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https://www.readbyqxmd.com/read/29324798/qualitative-metabolomics-profiling-of-serum-and-bile-from-dogs-with-gallbladder-mucocele-formation
#1
Jody L Gookin, Kyle G Mathews, John Cullen, Gabriela Seiler
Mucocele formation is characterized by secretion of abnormally thick mucus by the gallbladder epithelium of dogs that may cause obstruction of the bile duct or rupture of the gallbladder. The disease is increasingly recognized and is associated with a high morbidity and mortality. The cause of gallbladder mucocele formation in dogs is unknown. There is a strong breed predisposition and affected dogs have a high incidence of concurrent endocrinopathy or hyperlipidemia. These observations suggest a significant influence of both genetic and metabolic factors on disease pathogenesis...
2018: PloS One
https://www.readbyqxmd.com/read/29322226/nebivolol-a-%C3%AE-blocker-abrogates-streptozotocin-induced-behavioral-biochemical-and-neurophysiological-deficit-by-attenuating-oxidative-nitrosative-stress-a-possible-target-for-the-prevention-of-diabetic-neuropathy
#2
Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami
Metabolic abnormalities including hyperglycemia, hyperlipidemia, and oxidative-nitrosative stress are involved in the progression of diabetic neuropathy. In the present study, we targeted oxidative-nitrosative stress using nebivolol, a β1-receptor antagonist with vasodilator and antioxidant property, to evaluate its neuroprotective effect in streptozotocin-induced diabetic neuropathy in rats. Diabetic neuropathy develops within 4-6 weeks after administration of streptozotocin (55 mg/kg, i.p.). Therefore, after confirmation of diabetes, subtherapeutic doses of nebivolol (1 and 2 mg/kg, p...
January 11, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29316682/effect-of-omega-3-fatty-acid-supplementation-on-oxylipins-in-a-routine-clinical-setting
#3
Christoph Schmöcker, Ingrid W Zhang, Stefanie Kiesler, Ursula Kassner, Annika I Ostermann, Elisabeth Steinhagen-Thiessen, Nils H Schebb, Karsten-H Weylandt
Omega-6 polyunsaturated fatty acid (n-6 PUFA) is the predominant polyunsaturated fatty acid (PUFA), especially in Western diet. A high omega-6/omega-3 ratio in Western diets is implicated in the development of cardiovascular diseases and inflammatory processes. Studies in animal models and in humans have demonstrated beneficial effects of omega-3 PUFA (n-3 PUFA) in a variety of diseases, including cardiac arrhythmias and inflammatory diseases, as well as breast and colon cancer. The molecular mechanisms underlying the effects of n-3 PUFA are still not well understood...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29313284/endocrinological-aspects-of-hiv-infection
#4
REVIEW
F S Mirza, P Luthra, L Chirch
PURPOSE: Patients with human immunodeficiency virus (HIV) are living longer with effective antiretroviral therapies and are enjoying near normal life span. Therefore, they are encountering endocrine issues faced by the general population along with those specific to HIV infection. The purpose of this article is to review the common endocrine aspects of HIV infection, and the early detection and management strategies for these complications. METHODS: Recent literature on HIV and endocrine disease was reviewed...
January 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29310516/assessment-of-squalene-eligibility-in-bettering-some-maternal-and-fetal-disorders-instigated-by-gamma-irradiation-of-rats-at-mid-gestation
#5
M F Ibrahim, N Abdelaziz
Squalene is an eminent vital part of the synthesis of steroid hormones in the body as well as the first specific intermediate in cholesterol biosynthesis that plays an essential role in normal embryogenesis. PURPOSE: The present work was designed to test the maternal and embryonic response to the modulating capacity of Squalene (0.4 mL/kg/day), when supplemented to rats from Day 1-18 of pregnancy, against the damaging consequences induced by maternal subjection to 3 Gy gamma irradiation on Day 10 post conception...
