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Fibromyalgia treatment

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https://www.readbyqxmd.com/read/29927949/snps-in-inflammatory-genes-ccl11-ccl4-and-mefv-in-a-fibromyalgia-family-study
#1
Zhifang Zhang, Jinong Feng, Allen Mao, Keith Le, Deirdre La Placa, Xiwei Wu, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Susan L Neuhausen, John E Shively
BACKGROUND: Fibromyalgia (FM) is a chronic pain syndrome with a high incidence in females that may involve activation of the immune system. We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide family association study. METHODS AND FINDINGS: Exome sequence analysis of 100 FM probands was performed at 17p13.3-q25 followed by functional analysis of SNPs found in the chemokine gene locus. Missense SNPs (413) in 17p13...
2018: PloS One
https://www.readbyqxmd.com/read/29923953/ketamine-for-refractory-headache-a-retrospective-analysis
#2
Eric S Schwenk, Amir C Dayan, Ashwin Rangavajjula, Marc C Torjman, Mauricio G Hernandez, Clinton G Lauritsen, Stephen D Silberstein, William Young, Eugene R Viscusi
BACKGROUND AND OBJECTIVES: The burden of chronic headache disorders in the United States is substantial. Some patients are treatment refractory. Ketamine, an N-methyl-D-aspartate antagonist, provides potent analgesia in subanesthetic doses in chronic pain, and limited data suggest it may alleviate headache in some patients. METHODS: We performed a retrospective study of 61 patients admitted over 3 years for 5 days of intravenous therapy that included continuous ketamine to determine responder rate and patient and ketamine infusion characteristics...
June 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29913906/using-fmri-to-evaluate-the-effects-of-milnacipran-on-central-pain-processing-in-patients-with-fibromyalgia
#3
F Petzke, K B Jensen, E Kosek, E Choy, S Carville, P Fransson, S C R Williams, H Marcus, Y Mainguy, M Ingvar, R H Gracely
Background In recent years, the prescription of serotonin-noradrenalin reuptake inhibitors (SNRIs) for treatment of fibromyalgia (FM) has increased with reports of their efficacy. The SNRI milnacipran is approved by the U.S. Food and Drug Administration (FDA) for treatment of FM, yet, the mechanisms by which milnacipran reduces FM symptoms are unknown. A large number of neuroimaging studies have demonstrated altered brain function in patients with FM but the effect of milnacipran on central pain processing has not been investigated...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913852/acceptance-and-commitment-therapy-for-fibromyalgia-a-randomized-controlled-trial
#4
G L Olsson, M Kemani, K Jensen, E Kosek, D Kadetoff, K Sorjonen, M Ingvar, R Wicksell
Background Recent developments within cognitive behavior therapy (CBT) have emphasized the utility of acceptance and mindfulness strategies, contrasting interventions focused on reduction or control of symptoms. A study of fMRI changes after CBT in females with fibromyalgia (FM) has been performed and results are presented elsewhere (under review). The aim of the present study was evaluate the effectiveness of Acceptance and Commitment Therapy (ACT)-based intervention for patient diagnosed with FM in comparison with a wait-list control Method Female patients aged 18-55 years, fulfilling the American College of Rheumatology classification criteria for FM, and with a weekly self-reported average pain intensity of >40 (VAS 0-100) were considered eligible for inclusion...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913759/validation-of-a-finnish-version-of-the-fibromyalgia-impact-questionnaire-finn-fiq
#5
Jarno Gauffin, Tiina Hankama, Hannu Kautiainen, Marja Arkela-Kautiainen, Pekka Hannonen, Maija Haanpää
Background and purpose Fibromyalgia (FM) is a chronic pain syndrome, which affects up to 5% of the general population. The aetiology of FM is unclear. The lack of specific diagnostic laboratory tests or imaging options combined with the severe burden on both patients and society caused by the FM syndrome demands the development of valid instruments able to measure the current health status of the FM patients. The Fibromyalgia Impact Questionnaire (FIQ) is the most widely used of these instruments. Our objective was to translate the Fibromyalgia Impact Questionnaire (FIQ) into Finnish and evaluate its validity in Finnish speaking FM patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913681/long-term-efficacy-of-spironolactone-on-pain-mood-and-quality-of-life-in-women-with-fibromyalgia-an-observational-case-series
