OIT for milk, peanut or egg allergy, at the beginning and after 4 months of treatment. Patients were categorized as improved, unchanged, or diminished FAQLQ-PF (>0...
May 22, 2017: Allergy
https://www.readbyqxmd.com/read/28542026/combination-drug-therapy-of-pioglitazone-and-d-cycloserine-attenuates-chronic-orofacial-neuropathic-pain-and-anxiety-by-improving-mitochondrial-function-following-trigeminal-nerve-injury
#9
Danielle N Lyons, Liping Zhang, Jignesh D Pandya, Robert J Danaher, Fei Ma, Craig S Miller, Patrick G Sullivan, Cristian Sirbu, Karin N Westlund
OBJECTIVES: The study aim was to determine how peripheral trigeminal nerve injury affects mitochondrial respiration and to test efficacy of combined treatment with two FDA approved drugs with potential for improving mitochondrial bioenergetics, pain and anxiety related behaviors in a chronic orofacial neuropathic pain mouse model. METHODS: Efficacy of (R)-(+)-4-amino-3-isoxazolidinone (D-cycloserine, DCS), an NMDA antagonist/agonist, and Pioglitazone (PIO), a selective agonist of nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) was investigate in the trigeminal inflammatory compression (TIC) neuropathic nerve injury mouse model...
May 24, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28542025/brief-psychological-screening-questions-can-be-useful-for-ruling-out-psychological-conditions-in-patients-with-chronic-pain
#10
Henrik Bjarke Vaegter, Gitte Handberg, Peter Kent
OBJECTIVES: Psychological symptoms are highly prevalent in chronic pain patients. Timely and accurate identification may enable individualized treatment and improve outcomes. The aims of this study were to (i) investigate the concurrent validity of brief psychological screening questions assessing anxiety, fear of movement, stress, pain catastrophization, and depression in chronic pain patients, and (ii) to determine screening question cut-points at which the likely probability of having these psychological states was less than 10%...
May 24, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28541239/psychological-parameters-of-psoriasis
#11
A Kouris, E Platsidaki, C Kouskoukis, C Christodoulou
Psoriasis is a chronic, inflammatory scaling dermatosis. The marked visible appearance of the lesions have a negative impact on body image that leads to decreased self-esteem, hence seriously compromising the patient's quality of life. The clinical picture critically affects the social well-being of the patient since the disease is commonly misunderstood and feared by the social environment as being contagious. The patient feels stigmatized and this further intensifies their lack of self-confidence and self-esteem...
January 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28541060/metacognition-and-cognition-in-inpatient-mct-and-cbt-for-comorbid-anxiety-disorders-a-study-of-within-person-effects
#12
Sverre Urnes Johnson, Asle Hoffart, Hans M Nordahl, Pål G Ulvenes, KariAnne Vrabel, Bruce E Wampold
Psychotherapists have long questioned what mediating processes are linked to outcome of psychotherapy. Few studies examining this question have assessed within-person changes in the process outcome relationship over time. The present study examined changes in cognition and metacognition over the course of therapy using a dataset from a randomized controlled trial comparing Metacognitive therapy (MCT) and Cognitive-behavioral therapy (CBT). The sample included 74 patients measured on process and symptom instruments weekly throughout therapy...
May 25, 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28540609/mental-health-problems-in-austrian-adolescents-a-nationwide-two-stage-epidemiological-study-applying-dsm-5-criteria
#13
Gudrun Wagner, Michael Zeiler, Karin Waldherr, Julia Philipp, Stefanie Truttmann, Wolfgang Dür, Janet L Treasure, Andreas F K Karwautz
This is a nationwide epidemiological study using DSM-5 criteria to assess the prevalence of mental disorders in a large sample of Austrian adolescents between 10 and 18 years including hard-to-reach samples. A sample of 3615 adolescents from four cohorts (school grades 5, 7, 9, 11; age range 10-18 years) was recruited from 261 schools, samples of unemployed adolescents (n = 39) and adolescents from mental health institutions (n = 137) were added. The Youth Self-Report and SCOFF were used to screen for mental health problems...
May 24, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28540442/outcome-after-brachial-plexus-injury-surgery-and-impact-on-quality-of-life
#14
Lukas Rasulić, Andrija Savić, Bojana Živković, Filip Vitošević, Mirko Mićović, Vladimir Baščarević, Vladimir Puzović, Nenad Novaković, Milan Lepić, Miroslav Samardžić, Stefan Mandić-Rajčević
BACKGROUND: The aim of this study was to investigate outcomes after surgery for brachial plexus injury (BPI), not only motor outcomes but also the quality of life of the patients. METHODS: We operated on 128 consecutive patients with BPI from 1992 to 2012. We documented the information on the injured nerve, level of injury, type of treatment used, timing of surgery, patient age, and preoperative and postoperative motor deficits. In 69 patients who agreed to participate in a quality of life study, additional assessments included functionality, pain, quality of life, patient satisfaction, and psychosocial health...