January 9, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29303029/the-use-of-ecmo-for-the-treatment-of-refractory-cardiac-arrest-or-postarrest-cardiogenic-shock-following-in-hospital-cardiac-arrest-a-10-year-experience
#6
Meshe Chonde, Penny Sappington, Robert Kormos, Andrew Althouse, Arthur Boujoukos
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has been increasingly used in the treatment of refractory cardiac arrest (extracorporeal cardiopulmonary resuscitation [ECPR]) and postarrest cardiogenic shock (PACS). Our primary objective was to determine the 1-year survival of patients who were treated with ECMO for PACS or in ECPR. METHODS: We conducted a retrospective analysis of hospitalized patients in a tertiary care facility who underwent treatment with ECMO for ECPR or PACS...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29299589/hypolipidemic-effect-and-protection-ability-of-liver-kidney-functions-of-melanin-from-lachnum-ym226-in-high-fat-diet-fed-mice
#7
Fang Shi, Jinglei Li, Liuqing Yang, Guohua Hou, Ming Ye
In the present study, we investigated the hypolipidemic properties of melanin from Lachnum YM226 (LM) in high-fat diet induced hyperlipidemic mice. After the hyperlipidemic model was established, mice were randomly divided into six groups, as follows: normal control group (NC), hyperlipidemic control group (HC), positive control group (7 mg kg-1 d-1 simvastatin) (PC) and LM groups (50, 100 and 200 mg kg-1 d-1 denoted as LM-50, LM-100 and LM-200, respectively). Subsequently, the body weight, organ indices, lipid metabolism, antioxidant properties and liver-kidney functions of the mice were examined...
January 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29296187/effect-modification-by-region-in-the-associations-of-lep-g2548a-and-lepr-q223r-polymorphisms-with-statin-induced-ck-elevation
#8
Shanqun Jiang, Scott A Venners, Kang Li, Yi-Hsiang Hsu, Justin Weinstock, Yanfeng Zou, Faming Pan, Xiping Xu
We investigated the associations of LEP G2548A and LEPR Q223R polymorphisms with statin-induced creatine kinase (CK) elevation among Chinese patients with hyperlipidemia. A total of587 enrolled individuals were treated with 20 mg/d oral simvastatin for 8 consecutive weeks. Genotyping of LEP G2548A and LEPR Q223R were conducted using PCR-RFLP. Multiple regression analyses showed that, in the Dongzhi region only, patients carrying the LEP AA genotype had a significantly greater increase in CK levels compared to those carrying the AG+GG genotypes after four weeks (P = 0...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29296091/xanthelasma-palpebrarum-a-brief-review
#9
REVIEW
Pragya A Nair, Rochit Singhal
Xanthelasma palpebrarum is the most common cutaneous xanthoma, characterized by yellowish plaques over eyelids - most commonly, over the inner canthus of the upper lid. It is triggered by hyperlipidemia, thyroid dysfunction, and diabetes mellitus. Xanthelasma results from perivascular infiltration of mono- and multinucleated foam cells within lipid-laden cytoplasmic vacuoles in the superficial reticular dermis. Different modalities of treatment, such as simple surgical excision, cryotherapy, chemical peeling with trichloroacetic acid, radiofrequency, and laser, are used in the treatment of xanthelasma palpebrarum...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29296058/myocardial-perfusion-abnormalities-in-asymptomatic-type-2-diabetic-patients
#10
Ghada Al-Humaidi, Ismet Sarikaya, Abdelhamid H Elgazzar, Azu Owunwanne
Objective: The prevalence of coronary artery disease (CAD) is high in patients with diabetes. Because ischemia and infarction are often silent in diabetic patients, diagnosis of CAD occurs inevitably late. It is essential to identify the presence of CAD in diabetic patients to start early treatment. Therefore, the aim of this study was to determine the prevalence of abnormal myocardial perfusion in asymptomatic type 2 diabetic patients using myocardial perfusion imaging. Methods: Fifty-nine patients with type 2 diabetes, who did not have any history of CAD, but did have risk factors underwent myocardial perfusion single-photon emission computed tomography (SPECT) imaging using 99mTc-tetrofosmin and a 2-day stress-rest protocol...