#6
Heinrich Wernze, Thomas Herdegen
Objective No single drug is broadly efficacious in the long-term treatment of fibromyalgia syndrome (FMS). Spironolactone is known to ameliorate mood and tension headache or migraine in women with premenstrual syndrome or clinical signs of hyperandrogenism. In a case series of women with treatment resistant FMS spironolactone was therefore added to their medication, and they were observed for at least 12 months. Methods 31 women with treatment-resistant FMS received spironolactone as add-on medication to various pain modulating drugs...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913664/a118g-polymorphism-in-the-%C3%AE-opioid-receptor-gene-and-levels-of-%C3%AE-endorphin-are-associated-with-provoked-vestibulodynia-and-pressure-pain-sensitivity
#7
Ulrika Heddini, Ulrika Johannesson, Alfhild Grönbladh, Fred Nyberg, Kent W Nilsson, Nina Bohm-Starke
Background and aims Provoked vestibulodynia (PVD) is the most common cause of dyspareunia among young women. The aetiology is largely unknown and treatment is often extensive and longstanding with varying outcomes. Patients display general pain hypersensitivity and there are correlations with other chronic pain syndromes such as fibromyalgia later in life. The A118G polymorphism in the μ-opioid receptor (OPRM1) gene influences endogenous pain regulation and pain sensitivity, but has not been studied in this patient group before...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913651/effectiveness-of-multidisciplinary-rehabilitation-treatment-for-patients-with-chronic-pain-in-a-primary-health-care-unit
#8
Klaus Felix Stein, Adriana Miclescu
Background In recent years, multidisciplinary rehabilitation (MDR) became an alternative treatment option for chronic non-cancer pain. MDR is mostly available in specialized pain units, usually at rehabilitation centers where the level of knowledge and therapeutically options to treat pain conditions are considered to be high. There is strong evidence that MDR in specialized pain units is affecting pain and improves the quality of life in a sustainable manner. There are few studies about MDR outcome in primary health care, especially in those units situated in rural areas and with a different population than that encountered in specialized hospitals...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911653/cognitive-behaviour-therapy-in-women-with-fibromyalgia-a-randomized-clinical-trial
#9
Bo Karlsson, Gunilla Burell, Ulla-Maria Anderberg, Kurt Svärdsudd
Background and aims Stress has been pointed out as an important influential factor in the development and maintaining of the fibromyalgia syndrome (FMS) . Since stress may worsen the pain experience, the development of individual strategies for coping with stress is essential to reduce the impact of FMS on daily life. The aim of the study was to investigate whether a group based stress management cognitive behaviour therapy (CBT) programme could influence self-reported stress, wellbeing and life control, as well as self-reported pain behaviour in female FMS patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911614/treatment-of-chronic-canalithiasis-can-be-beneficial-for-patients-with-vertigo-dizziness-and-chronic-musculoskeletal-pain-including-whiplash-related-pain
#10
Wenche Iglebekk, Carsten Tjell, Peter Borenstein
Background and aim Chronic musculoskeletal pain, e.g. whiplash associated disorders (WAD), fibromyalgia and myalgia, causes significant burden on both the individual and on society as a whole. In a previous study, the authors concluded that there is a likely connection between chronic benign paroxysmal positional vertigo (BPPV)/canalithiasis and headache, neck pain, generalized pain, fatigue, cognitive dysfunctions as well as tinnitus. The balance dysfunction in BPPV/canalithiasis is dynamic and not static...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29904802/an-update-on-repetitive-transcranial-magnetic-stimulation-for-the-treatment-of-co-morbid-pain-and-depressive-symptoms
#11
REVIEW
Jonathan H Hsu, Zafiris J Daskalakis, Daniel M Blumberger
PURPOSE: Review recent meta-analyses and clinical trials investigating the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) for concurrent pain and depressive symptoms. RECENT FINDINGS: Recent meta-analyses have included both pain and depression outcomes in fibromyalgia and chronic pain. Randomized controlled trials have also been conducted in post-herpetic neuralgia, trauma-related headache, and neuropathic pain with attention to both pain and depressive symptoms...
