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Mechanical axis limbs

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https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#1
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28035386/microduplication-of-7q36-3-encompassing-the-shh-long%C3%A2-range-regulator-zrs-in-a-patient-with-triphalangeal-thumb%C3%A2-polysyndactyly-syndrome-and-congenital-heart-disease
#2
Zhenghua Liu, Ni Yin, Lianghui Gong, Zhiping Tan, Bangliang Yin, Yifeng Yang, Cheng Luo
Triphalangeal thumb‑polysyndactyly syndrome (TPT‑PS) is an autosomal dominant disorder with complete penetrance and a variable expression consisting of opposable triphalangeal thumbs, duplication of the distal thumb phalanx, pre‑axial polydactyly and duplication of the big toes (hallux). The causative gene of TPT‑PS has been mapped to 7q36.3. Sonic hedgehog (SHH) expressed in the zone of polarizing activity (ZPA) has an important role in defining the anterior‑posterior axis and numbers of digits in limb bud development...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28027146/gradual-deformity-correction-in-blount-disease
#3
Stephanie W Mayer, Elizabeth W Hubbard, Dan Sun, Robert K Lark, Robert D Fitch
BACKGROUND: Blount disease is a disorder of the posteromedial proximal tibial physis which causes a progressive varus, procurvatum, and internal rotation deformity of the tibia. Untreated, it can cause significant limb malalignment. The goal of this study is to evaluate the results of correction of Blount disease using types of external fixation. METHODS: We conducted a retrospective review of 41 patients (51 limbs) who underwent correction of Blount disease with an Ilizarov external fixator or a Taylor spatial frame (TSF) by a single surgeon...
December 23, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28025254/shaping-the-output-of-lumbar-flexor-motoneurons-by-sacral-neuronal-networks
#4
Meir Cherniak, Lili Anglister, Aharon Lev-Tov
: The ability to improve motor function in spinal cord injury patients by reactivating spinal central pattern generators (CPGs) requires the elucidation of neurons and pathways involved in activation and modulation of spinal networks in accessible experimental models. Previously we reported on adrenoceptor-dependent sacral control of lumbar-flexor motoneuron firing in newborn rats. The current work focuses on clarification of the circuitry and connectivity involved in this unique modulation and its potential use...
December 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28005167/patient-specific-instrumentation-development-in-tka-1st-and-2nd-generation-designs-in-comparison-with-conventional-instrumentation
#5
Oh-Ryong Kwon, Kyoung-Tak Kang, Juhyun Son, Dong-Suk Suh, Dong Beom Heo, Yong-Gon Koh
INTRODUCTION: This study was conducted to determine if the difference in magnetic resonance imaging (MRI)-based 2nd generation patient-specific instrumentation (PSI) design affects post-operative restoration of neutral mechanical alignment in total knee arthroplasty (TKA) compared with the 1st generation PSI design and conventional surgical techniques. In addition, it is aimed at elucidating whether PSI improves surgical efficiency with respect to operating room time, estimated blood loss and the number of instrument trays used intra-operatively...
December 22, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28005142/no-correlation-between-coronal-alignment-of-total-knee-arthroplasty-and-clinical-outcomes-a-prospective-clinical-study-using-3d-ct
#6
Omer Slevin, Felix Amsler, Michael T Hirschmann
PURPOSE: The aim of this study was to evaluate femoral and tibial as well as whole leg coronal TKA alignment using 3D-reconstructed CTs and to assess the relationship of coronal TKA alignment and clinical outcome in a large prospective series of patients. It was hypothesized that a coronal deviation of TKA position and leg alignment from the mechanical axis is correlated with poorer patients' outcome after TKA. METHODS: A total of 81 consecutive patients who underwent primary TKA were prospectively included...
December 22, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27974739/full-body-analysis-of-age-adjusted-alignment-in-adult-spinal-deformity-patients-and-lower-limb-compensation
#7
Cyrus M Jalai, Dana L Cruz, Bassel G Diebo, Gregory Poorman, Renaud Lafage, Shay Bess, Subaraman Ramachandran, Louis M Day, Shaleen Vira, Barthélemy Liabaud, Jensen K Henry, Frank J Schwab, Virginie Lafage, Peter G Passias
STUDY DESIGN: Single-center retrospective review. OBJECTIVE: This study evaluates the impact of increasing spinal deformity deviation from age-adjusted alignment ideals on lower extremity compensation. SUMMARY OF BACKGROUND DATA: Though current understanding of compensatory mechanisms in adult spinal deformity (ASD) is progressing due to full-body stereographic assessment, the impact of age-adjusted deformity targets on lower limb compensation remains unexamined...
August 23, 2016: Spine
https://www.readbyqxmd.com/read/27925633/shock-wave-enhances-angiogenesis-through-vegfr2-activation-and-recycling
#8
Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Ching-Jen Wang, Tsung-Cheng Yin, Mel S Lee, Hon-Kan Yip
Although low-energy shock wave (SW) is adopted to treat ischemic diseases because of its pro-angiogenic properties, the underlying mechanism remains unclear. This study aimed at testing whether SW-induced angiogenesis may be through endothelial vascular endothelial growth factor receptor 2 (VEGFR2) signaling and trafficking. Phosphorylation of VEGFR2-Akt-eNOS axis and production of nitric oxide (NO) were determined in human umbilical vein endothelial cells (HUVECs) treated with SW. Carotid artery in ob/ob mice was treated with SW before evaluation with sprouting assay...