January 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29288408/muscle-specific-deletion-of-prkaa1-enhances-skeletal-muscle-lipid-accumulation-in-mice-fed-a-high-fat-diet
#11
Weiche Wu, Ziye Xu, Ling Zhang, Jiaqi Liu, Jie Feng, Xinxia Wang, Tizhong Shan, Yizhen Wang
Excessive intramyocellular triacylglycerols (IMTGs, muscle lipids) are associated with the abnormal energy metabolism and insulin resistance of skeletal muscle. AMP-activated protein kinase (AMPK), a crucial cellular energy sensor, consists of α, β and γ subunits. Researchers have not clearly determined whether Prkaa1 (also known as AMPKα1) affects IMTG accumulation in skeletal muscle. Here, we show an important role of Prkaa1 in skeletal muscle lipid metabolism. Deletion of muscle Prkaa1 leads to the delayed development of skeletal muscles but does not affect glucose tolerance or insulin sensitivity in animals fed a normal diet...
December 29, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29282357/risk-factors-for-arterial-versus-venous-thrombosis-in-polycythemia-vera-a-single-center-experience-in-587-patients
#12
S Cerquozzi, D Barraco, T Lasho, C Finke, C A Hanson, R P Ketterling, A Pardanani, N Gangat, A Tefferi
In a recent International Working Group on Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) study, prior arterial events and hypertension were predictors of subsequent arterial thrombosis whereas prior venous events and age ≥65 years predicted venous thrombosis in polycythemia vera (PV). In the current study, we sought to validate the above findings and identify additional predictors of arterial versus venous thrombosis. At a median follow up of 109 months, thrombosis after diagnosis occurred in 128 (22%) patients; 82 (14%) arterial and 57 (10%) venous events...
December 27, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/29276845/cardiometabolic-comorbidities-and-life-expectancy-in-people-on-medication-for-schizophrenia-in-australia
#13
David J Castle, Eric Chung
OBJECTIVE: We aimed to assess the risks of people on medication for schizophrenia, of developing different components of the metabolic syndrome and life expectancy, through reference to a representative population of Australians without schizophrenia. METHOD: Pharmacy payment-claim records from the Pharmaceutical Benefits Scheme were analyzed based on a representative 10% sample of Medicare numbers supplied by the Department of Human Services. Records were analyzed based on the date of supply of the prescription and the data set included year of death information...
December 25, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29275298/association-of-antituberculosis-treatment-and-lower-risk-of-hyperlipidemia-in-taiwanese-patients-a-population-based-case-control-study
#14
Ying-Ray Lee, N I Tien, Cheng-Li Lin, Hsin-Yi Shen, DA-Tian Bau, Yun-Ping Lim
The association between anti-tuberculosis (TB) treatments and the risk of developing hyperlipidemia remains unclear. Data were obtained from the Longitudinal Health Insurance Database 2000 (LHID2000). The case group included patients newly diagnosed with hyperlipidemia (n=16,054) between 2006 and 2011 selected from the LHID2000. A four-fold number of hyperlipidemia-free cases (n=64,216) were matched with case patients by age, sex, and index year to create the control group. Univariable and multivariable unconditional logistic regression analyses were conducted to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between hyperlipidemia and anti-TB medication use...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29260378/%C3%AF-3-fatty-acid-synergized-novel-nanoemulsifying-system-for-rosuvastatin-delivery-in-vitro-and-in-vivo-evaluation
#15
Chandra Bhushan Tripathi, Neha Gupta, Pranesh Kumar, Ashok Kumar Singh, Vinit Raj, Poonam Parashar, Mahendra Singh, Jovita Kanoujia, Malti Arya, Shubhini A Saraf, Sudipta Saha
The present study was undertaken to improve rosuvastatin (RSV) bioavailability and pharmacological response through formation of SNES using Perilla frutescens oil as lipid carrier. The composition of oil was estimated by fatty acid methyl ester (FAME) analysis using gas chromatography. Solubility of RSV in Perilla frutescens oil and Cremophor EL was 25.0 ± 3.0 and 60.0 ± 5.0 mg/mL, respectively. Later, nanophasic maps and a central composite design were employed to determine the maximum nanoemulsion region and further optimize SNES in this study...
