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https://www.readbyqxmd.com/read/28428035/evaluation-of-the-external-fixator-truelok-hexapod-system-for-tibial-deformity-correction-in-children
#1
Sébastien Pesenti, Christopher A Iobst, Franck Launay
BACKGROUND: Tibial deformities are common in paediatric orthopaedic practice. Correcting multiplanar tibial deformities associated with lower limb length discrepancycan be challenging. Hexapod external fixation with gradual correction has been proven effective in this situation. OBJECTIVE: To assess clinical and radiological outcomes of gradual tibial deformity correction using the external fixator TL-HEX(TM)(Orthofix) in children. HYPOTHESIS: TL-HEX™ is effective in correcting tibial deformities in children...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28376828/all-polyethylene-tibial-components-in-distal-femur-limb-salvage-surgery-a-finite-element-analysis-based-on-promising-clinical-outcomes
#2
Fan Tang, Yong Zhou, Wenli Zhang, Li Min, Rui Shi, Yi Luo, Hong Duan, Chongqi Tu
BACKGROUND: Whether all-polyethylene tibial (APT) components are beneficial to patients who received distal femur limb-salvage surgery lacks high-quality clinical follow-up and mechanical evidence. This study aimed to investigate the biomechanics of the distal femur reconstructed with APT tumor knee prostheses using finite element (FE) analysis based on our previous, promising clinical outcome. METHODS: Three-dimensional FE models that use APT and metal-backed tibial (MBT) prostheses to reconstruct distal femoral bone defects were developed and input into the Abaqus FEA software version 6...
April 4, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28361018/spinal-alignment-evolution-with-age-a-prospective-gait-analysis-study
#3
Sébastien Pesenti, Benjamin Blondel, Emilie Peltier, Elke Viehweger, Vincent Pomero, Guillaume Authier, Stéphane Fuentes, Jean-Luc Jouve
AIM: To describe, using gait analysis, the development of spinal motion in the growing child. METHODS: Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis (9 m-walk). Various kinematic parameters were recorded and analyzed such as thoracic angle (TA), lumbar angle (LA) and sagittal vertical axis (SVA). The kinetic parameters were the net reaction moments (N.m/kg) at the thoracolumbar and lumbosacral junctions. RESULTS: TA and LA curves were not statistically correlated to the age (respectively, P = 0...
March 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28356555/prevalence-of-polymorphisms-in-opg-rankl-and-rank-as-potential-markers-for-charcot-arthropathy-development
#4
Bożena Bruhn-Olszewska, Anna Korzon-Burakowska, Grzegorz Węgrzyn, Joanna Jakóbkiewicz-Banecka
Charcot arthropathy is one of the most serious complications of diabetic foot syndrome that leads to amputation of the affected limb. Since there is no cure for Charcot arthropathy, early diagnosis and implementation preventive care are the best available treatment. However, diagnosis is hindered by obscure clinical picture of the disease and lack of molecular markers for its early detection. Results of recent research suggest that OPG-RANKL-RANK axis regulating bone metabolism can be associated with Charcot arthropathy and that SNPs in OPG gene are associated with the disease...
March 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344068/interlimb-differences-in-coordination-of-unsupported-reaching-movements
#5
Jacob E Schaffer, Robert L Sainburg
Previous research suggests that interlimb differences in coordination associated with handedness might result from specialized control mechanisms that are subserved by different cerebral hemispheres. Based largely on the results of horizontal plane reaching studies, we have proposed that the hemisphere contralateral to the dominant arm is specialized for predictive control of limb dynamics, while the non-dominant hemisphere is specialized for controlling limb impedance. The current study explores interlimb differences in control of 3-D unsupported reaching movements...
March 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28342821/correction-of-axial-deformity-during-lengthening-in-fibular-hypoplasia-hexapodal-versus-monorail-external-fixation
#6
Antoine Chalopin, Loïc Geffroy, Sébastien Pesenti, Antoine Hamel, Franck Launay
INTRODUCTION: Childhood fibular hypoplasia is a rare pathology which may or may not involve limb-length discrepancy and axial deformity in one or more dimensions. The objective of the present study was to compare the quality of the axial correction achieved in lengthening procedures by hexapodal versus monorail external fixators. The hypothesis was that the hexapodal fixator provides more precise correction. MATERIAL AND METHODS: A retrospective multicenter study included 52 children with fibular hypoplasia...
