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Fibromyalgia treatment

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https://www.readbyqxmd.com/read/29235496/involvement-of-trpm2-and-trpv1-channels-on-hyperalgesia-apoptosis-and-oxidative-stress-in-rat-fibromyalgia-model-protective-role-of-selenium
#1
Esra Yüksel, Mustafa Nazıroğlu, Mehmet Şahin, Bilal Çiğ
Fibromyalgia (FM) results in pain characterized by low selenium (Se) levels, excessive Ca2+ influx, reactive oxygen species (ROS) production, and acidic pH. TRPM2 and TRPV1 are activated by ROS and acid; nevertheless, their roles have not been elucidated in FM. Therefore, we investigated the contribution of TRPM2 and TRPV1 to pain, oxidative stress, and apoptosis in a rat model of FM and the therapeutic potential of Se. Thirty-six rats were divided into four groups: control, Se, FM, and FM + Se. The Se treatment reduced the FM-induced increase in TRPM2 and TRPV1 currents, pain intensity, intracellular free Ca2+, ROS, and mitochondrial membrane depolarization in the sciatic (SciN) and dorsal root ganglion (DRGN) neurons...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220534/effects-of-acupuncture-treatment-on-fibromyalgia-symptoms-serotonin-and-substance-p-levels-a-randomized-sham-and-placebo-controlled-clinical-trial
#2
Saliha Karatay, Sibel Caglar Okur, Hulya Uzkeser, Kadir Yildirim, Fatih Akcay
Objective: The aim of this study was to evaluate the effects of acupuncture treatment on serum levels of serotonin and substance P (SP) as well as on clinical parameters in patients with fibromyalgia (FM). Methods: This is a randomized controlled clinical trial. Seventy-five women with FM were randomized into one of three kinds of acupuncture treatment: real acupuncture group (AcG), sham acupuncture group (ShG), and simulated acupuncture group (SiG). Treatments were applied semiweekly for four weeks...
December 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29214470/clinical-and-anti-aging-effect-of-mud-bathing-therapy-for-patients-with-fibromyalgia
#3
Toyoki Maeda, Yoshihiro Kudo, Takahiko Horiuchi, Naoki Makino
Spa bathing is known as a medical treatment for certain diseases causing chronic pains. Spa water contains mineral components which lower the specific heat of the water, resulting in a higher efficiency to warm body-core temperature. This phenomenon yields pain-relieving effect for rheumatoid arthritis, low back pain, sciatic neuralgia, fibromyalgia, etc. Here we introduce medical and biological effects of mud-spa-bathing therapy for fibromyalgia other than pain relief, the changes of blood examination data, and the telomere length of circulating leukocytes...
December 6, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29209204/reward-circuitry-plasticity-in-pain-perception-and-modulation
#4
REVIEW
Marcos F DosSantos, Brenda de Souza Moura, Alexandre F DaSilva
Although pain is a widely known phenomenon and an important clinical symptom that occurs in numerous diseases, its mechanisms are still barely understood. Owing to the scarce information concerning its pathophysiology, particularly what is involved in the transition from an acute state to a chronic condition, pain treatment is frequently unsatisfactory, therefore contributing to the amplification of the chronic pain burden. In fact, pain is an extremely complex experience that demands the recruitment of an intricate set of central nervous system components...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29197121/the-clinical-anatomy-of-fibromyalgia
#5
REVIEW
Shehzad Khalid, Emily Simonds, Marios Loukas, R Shane Tubbs
INTRODUCTION: Fibromyalgia is a disorder characterized by pain and a spectrum of psychological comorbidities, rendering treatment difficult and often a financial burden. Findings regarding diagnosis, prevalence, comorbidities, and potential pathophysiological links are discussed herein. Fibromyalgia is a complex disorder and there are specific criteria that patients must meet for diagnosis, including scores on fibromyalgia questionnaires, commonalities of age, gender, menopause status, sleep disturbances, and mood symptoms...
December 2, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29185675/muscle-stretching-exercises-and-resistance-training-in-fibromyalgia-which-is-better-a-three-arm-randomized-controlled-trial
#6
Ana Assumpção, Luciana A Matsutani, Susan L Yuan, Adriana S Santo, Juliana Sauer, Pamela Mango, Amelia P Marques
BACKGROUND: Exercise therapy is an effective component of fibromyalgia (FM) treatment. However, it is important to know the effects and specificities of the different types of exercise: muscle stretching and resistance training. AIM: To verify and compare the effectiveness of muscle stretching exercise and resistance training for symptoms and quality of life in FM patients. DESIGN: Randomized controlled trial. SETTING: Physical therapy service, FM outpatient clinic...
