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Tinnitus treatment

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https://www.readbyqxmd.com/read/28089238/ruxolitinib-for-symptom-control-in-patients-with-chronic-lymphocytic-leukaemia-a-single-group-phase-2-trial
#1
Preetesh Jain, Michael Keating, Sarah Renner, Charles Cleeland, Huang Xuelin, Graciela Nogueras Gonzalez, David Harris, Ping Li, Zhiming Liu, Ivo Veletic, Uri Rozovski, Nitin Jain, Phillip Thompson, Prithviraj Bose, Courtney DiNardo, Alessandra Ferrajoli, Susan O'Brien, Jan Burger, William Wierda, Srdan Verstovsek, Hagop Kantarjian, Zeev Estrov
BACKGROUND: Disease-related symptoms impair the quality of life of patients with chronic lymphocytic leukaemia (CLL) who do not require systemic therapy. Available therapies are not specifically aimed at symptom control. Because stimulation of the B-cell receptor activates JAK2 in CLL cells and the JAK2 inhibitor ruxolitinib improves symptoms in patients with myelofibrosis, we postulated that ruxolitinib would improve disease-related symptoms in patients with CLL. We did a phase 2 trial of ruxolitinib to test this hypothesis...
January 11, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28072813/a-case-report-on-red-ear-syndrome-with-tinnitus-successfully-treated-with-transcranial-random-noise-stimulation
#2
Peter M Kreuzer, Veronika Vielsmeier, Timm B Poeppl, Berthold Langguth
BACKGROUND: The red ear syndrome represents a rare symptom complex consisting of auricular erythema associated with painful and burning sensations. It has been described in combination with tinnitus rarely. It has been hypothesized to be etiologically related to altered trigeminal afferent input, temporomandibular disorders, and thalamic dysfunction. OBJECTIVES: The initial objective of applying transcranial random noise stimulation (tRNS) in a case of red ear syndrome in combination with tinnitus was the alleviation of the phantom sounds...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28068305/comparison-of-treatment-outcomes-following-either-prefrontal-cortical-only-or-dual-site-repetitive-transcranial-magnetic-stimulation-in-chronic-tinnitus-patients-a-double-blind-randomized-study
#3
Tae-Soo Noh, Jeong Sug Kyong, Mun Young Chang, Moo-Kyun Park, Jun-Ho Lee, Seung-Ha Oh, June Sic Kim, Chun Kee Chung, Myung-Whan Suh
OBJECTIVES: We evaluated treatment outcomes following single-site repetitive transcranial magnetic stimulation (rTMS) in the dorsolateral prefrontal cortex (DLPFC) and dual-site rTMS in the auditory cortex (AC) and DLPFC (AC + FC). STUDY DESIGN AND PATIENTS: This prospective randomized double-blind trial initially included 19 patients with chronic tinnitus and 17 of these patients received rTMS on the left AC and left DLPFC or only the left DLPFC. The subjects were randomly allocated to either the dual-site rTMS (AC + FC) protocol (Group 1, n = 9) or the singlesite rTMS (DLPFC) protocol (Group 2, n = 8)...
February 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28050631/head-to-head-comparison-between-18-f-fdopa-pet-ct-and-mr-ct-angiography-in-clinically-recurrent-head-and-neck-paragangliomas
#4
Céline Heimburger, Francis Veillon, David Taïeb, Bernard Goichot, Sophie Riehm, Julie Petit-Thomas, Gerlinde Averous, Marcela Cavalcanti, Fabrice Hubelé, Gerard Chabrier, Izzie Jacques Namer, Anne Charpiot, Alessio Imperiale
PURPOSE: Head and neck paragangliomas (HNPGLs) can relapse after primary treatment. Optimal imaging protocols have not yet been established for posttreatment evaluation. The aim of the present study was to assess the diagnostic value of (18)F-FDOPA PET/CT and MR/CT angiography (MRA/CTA) in HNPGL patients with clinical relapse during their follow-up. METHODS: Sixteen consecutive patients presenting with local pain, tinnitus, dysphagia, hoarse voice, cranial nerve involvement, deafness, or retrotympanic mass appearing during follow-up after the initial treatment of HNPGLs were retrospectively evaluated...