June 14, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29904631/chronic-diffuse-pain-and-functional-gastrointestinal-disorders-after-traumatic-stress-pathophysiology-through-a-polyvagal-perspective
#12
Jacek Kolacz, Stephen W Porges
Chronic diffuse pain disorders, such as fibromyalgia, and functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome, place substantial burden on those affected and on the medical system. Despite their sizable impact, their pathophysiology is poorly understood. In contrast to an approach that focuses on the correlation between heart rate variability (HRV) and a specific organ or symptom, we propose that a bio-evolutionary threat-related autonomic response-as outlined in the Polyvagal Theory-may serve as a plausible explanation of how HRV, particularly respiratory sinus arrhythmia (RSA), would index the pathophysiology of these disorders...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29904327/pregabalin-misuse-and-abuse-in-jordan-a-qualitative-study-of-user-experiences
#13
Amneh Al-Husseini, Mayyada Wazaify, Marie Claire Van Hout
Pregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder, neuropathic pain, and fibromyalgia. A qualitative study was undertaken in Jordan, where concerns have been raised about its unprescribed availability in community pharmacies and thereby its abuse. Semi-structured interviews were conducted with all patients with a history of pregabalin use in two Jordanian addiction treatment centers. All were male patients aged 21-30 years ( n  = 11). The majority was poly-drug abusers and had a previous history of substance abuse (tramadol, Captagon, synthetic cannabinoids, and marijuana) ...
2018: International Journal of Mental Health and Addiction
https://www.readbyqxmd.com/read/29898009/pain-perception-and-pain-coping-mechanisms-in-children-and-adolescents-with-juvenile-fibromyalgia-and-polyarticular-juvenile-idiopathic-arthritis
#14
Melissa Mariti Fraga, Maria Teresa Terreri, Rafael Teixeira Azevedo, Maria Odete Esteves Hilário, Claudio Arnaldo Len
OBJECTIVE: To measure and compare musculoskeletal pain in patients with juvenile fibromyalgia (JFM) and polyarticular juvenile idiopathic arthritis (JIA), and to evaluate and compare pain perception and pain coping mechanisms in these patients. METHODS: In this cross sectional study, we evaluated 150 children and adolescents, and their respective parents, from 3 different groups: JFM, polyarticular JIA, and healthy controls. Pain intensity and pain coping mechanisms were measured using specific questionnaires...
June 11, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29897267/efficacy-and-mode-of-action-of-external-trigeminal-neurostimulation-in-migraine
#15
Jean Schoenen, Gianluca Coppola
Available preventive drug treatments for migraine lack complete efficacy and often have unpleasant adverse effects. Hence their clinical utility and therapeutic adherence are limited. Hence, non-invasive neurostimulation methods applied over various peripheral sites (forehead, mastoid, upper arm, cervical vagus nerve) have raised great interest because of their excellent efficacy/tolerance profile. Amongst them external trigeminal nerve stimulation (eTNS) was first to obtain FDA approval for migraine therapy...