November 29, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29185281/ankylosing-spondylitis-and-neck-pain-mri-evidence-for-joint-and-entheses-inflammation-at-the-craniocervial-junction
#7
Cheri Korb, Abid Awisat, Doron Rimar, Itzhak Rosner, Arsen Schpigelman, Daniela Militianu, Gleb Slobodin
BACKGROUND: Magnetic resonance imaging (MRI), which has recently become the leading imaging modality in the study of ankylosing spondylitis (AS), has not been evaluated in the assessment of disease-specific changes at the craniocervical junction (CCJ) in patients with AS. OBJECTIVES: To describe the spectrum of active inflammatory lesions at the CCJ using MRI in a cohort of patients with AS and neck pain. METHODS: The study included 18 patients with AS presenting with neck pain and a control group of 9 fibromyalgia patients matched for age and levels of neck pain...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29183878/evaluation-of-the-impact-of-concomitant-fibromyalgia-on-tnf-alpha-blockers-effectiveness-in-axial-spondyloarthritis-results-of-a-prospective-multicentre-study
#8
Anna Moltó, Adrien Etcheto, Laure Gossec, Nadia Boudersa, Pascal Claudepierre, Nicolas Roux, Lucie Lemeunier, Antoine Martin, Lartitia Sparsa, Pascal Coquerelle, Martin Soubrier, Serge Perrot, Maxime Dougados
OBJECTIVE: To describe the prevalence of fibromyalgia (FM) in an axial spondyloarthritis (axSpA) population and to confirm that concomitant FM had a negative impact on tumour necrosis factor blockers' (TNFb) response. DESIGN: Prospective observational study with two visits 3 months apart. PATIENTS: Adult patients with AxSpa initiating a TNFb. STUDY GROUPS: FM was defined by the Fibromyalgia Rapid Screening Tool (FiRST) at baseline and also by a sustained positive FiRST (both visits) and by a fulfilment of the 1990 American College of Rheumatology criteria for FM...
November 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29178378/prevalence-of-arthritis-revisited
#9
EDITORIAL
Jeffrey N Katz
Estimates of disease prevalence have far-reaching consequences. By providing a baseline understanding of a disease's impact, these estimates are used to justify investment in research, prevention and treatment. For years, estimates of arthritis prevalence have been derived from a single screening question on the National Health Interview Survey (NHIS): "Have you ever been told by a doctor or other health professional that you have some form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia?" This question alone grounds the prevailing estimates of about 54 million US adults living with arthritis...
November 27, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29170901/randomized-blinded-controlled-trial-on-effectiveness-of-photobiomodulation-therapy-and-exercise-training-in-the-fibromyalgia-treatment
#10
Mariana Moreira da Silva, Regiane Albertini, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior, Sandra Kalil Bussadori, Stella Sousa Vieira, Danilo Sales Bocalini, Luis Vicente Franco de Oliveira, Vanessa Grandinetti, José Antonio Silva, Andrey Jorge Serra
This study evaluated the role of the phototherapy and exercise training (EXT) as well as the combined treatment in general symptoms, pain, and quality of life in women suffering from fibromyalgia (FM). A total of 160 women were enrolled and measures were carried out in two sets: it was sought to identify the acute effect for a single phototherapy and EXT session (Set 1); long-term effect (10 weeks) of the interventions (Set 2). Phototherapy irradiation was performed at 11 locations in their bodies, employing a cluster with nine diodes (one super-pulsed infrared 905 nm, four light-emitting diodes [LEDs] of 640 nm, and four LEDs of 875 nm, 39...
November 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29163236/poor-illness-perceptions-are-a-risk-factor-for-depressive-and-anxious-symptomatology-in-fibromyalgia-syndrome-a-longitudinal-cohort-study
#11
Eric W de Heer, Johanna E Vriezekolk, Christina M van der Feltz-Cornelis
Background: Patients with widespread pain, such as in fibromyalgia, are vulnerable for depression and anxiety, which composes a relevant public health problem. Identifying risk factors for the onset of depression and anxiety is therefore warranted. Objective of this study was to determine whether severe pain, maladaptive coping, and poor illness perceptions are associated with depressive and anxious symptomatology in fibromyalgia. Method: Consecutive patients referred to an outpatient clinic completed sets of physical and psychological questionnaires at baseline and at 18-month follow-up...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29149921/gastrointestinal-and-hepatic-disease-in-fibromyalgia
#12
REVIEW
Richard A Schatz, Baharak Moshiree
Fibromyalgia (FM) has historically been associated with several diseases in gastroenterology and hepatology. The most substantiated evidence pertains to irritable bowel syndrome (IBS). The pathogeneses of FM and IBS remain unclear, but it is likely related to dysregulation within the brain-gut axis, resulting in a hyperalgesic state. IBS and FM share other similarities, including a female predominance, fatigue, insomnia, and susceptibility to psychiatric state. These common manifestations and pathogeneses serve as a foundation for overlapping, multidisciplinary treatment modalities...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#13
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29130724/probiotics-for-fibromyalgia-study-design-for-a-pilot-double-blind-randomized-controlled-trial
#14
Pablo Roman, Ángeles F Estévez, Nuria Sánchez-Labraca, Fernando Cañadas, Alonso Miras, Diana Cardona
BACKGROUND: Fibromyalgia syndrome (FMS) is a chronic, generalized and diffuse pain disorder accompanied by other symptoms such as emotional and cognitive deficits. The FMS patients show a high prevalence of gastrointestinal symptoms. Recently it has been found that microbes in the gut may regulate brain processes through the gut-microbiota-brain axis, modulating thus affection, motivation and higher cognitive functions. Therefore, the use of probiotics might be a new treatment that could improve the physical, psychological and cognitive state in FMS; however, no evidence about this issue is available...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29109601/treatment-of-fibromyalgia
#15
REVIEW
Richard Kwiatek
No abstract text is available yet for this article.
