keyword
MENU ▼
Read by QxMD icon Read
search

Liposarcoma treatment

keyword
https://www.readbyqxmd.com/read/29440930/advances-in-the-treatment-of-soft-tissue-sarcoma-focus-on-eribulin
#1
REVIEW
Panagiotis Koliou, Vasilios Karavasilis, Maria Theochari, Seth M Pollack, Robin L Jones, Khin Thway
Eribulin mesylate is a synthetic derivative of halichondrin B isolated from a marine sponge. Its mechanism of action is through microtubule inhibition, which is different from that of taxanes. Eribulin has been approved for the treatment of metastatic breast cancer and more recently for non-operable or metastatic liposarcoma in patients who have received prior anthracycline chemotherapy. The major side effects of eribulin are bone marrow suppression including neutropenia, leukopenia, anemia, and fatigue/weakness, which can be well managed...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29429159/-retroperitoneal-dedifferentiated-liposarcoma-with-rhabdomyoblastic-differentiation-a-clinicopathological-analysis
#2
L Liu, L H Wang, Y B Ren, X S Rao, S M Yang
Objective: To investigate the clinicopathological features, differential diagnosis, treatment and prognosis of dedifferentiated liposarcoma with rhabdomyoblastic differentiation. Methods: Six cases of retroperitoneal dedifferentiated liposarcoma with rhabdomyoblastic features were collected from December 2014 to August 2017 at Peking University International Hospital. The clinical manifestations, histomorphology, immunophenotype, treatment and follow-up data were analyzed, and relevant literature reviewed. Results: The six patients included two males and four females, with age range of 47 to 66 years (mean 56 years)...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29426349/neurofibroma-involving-obturator-nerve-mimicking-an-adnexal-mass-a-rare-case-report-and-prisma-driven-systematic-review
#3
Wei-Ting Chao, Chia-Hao Liu, Yi-Jen Chen, Hua-Hsi Wu, Chi-Mu Chuang, Peng-Hui Wang
BACKGROUND: Pelvic masses are a common gynecologic problem, and majority of them are diagnosed as ovarian tumors finally. Sometimes, it is hard to distinguish the origin of these pelvic masses. The following case is a solitary neurofibroma arising from the right-side obturator nerve, which was impressed as a right-side ovarian tumor initially. We reported this case, and also performed a PRISMA-driven systematic review to summary the similar cases in the literature. This review includes image, molecular and pathological findings and outcome of neurofibroma...
February 9, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29423155/successful-surgical-treatment-for-huge-retroperitoneal-liposarcoma-involving-the-pancreas-right-kidney-abdominal-aorta-and-inferior-vena-cava
#4
Mariko Tanaka, Toshiyasu Kawahara, Takahiro Nishikoshi, Masahiro Hagiwara, Koji Imai, Kimiharu Hasegawa, Atsuhiro Koya, Naoto Matsuno, Hidehiro Takei, Nobuyoshi Azuma, Hiroyuki Furukawa
Retroperitoneal liposarcoma is a rare neoplasm that often involves other organs and major blood vessels. Complete surgical resection with negative margins is the only potential curative treatment. Here, we report the case of a patient with a large retroperitoneum liposarcoma that was removed by resection of the descending abdominal aorta and infrahepatic inferior vena cava, right nephrectomy and pancreatoduodenectomy following creation of an extra anatomical femoro-femoral crossover bypass after left axillo-left femoral bypass...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29414432/clinicopathologic-features-and-outcomes-of-primary-cardiac-tumors-a-16-year-experience-with-212-patients-at-a-chinese-medical-center
#5
Ji-Gang Wang, Baolei Wang, Yanjiao Hu, Ji-Hua Liu, Bing Liu, Hui Liu, Peng Zhao, Lijuan Zhang, Yu-Jun Li
Primary cardiac tumors are uncommon, and the majority of them are benign which are curable but can cause significant morbidity if not diagnosed and treated in a timely fashion. The objective of this study was to review the clinicopathologic features and surgical outcomes of patients with primary cardiac tumors in a single medical center in China. We have retrospectively reviewed 212 consecutive adult patients who underwent surgical resection of primary cardiac tumors at our center from January of 2001 to June of 2017...