January 3, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28045920/alterations-in-evoked-otoacoustic-emissions-by-the-use-of-meglumine-antimoniate-in-american-tegumentary-leishmaniasis-patients
#5
Débora Cristina de Oliveira Bezerra, Renata Oliveira de Barcelos, Ellen Carvalho de Castro, Claudia Cristina Jardim Duarte, Raquel de Vasconcellos Carvalhaes Oliveira, Tania Salgado de Sousa Torraca, Maria Helena de Araújo-Melo, Frederico Pereira Bom Braga, Benivaldo Ramos Ferreira Terceiro, Lúcia Regina do Nascimento Brahim Paes, Armando de Oliveira Schubach, Cláudia Maria Valete-Rosalino
INTRODUCTION: Tegumentary Leishmaniasis (TL) is a neglected, non-contagious, infectious disease, caused by different protozoa species of the Leishmania genus that affects skin and mucous membranes. Meglumine Antimoniate (MA), the first drug of choice for TL treatment in Brazil, has already been associated with cochlear toxicity, which is defined as damages of the cochlea caused by exposure to chemical substances, resulting in reversible or irreversible hearing loss. Auditory monitoring for cochlear toxicity aims at the early detection of auditory disorders, enabling, when possible, hearing to be preserved or an early auditory rehabilitation...
2017: PloS One
https://www.readbyqxmd.com/read/28043617/bedaquiline-in-the-multidrug-resistant-tuberculosis-treatment-belarus-experience
#6
Alena Skrahina, Hennadz Hurevich, Dennis Falzon, Liudmila Zhilevich, Valiantsin Rusovich, Masoud Dara, Svetlana Setkina
BACKGROUND/OBJECTIVE: Outcomes of treatment for multidrug-resistant tuberculosis (MDR-TB) remain poor worldwide. Among patients with MDR-TB in Belarus who started treatment in 2012, only 54% completed it successfully, with treatment failure reported in 22% of the patients; additionally, 11% died and 13% were lost to follow-up or remained unevaluated. In Belarus, to improve outcomes, bedaquiline was introduced in MDR-TB treatment in June 2015. The national TB program developed measures to monitor safety and effectiveness of bedaquiline-containing regimens in line with the World Health Organization recommendations...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28033228/sub-tenon-triamcinolone-acetonide-injection-in-a-pregnant-patient-with-vogt-koyanagi-harada-disease
#7
Tomoko Nakamura, Hiroshi Keino, Annabelle A Okada
PURPOSE: To report a case of new-onset Vogt-Koyanagi-Harada disease treated with sub-Tenon injection of triamcinolone acetonide in a 16-week pregnant patient. METHODS: Review of clinical records. RESULTS: A 33-year-old woman in her 16th week of pregnancy presented with bilateral serous retinal detachments associated with anterior chamber inflammation. Enhanced depth imaging optical coherence topography showed marked choroidal thickening. Headache and tinnitus developed 3 days later...
December 28, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28031156/endolymphatic-duct-blockage-for-refractory-m%C3%A3-ni%C3%A3-re-s-disease-assessment-of-endolymphatic-sac-biopsy-on-short-term-surgical-outcomes
#8
Marc Henri Asmar, Issam Saliba
OBJECTIVE: Endolymphatic sac decompression (ESD) for the treatment of Ménière's disease (MD) has had limited success and variable results in the literature. We have devised a novel technique that involves blocking the endolymphatic duct with surgical clips. In a separate effort to study the endolymphatic sac (ELS), we have sectioned the lateral part of the main body of the ELS as biopsies from a subset of patients. We aimed to evaluate the effect of the lateral part sectioning of the ELS on short-term surgical outcomes...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28031153/surgical-management-and-hearing-outcome-of-traumatic-ossicular-injuries
#9
Stefan Delrue, Nicolas Verhaert, Joost van Dinther, Andrzej Zarowski, Thomas Somers, Christian Desloovere, Erwin Offeciers
OBJECTIVE: The purpose of this study was to investigate etiological, clinical, and pathological characteristics of traumatic injuries of the middle ear ossicular chain and to evaluate hearing outcome after surgery. MATERIAL AND METHODS: Thirty consecutive patients (31 ears) with traumatic ossicular injuries operated on between 2004 and 2015 in two tertiary referral otologic centers were retrospectively analyzed. Traumatic events, clinical features, ossicular lesions, treatment procedures, and audiometric results were evaluated...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28027920/examining-the-short-term-effects-of-emotion-under-an-adaptation-level-theory-model-of-tinnitus-perception
#10
Mithila Durai, Mary G O'Keeffe, Grant D Searchfield
OBJECTIVES: Existing evidence suggests a strong relationship between tinnitus and emotion. The objective of this study was to examine the effects of short-term emotional changes along valence and arousal dimensions on tinnitus outcomes. Emotional stimuli were presented in two different modalities: auditory and visual. The authors hypothesized that (1) negative valence (unpleasant) stimuli and/or high arousal stimuli will lead to greater tinnitus loudness and annoyance than positive valence and/or low arousal stimuli, and (2) auditory emotional stimuli, which are in the same modality as the tinnitus, will exhibit a greater effect on tinnitus outcome measures than visual stimuli...
