keyword
MENU ▼
Read by QxMD icon Read
search

Mechanical axis limbs

keyword
https://www.readbyqxmd.com/read/28635661/hypoxic-preconditioning-promotes-the-bioactivities-of-mesenchymal-stem-cells-via-the-hif-1%C3%AE-grp78-akt-axis
#1
Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee
Mesenchymal stem cells (MSC) are ideal materials for stem cell-based therapy. As MSCs reside in hypoxic microenvironments (low oxygen tension of 1% to 7%), several studies have focused on the beneficial effects of hypoxic preconditioning on MSC survival; however, the mechanisms underlying such effects remain unclear. This study aimed to uncover the potential mechanism involving 78-kDa glucose-regulated protein (GRP78) to explain the enhanced MSC bioactivity and survival in hindlimb ischemia. Under hypoxia (2% O₂), the expression of GRP78 was significantly increased via hypoxia-inducible factor (HIF)-1α...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28632063/kinetic-analysis-of-the-lower-limbs-in-baseball-tee-batting
#2
Kazumichi Ae, Sekiya Koike, Norihisa Fujii, Michiyoshi Ae, Takashi Kawamura
The purpose of this study was to investigate effects of the ground reaction forces on the rotation of the body as a whole and on the joint torques of the lower limbs associated with trunk and pelvic rotation in baseball tee batting. A total of 22 male collegiate baseball players participated in this study. Three-dimensional coordinate data were acquired by a motion capture system (250 Hz), and ground reaction forces of both legs were measured with three force platforms (1,000 Hz). Kinetic data were used to calculate the moment about the vertical axis through the body's centre of mass resulting from ground reaction forces, as well as to calculate the torque and mechanical work in the lower limb joints...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28628195/heterogeneity-of-tight-junctions-in-the-thick-ascending-limb
#3
REVIEW
Markus Bleich, Vera C Wulfmeyer, Nina Himmerkus, Susanne Milatz
Renal tubular transport mechanisms are optimized to be energy efficient and tailored to local gradients and transport rates. The combined transcellular action of ion channels, transporters, and pumps, together with the paracellular pathway, enables kidney function. Monogenetic diseases and mouse models indicate that both trans- and paracellular proteins can become disease-causing candidates and may be targets for future therapeutic approaches. Recent advances in tight junction research have provided new insights into their structure, function, and regulation...
June 19, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28625869/an-historical-perspective-on-the-pioneering-experiments-of-john-saunders
#4
REVIEW
Cheryll Tickle
John Saunders was a highly skilled embryologist who pioneered the study of limb development. His studies on chick embryos provided the fundamental framework for understanding how vertebrate limbs develop. This framework inspired generations of scientists and formed the bridge from experimental embryology to molecular mechanisms. Saunders investigated how feathers become organized into tracts in the skin of the chick wing and also identified regions of programmed cell death. He discovered that a region of thickened ectoderm that rims the chick wing bud - the apical ectodermal ridge - is required for outgrowth and the laying down of structures along the proximo-distal axis (long axis) of the wing, identified the zone of polarizing activity (ZPA; polarizing region) that controls development across the anteroposterior axis ("thumb to little finger "axis) and contributed to uncovering the importance of the ectoderm in development of structures along the dorso-ventral axis ( "back of hand to palm" axis)...
June 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28620013/the-evolution-of-vertical-climbing-in-primates-evidence-from-reaction-forces
#5
Jandy B Hanna, Michael C Granatosky, Pooja Rana, Daniel Schmitt
Vertical climbing is an essential behavior for arboreal animals, yet limb mechanics during climbing are poorly understood and rarely compared to those observed during horizontal walking. Primates commonly engage in both arboreal walking and vertical climbing, and this makes them an ideal taxa in which to compare these locomotor forms. Additionally, primates exhibit unusual limb mechanics compared to most other quadrupeds, with weight distribution biased towards the hindlimbs, a pattern that is argued to have evolved in response to the challenges of arboreal walking...
June 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28593581/intraoperative-adjustment-of-alignment-under-valgus-stress-reduces-outliers-in-patients-undergoing-medial-opening-wedge-high-tibial-osteotomy
#6
Man Soo Kim, Jong Min Son, In Jun Koh, Ji Hoon Bahk, Yong In
INTRODUCTION: A considerable percentage of outliers with under- or over-correction continue to be reported despite precise preoperative planning and cautious intraoperative correction of lower limb alignment in medial opening-wedge high tibial osteotomy (MOWHTO). The purpose of this study was to determine whether our novel technique for the intraoperative adjustment of alignment under valgus stress reduces the number of outliers in patients undergoing MOWHTO compared to the conventional technique, which corrects alignment according to the cable method only...