December 19, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29259181/comparison-of-the-effect-of-omega-3-supplements-and-fresh-fish-on-lipid-profile-a-randomized-open-labeled-trial
#16
Mohammad Javad Zibaeenezhad, Maryam Ghavipisheh, Armin Attar, Amir Aslani
BACKGROUND: Dietary fish is a rich source of Omega-3 poly-unsaturated fatty acids (PUFAs). These compounds may have protective effect against cardiovascular events possibly by modifying lipid profiles. Consequently, fish oil supplements are produced commercially to complement low fish intake. It is not clear if both interventions have similar effects. The aim of this trial was to compare the anti-hyperlipidemic effect of omega3 fatty acid supplements with fresh fish. METHOD: A total of 106 patients with hyperlipidemia were randomized...
December 19, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29246631/assessment-of-percheron-infarction-in-images-and-clinical-findings
#17
Zhihua Xu, Lingling Sun, Yang Duan, Jinghua Zhang, Mengzhi Zhang, Xiaonan Cai
OBJECTIVE: To assess the imaging and clinical features of patients with an artery of Percheron infarction comprehensively. METHODS: Of 6539 patients with a first-ever stroke, 18 patients with a Percheron infarction were enrolled, and their images and clinical data were retrospectively investigated. RESULTS: All patients underwent neurological intensive care unit (NICU) management. The initial symptom of a Percheron infarction included dizziness, transient blurred vision, double vision, barylalia, cerebellar ataxia, drowsiness, and a coma...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29238904/anti-inflammatory-activity-of-anti-hyperlipidemic-drug-fenofibrate-and-its-phase-i-metabolite-fenofibric-acid-in-silico-in-vitro-and-in-vivo-studies
#18
G Shyam Prasad, P Govardhan, G Deepika, V Vakdevi, R B Sashidhar
Fenofibrate, an anti-hyperlipidemic drug and its phase-I biotransformed metabolite fenofibric acid, was studied for COX-1 (PDB ID: 3N8Y) and COX-2 (PDB ID: 1PXX) inhibition potentials in silico and in vitro for their effects on human recombinant COX-2 enzyme isolated from a Baculovirus expression system in sf21 cells (EC 1.14.99.1) using a conventional spectrophotometric assay. Furthermore, the compounds were also screened for their anti-inflammatory potentials in vivo using carrageenan-induced paw oedema method in Wistar rats...
December 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29235746/clinical-problem-solving-a-tobacco-merchant-who-can-t-spit
#19
Sandra Benizri, Nancy Agmon-Levin, Noam D Kitrey, Dan Carter, Elinor Goshen, Yehonathan Sharabi
A 47 year old man presented with a combination of dry mouth and lightheadedness while standing. His medical background was unremarkable except for cigarette smoking and hyperlipidemia. Sjögren's syndrome was ruled out, and he was referred for evaluation of orthostatic hypotension, which by then included syncopal episodes and injuries. Additional symptoms included dry eyes, constipation, reduced sweating, and erectile dysfunction. After excluding medications and structural cardiac abnormalities as causes of orthostatic hypotension, a clinical autonomic evaluation was performed...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29229235/valproic-acid-disrupts-the-oscillatory-expression-of-core-circadian-rhythm-transcription-factors
#20
Chanel A Griggs, Scott W Malm, Rosa Jaime-Frias, Catharine L Smith
Valproic acid (VPA) is a well-established therapeutic used in treatment of seizure and mood disorders as well as migraines and a known hepatotoxicant. About 50% of VPA users experience metabolic disruptions, including weight gain, hyperlipidemia, and hyperinsulinemia, among others. Several of these metabolic abnormalities are similar to the effects of circadian rhythm disruption. In the current study, we examine the effect of VPA exposure on the expression of core circadian transcription factors that drive the circadian clock via a transcription-translation feedback loop...
December 8, 2017: Toxicology and Applied Pharmacology
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