January 6, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29411654/eribulin-therapy-for-the-treatment-of-patients-with-advanced-soft-tissue-sarcoma
#6
Mahesh Seetharam, Kantha R Kolla, Sant P Chawla
Eribulin is a structurally simplified, synthetic macrocyclic ketone analog of halichondrin B, which is a natural, polyether macrolide derived from marine sponges. Eribulin exerts its cytotoxicity by its unique microtubule dynamics inhibitory action. Eribulin was approved in 2010 by the US FDA as a third-line therapy for metastatic breast cancer patients previously treated with an anthracycline and a taxane. In 2016, it was approved for treatment of metastatic liposarcoma for patients who have progressed with anthracycline treatment...
February 7, 2018: Future Oncology
https://www.readbyqxmd.com/read/29403596/primary-atypical-lipomatous-tumor-of-the-orbit-a-case-report
#7
Douglas P Dworak, Shyam A Patel, Rohini Chennuri, Daniel Falco
Purpose: To describe a case of primary atypical orbital lipomatous tumor (ALT). Case Report: A 35-year-old man presented with a two-month history of left eye proptosis and vertical diplopia. His visual acuity was 20/30 OD and 20/60 OS. External examination showed proptosis and downward displacement of the left eye with mild lid erythema. Extraocular movements were reduced in the left eye, with 10% and 70% motility in upgaze and abduction/adduction, respectively...
January 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29394566/-a-case-of-retroperitoneal-liposarcoma-that-required-three-times-surgical-resections-during-four-years
#8
Ryohei Koreyasu, Hirotoshi Maruo, Raisuke Nishiyama, Masanori Yamazaki, Tsuyoshi Shoji, Yukihiro Higashi, Koichi Nakamura, Tadahiro Kojima, Hajime Tsuyuki
The patient was a 64-year-old man, who had undergone surgical resection for a right retroperitoneal giant tumor. The histopathological diagnosis was a well-differentiated liposarcoma. Two years and 4 months after the initial surgery, 3 recurrent lesions were found on the dorsal side of the colon hepatic flexure, and resection was performed. One year and 1 month after the secondary surgery, the tumor recurred again, and invaded the right abdominal wall and right transverse colon. Tumor was completely resected macroscopically...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29353660/intraoperative-electron-radiation-therapy-in%C3%A2-retroperitoneal-sarcoma
#9
Falk Roeder, Ingo Alldinger, Matthias Uhl, Ladan Saleh-Ebrahimi, Simon Schimmack, Gunhild Mechtersheimer, Markus W Büchler, Jürgen Debus, Robert Krempien, Alexis Ulrich
PURPOSE: To report our experience with surgery, intraoperative radiation therapy (IORT), and external beam radiation therapy (EBRT) in retroperitoneal soft-tissue sarcoma. METHODS AND MATERIALS: We conducted a retrospective evaluation of 156 patients (69 primary, 87 recurrent) treated with IORT since 1991. The dominant histology was dedifferentiated liposarcoma (49%); 89% of lesions were high grade. Median tumor size was 11 cm. Surgery resulted in gross complete resection in 92%, and 65% had microscopically positive margins...
February 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29352382/hibernation-of-masses-suspected-to-be-remnant-tumors-after-surgical-resection-of-retroperitoneal-liposarcoma-is-related-to-improved-overall-survival
#10
Jinsoo Rhu, Kyo Won Lee, Jae Berm Park, Sung Joo Kim
BACKGROUND: Although complete surgical resection is considered the best treatment for retroperitoneal liposarcoma, it is related to a high local recurrence rate. This study analyzed patterns of recurrence of retroperitoneal liposarcoma. METHODS: Records of patients who experienced recurrence after surgery for retroperitoneal liposarcoma from January 2000 to May 2017 were analyzed. Site, number, and characteristics of recurrent mass on computed tomography were serially collected...