June 7, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28578106/investigating-peri-limb-interaction-between-nociception-and-vision-using-spatial-depth
#7
Camille Vanderclausen, Lieve Filbrich, Andrea Alamia, Valéry Legrain
In order to adapt behavior to a potentially body damaging threat, it is crucial to coordinate the perception of the location of the threat in external space and that of the location of the potential damage on the body surface. Such ability presupposes interactions between nociceptive stimuli and visual stimuli occurring close to the body. We hypothesized that these interactions would rely on multisensory representations of each limb itself, extending its boundaries slightly into external space, with less influence of the global representation of the body as a whole...
May 31, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28577508/change-in-gait-after-high-tibial-osteotomy-a-systematic-review-and-meta-analysis
#8
Seung Hoon Lee, O-Sung Lee, Seow Hui Teo, Yong Seuk Lee
We conducted a meta-analysis to analyze how high tibial osteotomy (HTO) changes gait and focused on the following questions: (1) How does HTO change basic gait variables? (2) How does HTO change the gait variables in the knee joint? Twelve articles were included in the final analysis. A total of 383 knees was evaluated. There were 237 open wedge (OW) and 143 closed wedge (CW) HTOs. There were 4 level II studies and 8 level III studies. All studies included gait analysis and compared pre- and postoperative values...
May 26, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28577470/ankle-foot-orthosis-bending-axis-influences-running-mechanics
#9
Elizabeth Russell Esposito, Ellyn C Ranz, Kelly A Schmidtbauer, Richard R Neptune, Jason M Wilken
Passive-dynamic ankle-foot orthoses (AFOs) are commonly prescribed to improve locomotion for people with lower limb musculoskeletal weakness. The clinical prescription and design process are typically qualitative and based on observational assessment and experience. Prior work examining the effect of AFO design characteristics generally excludes higher impact activities such as running, providing clinicians and researchers limited information to guide the development of objective prescription guidelines. The proximal location of the bending axis may directly influence energy storage and return and resulting running mechanics...
July 2017: Gait & Posture
https://www.readbyqxmd.com/read/28567347/effect-of-lengthening-along-the-anatomical-axis-of-the-femur-and-its-clinical-impact
#10
Khaled M Emara, Ahmed Nageeb Mahmoud, Ahmed K Emara, Mariam K Emara
AIM: To review and study the effect of lengthening along the anatomical axis of long bones and its relation to the mechanical axis deviation. METHODS: We try in this review to calculate and discuss the exact clinical impact of lengthening along the anatomical axis of the femur on affecting the limb alignment. Also we used a trigonometric formula to predict the change of the femoral distal anatomical mechanical angle (AMA) after lengthening along the anatomical axis...
May 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28532505/do-small-changes-in-rotation-affect-measurements-of-lower-extremity-limb-alignment
#11
Amir A Jamali, John P Meehan, Nathan M Moroski, Matthew J Anderson, Ramit Lamba, Carol Parise
BACKGROUND: The alignment of the lower extremity has important implications in the development of knee arthritis. The effect of incremental rotations of the limb on common parameters of alignment has not been studied. The purpose of the study was to (1) determine the standardized neutral position measurements of alignment and (2) determine the effect of rotation on commonly used measurements of alignment. METHODS: Eighty-seven full length CT angiography studies (49 males and 38 females, average age 66 years old) were included...
May 22, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28525408/rebound-deformity-after-growth-modulation-in-patients-with-coronal-plane-angular-deformities-about-the-knee-who-gets-it-and-how-much
#12
Lise A Leveille, Ozan Razi, Charles E Johnston
BACKGROUND: With observed success and increased popularity of growth modulation techniques, there has been a trend toward use in progressively younger patients. Younger age at growth modulation increases the likelihood of complete deformity correction and need for implant removal before skeletal maturity introducing the risk of rebound deformity. The purpose of this study was to quantify magnitude and identify risk factors for rebound deformity after growth modulation. METHODS: We performed a retrospective review of all patients undergoing growth modulation with a tension band plate for coronal plane deformity about the knee with subsequent implant removal...
May 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28502890/a-quantitative-approach-to-understanding-vertebrate-limb-morphogenesis-at-the-macroscopic-tissue-level
#13
REVIEW
Takayuki Suzuki, Yoshihiro Morishita
To understand organ morphogenetic mechanisms, it is essential to clarify how spatiotemporally-regulated molecular/cellular dynamics causes physical tissue deformation. In the case of vertebrate limb development, while some of the genes and oriented cell behaviors underlying morphogenesis have been revealed, tissue deformation dynamics remains incompletely understood. We here introduce our recent work on the reconstruction of tissue deformation dynamics in chick limb development from cell lineage tracing data...
