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https://www.readbyqxmd.com/read/29782000/induction-of-nephrotic-syndrome-in-mice-by-retrobulbar-injection-of-doxorubicin-and-prevention-of-volume-retention-by-sustained-release-aprotinin
#1
Bernhard N Bohnert, Ferruh Artunc
Nephrotic syndrome is the most extreme manifestation of proteinuric kidney disease and characterized by heavy proteinuria, hypoalbuminemia, and edema due to sodium retention and hyperlipidemia. To study the pathophysiology of this syndrome, rodent models have been developed based on the injection of toxic substances such as doxorubicin causing podocyte damage. In mice, only few strains are susceptible to this model. In wildtype 129S1/SvImJ mice, the administration of doxorubicin by rapid intravenous injection to the retrobulbar sinus induces experimental nephrotic syndrome that features all the symptoms of human disease including sodium retention and edema...
May 6, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781491/oleuropein-and-hydroxytyrosol-rich-extracts-from-olive-leaves-attenuate-liver-injury-and-lipid-metabolism-disturbance-in-bisphenol-a-treated-rats
#2
Asma Mahmoudi, Fatma Hadrich, Ines Feki, Hela Ghorbel, Zouhaier Bouallagui, Rim Marrekchi, Hela Fourati, Sami Sayadi
In the present study, we investigated the protective effects of oleuropein- and hydroxytyrosol-rich extracts obtained from olive leaves against bisphenol A (BPA)-induced hyperlipidemia and liver injury in male rats. For this purpose, four groups of male rats (8 per group) were used: control group (Control), rats treated with BPA, rats treated with both BPA and oleuropein (OLE-BPA), and rats treated with both BPA and hydroxytyrosol (HYT-BPA). After 60 days of treatment, the results obtained using the DXA technique showed that treatment with BPA (10 mg per kg b...
May 21, 2018: Food & Function
https://www.readbyqxmd.com/read/29780784/risk-factors-and-factors-affecting-the-severity-of-overactive-bladder-symptoms-in-korean-women-who-use-public-health-centers
#3
Jungsoo Chae, Eun-Hee Yoo, Yeonseong Jeong, Seungyeon Pyeon, Donguk Kim
Objective: To investigate the prevalence, risk factors of overactive bladder (OAB) and the factors affecting the severity of OAB symptoms. Methods: A total 822 interviews with women aged 18-80 years who visited public health centers were conducted between April 2014 and April 2015. The questionnaire was composed of 16 questions about urinary symptoms, 14 questions about self-treatment and the use of complementary and alternative medicine, and 21 questions about socio-demographic characteristics...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29780007/hidradenitis-suppurativa-metabolic-syndrome-and-demodex-spp-infestation
#4
Emine Ünal, Ulviye Güvendi Akçınar, Ayşe Arduç
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. This type of dermatosis with underlying chronic inflammation significantly affects the quality of life and may be accompanied by many comorbidities. In this case, Demodex spp. was associated with treatment-resistant and persistent course of skin diseases. A 46-year-old female patient applied to our clinic with complaints of lesions on the body and hip. Her dermatological examination revealed abscess formation and post-inflammatory pigmentation...
May 21, 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29779403/lipids-glucose-and-iron-metabolic-alterations-in-chronic-hepatitis-c-after-viral-eradication-comparison-of-the-new-direct-acting-antiviral-agents-with-the-old-regimens
#5
Joana Rita Carvalho, José Velosa, Fátima Serejo
BACKGROUND: Hepatitis C virus (HCV) is a unique virus which interacts with cholesterol, iron and insulin metabolism. There is limited data on the effects of direct-acting antiviral agents (DAAs) on metabolic profiles. We aimed at evaluating the behavior of metabolic risk factors of chronically HCV-infected patients after sustained virologic response (SVR), comparing the outcomes with the new DAAs versus the old treatment regimen Peg-interferon ± ribavirin. METHODS: A total of 178 patients who achieved SVR and completed one year of follow-up were prospectively included in this study: group 1 with 105 patients treated with DAAs and group 2 with 73 patients treated with old regimens...