March 22, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28333962/different-regulation-of-limb-development-by-p63-transcript-variants
#7
Manabu Kawata, Yuki Taniguchi, Daisuke Mori, Fumiko Yano, Shinsuke Ohba, Ung-Il Chung, Tomomi Shimogori, Alea A Mills, Sakae Tanaka, Taku Saito
The apical ectodermal ridge (AER), located at the distal end of each limb bud, is a key signaling center which controls outgrowth and patterning of the proximal-distal axis of the limb through secretion of various molecules. Fibroblast growth factors (FGFs), particularly Fgf8 and Fgf4, are representative molecules produced by AER cells, and essential to maintain the AER and cell proliferation in the underlying mesenchyme, meanwhile Jag2-Notch pathway negatively regulates the AER and limb development. p63, a transcription factor of the p53 family, is expressed in the AER and indispensable for limb formation...
2017: PloS One
https://www.readbyqxmd.com/read/28321477/total-knee-arthroplasty-after-varus-distal-femoral-osteotomy-vs-native-knee-similar-results-in-a-case-control-study
#8
Romain Gaillard, Timothy Lording, Sebastien Lustig, Elvire Servien, Philippe Neyret
PURPOSE: The aim of this study was to investigate the results of total knee arthroplasty (TKA) performed after varus distal femoral osteotomy (VrDFO), in comparison to a control group of TKAs performed as the primary intervention for arthrosis. Main hypothesis was that the medium term results for the two groups would be similar. METHODS: All TKAs performed after VrDFO were extracted from a single centre, prospective database of 4046 arthroplasties. A case-control study was performed with a control group comprising two TKAs performed as the primary intervention for each TKA after VrDFO, and matched for sex, age at intervention, body mass index, the type of arthrosis and the type of implant...
March 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28302462/the-impact-of-mechanical-and-restricted-kinematic-alignment-on-knee-anatomy-in-total-knee-arthroplasty
#9
Abdulaziz M Almaawi, Jonathan R B Hutt, Vincent Masse, Martin Lavigne, Pascal-Andre Vendittoli
BACKGROUND: Total knee arthroplasty (TKA), aiming at neutral mechanical alignment (MA), inevitably modifies the patient's native knee anatomy. Another option is kinematic alignment (KA), which aims to restore the original anatomy of the knee. The aim of this study was to evaluate the variations in lower limb anatomy of a patient population scheduled for TKA, and to assess the use of a restricted KA TKA protocol and compare the resulting anatomic modifications with the standard MA technique...
February 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28288078/idiopathic-genu-valgum-and-its-association-with-obesity-in-children-and-adolescents
#10
Janet L Walker, Pooya Hosseinzadeh, Hank White, Kevin Murr, Todd A Milbrandt, Vishwas J Talwalkar, Henry Iwinski, Ryan Muchow
BACKGROUND: Obesity as a cause of lower extremity deformity in children has been well established. This deformity is most often seen as tibia vara, however, at our institution we have observed more obese children and adolescents over age 7 years with excessive or progressive idiopathic genu valgum. Our hypothesis is that children with idiopathic genu valgum have high rates of obesity which impact the severity of their disease. METHODS: Retrospective review of existing data was performed on 66 consecutive children/112 limbs over age 7 years with idiopathic genu valgum, seen from 2010 to 2013...
March 10, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28283405/coordination-of-limb-development-by-crosstalk-among-axial-patterning-pathways
#11
REVIEW
Irene Delgado, Miguel Torres
Vertebrate limb development relies on the activity of signaling centers that promote growth and control patterning along three orthogonal axes of the limb bud. The apical ectodermal ridge, at the distal rim of the limb bud ectoderm, produces WNT and FGF signals, which promote limb bud growth and progressive distalization. The zone of polarizing activity, a discrete postero-distal mesenchymal domain, produces SHH, which stimulates growth and organizes patterning along the antero-posterior axis. The dorsal and ventral ectoderms produce, respectively, WNT7A and BMPs, which induce dorso-ventral limb fates...
March 7, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28241085/using-accelerometer-based-portable-navigation-to-perform-accurate-total-knee-arthroplasty-bone-resection-in-asian-patients
#12
Hideki Ueyama, Yoshio Matsui, Yukihide Minoda, Masanori Matsuura, Hiroaki Nakamura
Implant alignment is an important factor affecting clinical results associated with total knee arthroplasty (TKA). No report exists showing the utility of an accelerometer-based portable navigation system among patients with marked femoral bowing. The aim of this study was to evaluate the accuracy of a portable navigation system for implant alignment in Asian patients with marked femoral bowing. The authors evaluated 142 consecutive TKAs performed for primary osteoarthritis since July 2013. A portable navigation system was used in 67 knees, and a conventional jig was used in 75 knees...
February 27, 2017: Orthopedics
https://www.readbyqxmd.com/read/28236551/soft-tissue-releases-in-total-knee-arthroplasty-for-valgus-deformities
#13
Ke Xie, Steven T Lyons
BACKGROUND: Primary total knee arthroplasty (TKA) for valgus knee deformities can be challenging. Soft tissue releases are often necessary to achieve a well-balanced knee. We reviewed the frequency of soft tissue releases including lateral retinacular release (LRR) as it pertains to preoperative limb alignment. Postoperatively, we evaluated limb alignment, knee range of motion, and complications. METHODS: From 2010 to 2016, 214 primary TKAs with valgus deformity were performed by a single surgeon...