May 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28540436/premedication-with-melatonin-vs-midazolam-efficacy-on-anxiety-and-compliance-in-paediatric-surgical-patients
#15
Pietro Impellizzeri, Enrica Vinci, Maria Cristina Gugliandolo, Francesca Cuzzocrea, Rosalba Larcan, Tiziana Russo, Maria Rosaria Gravina, Salvatore Arena, Gabriella D'Angelo, Eloisa Gitto, Angela Simona Montalto, Angela Alibrandi, Lucia Marseglia, Carmelo Romeo
Preoperative anxiety is a major problem in paediatric surgical patients. Melatonin has been used as a premedicant agent and data regarding effectiveness are controversial. The primary outcome of this randomized clinical trial was to evaluate the effectiveness of oral melatonin premedication, in comparison to midazolam, in reducing preoperative anxiety in children undergoing elective surgery. As secondary outcome, compliance to intravenous induction anaesthesia was assessed. There were 80 children undergoing surgery randomly assigned, 40 per group, to receive oral midazolam (0...
May 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28540411/negative-symptoms-anxiety-and-depression-as-mechanisms-of-change-of-a-12-month-trial-of-assertive-community-treatment-as-part-of-integrated-care-in-patients-with-first-and-multi-episode-schizophrenia-spectrum-disorders-access-i-trial
#16
Stefanie J Schmidt, Matthias Lange, Daniel Schöttle, Anne Karow, Benno G Schimmelmann, Martin Lambert
Assertive community treatment (ACT) has shown to be effective in improving both functional deficits and quality of life (QoL) in patients with severe mental illness. However, the mechanisms of this beneficial effect remained unclear. We examined mechanisms of change by testing potential mediators including two subdomains of negative symptoms, i.e. social amotivation as well as expressive negative symptoms, anxiety, and depression within a therapeutic ACT model (ACCESS I trial) in a sample of 120 first- and multi-episode patients with a schizophrenia spectrum disorder (DSM-IV)...
May 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28539997/interaction-between-the-cannabinoid-and-vanilloid-systems-on-anxiety-in-male-rats
#17
Nafiseh Faraji, Alireza Komaki, Iraj Salehi
INTRODUCTION: Previous studies have shown that the cannabinoid system is involved in anxiety. In addition, transient receptor potential vanilloid type-1 (TRPV1) channels are new targets for the development of anxiolytics. The present study investigated the possible interaction between the cannabinoid and vanilloid systems on anxiety-like behavior in rats. METHODS: Four different groups of male Wistar rats received intraperitoneal (IP) injections of (1) vehicle (DMSO+saline), (2) cannabinoid receptor agonist WIN55212-2 (WIN) (1 mg/kg), (3) TRPV1 receptor antagonist capsazepine (CPZ) (5 mg/kg), or (4) combined WIN (1 mg/kg) and CPZ (5 mg/kg) treatment 30 minutes before testing in the elevated plus maze...
March 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28539995/the-effect-of-luteinizing-hormone-reducing-agent-on-anxiety-and-novel-object-recognition-memory-in-gonadectomized-rats
#18
Paria Arfa-Fatollahkhani, Arezo Nahavandi, Hossein Abtahi, Shabnam Anjidani, Sahar Borhani, Seyed Behnam Jameie, Mohammad Shabani, Saeed Mehrzadi, Ali Shahbazi
INTRODUCTION: Mood disorders such as anxiety and depression are common following menopause and andropause. Lack of sex steroid hormones is suggested as the primary cause of these disturbances. The level of luteinizing hormone (LH) would also rise 3-4 times than normal in these people. The potential effects of LH on mood and cognitive symptoms following menopause and andropause are still unknown. This study aimed to investigate the effect of increased LH on novel object discrimination (NOD) memory and anxiety like behavior in gonadectomized rats...
March 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28539950/association-of-changes-in-mood-status-and-psychosocial-well-being-with-depression-during-interferon-based-treatment-for-hepatitis-c
#19
Jung-Seok Choi, Won Kim, Bo Kyung Sohn, Jun-Young Lee, Hee Yeon Jung, Sohee Oh, Sae Kyoung Joo, Hwi Young Kim, Yong Jin Jung
OBJECTIVE: The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and personality traits predicted the evolution of depression. METHODS: CHC patients without depression were screened with laboratory tests; psychiatric interviews; and evaluations of mood symptoms, level of distress, and personality traits...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28538748/quality-of-life-considerations-and-pain-management-in-hidradenitis-suppurativa
#20
Gregor Be Jemec
All skin diseases involve some element of stigmatization and psychosocial consequence for the individual patient, but few, if any, skin diseases can match the impact of hidradenitis suppurativa (HS) on the patient. The inflamed lesions progressing to noninflamed nodules and abscesses are not only perceived as unclean and stigmatizing by the patients, but also cause pain and scarring making this inflammatory skin disorder unique. It is obvious that the disease has a significant negative impact on the patients' quality of life (QOL)...
June 2017: Seminars in Cutaneous Medicine and Surgery
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