May 20, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29764192/simvastatin-suppresses-interleukin-i%C3%AE-release-in-human-peripheral-blood-mononuclear-cells-stimulated-with-cholesterol-crystals
#6
Anna J Boland, Nisha Gangadharan, Pierce Kavanagh, Linda Hemeryck, Jennifer Kieran, Michael Barry, Patrick T Walsh, Margaret Lucitt
Statins are mainstream therapy in the treatment and prevention of cardiovascular disease through inhibitory effects on cholesterol synthesis. However, statins' beneficial effects in cardiovascular disease may also be attributable to their role as anti-inflammatory mediators. Here, we investigated the effects of simvastatin treatment on expression levels of interleukin (IL) 1β in both patient with hyperlipidemia and healthy human peripheral blood mononuclear cells (PBMCs) using cholesterol crystals (CC), a cardiovascular pathogenic stimulus for activation of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29763925/the-influence-of-hyperlipidemia-on-endothelial-function-of-fpn1-tek-cre-mice-and-the-intervention-effect-of-tetramethylpyrazine
#7
Ming-Yue Sun, Miao Zhang, Shui-Ling Chen, Shu-Ping Zhang, Chun-Yu Guo, Jing-Shang Wang, Xin Liu, Yang Miao, Hui-Jun Yin
BACKGROUND/AIMS: Systemic iron homeostasis is strictly governed in mammals; however, disordered iron metabolism (such as excess iron burden) is recognized as a risk factor for various types of diseases including AS (Atherosclerosis). The hepcidin-ferroportin axis plays the key role in regulation of iron homeostasis and modulation of this signaling could be a potential therapeutic strategy in the treatment of these diseases. TMP (Tetramethylpyrazine) has been reported to have therapeutical effect on AS...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29763911/clinical-correlates-of-ambulatory-blood-pressure-phenotypes-at-a-tertiary-care-hospital-in-turkey
#8
Siyar Erdogmus, Sim Kutlay, Zeynep Kendi Celebi, Tolga Aydın, Damla Ors Sendogan, Gizem Kumru, Kenan Keven, Gokhan Nergizoglu, Sehsuvar Erturk, Sule Sengul
BACKGROUND/AIMS: Hypertension and its complications are major public health issues worldwide due to their association with high cardiovascular morbidity and mortality. Despite significant progress in health, the prevalence of hypertension is increasing. Ambulatory blood pressure monitoring (ABPM) is becoming increasingly important for the management of hypertension. In this study, we aimed to investigate the clinical and laboratory correlates of ambulatory blood pressure (ABP) phenotypes at a tertiary care hospital in Turkey...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29757558/-clinical-features-of-the-recurrence-of-idiopathic-benign-paroxysmal-positional-vertigo
#9
Yong Sheng Tian, Shu Zhen Wang, Ying Liu, Dan Wang, Liang Rong Guo
Objective: To investigate the clinical features of the recurrence of idiopathic benign paroxysmal positional vertigo(IBPPV)patients. Method: Patients with IBPPV were enrolled and were followed-up for 36 months after being well controlled.The data of the patients including age,gender,and co-morbidities(hypertension,diabetes,hyperlipidemia)were analyzed.Characteristics of the patients with recurrent BPPV were compared with those without recurrence. Result: Two hundred and one patients were enrolled and twenty-two(10...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29754804/diabetes-mellitus-and-cardiovascular-risk-update-of-the-recommendations-of-the-diabetes-and-cardiovascular-disease-working-group-of-the-spanish-diabetes-society-sed-2018
#10
Francisco Arrieta, Pedro Iglesias, Juan Pedro-Botet, Antonio Becerra, Emilio Ortega, Juan Carlos Obaya, Andreu Nubiola, Gonzalo Fernando Maldonado, Maria Del Mar Campos, Romina Petrecca, José Luis Pardo, Víctor Sánchez-Margalet, José Juan Alemán, Jorge Navarro, Santiago Duran, Francisco Javier Tébar, Manuel Aguilar, Fernando Escobar
This document is an update to the clinical practice recommendations for the management of cardiovascular risk factors in diabetes mellitus. The consensus is made by members of the Cardiovascular Risk Group of the Spanish Diabetes Society. We have proposed and updated interventions on lifestyle, pharmacological treatment indicated to achieve therapeutic objectives according to the levels of HbA1c, degree of obesity, hypertension, hyperlipidemia, heart failure, platelet antiagregation, renal insufficiency, and diabetes in the elderly, as well as new biomarkers of interest in the evaluation of cardiovascular risk in individuals with diabetes mellitus...
