Carolina Ciacci, Julio Cesar Bai, Geoffrey Holmes, Abdulbaqi Al-Toma, Federico Biagi, Antonio Carroccio, Rachele Ciccocioppo, Antonio Di Sabatino, Rachel Gingold-Belfer, Mariana Jinga, Govind Makharia, Sonia Niveloni, Gary L Norman, Kamran Rostami, David S Sanders, Edgardo Smecuol, Vincenzo Villanacci, Santiago Vivas, Fabiana Zingone
BACKGROUND: Whether coeliac disease in adults can be diagnosed with serology alone remains controversial. We aimed to evaluate the accuracy of serum anti-tissue transglutaminase IgA (tTG-IgA) in the diagnosis of coeliac disease. METHODS: In this multicentre, prospective cohort study, adult participants (aged ≥18 years) with suspected coeliac disease without IgA deficiency who were not on a gluten-free diet and who had a local serum tTG-IgA measurement, were enrolled from Feb 27, 2018, to Dec 24, 2020, by 14 tertiary referral centres (ten from Europe, two from Asia, one from Oceania, and one from South America) to undergo local endoscopic duodenal biopsy...
November 2023: Lancet. Gastroenterology & Hepatology