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Arthritis treatment

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https://www.readbyqxmd.com/read/29161466/treating-early-undifferentiated-arthritis-a-systematic-review-and-meta-analysis-of-direct-and-indirect-trial-evidence
#1
Maria A Lopez-Olivo, Voke Kakpovbia-Eshareturi, Jude des Bordes, Andrea Barbo, Robin Christensen, Maria E Suarez-Almazor
OBJECTIVE: We undertook a systematic review and meta-analysis of direct and indirect trial evidence to evaluate the efficacy of treatments for patients with undifferentiated arthritis (UA). METHODS: We searched four electronic databases from inception to January 2016, clinicaltrials. gov, and bibliographies of relevant articles. Two reviewers independently screened and evaluated the studies. The primary outcome was development of rheumatoid arthritis (RA). RESULTS: Nine studies were included...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29160881/effect-of-nobiletin-on-the-mapk-nf-%C3%AE%C2%BAb-signaling-pathway-in-the-synovial-membrane-of-rats-with-arthritis-induced-by-collagen
#2
Guliang Yang, Shiming Li, Li Yuan, Yiwen Yang, Min-Hsiung Pan
Nobiletin (5,6,7,8,3',4'-hexamethoxyflavone) is a natural compound in the fruit peel of citrus fruit in the Rutaceae family. It is active in inhibiting inflammation, reducing plasma lipids and has anti-oxidative properties. In studying the effect of nobiletin on rheumatoid arthritis (RA), the collagen-induced arthritis (CIA) model on Sprague-Dawley (SD) rats was established by bovine type II collagen (BIIC), and the effect of nobiletin on RA was investigated using hematoxylin-eosin (H&E) staining, serum enzyme linked immunosorbent assay (ELISA) detection and western blotting...
November 21, 2017: Food & Function
https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#3
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160173/gene-delivery-to-joints-by-intra-articular-injection
#4
Christopher H Evans, Steven Craig Ghivizzani, Paul D Robbins
Most forms of arthritis are incurable, difficult to treat and a major cause of disability in western countries. Better local treatment of arthritis is impaired by the pharmacokinetics of the joint that make it very difficult to deliver drugs to joints at sustained, therapeutic concentrations. This is especially true of biologic drugs, such as proteins and RNA, many of which show great promise in pre-clinical studies. Gene transfer provides a strategy for overcoming this limitation. The basic concept is to deliver cDNAs encoding therapeutic products by direct intra-articular injection, leading to sustained, endogenous synthesis of the gene products within the joint...
November 21, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29159853/the-use-of-cell-conditioned-medium-for-musculoskeletal-tissue-regeneration
#5
REVIEW
Francesca Veronesi, Veronica Borsari, Maria Sartori, Monia Orciani, Monica Mattioli-Belmonte Cima, Milena Fini
Tissue regenerative medicine combines the use of cells, scaffolds and molecules to repair damaged tissues. Different cell types are employed for musculoskeletal diseases, both differentiated and mesenchymal stromal cells (MSCs). In recent years, the hypothesis that cell-based therapy is guided principally by cell-secreted factors has become increasingly popular. The aim of the present literature review was to evaluate preclinical and clinical studies that used conditioned medium (CM), rich in cell-factors, for musculoskeletal regeneration with a cell-free approach...
November 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29158574/immunogenicity-and-loss-of-response-to-tnf-inhibitors-implications-for-rheumatoid-arthritis-treatment
#6
REVIEW
Joachim R Kalden, Hendrik Schulze-Koops
The availability of monoclonal antibodies has revolutionized the treatment of an increasingly broad spectrum of diseases. Inflammatory diseases are among those most widely treated with protein-based therapeutics, termed biologics. Following the first large-scale clinical trials with monoclonal antibodies performed in the 1990s by rheumatologists and clinical immunologists, the approval of these agents for use in daily clinical practice led to substantial progress in the treatment of rheumatic diseases. Despite this progress, however, only a proportion of patients achieve a long-term clinical response...
November 21, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29158573/enthesitis-from-pathophysiology-to-treatment
#7
REVIEW
Georg Schett, Rik J Lories, Maria-Antonietta D'Agostino, Dirk Elewaut, Bruce Kirkham, Enrique R Soriano, Dennis McGonagle
Entheses are the insertion sites of tendons and ligaments to the bone surface and are essential structures for locomotion. Inflammation of the entheses (enthesitis) is a key feature of psoriatic arthritis and spondyloarthritis. To date, our conceptual understanding of enthesitis remains limited. This Review provides an insight into the pathophysiology of enthesitis, addressing the role of biomechanics, prostaglandin E2-mediated vasodilation and the activation of innate immune cells in the initiation phase of enthesitis, as well as the role of entheseal IL-23-responsive cells that augment inflammation by producing pro-inflammatory mediators such as IL-17A, IL-22 and TNF...
