keyword
https://read.qxmd.com/read/38545092/efficacy-and-safety-of-phospholipid-nanoparticles-vbi-s-in-reversing-intractable-hypotension-in-patients-with-septic-shock-a-multicentre-open-label-repeated-measures-phase-2a-clinical-pilot-trial
#1
JOURNAL ARTICLE
Cuthbert Simpkins, Michael Moncure, Heather Klepacz, Kristopher Roach, Sadia Benzaquen, Luis Diaz-Caballero, Jonathan Cohen, Daniel Haase, Mukesh Kumar, Harven DeShield, Anthony Manasia, Juan Rodriguez, Prashanth Anamthathmakula, Nik Hurt, Bhaswati Mukherjee, Krishna Talluri
BACKGROUND: Since the 1990's attempts to favorably modulate nitric oxide (NO) have been unsuccessful. We hypothesized that because NO is lipophilic it would preferentially localize into intravascularly infused hydrophobic nanoparticles, thereby reducing its bioavailability and adverse effects without inhibiting its production. We aimed to determine the efficacy and safety of intravenous infusion of a fluid comprised of hydrophobic phospholipid nanoparticles (VBI-S) that reversibly absorb NO in the treatment of hypotension of patients in severe septic shock...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38539242/lipid-droplet-accumulation-in-wdr45-deficient-cells-caused-by-impairment-of-chaperone-mediated-autophagic-degradation-of-fasn
#2
JOURNAL ARTICLE
Qiuhong Xiong, Huimin Sun, Yanlin Wang, Qian Xu, Yu Zhang, Mei Xu, Zhonghua Zhao, Ping Li, Changxin Wu
BACKGROUND: β-Propeller protein-associated neurodegeneration (BPAN) is a genetic neurodegenerative disease caused by mutations in WDR45. The impairment of autophagy caused by WDR45 deficiency contributes to the pathogenesis of BPAN; however, the pathomechanism of this disease is largely unknown. Lipid dyshomeostasis is involved in neurogenerative diseases, but whether lipid metabolism is affected by Wdr45 deficiency and whether lipid dyshomeostasis contributes to the progression of BPAN are unclear...
March 28, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38528584/potential-use-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibition-and-prevention-method-in-viral-infection
#3
REVIEW
Khursheed Muzammil, Mohammad Hosseini Hooshiar, Shirin Varmazyar, Thabit Moath Omar, Manal Morad Karim, Sadeq Aadi, Shaylan Kalavi, Saman Yasamineh
Cellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend significantly on lipid rafts for infection at virtually every stage of their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) and promoting its lysosomal degradation, has garnered increasing interest...
March 25, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38528544/mg-zif-nanozyme-regulates-the-switch-between-osteogenic-and-lipogenic-differentiation-in-bmscs-via-lipid-metabolism
#4
JOURNAL ARTICLE
Jinying Li, Yongshao Chen, Dingsheng Zha, Chunhui Wu, Xiaofen Li, Li Yang, Hui Cao, Shexing Cai, Yuebo Cai
The accumulation of reactive oxygen species (ROS) within the bone marrow microenvironment leads to diminished osteogenic differentiation and heightened lipogenic differentiation of mesenchymal stem cells residing in the bone marrow, ultimately playing a role in the development of osteoporosis (OP). Mitigating ROS levels is a promising approach to counteracting OP. In this study, a nanozyme composed of magnesium-based zeolitic imidazolate frameworks (Mg-ZIF) was engineered to effectively scavenge ROS and alleviate OP...