May 10, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29753234/effect-of-short-term-hazelnut-consumption-on-dna-damage-and-oxidized-ldl-in-children-and-adolescents-with-primary-hyperlipidemia-a-randomized-controlled-trial
#11
Federica Guaraldi, Valeria Deon, Cristian Del Bo', Stefano Vendrame, Marisa Porrini, Patrizia Riso, Ornella Guardamagna
Children with primary hyperlipidemia are prone to develop premature atherosclerosis, possibly associated with increased oxidative stress. Nutritional therapy is the primary strategy in the treatment of hyperlipidemia and associated conditions. Dietary interventions with bioactive-rich foods, such as nuts, may contribute to the modulation of both lipid profile and the oxidative/antioxidant status. Our study aimed to assess the impact of a dietary intervention with hazelnuts on selected oxidative stress markers in children and adolescents with primary hyperlipidemia...
March 20, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29747507/biological-profiling-based-systematic-analysis-of-rhizoma-coptidis-from-different-growing-regions-and-its-anti-cholesterol-biosynthesis-activity-on-hepg2-cells
#12
Juan Feng, Haoxun Li, Wenlong Zhao, Honglei Dang, Ruijun Wang, Kun Luo, Hongyan Guo, Wanli Xing, Jing Cheng, Weifang Song, Yimin Sun, Lan Xie
Rhizoma Coptidis is a widely cultivated traditional Chinese herb. Although the chemical profiles of Rhizoma Coptidis have been established previously, the biological profiling of Rhizoma Coptidis has not been conducted yet. In this study, we collected Rhizoma Coptidis varieties from four distinct growing regions and performed genome-wide biological response fingerprinting (BioReF) on HepG2 cells using a gene expression array. Similar biological pathways were affected by extracts of all four Rhizoma Coptidis varieties but not by their analogue, Mahoniae Caulis...
May 11, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29743974/simvastatin-treatment-upregulates-ho-1-in-patients-with-abdominal-aortic-aneurysm-but-independently-of-nrf2
#13
Aleksandra Piechota-Polanczyk, Aleksandra Kopacz, Damian Kloska, Branislav Zagrapan, Christoph Neumayer, Anna Grochot-Przeczek, Ihor Huk, Christine Brostjan, Jozef Dulak, Alicja Jozkowicz
Heme oxygenase-1 (HO-1), encoded by HMOX1 gene and regulated by Nrf2 transcription factor, is a cytoprotective enzyme. Its deficiency may exacerbate abdominal aortic aneurysm (AAA) development, which is also often associated with hyperlipidemia. Beneficial effects of statins, the broadly used antilipidemic drugs, were attributed to modulation of Nrf2/HO-1 axis. However, the effect of statins on Nrf2/HO-1 pathway in patients with AAA has not been studied yet. We analyzed AAA tissue from patients treated with simvastatin ( N  = 28) or without statins ( N  = 14)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29736889/population-pharmacokinetics-and-exposure-response-modeling-and-simulation-for-evolocumab-in-healthy-volunteers-and-patients-with-hypercholesterolemia
#14
Mita Kuchimanchi, Anita Grover, Maurice G Emery, Ransi Somaratne, Scott M Wasserman, John P Gibbs, Sameer Doshi
Evolocumab, a novel human monoclonal antibody, inhibits proprotein convertase subtilisin/kexin type 9, a protein that targets low-density lipoprotein-cholesterol (LDL-C) receptors for the treatment of hyperlipidemia. The primary objective of this analysis was to characterize the population pharmacokinetics (popPK) and exposure-response relationship of evolocumab to assess if dose adjustment is needed across differing patient populations. Data were pooled for 5474 patients in 11 clinical studies who received evolocumab doses of 7-420 mg at various frequencies, either intravenously or subcutaneously...
May 7, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29735636/potential-protective-mechanism-in-the-cardiac-microvascular-injury
#15
Xiuchuan Li, Juanni Hou, Jin Du, Jian Feng, Yi Yang, Yang Shen, Sha Chen, Juan Feng, Dachun Yang, De Li, Haifeng Pei, Yongjian Yang
Cardiac microvascular injury often occurs in patients with type 2 diabetes mellitus (T2DM) who develop hyperglycemia and hyperlipidemia. However, besides reported contradictory roles in cardiac diseases, the function of TRPV1 (transient receptor potential vanilloid 1) in cardiac microvessels is not well defined. This study was performed to determine the detailed role of TRPV1 in cardiac microvascular endothelial cells (CMECs) in T2DM. T2DM mice were established by multiple injections of low-dose streptozotocin and high-fat feeding...