January 19, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29335908/surgery-for-abdominal-well-differentiated-liposarcoma
#11
REVIEW
Sara A Mansfield, Raphael E Pollock, Valerie P Grignol
Retroperitoneal sarcomas are rare tumors of which liposarcoma is the most common histology. Surgical resection remains the mainstay of therapy, particularly for the well-differentiated subtype. They can grow to massive size before causing symptoms or detection. Well-differentiated liposarcoma, while having a negligible metastatic rate, is fraught with a high local recurrence rate, despite a complete surgical resection. Reasons for this are not completely known but may be related to a field defect of the retroperitoneal fat creating a niche for recurrence...
January 16, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29303371/the-management-of-deep-seated-low-grade-lipomatous-lesions
#12
Zeid Al-Ani, Malee Fernando, Victoria Wilkinson, Nikhil Kotnis
Deep-seated, low grade lipomatous lesions detected on imaging often cause uncertainty for diagnosis and treatment. Confidently distinguishing lipomas from well-differentiated liposarcomas (WDL) is often not possible on imaging. The approach to management of such lesions varies widely between institutions. Applying an evidenced-based approach set around published literature that clearly highlights how criteria such as lesion size, location, age and imaging features can be used to predict the risk of WDL and subsequent de-differentiation would seem sensible...
January 5, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29280411/the-potential-of-the-cmb305-vaccine-regimen-to-target-ny-eso-1-and-improve-outcomes-for-synovial-sarcoma-and-myxoid-round-cell-liposarcoma-patients
#13
Seth M Pollack
Synovial Sarcoma (SS) and Myxoid Round Cell Liposarcoma (MRCL) are devastating sarcoma subtypes with few treatment options and poor outcomes in the advanced setting. However, both these diseases may be ideal for novel immunotherapies targeting the cancer-testis antigen, NY-ESO-1. Areas covered: In this review, we discuss the novel NY-ESO-1 targeted vaccine regimen, CMB305. This regimen uses a unique integration-deficient, dendritic-cell targeting lentiviral vector from the ZVex® platform, LV305, in order to prime NY-ESO-1 specific T cells...
December 27, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29250486/systemic-therapy-in-metastatic-or-unresectable-well-differentiated-dedifferentiated-liposarcoma
#14
REVIEW
Yevette McGovern, Charlie D Zhou, Robin L Jones
Liposarcoma is one of the most common subtypes of soft-tissue sarcoma and consists of three main subtypes, of which well-differentiated liposarcoma and dedifferentiated liposarcoma account for 40-45%. The current mainstay of systemic treatment for patients with metastatic or unresectable disease remains doxorubicin with or without ifosfamide in the first-line setting. Recently, eribulin and trabectedin have been approved by the US Food and Drug Administration for recurrent liposarcomas and progress in molecular characterization of these tumors has opened up new and potential novel treatment targets...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29247978/advances-in-chromosomal-translocations-and-fusion-genes-in-sarcomas-and-potential-therapeutic-applications
#15
REVIEW
Xin Xiao, Cassandra C Garbutt, Francis Hornicek, Zheng Guo, Zhenfeng Duan
Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. The discovery of novel chromosomal translocations and fusion genes in different tumors are due to the advancement of next-generation sequencing (NGS) technologies such as whole genome sequencing. Recently, many novel chromosomal translocations and gene fusions have been identified in different types of sarcoma through NGS approaches...
December 6, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29234568/long-term-quality-of-life-of-retroperitoneal-sarcoma-patients-treated-with-pre-operative-radiotherapy-and-surgery
#16
Philip Wong, Zahra Kassam, Amanda N Springer, Rebecca Gladdy, Peter Chung, Jolie Ringash, Charles Catton
PURPOSE: Retroperitoneal sarcomas (RPS) are connective tissue cancers that are often large and anatomically in close proximity to critical and radiation-sensitive normal structures and organs within the abdomen and pelvis. The management of RPS may include preoperative radiotherapy (RT) and surgery. We aimed to examine how treatment-related toxicities affect patient quality of life (QOL).  Methods and materials: Within two prospective cohort studies, 48 RPS patients who were treated with preoperative RT from 1998-2012 were recruited and assessed for QOL (EORTC-QLQ-C30) and to determine toxicities potentially related to RT and surgery (graded using CTCAE V...