June 13, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29890676/the-role-of-genetic-polymorphisms-in-chronic-pain-patients
#16
REVIEW
Nebojsa Nick Knezevic, Tatiana Tverdohleb, Ivana Knezevic, Kenneth D Candido
It is estimated that the total annual financial cost for pain management in the U.S. exceeds 100 billion dollars. However, when indirect costs are included, such as functional disability and reduction in working hours, the cost can reach more than 300 billion dollars. In chronic pain patients, the role of pharmacogenetics is determined by genetic effects on various pain types, as well as the genetic effect on drug safety and efficacy. In this review article, we discuss genetic polymorphisms present in different types of chronic pain, such as fibromyalgia, low back pain, migraine, painful peripheral diabetic neuropathy and trigeminal neuralgia...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29885369/the-relationship-of-endocannabinoidome-lipid-mediators-with-pain-and-psychological-stress-in-women-with-fibromyalgia-a-case-control-study
#17
Niclas Stensson, Nazdar Ghafouri, Malin Ernberg, Kaisa Mannerkorpi, Eva Kosek, Björn Gerdle, Bijar Ghafouri
Characterized by chronic widespread pain, generalized hyperalgesia, and psychological stress fibromyalgia (FM) is difficult to diagnose and lacks effective treatments. The endocannabinoids - arachidonoylethanolamide (AEA), 2-arachidonoylglycerol (2-AG), and the related oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and stearoylethanolamide (SEA) - are endogenous lipid mediators with analgesic and anti-inflammatory characteristics, in company with psychological modulating properties (e.g., stress and anxiety), and are included in a new emerging "ome", the endocannabinoidome...
June 6, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29884803/cannabinoids-for-the-treatment-of-rheumatic-diseases-where-do-we-stand
#18
REVIEW
Daphna Katz-Talmor, Itay Katz, Bat-Sheva Porat-Katz, Yehuda Shoenfeld
As medical use of cannabis is increasingly legalized worldwide, a better understanding of the medical and hazardous effects of this drug is imperative. The pain associated with rheumatic diseases is considered a prevalent indication for medicinal cannabis in various countries. Thus far, preliminary clinical trials have explored the effects of cannabis on rheumatoid arthritis, osteoarthritis and fibromyalgia; preliminary evidence has also found an association between the cannabinoid system and other rheumatic conditions, including systemic sclerosis and juvenile idiopathic arthritis...
June 8, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29882635/efficacy-of-systolic-extinction-training-set-in-fibromyalgia-patients-with-elevated-blood-pressure-response-to-stress-a-tailored-rct-study
#19
Kati Thieme, Tina Meller, Ulrika Evermann, Robert Malinowski, Marc Mathys, Richard H Gracely, William Maixner, Dennis C Turk
AIM: An intrinsic pain regulatory system is modulated by both cardiovascular dynamics that influence baroreflex sensitivity (BRS) and diminished in Fibromyalgia (FM). Baroreceptors relay cardiovascular output to the dorsal medial nucleus tractus solitarius reflex arcs that regulate pain, sleep, anxiety, and blood pressure. This study evaluated the effects of Systolic Extinction Training (SET), which combines operant treatment (OT) with BaroReflexTraining (BRT). BRT delivers peripheral electrical stimulation within a few milliseconds of the systolic or diastolic peak of the cardiac cycle...
June 8, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29879988/ammoxetine-attenuates-diabetic-neuropathic-pain-through-inhibiting-microglial-activation-and-neuroinflammation-in-the-spinal-cord
#20
Ting-Ting Zhang, Rui Xue, Shi-Yong Fan, Qiong-Yin Fan, Lei An, Juan Li, Lei Zhu, Yu-Hua Ran, Li-Ming Zhang, Bo-Hua Zhong, Yun-Feng Li, Cai-Ying Ye, You-Zhi Zhang
BACKGROUND: Diabetic neuropathic pain (DNP) is a common and distressing complication in patients with diabetes, and the underlying mechanism remains unclear. Tricyclic antidepressants (TCAs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are recommended as first-line drugs for DNP. Ammoxetine is a novel and potent SNRI that exhibited a strong analgesic effect on models of neuropathic pain, fibromyalgia-related pain, and inflammatory pain in our primary study. The present study was undertaken to investigate the chronic treatment properties of ammoxetine on DNP and the underlying mechanisms for its effects...
June 7, 2018: Journal of Neuroinflammation
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