March 25, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38523132/exposure-to-statin-therapy-decreases-the-incidence-of-venous-thromboembolism-after-trauma
#5
JOURNAL ARTICLE
Kelly E Sanders, Gabrielle E Hatton, Atharwa R Mankame, Addison C Allen, Sarah Cunningham, Jan Michael Van Gent, Erin E Fox, Xu Zhang, Charles E Wade, Bryan A Cotton, Jessica C Cardenas
INTRODUCTION: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in trauma patients, despite chemoprophylaxis. Statins have been shown capable of acting upon the endothelium. We hypothesized that statin therapy in the pre- or in-hospital settings leads to a decreased incidence of VTE. METHODS: We conducted a retrospective cohort study of injured patients who received statin therapy pre- or in-hospital. Adult, highest-level trauma activation patients admitted January 2018 - June 2022 were included...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38521433/antihyperglycemic-and-antihyperlipidemic-effects-of-fruit-extract-of-hodgsonia-heteroclita-roxb-hook-f-thomson-in-diabetic-mice
#6
JOURNAL ARTICLE
Silu Basumatary, Partha Pradip Adhikari, Ajit Kumar Das, Nanjian Raaman, Gauri Dutt Sharma, Jatin Sarmah, Anjum Dihingia, Rinku Baishya, Prasenjit Manna, Jatin Kalita
ETHNOPHARMACOLOGICAL RELEVANCE: Hodgsonia heteroclita has been known as an important traditionally consumed medicinal plant of North-East India known to have antidiabetic properties. This study aims to investigate the effects of the ethanolic fruit extract of Hodgsonia heteroclita against hyperglycemia and hyperlipidemia by using streptozotocin (STZ) treated diabetic mice. MATERIALS AND METHODS: The fruits of H. heteroclita were collected from the various parts of Kokrajhar district, Assam India (Geographic coordinates: 26°24'3...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38520833/alisol-b-regulates-ampk-mtor-srebps-via-directly-targeting-vdac1-to-alleviate-hyperlipidemia
#7
JOURNAL ARTICLE
Gai Gao, Jie Zhao, Jing Ding, Shuyan Liu, Yanyan Shen, Changxin Liu, Huifen Ma, Yu Fu, Jiangyan Xu, Yiran Sun, Xiaowei Zhang, Zhenqiang Zhang, Zhishen Xie
BACKGROUND: The occurrence of hyperlipidemia is significantly influenced by lipid synthesis, which is regulated by sterol regulatory element binding proteins (SREBPs), thus the development of drugs that inhibit lipid synthesis has become a popular treatment strategy for hyperlipidemia. Alisol B (ALB), a triterpenoid compound extracted from Alisma, has been reported to ameliorate no-nalcoholic steatohepatitis (NASH) and slow obesity. However, the effect of ALB on hyperlipidemia and mechanism are unclear...
December 25, 2023: Phytomedicine
https://read.qxmd.com/read/38519278/acupuncture-for-obesity-and-related-diseases-insight-for-regulating-neural-circuit
#8
REVIEW
Lin-Yan Jiang, Jun Tian, Ya-Nan Yang, Shao-Hui Jia, Qing Shu
Obesity is defined as abnormal or excessive fat accumulation that may impair health. Obesity is associated with numerous pathological changes including insulin resistance, fatty liver, hyperlipidemias, and other obesity-related diseases. These comorbidities comprise a significant public health threat. Existing anti-obesity drugs have been limited by side effects that include depression, suicidal thoughts, cardiovascular complications and stroke. Acupuncture treatment has been shown to be effective for treating obesity and obesity-related conditions, while avoiding side effects...
March 6, 2024: Journal of Integrative Medicine
https://read.qxmd.com/read/38516498/exploring-the-relationship-between-hepatitis-c-virus-infection-and-prostate-cancer-risk-a-national-health-and-nutrition-examination-survey-analysis
#9
JOURNAL ARTICLE
Marc Ganz, Christopher Alessandro, Menachem Jacobs, Yehuda Gejerman, Daniel Miller, Frederick Okoye, Scott Jamieson, Andrew Winer
Introduction Prostate cancer and hepatitis C virus (HCV) infection stand as notable worldwide health issues. Investigating the connection between HCV infection and the risk of prostate cancer remains an ongoing endeavor, complicated by contradictory findings in prior research. It is imperative to comprehend this potential relationship in order to enhance strategies for prevention and treatment. This paper seeks to delve into the association between HCV infection and prostate cancer by analyzing data from the National Health and Nutrition Examination Survey (NHANES), a comprehensive cross-section of the US population...