October 11, 2017: Curēus
https://www.readbyqxmd.com/read/29220294/clinical-and-molecular-spectrum-of-liposarcoma
#17
Alex Thomas John Lee, Khin Thway, Paul H Huang, Robin Lewis Jones
Liposarcomas are rare malignant tumors of adipocytic differentiation. The classification of liposarcomas into four principal subtypes reflects the distinct clinical behavior, treatment sensitivity, and underlying biology encompassed by these diseases. Increasingly, clinical management decisions and the development of investigational therapeutics are informed by an improved understanding of subtype-specific molecular pathology. Well-differentiated liposarcoma is the most common subtype and is associated with indolent behavior, local recurrence, and insensitivity to radiotherapy and chemotherapy...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29216884/intensity-modulated-radiation-therapy-and-surgery-for-management-of-retroperitoneal-sarcomas-a-single-institution-experience
#18
Pippa F Cosper, Jeffrey Olsen, Todd DeWees, Brian A Van Tine, William Hawkins, Jeff Michalski, Imran Zoberi
BACKGROUND: Peri-operative radiation of retroperitoneal sarcomas (RPS) is an important component of multidisciplinary treatment. All retrospective series thus far included patients treated with older radiation therapy (RT) techniques including 2D and 3DRT. Intensity modulated radiation therapy (IMRT) allows for selective dose escalation while sparing adjacent organs. We therefore report the first series of patients with RPS treated solely with IMRT, surgery and chemotherapy. We hypothesized that IMRT would permit safe dose escalation and superior rates of local control (LC) in this high-risk patient population...
December 8, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29203756/12-years-of-fighting-liposarcoma-a-case-report
#19
Mykola Kononenko, Ihor Vynnychenko, Yuliia Moskalenko, Oleksandr Vynnychenko
The proportion of liposarcoma in the structure of cancer incidence is from 10 to 35% of all mesenchymal tumors. This clinical observation describes an 12-year struggle with myxoid liposarcoma of the left upper arm, during which 17 surgeries were performed due to local recurrences, 17 radiation therapy courses and 5 chemotherapy courses were conducted. Clinical observation shows the whole complexity of myxoid liposarcoma treatment. The effectiveness of therapeutic management is determined by persistent surgery, and also by the lack of expression of Pgp, glutathione-S-transferase, metallothionein and mutant p53 in tumor structure...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29197031/preclinical-evaluation-of-the-aurora-kinase-inhibitors-amg-900-azd1152-hqpa-and-mk-5108-on-sw-872-and-93t449-human-liposarcoma-cells
#20
Sandhya Noronha, Lauren A C Alt, Taylor E Scimeca, Omran Zarou, Justyna Obrzut, Brian Zanotti, Elizabeth A Hayward, Akhil Pillai, Shubha Mathur, Joseph Rojas, Ribhi Salamah, Nalini Chandar, Michael J Fay
Liposarcoma is a malignant soft tissue tumor that originates from adipose tissue and is one of the most frequently diagnosed soft tissue sarcomas in humans. There is great interest in identifying novel chemotherapeutic options for treating liposarcoma based upon molecular alterations in the cancer cells. The Aurora kinases have been identified as promising chemotherapeutic targets based on their altered expression in many human cancers and cellular roles in mitosis and cytokinesis. In this study, we investigated the effects of an Aurora kinase A inhibitor (MK-5108), an Aurora kinase B inhibitor (AZD1152-HQPA), and a pan-Aurora kinase inhibitor (AMG 900) on undifferentiated SW-872 and well-differentiated 93T449 human liposarcoma cells...
December 1, 2017: In Vitro Cellular & Developmental Biology. Animal
keyword
keyword
64164
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"