December 24, 2016: Hearing Research
https://www.readbyqxmd.com/read/28025604/evidence-and-evidence-gaps-in-tinnitus-therapy
#11
REVIEW
Gerhard Hesse
A nearly endless number of procedures has been tried and in particular sold for the treatment of tinnitus, unfortunately they have not been evaluated appropriately in an evidence-based way. A causal therapy, omitting the tinnitus still does not exist, actually it cannot exist because of the various mechanisms of its origin. However or perhaps because of that, medical interventions appear and reappear like fashion trends that can never be proven by stable and reliable treatment success. This contribution will discuss and acknowledge all current therapeutic procedures and the existing or non-existing evidence will be assessed...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/28018210/measuring-the-moment-to-moment-variability-of-tinnitus-the-trackyourtinnitus-smart-phone-app
#12
Winfried Schlee, Rüdiger C Pryss, Thomas Probst, Johannes Schobel, Alexander Bachmeier, Manfred Reichert, Berthold Langguth
Tinnitus, the phantom perception of sound without a corresponding external sound, is a frequent disorder which causes significant morbidity. So far there is no treatment available that reliably reduces the tinnitus perception. The research is hampered by the large heterogeneity of tinnitus and the fact that the tinnitus perception fluctuates over time. It is therefore necessary to develop tools for measuring fluctuations of tinnitus perception over time and for analyzing data on single subject basis. However, this type of longitudinal measurement is difficult to perform using the traditional research methods such as paper-and-pencil questionnaires or clinical interviews...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28017747/complications-and-their-managements-of-large-intracranial-vestibular-schwannoma-via-retrosigmoid-approach
#13
Xiang Huang, Ming Xu, Jian Xu, Liangfu Zhou, Ping Zhong, Mingyu Chen, Kaiyuan Ji, Huiyu Chen, Ying Mao
OBJECTIVE: To investigate the common complications from the microsurgical treatment of large intracranial vestibular schwannoma (VS) via suboccipital retrosigmoid approach and to propose strategies for minimizing such complications. METHODS: We selected all large unilateral VS patients from the collected database (1999-2013) who underwent microsurgical resection as their initial treatment for histopathologically confirmed VS. Tumors larger than 30 x 20 mm were defined as large...
December 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28012597/cervical-spine-disorders-and-its-association-with-tinnitus-the-triple-hypothesis
#14
Federica Bressi, Manuele Casale, Rocco Papalia, Antonio Moffa, Alberto Di Martino, Sandra Miccinilli, Fabrizio Salvinelli, Vincenzo Denaro, Silvia Sterzi
Subjective tinnitus and cervical spine disorders (CSD) are among the most common complaints encountered by physicians. Although the relationship between tinnitus and CSD has attracted great interest during the past several years, the pathogenesis of tinnitus induced by CSD remains unclear. Conceivably, CSD could trigger a somatosensory pathway-induced disinhibition of dorsal cochlear nucleus (DCN) activity in the auditory pathway; furthermore, CSD can cause inner ear blood impairment induced by vertebral arteries hemodynamic alterations and trigeminal irritation...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28011121/temporal-bone-paragangliomas-15-years-experience
#15
Mehmet Düzlü, Hakan Tutar, Recep Karamert, Furkan Karaloğlu, Muammer Melih Şahin, Mehmet Göcek, Mehmet Birol Uğur, Nebil Göksu
INTRODUCTION: Temporal bone paragangliomas (TBPs) are benign tumors arising from neural crest cells located along the jugular bulbus and the tympanic plexus. In general surgical excision, radiotherapy and wait-and-scan protocols are the main management modalities for TBPs. OBJECTIVE: In this paper we aim to present our clinical experience with TBPs and to review literature data. METHODS: The patients who were operated for tympanomastoid paraganglioma (TMP) or tympanojugular paraganglioma (TJP) in our clinic in the last 15 years were enrolled in the study...