May 11, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28467430/analysis-of-transcription-factors-expressed-at-the-anterior-mouse-limb-bud
#14
Shigetoshi Yokoyama, Soichi Furukawa, Shoya Kitada, Masaki Mori, Takeshi Saito, Koichi Kawakami, Juan Carlos Izpisua Belmonte, Yasuhiko Kawakami, Yoshiaki Ito, Tempei Sato, Hiroshi Asahara
Limb bud patterning, outgrowth, and differentiation are precisely regulated in a spatio-temporal manner through integrated networks of transcription factors, signaling molecules, and downstream genes. However, the exact mechanisms that orchestrate morphogenesis of the limb remain to be elucidated. Previously, we have established EMBRYS, a whole-mount in situ hybridization database of transcription factors. Based on the findings from EMBRYS, we focused our expression pattern analysis on a selection of transcription factor genes that exhibit spatially localized and temporally dynamic expression patterns with respect to the anterior-posterior axis in the E9...
2017: PloS One
https://www.readbyqxmd.com/read/28460410/comparative-study-for-alignment-of-extramedullary-guides-versus-portable-accelerometer-based-navigation-in-total-knee-arthroplasty
#15
Kazu Matsumoto, Hiroyasu Ogawa, Masashi Fukuta, Nobuyuki Mori, Haruhiko Akiyama
The use of portable, accelerometer-based navigation (PN) devices for positioning of the components of total knee arthroplasty (TKA) is emerging as an alternative to standard extramedullary (EM) systems, which was needed to the image intensifier. The aim of our study was to compare the accuracy of component positioning in TKA using an EM and PN systems. Data from 100 consecutive primary TKAs, performed by multiple surgeons in 87 patients between October 2010 and June 2015, were analyzed. Coronal and sagittal plane alignments of the TKA components, relative to the mechanical axis of the limb, were evaluated by radiography...
May 1, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28460408/does-kinematic-alignment-improve-short-term-functional-outcomes-after-total-knee-arthroplasty-compared-with-mechanical-alignment-a-systematic-review-and-meta-analysis
#16
Yanhong Li, Shuanke Wang, Yuliang Wang, Mingxuan Yang
This meta-analysis was conducted to study whether kinematically aligned total knee arthroplasty (TKA) improves short-term functional outcomes compared with mechanical alignment without changing the hip-knee-ankle angle. Prospective cohort studies were searched from electronic literature databases, including PubMed, Web of Science, Embase (Ovid interface), and Cochrane Library (Ovid interface). Total 1,159 records were identified. Six trials involving 561 patients were eligible for data extraction and meta-analysis...
May 1, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28439314/correction-of-lower-limb-deformities-in-children-with-renal-osteodystrophy-by-guided-growth-technique
#17
C Gigante, A Borgo, M Corradin
PURPOSE: Renal osteodystrophy (ROD) may cause severe lower limb deformities in children. The purpose of this study is to evaluate the efficacy of the temporary hemiepiphysiodesis for the correction of lower limb deformities in children with ROD. METHODS: Guided growth correction by hemiepiphysiodesis has been performed in skeletally immature patients with deformities of the lower limbs caused by ROD. The correction of the mechanical axes of the lower limbs and its correction speed have been evaluated...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28439302/femoral-osteochondritis-of-the-knee-prognostic-value-of-the-mechanical-axis
#18
P Gonzalez-Herranz, M L Rodriguez, C de la Fuente
PURPOSE: Femoral osteochondritis dissecans (OCD) is a disorder of unknown aetiology and variable prognosis that causes knee pain. In this paper, the authors study the impact of lower limb malalignment on the development and prognosis of OCD. METHODS: After anteroposterior (AP) and lateral radiograph and MRI of the knee, 53 cases of OCD were diagnosed. All patients were studied by standing full-length AP radiograph of the lower extremities in order to analyse the relationship between the femorotibial and mechanical axis and the location and stability of the osteochondritis...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28437841/characterizing-the-evolution-of-wide-gauge-features-in-stylopodial-limb-elements-of-titanosauriform-sauropods-via-geometric-morphometrics
#19
Paul V Ullmann, Matthew F Bonnan, Kenneth J Lacovara
Wide-gauge posture of titanosauriform sauropods remains an enigmatic peculiarity among terrestrial vertebrates. Here, two-dimensional geometric morphometrics and thin plate splines analyses were used to quantitatively analyze shape differences among sauropodomorph humeri and femora to identify how these elements may differ according to body gauge. Results demonstrate that titanosauriforms generally possess proportionately gracile humeri in comparison to other sauropods, with relatively more medially oriented humeral heads and proximally located deltopectoral crests...
April 24, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28428035/evaluation-of-the-external-fixator-truelok-hexapod-system-for-tibial-deformity-correction-in-children
#20
Sébastien Pesenti, Christopher A Iobst, Franck Launay
BACKGROUND: Tibial deformities are common in paediatric orthopaedic practice. Correcting multiplanar tibial deformities associated with lower limb length discrepancycan be challenging. Hexapod external fixation with gradual correction has been proven effective in this situation. OBJECTIVE: To assess clinical and radiological outcomes of gradual tibial deformity correction using the external fixator TL-HEX(TM)(Orthofix) in children. HYPOTHESIS: TL-HEX™ is effective in correcting tibial deformities in children...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
keyword
keyword
64148
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"