February 2024: Curēus
https://read.qxmd.com/read/38516265/efficacy-of-ehealth-interventions-to-reduce-depression-symptoms-in-individuals-with-obesity-a-systematic-review-of-randomized-controlled-trials
#10
Dilara Kocol, Alexander Bäuerle, Theresa Schadendorf, Sheila Geiger, Julia Barbara Krakowczyk, Eva-Maria Skoda, Martin Teufel
INTRODUCTION: Obesity and depression are inter-related health concerns, demanding a high level of treatment and costs in the health care system. The development of eHealth interventions that simultaneously address obesity and mental health can be supportive in this regard. However, evidence of the efficacy of eHealth interventions in the treatment of depression symptoms in individuals with obesity is lacking. The aim of this systematic literature review is to evaluate the efficacy of existing eHealth interventions for individuals with obesity that target depression symptoms...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38515677/the-influence-of-triglyceride-and-low-density-lipoprotein-target-levels-on-microcirculation-is-there-a-difference
#11
JOURNAL ARTICLE
Gergely Galos, Miklos Rabai, Reka Szabo, Rita Szalai, Kalman Toth, Peter Hegyi, Barbara Sandor
BACKGROUND AND AIMS: This study aimed to validate the role of high low-density lipoprotein cholesterol [LDL-C] and triglyceride [TG] treatment target levels on the microcirculation in a very high and high cardiovascular risk group. METHODS: 119 patients with high or very high cardiovascular [CV] risk were included. We have registered the main co-morbidities, smoking habits, body mass index [BMI] and the lipid lowering medication. Hematocrit, whole blood viscosity [WBV] and plasma viscosity [PV], red blood cell [RBC] aggregation and deformability and fibrinogen, total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], LDL-C and TG levels were determined...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38511752/a-retrospective-study-of-pregnant-patients-with-acute-pancreatitis
#12
JOURNAL ARTICLE
Şehmus Ölmez, Bünyamin Sarıtaş, Mehmet Suat Yalçın, Raziye Narin, Adnan Taş, Nevin Akçaer Öztürk, Mustafa Muslu, Haşim Nar, Ekrem Sapmaz, Banu Kara
OBJECTIVE: Acute pancreatitis is a rare disease in pregnant patients. Although it may have serious maternal and fetal consequences, morbidity and mortality rates have decreased recently due to appropriate and rapid treatment with earlier diagnosis. The aim of this study was to evaluate pregnant patients diagnosed with acute pancreatitis. METHODS: The study included pregnant patients diagnosed with acute pancreatitis who were admitted to Adana City Training and Research Hospital in Adana, Turkey, between January 2014 and January 2022...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38509578/gene-variants-and-clinical-characteristics-of-children-with-sitosterolemia
#13
JOURNAL ARTICLE
Rui Gu, Hui Wang, Chun-Lin Wang, Mei Lu, Miao Miao, Meng-Na Huang, Yi Chen, Yang-Li Dai, Ming-Qiang Zhu, Qiong Zhou, Chao-Chun Zou
OBJECTIVE: To enhance the detection, management and monitoring of Chinese children afflicted with sitosterolemia by examining the physical characteristics and genetic makeup of pediatric patients. METHODS: In this group, 26 children were diagnosed with sitosterolemia, 24 of whom underwent genetic analysis. Patient family medical history, physical symptoms, tests for liver function, lipid levels, standard blood tests, phytosterol levels, cardiac/carotid artery ultrasounds, fundus examinations, and treatment were collected...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38505622/unleashing-the-potential-of-adipose-organoids-a-revolutionary-approach-to-combat-obesity-related-metabolic-diseases
#14
REVIEW
Xingran Liu, Jing Yang, Yuxin Yan, Qingfeng Li, Ru-Lin Huang
Obesity-related metabolic diseases, including obesity, diabetes, hyperlipidemia, and non-alcoholic fatty liver diseases pose a significant threat to health. However, comprehensive pathogenesis exploration and effective therapy development are impeded by the limited availability of human models. Notably, advances in organoid technology enable the generation of adipose organoids that recapitulate structures and functions of native human adipose tissues to investigate mechanisms and develop corresponding treatments for obesity-related metabolic diseases...
2024: Theranostics
https://read.qxmd.com/read/38505559/gut-microbiota-s-causative-relationship-with-peripheral-artery-disease-a-mendelian-randomization-study
#15
JOURNAL ARTICLE
Yu Tian, Guanqun Yao, Loren Skudder-Hill, Guangyang Xu, Yuxuan Qian, Feng Tang, Qian Wang, Qianhui Bao, Lei Li
INTRODUCTION: The relationship between gut microbiota and peripheral artery disease (PAD) remains understudied. While traditional risk factors like smoking and hyperlipidemia are well-understood, our study aims to determine the potential causative association of gut microbiota with PAD using Mendelian Randomization. METHODS: Data from the International MiBioGen Consortium and the FinnGen research project were used to study 211 bacterial taxa. Instrumental variables, comprising 2079 SNPs, were selected based on significance levels and linkage disequilibrium...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38504356/exploring-the-role-of-genetic-variations-in-nafld-implications-for-disease-pathogenesis-and-precision-medicine-approaches
#16
REVIEW
Seyedeh Kosar Mahmoudi, Shadi Tarzemani, Taha Aghajanzadeh, Mohammadreza Kasravi, Behzad Hatami, Mohammad Reza Zali, Kaveh Baghaei
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases, affecting more than one-quarter of people worldwide. Hepatic steatosis can progress to more severe forms of NAFLD, including NASH and cirrhosis. It also may develop secondary diseases such as diabetes and cardiovascular disease. Genetic and environmental factors regulate NAFLD incidence and progression, making it a complex disease. The contribution of various environmental risk factors, such as type 2 diabetes, obesity, hyperlipidemia, diet, and sedentary lifestyle, to the exacerbation of liver injury is highly understood...