November 21, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29157669/the-combination-of-il-6-and-its-soluble-receptor-is-associated-with-the-response-of-rheumatoid-arthritis-patients-to-tocilizumab
#8
Cesar Diaz-Torne, Maria Dels Angels Ortiz, Patricia Moya, Maria Victoria Hernandez, Delia Reina, Ivan Castellvi, Juan Jose De Agustin, Diana de la Fuente, Hector Corominas, Raimon Sanmarti, Carlos Zamora, Elisabet Cantó, Silvia Vidal
BACKGROUND: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Tocilizumab, a humanized anti-human IL-6 receptor antibody that blocks the signaling originated by the IL-6/IL-6R complex, is an effective treatment. However, predictors of the response to tocilizumab are still required. We aimed to combine IL-6 and soluble IL-6R (sIL-6R) levels to identify groups of responses. METHODS: Heparinized blood and clinical data from 63 RA patients were collected before treatment and after 3 and 6 months...
November 17, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29157059/90k-immunostimulatory-glycoprotein-in-children-with-juvenile-idiopathic-arthritis
#9
Cristina Cecamore, Manuela Marsili, Roberta Salvatore, Roberto Troiani, Maurizia D'Egidio, Nicola Tinari, Piernicola Pelliccia, Francesco Chiarelli, M Loredana Marcovecchio, Luciana Breda
OBJECTIVES: To assess whether circulating levels of 90K glycoprotein are increased in children with juvenile idiopathic arthritis (JIA) at different stages of the disease, compared to healthy controls and to evaluate potential over time changes in its concentrations following treatment with the antitumor-necrosis factor (TNF) drug etanercept. METHODS: 90K glycoprotein, C-reactive protein, erythrocyte sedimentation rate, TNF, antinuclear antibodies, rheumatoid factor and the Juvenile Arthritis Disease Activity Score were assessed in 71 children: 23 with newly diagnosed JIA, 23 with established and active JIA and 25 healthy controls...
November 20, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29156638/development-of-evidence-based-disease-education-literature-for-pakistani-rheumatoid-arthritis-patients
#10
Atta Abbas Naqvi, Mohamed Azmi Hassali, Muhammad Tariq Aftab, Syed Baqir Shyum Naqvi, Fatima Zehra, Rizwan Ahmad, Niyaz Ahmad
Rheumatoid arthritis affects 0.5% to 1% of the population globally and is one of the most common causes of disability. Patient education plays a key role in improving treatment outcomes. The purpose of this study was to discuss the process involved in designing an evidence-based disease education literature for rheumatoid arthritis patients of Pakistan in Urdu language with culturally relevant illustrations. A study was conducted to develop disease education literature using Delphi consensus, content validity, and patient feedback...
November 20, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/29156170/computed-navigation-guidance-for-ankle-replacement-in-the-setting-of-ankle-deformity
#11
REVIEW
Feras J Waly, Nicholas E Yeo, Murray J Penner
Total ankle replacement (TAR) has evolved over the past decade as a treatment for end-stage ankle arthritis with improved survivorship. Despite the improving outcomes, ankle deformity represents a challenge to the foot and ankle surgeon with increased risk of implant failure. The use of preoperative computer-assisted guidance has led to better understanding the 3-dimensional ankle anatomy and associated deformities and allows for reproducible, anatomic placement of the TAR components.
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29155868/tocilizumab-potentially-prevents-bone-loss-in-patients-with-anticitrullinated-protein-antibody-positive-rheumatoid-arthritis
#12
Yi-Ming Chen, Hsin-Hua Chen, Wen-Nan Huang, Tsai-Ling Liao, Jun-Peng Chen, Wen-Cheng Chao, Ching-Tsai Lin, Wei-Ting Hung, Chia-Wei Hsieh, Tsu-Yi Hsieh, Yi-Hsing Chen, Der-Yuan Chen
Rheumatoid arthritis (RA) is associated with a high risk of osteoporosis and fracture. Interleukin (IL)-6 inhibitors may suppress osteoclast activation. Anticitrullinated protein antibody (ACPA) titers are inversely associated with bone mineral density (BMD). However, the differential effect of ACPA on bone turnover marker (BTM) and BMD changes after IL-6 inhibition remains unclear. This prospective study recruited patients with active RA with inadequate response to methotrexate or biologics. BMD was measured before and after 2-year tocilizumab (TCZ) treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29155104/treatment-strategies-for-psoriatic-arthritis
#13
Julien Schemoul, Cécile Poulain, Pascal Claudepierre
The therapeutic management of psoriatic arthritis has seen major changes over the last few years, as illustrated by the recent updates of the GRAPPA and EULAR recommendations. These changes were driven by new studies establishing important benefits from early management and tight control of disease activity. The concepts underlying the treatment of psoriatic arthritis must be reappraised in the light of these new data. The objectives of this review are to discuss new concepts, to describe and assess the new drug classes introduced for psoriatic arthritis and, whenever possible, to define the specific indications of each class based on the rheumatic disease phenotype and presence of extraarticular manifestations...