December 8, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27995315/a-multidisciplinary-systematic-review-of-the-treatment-for-chronic-idiopathic-tinnitus
#16
REVIEW
Hans-Peter Zenner, Wolfgang Delb, Birgit Kröner-Herwig, Burkhard Jäger, Ingrid Peroz, Gerhard Hesse, Birgit Mazurek, Gerhard Goebel, Christian Gerloff, Regina Trollmann, Eberhard Biesinger, Harald Seidler, Berthold Langguth
The majority of tinnitus patients are affected by chronic idiopathic tinnitus, and almost 60 different treatment modalities have been reported. The present study is a multidisciplinary systematic analysis of the evidence for the different forms of treatment for chronic tinnitus. The results are used to form the basis of an S3 guideline. A systematic search was carried out in PubMed and the Cochrane Library. The basis for presenting the level of evidence was the evidence classification of the Oxford Centre of Evidence-based Medicine...
December 19, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27990155/dietary-supplement-comprised-of-%C3%AE-carotene-vitamin-c-vitamin-e-and-magnesium-failure-to-prevent-music-induced-temporary-threshold-shift
#17
C G Le Prell, A Fulbright, C Spankovich, S K Griffiths, E Lobarinas, K C M Campbell, P J Antonelli, G E Green, K Guire, J M Miller
This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. There were no group differences in post-exposure TTS or music-induced decreases in distortion product otoacoustic emission (DPOAE) amplitude...
May 2016: Audiology and Neurotology. Extra
https://www.readbyqxmd.com/read/27989950/plastic-changes-along-auditory-pathway-during-salicylate-induced-ototoxicity-hyperactivity-and-cf-shifts
#18
Chen Jiang, Bin Luo, Senthilvelan Manohar, Guang-Di Chen, Richard Salvi
High dose of salicylate, the active ingredient in aspirin, has long been known to induce transient hearing loss, tinnitus and hyperacusis making it a powerful experimental tool. These salicylate-induced perceptual disturbances are associated with a massive reduction in the neural output of the cochlea. Paradoxically, the diminished neural output of the cochlea is accompanied by a dramatic increase in sound-evoked activity in the auditory cortex (AC) and several other parts of the central nervous system. Exactly where the increase in neural activity begins and builds up along the central auditory pathway are not fully understood...
October 27, 2016: Hearing Research
https://www.readbyqxmd.com/read/27979609/tinnitus-therapy-using-tailor-made-notched-music-delivered-via-a-smartphone-application-and-ginko-combined-treatment-a-pilot-study
#19
So Young Kim, Mun Young Chang, Min Hong, Sun-Gil Yoo, Dongik Oh, Moo Kyun Park
OBJECTIVE: Notched music therapy has been suggested to be effective for relieving tinnitus. We have developed a smartphone application using tailor-made notched music for tinnitus patients. This study aimed to evaluate the effect of this smartphone application on reducing tinnitus. In addition, we investigated the predictive factors for tinnitus treatment outcome using this smartphone application. METHODS: A total of 26 patients who were chronically distressed by tinnitus with a ≥18 Tinnitus Handicap Inventory (THI) score were recruited from March 2013 to March 2015 (National Clinical Trial (NCT) Identifier Number 01663467)...
December 12, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27965530/the-effect-of-physical-therapy-treatment-in-patients-with-subjective-tinnitus-a-systematic-review
#20
REVIEW
Sarah Michiels, Sebastiaan Naessens, Paul Van de Heyning, Marc Braem, Corine M Visscher, Annick Gilles, Willem De Hertogh
Background: Tinnitus is a very common symptom that often causes distress and decreases the patient's quality of life. Apart from the well-known causes, tinnitus can in some cases be elicited by dysfunctions of the cervical spine or the temporomandibular joint (TMJ). To date however, it is unclear whether alleviation of these dysfunctions, by physical therapy treatment, also decreases the tinnitus complaints. Such physical therapy could be an interesting treatment option for patients that are now often left without treatment...
2016: Frontiers in Neuroscience
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