May 7, 2018: Hypertension
https://www.readbyqxmd.com/read/29729169/optimization-of-the-complex-therapy-of-chronic-pancreatitis-with-metabolic-syndrome
#16
Liliya S Babinets, Nataliia A Melnyk, Nataliia O Shevchenko, Galina M Sasyk, Olexandr S Zemlyak, Olexandra Ye Kopach, Olga Ye Fedoriv
OBJECTIVE: Inroduction: The most common reasons of chronic pancreatitis are alcohol abuse, biliary tract and liver diseases, stomach and duodenum, hyperlipidemia, which is often associated with metabolic syndrome. The aim: to study the effectiveness of using medicine omega-3 polyunsaturated fatty acids in standard therapy to the correction of lipids and prooxidant-antioxidant disorders in patients with chronic pancreatitis and metabolic syndrome. PATIENTS AND METHODS: Materials and methods: The study included 90 patients with chronic pancreatitis with metabolic syndrome...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29725814/inhibition-of-mir-486-and-mir-92a-decreases-liver-and-plasma-cholesterol-levels-by-modulating-lipid-related-genes-in-hyperlipidemic-hamsters
#17
Loredan S Niculescu, Natalia Simionescu, Elena V Fuior, Camelia S Stancu, Mihaela G Carnuta, Madalina D Dulceanu, Mina Raileanu, Emanuel Dragan, Anca V Sima
In the present study we aimed to evaluate the potential of in vivo inhibition of miR-486 and miR-92a to reverse hyperlipidemia, then to identify and validate their lipid metabolism-related target genes. Male Golden-Syrian hamsters fed a hyperlipidemic (HL) diet (standard chow plus 3% cholesterol and 15% butter, 10 weeks) were injected subcutaneously with lock-nucleic acid inhibitors for either miR-486 or miR-92a. Lipids and miRNAs levels in liver and plasma, and hepatic expression of miRNAs target genes were assessed in all HL hamsters...
May 3, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29725365/effects-of-recombinant-human-growth-hormone-on-protein-malnutrition-and-igf-1-and-il-2-gene-expression-levels-in-chronic-nephrotic-syndrome
#18
Guang Dai, Donghai Wang, Hua Dong
The aim of the study was to investigate the effects of recombinant human growth hormone on protein malnutrition and insulin-like growth factor-1 ( IGF-1 ) and interleukin-2 ( IL-2 ) gene expressions in chronic nephrotic syndrome. Eighty patients with chronic nephrotic syndrome were admitted to our hospital. The patients were included in the study period from January 2015 to December 2016 and were divided into two groups (40 cases in each group) according to the random number method. All the patients enrolled received symptomatic and supportive treatment...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29722330/use-of-curcumin-in-diagnosis-prevention-and-treatment-of-alzheimer-s-disease
#19
REVIEW
Min Chen, Zhi-Yun Du, Xi Zheng, Dong-Li Li, Ren-Ping Zhou, Kun Zhang
This review summarizes and describes the use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. Curcumin was developed as an early diagnostic probe based on its natural fluorescence and high binding affinity to amyloid-β. Because of its multi-target effects, curcumin has protective and preventive effects on many chronic diseases such as cerebrovascular disease, hypertension, and hyperlipidemia...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29716860/in-vivo-evaluation-of-antihyperlipidemic-antihyperglycemic-and-hepatoprotective-effects-of-vernonia-anthelmintica-seeds-in-diet-model
#20
Subia Jamil, Rafeeq Alam Khan, Shadab Ahmed
Anti-hyperglycemic, anti-hyperlipidemic and hepatoprotective effects of Vernonia anthelmintica seeds were evaluated in diet rat model. The study included forty eight Sprague Dawley rats of either sex with eight animals in each group. Except for control the disease control, standard and treatment groups were treated with high-fat high-sugar diet for 8 weeks. After confirmation of hyperlipidemia and hyperglycemia, the standard group received atorvastatin (2.1 mg.kg-1 ), treatment groups received hexane extract, ethanol extract and water decoction of Vernonia anthelmintica seeds (300mg...
May 2018: Pakistan Journal of Pharmaceutical Sciences
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