November 16, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29154372/kaposiform-hemangioendothelioma-in-an-adult-with-rheumatoid-arthritis
#14
M Filotico, R Filotico
This report describes a case of kaposiform hemangioendothelioma arising in an adult man during the course of rheumatoid arthritis treated with steroids and methotrexate. The vascular proliferation began in the terminal phase of the disease, which culminated in acute renal failure and death. We discuss the possible relationship between rheumatoid arthritis, its treatment, and the onset of vascular proliferation, as well as the role of kaposiform hemangioendothelioma in aggravating the autoimmune disease and leading to its fatal outcome...
September 2017: Pathologica
https://www.readbyqxmd.com/read/29153870/factors-associated-with-use-of-disease-modifying-agents-for-rheumatoid-arthritis-in-the-national-hospital-and-ambulatory-medical-care-survey
#15
Priyanka Gaitonde, Laura M Bozzi, Fadia T Shaya
OBJECTIVE: We examined the treatment patterns among adults with rheumatoid arthritis (RA) and identified factors influencing access to traditional and biological disease modifying antirheumatic drugs (DMARDs). METHODS: We analyzed visits recorded in the National Ambulatory Medical Care Survey from 2005 to 2014 with a RA diagnosis. The primary outcome was DMARD use (traditional and/or biological). We included prescriptions of all RA-related treatments such as traditional and biological DMARDs, glucocorticoids, gold preparations, immunosuppressants, and non-steroidal anti-inflammatory drugs...
October 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29153241/treatment-of-the-temporomandibular-joint-in-a-child-with-juvenile-idiopathic-arthritis
#16
REVIEW
Eric J Granquist
The oral and maxillofacial surgeon is instrumental in the management and care of pediatric patients with juvenile idiopathic arthritis (JIA) and should include JIA in the differential when evaluating pediatric patients with temporomandibular joint (TMJ) dysfunction. Medical management has largely decreased the need for surgical intervention, but these patients may require intraarticular steroid injections of the TMJ, close follow-up to monitor their facial growth, and management of the subsequent postinflammatory degenerative TMJ changes...
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29153240/acquired-abnormalities-of-the-temporomandibular-joint
#17
REVIEW
Anne-Frédérique Chouinard, Leonard B Kaban, Zachary S Peacock
Mandibular growth is a complex process that involves the "functional matrix," an interaction of the muscles of mastication, occlusion, and jaw function. Although not a typical growth center, the mandibular condyle has a significant effect on the ultimate size, shape and function of the mandible and secondarily on overall facial form. Acquired temporomandibular joint (TMJ)/condylar abnormalities, such as juvenile idiopathic arthritis, idiopathic condylar resorption, TMJ ankylosis, and condylar hyperplasia, often result in facial deformity and functional deficits...
February 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29152095/tipe2-expression-is-increased-in-peripheral-blood-mononuclear-cells-from-patients-with-rheumatoid-arthritis
#18
Zhu Shi-Bai, Liu Rui-Min, Sun Ying-Chuan, Zhai Jie, Jiang Chao, Ye Can-Hua, Chen Xi, Qian Wen-Wei
We investigated the changes in mRNA and protein expression of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) and PEST-containing nuclear protein (PCNP) in peripheral blood lymphocytes from 54 patients with rheumatoid arthritis (RA) and the spleens of model mice with collagen-induced arthritis (CIA) to generate new ideas for clinical diagnosis and treatment. Expression levels of both TIPE2 and PCNP were higher in RA patients and CIA mice than in their respective controls. They were also higher in the 32 patients with active RA than in the 22 with inactive RA (P < 0...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152008/short-medium-and-long-term-complications-after-total-anatomical-shoulder-arthroplasty
#19
REVIEW
T M Gregory, B Boukebous, J Gregory, J Pierrart, E Masemjean
Total shoulder arthroplasty (TSA) is an effective approach for the treatment of a variety of clinical conditions affecting the shoulder, including osteoarthritis, inflammatory arthritis and osteonecrosis, and the number of TSA implanted has grown exponentially over the past decade. This review gives an update of the major complications, mainly infections, instability and loosening, encountered after TSA, based on a corpus of recent publications and a dynamic approach: The review focuses on the causes of glenoid loosening, which account for 80% of the complication, and underlines the importance of glenoid positioning in the recovery of early shouder function and in the long term survival rate of TSA...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29151999/mid-term-outcomes-after-open-reduction-internal-fixation-of-proximal-interphalangeal-joint-dorsal-fracture-dislocations-through-a-volar-shotgun-approach-and-a-review-of-the-literature
#20
REVIEW
Juan Marcelo Giugale, Juntian Wang, Robert A Kaufmann, John R Fowler
Background: Proximal interphalangeal (PIP) fracture dislocations remain a complex injury pattern to treat. There are several treatment methods available aimed to restore stability, preserve range of motion, and reconstitute the articular surface. This study looked at the mid-term clinical and radiographic results of open reduction internal fixation through a shotgun approach of comminuted PIP fracture dislocations. Methods: A retrospective review was conducted of all PIP fracture dislocations treated through a volar, shotgun approach at a single institution over a 15-year period...
2017: Open Orthopaedics Journal
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