January 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28236072/differences-in-limb-alignment-and-femoral-mechanical-anatomical-angles-using-two-dimension-versus-three-dimension-radiographic-imaging
#14
Frédéric Sailhan, Louis Jacob, Moussa Hamadouche
PURPOSE: The purpose of this study was to compare the femoral mechanical-anatomical (FMA) and mechanical femoro-tibial (MFT) angles in an osteoarthritic population using the 2D (two dimension) and the 3D (three dimension) EOS low-dose biplanar radiographic system (EOS). METHODS: FMA and MFT angles were calculated in 127 adults with osteoarthritis. In 2D, FMA angle was measured between the femoral mechanical axis and the femoral anatomical axis, and MFT angle between the femoral mechanical axis and the tibial mechanical axis...
February 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28196041/change-in-talar-translation-in-the-coronal-plane-after-mobile-bearing-total-ankle-replacement-and-its-association-with-lower-limb-and-hindfoot-alignment
#15
Young Yi, Jae-Ho Cho, Ji-Beom Kim, Jae-Young Kim, Su-Yeon Park, Woo Chun Lee
BACKGROUND: Mobile-bearing total ankle replacement (TAR) enables motion at the tibial implant-polyethylene insert interface. This motion could lead to coronal translation of the talus relative to the tibia and may affect radiographic outcome. We aimed to assess the translation of the talus before and after mobile-bearing TAR to determine whether translation of the talus after TAR is associated with coronal plane alignment of the lower limb and hindfoot as well as to investigate the complications associated with talar translation...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28148662/intra-articular-corrective-osteotomies-combined-with-the-ilizarov-technique-for-the-treatment-of-deformities-of-the-knee
#16
J Xu, Y Jia, Q Kang, Y Chai
AIMS: To present our experience of using a combination of intra-articular osteotomy and external fixation to treat different deformities of the knee. PATIENTS AND METHODS: A total of six patients with a mean age of 26.5 years (15 to 50) with an abnormal hemi-joint line convergence angle (HJLCA) and mechanical axis deviation (MAD) were included. Elevation of a tibial hemiplateau or femoral condylar advancement was performed and limb lengthening with correction of residual deformity using a circular or monolateral Ilizarov frame...
February 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28137437/pronation-and-supination-of-the-hand-anatomy-and-biomechanics
#17
M Soubeyrand, B Assabah, M Bégin, E Laemmel, A Dos Santos, M Crézé
Proper functioning of the hand relies on its capacity to rotate and point the palm upward (i.e. supination) or downward (i.e. pronation) when standing up with the elbow in 90° flexion. Hand rotation is possible because of forearm rotation and also rotation of the whole upper limb at the shoulder. Two distinct mechanisms contribute to hand rotation: one in which the ulna is immobile and another in which the ulna is mobile. In this review, we first summarize how evolution of the human species has led to the progressive development of specific forearm anatomy that allows for pronation and supination...
February 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#18
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
March 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28035386/microduplication-of-7q36-3-encompassing-the-shh-long%C3%A2-range-regulator-zrs-in-a-patient-with-triphalangeal-thumb%C3%A2-polysyndactyly-syndrome-and-congenital-heart-disease
#19
Zhenghua Liu, Ni Yin, Lianghui Gong, Zhiping Tan, Bangliang Yin, Yifeng Yang, Cheng Luo
Triphalangeal thumb‑polysyndactyly syndrome (TPT‑PS) is an autosomal dominant disorder with complete penetrance and a variable expression consisting of opposable triphalangeal thumbs, duplication of the distal thumb phalanx, pre‑axial polydactyly and duplication of the big toes (hallux). The causative gene of TPT‑PS has been mapped to 7q36.3. Sonic hedgehog (SHH) expressed in the zone of polarizing activity (ZPA) has an important role in defining the anterior‑posterior axis and numbers of digits in limb bud development...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28027146/gradual-deformity-correction-in-blount-disease
#20
Stephanie W Mayer, Elizabeth W Hubbard, Dan Sun, Robert K Lark, Robert D Fitch
BACKGROUND: Blount disease is a disorder of the posteromedial proximal tibial physis which causes a progressive varus, procurvatum, and internal rotation deformity of the tibia. Untreated, it can cause significant limb malalignment. The goal of this study is to evaluate the results of correction of Blount disease using types of external fixation. METHODS: We conducted a retrospective review of 41 patients (51 limbs) who underwent correction of Blount disease with an Ilizarov external fixator or a Taylor spatial frame (TSF) by a single surgeon...
December 23, 2016: Journal of Pediatric Orthopedics
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