October 2017: Australian Prescriber
https://www.readbyqxmd.com/read/29080932/treatment-of-drug-resistant-fibromyalgia-symptoms-using-high-intensity-laser-therapy-a-case-based-review
#16
REVIEW
Paul F White, Jason Zafereo, Ofelia Loani Elvir-Lazo, Hector Hernandez
Fibromyalgia is a chronic musculoskeletal condition characterized by widespread pain in the body and is associated with tender points at the shoulder, back and hip regions. A wide variety of pharmacologic drugs and dietary supplements have been used with limited success in treating the musculoskeletal pain. Early clinical studies with low level laser therapy (LLLT) alone or in combination with drugs commonly used to treat fibromyalgia suggested that LLLT may be effective in reducing musculoskeletal pain and stiffness, as well as the number of tender locations...
October 28, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29080671/sex-differences-and-estradiol-involvement-in-hyperalgesia-and-allodynia-in-an-experimental-model-of-fibromyalgia
#17
Alberto Hernandez-Leon, Yarim Elideth De la Luz-Cuellar, Vinicio Granados-Soto, María Eva González-Trujano, Alonso Fernández-Guasti
Fibromyalgia (FM) is a musculoskeletal chronic pain syndrome. Its prevalence in women is higher than in men possibly by hormonal factors given that symptoms are aggravated during sex hormone-related events, such as the premenstrual period, pregnancy, postpartum or menopause. The aim of the present study was to investigate whether hyperalgesia and allodynia, in reserpine-induced experimental FM, depend on sex, estrous cycle, ovariectomy and replacement with 17β-estradiol. To fulfill this objective, we compared males, intact females with known estrous cycle phases and ovariectomized (OVX) rats treated with 17β-estradiol...
November 8, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29077623/internet-based-exposure-therapy-for-fibromyalgia-a-randomized-controlled-trial
#18
Maria Hedman-Lagerlöf, Erik Hedman-Lagerlöf, Erland Axelsson, Brjánn Ljótsson, Johanna Engelbrektsson, Sofia Hultkrantz, Karolina Lundbäck, Daniel Björkander, Rikard Wicksell, Ida Flink, Erik Andersson
Fibromyalgia (FM) is a common and disabling chronic pain disorder, for which existing pharmacological and psychological treatments have yet yielded insufficient effects. Previous literature has shown that exposure therapy may be an effective treatment for chronic pain. This study constitutes the first randomized controlled trial evaluating exposure therapy for FM. One hundred and forty participants with diagnosed FM were randomized to a 10-week internet-based exposure treatment (iExp; n=70) or a waitlist control condition (WLC; n=70)...
October 26, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29076404/somatic-symptom-presentations-in-women-with-fibromyalgia-are-differentially-associated-with-elevated-depression-and-anxiety
#19
Katherine Hadlandsmyth, Dana L Dailey, Barbara A Rakel, M Bridget Zimmerman, Carol Gt Vance, Ericka N Merriwether, Ruth L Chimenti, Katharine M Geasland, Leslie J Crofford, Kathleen A Sluka
This study examined whether depression and anxiety differentially relate to fatigue, sleep disturbance, pain catastrophizing, fear of movement, and pain severity in women with fibromyalgia. Baseline data from the Fibromyalgia Activity Study with Transcutaneous Electrical Nerve Stimulation were analyzed. Of 191 participants, 50 percent reported high anxiety and/or depression (17% high anxiety, 9% high depression, and 24% both). Fatigue and sleep impairment were associated with high depression ( p < 0...
October 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29069952/-i-just-want-my-life-back-men-s-narratives-about-living-with-fibromyalgia
#20
Merja Sallinen, Anne Marit Mengshoel
BACKGROUND: Fibromyalgia is characterized by chronic widespread pain and an array of other symptoms. It is less common among men than among women and the results concerning the severity of men's symptoms are contradictory. The purpose of this study was to elucidate the impacts of fibromyalgia on men's daily life and work ability. METHODS: The data were collected through life story interviews of five men with fibromyalgia. RESULTS: The results of a narrative analysis are presented in a form of two model narratives: "Adjusting the life to match the illness" and "Being imprisoned by the pain"...
October 26, 2017: Disability and Rehabilitation
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