March 20, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38499796/evaluation-study-of-single-anastomosis-duodenal-ileal-bypass-with-sleeve-gastrectomy-in-the-treatment-of-chinese-obese-patients-based-on-efficacy-and-nutrition
#17
JOURNAL ARTICLE
Lifu Hu, Lun Wang, Shixing Li, Yang Liu, Zheng Zhang, Minghao Xiao, Zhenhua Zhang, Zhiqiang Wei, Liang Cui, Tao Jiang
To evaluate the efficacy and nutrition of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in Chinese obese patients in the first postoperative year. Clinical data of 66 obese patients who underwent SADI-S surgery at China-Japan Union Hospital of Jilin University from November 2018 to May 2022 were retrospectively collected. The weight, body mass index (BMI), percentage of excess weight loss (%EWL), and percentage of total weight loss (%TWL) were recorded at 3, 6, and 12 months after surgery...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38499259/hypolipidemic-effect-and-gut-microbiota-regulation-of-gypenoside-aglycones-in-rats-fed-a-high-fat-diet
#18
JOURNAL ARTICLE
Jian Xie, Mingxia Luo, Qiuyi Chen, Qianru Zhang, Lin Qin, Yuhe Wang, Yongxia Zhao, Yuqi He
ETHNOPHARMACOLOGICAL RELEVANCE: Gynostemma pentaphyllum (Thunb.) Makino has traditional applications in Chinese medicine to treat lipid abnormalities. Gypenosides (GPs), the main bioactive components of Gynostemma pentaphyllum, have been reported to exert hypolipidemic effects through multiple mechanisms. The lipid-lowering effects of GPs may be attributed to the aglycone portion resulting from hydrolysis of GPs by the gut microbiota. However, to date, there have been no reports on whether gypenoside aglycones (Agl), the primary bioactive constituents, can ameliorate hyperlipidemia by modulating the gut microbiota...
March 16, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38492358/deciphering-the-role-of-micrornas-in-diabetic-nephropathy-regulatory-mechanisms-and-molecular-insights
#19
REVIEW
Nourhan M Abdelmaksoud, Tohada M Al-Noshokaty, Rehab Abdelhamid, Nourhan Abdellatif, Abdallah Mansour, Reem Mohamed, Asmaa Hamouda Mohamed, Nada Abd Elatif Khalil, Sara Sobhy Abdelhamid, Alaa Mohsen, Heba Abdelaal, Ahmed Tawfik, Shereen Saeid Elshaer
A serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control, and hyperlipidemia are all important components of DN management. New research, however, points to microRNAs (miRNAs) as having a pivotal role in DN pathogenesis. Miniature non-coding RNA molecules such as miRNAs control gene expression and impact several biological processes. The canonical and non-canonical routes of miRNA biogenesis are discussed in this article...
March 4, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38491813/cardiovascular-anti-inflammatory-drugs-repurposed-for-treating-or-preventing-cancer-a-systematic-review-and-meta-analysis-of-randomized-trials
#20
JOURNAL ARTICLE
David J Benjamin, Alyson Haslam, Vinay Prasad
BACKGROUND: Due to encouraging pre-clinical data and supportive observational studies, there has been growing interest in applying cardiovascular drugs (including aspirin, angiotensin-converting enzyme [ACE] inhibitors, statins, and metformin) approved to treat diseases such as hypertension, hyperlipidemia, and diabetes mellitus to the field of oncology. Moreover, given growing costs with cancer care, these medications have offered a potentially more affordable avenue to treat or prevent recurrence of cancer...
March 2024: Cancer Medicine
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