December 6, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27918682/changes-in-the-force-velocity-mechanical-profile-after-short-resistance-training-programmes-differing-in-set-configurations
#9
Eliseo Iglesias-Soler, Miguel Fernández-Del-Olmo, Xián Mayo, Juan Fariñas, Dan Río-Rodríguez, Eduardo Carballeira, Elvis A Carnero, Robert A Standley, Manuel A Giráldez-García, Xurxo Dopico-Calvo, Jose Luis Tuimil
The main aim of this study was to analyse the effect of resistance training programs differing in set configuration on mechanical force-velocity profiles. Thirteen participants performed ten unilateral knee extension training sessions over 5 weeks. Each limb was randomised to one of the following set configurations: traditional (4 sets of 8 repetitions at maximum intended velocity, 10RM load, 3-min pause between sets), and inter-repetition rest (32 maximum intended velocity repetitions, 10RM load, 17.4 s of rest between each repetition)...
December 5, 2016: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/27916684/the-impact-of-obesity-on-compensatory-mechanisms-in-response-to-progressive-sagittal-malalignment
#10
Cyrus M Jalai, Bassel G Diebo, Dana L Cruz, Gregory W Poorman, Shaleen Vira, Aaron J Buckland, Renaud Lafage, Shay Bess, Thomas J Errico, Virginie Lafage, Peter G Passias
BACKGROUND CONTEXT: Obesity's impact on standing sagittal alignment remains poorly understood, especially with respect to the role of the lower-limbs. Given energetic expenditure in standing, a complete understanding of compensation in obese patients with sagittal malalignment remains relevant. PURPOSE: This study compares obese and non-obese patients with progressive sagittal malalignment for differences in recruitment of pelvic and lower limb mechanisms. STUDY DESIGN/SETTING: Single center retrospective review...
December 1, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27894175/comparison-of-cable-method-and-miniaci-method-using-picture-archiving-and-communication-system-in-preoperative-planning-for-open-wedge-high-tibial-osteotomy
#11
Seong-Dae Yoon, GuoFeng Zhang, Hee-June Kim, Byoung-Joo Lee, Hee-Soo Kyung
Purpose: The purpose was to compare the accuracy of Miniaci method using picture archiving and communication system (PACS) with a cable method in high tibial osteotomy (HTO). Materials and Methods: This study analyzed 47 patients (52 knees) with varus deformity and medial osteoarthritis. From 2007 to 2013, patients underwent HTO using either a cable method (20 knees) or Miniaci method based on a PACS image (32 knees). In the cable method, the 62.5% point of the mediolateral tibial plateau width was located using an electrocautery cord under fluoroscopy (cable group)...
December 1, 2016: Knee Surgery & related Research
https://www.readbyqxmd.com/read/27858886/fixator-assisted-tibial-lengthening-over-a-plate-in-a-patient-with-sequelae-of-poliomyelitis
#12
Haci Bayram Tosun, Sancar Serbest, Abuzer Uludag, Seyitali Gumustas, Suat Celik
There are many techniques for limb lengthening. Lengthening over a plate is an alternative choice of fixation in children or when nailing is difficult. We present a new technique for tibial lengthening with using a monolateral external fixator over a lengthening plate.Lengthening over an intramedullary nail is a commonly used method in patients with short stature or limb-length discrepancy. However, in patients with a narrow and excessively sclerotic intramedullary cavity in the pediatric age group where the skeletal system has not yet fully developed, difficulties have been observed in lengthening methods with nailing...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27857500/inter-observer-variability-and-its-correlation-to-experience-in-measurement-of-lower-limb-mechanical-axis-on-long-leg-radiographs
#13
Raju Vaishya, Vipul Vijay, Vikas P Birla, Amit Kumar Agarwal
INTRODUCTION: Restoration of mechanical axis (MA) is one of the most important aims of treatment of knee arthritis. The measurement of MA is often done on hip knee ankle (HKA) radiographs (LLR), but its measurement is often difficult and variable. We studied to check if inter-observer variability in the measurement of MA is dependent on the experience of the observer. MATERIALS AND METHODS: 48 patients (70 knees) underwent measurement of MA on HKA radiographs. The measurement was done by five observers of different experience...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27823847/accuracy-of-mri-based-vs-ct-based-patient-specific-instrumentation-in-total-knee-arthroplasty-a-meta-analysis
#14
Vincent V G An, Brahman S Sivakumar, Kevin Phan, Yadin David Levy, Warwick J M Bruce
INTRODUCTION: The technical objective of total knee arthroplasty (TKA) is to restore normal mechanical parameters to the knee. Patient-specific instrumentation (PSI) was developed to streamline the operative process and improve accuracy. PSI produces individualized cutting guides based on three-dimensional models of the patient's anatomy acquired from computed-tomography (CT) or magnetic-resonance imaging (MRI). However, the superiority of one modality over the other remains unclear. Therefore, we aimed to compare the accuracy of patient-specific cutting guides produced from MRI or CT imaging methods in TKA...
November 4, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27817976/return-to-sport-activity-after-anterior-cruciate-ligament-reconstruction-in-skeletally-immature-athletes-with-manual-drilling-original-all-inside-reconstruction-at-8-years-follow-up
#15
Giacomo Placella, Matteo Bartoli, Marco Peruzzi, Andrea Speziali, Valerio Pace, Giuliano Cerulli
OBJECTIVE: Anterior cruciate ligament (ACL) tears are common injuries in adolescent athletes, especially in those who bear high stress on their knees due to shearing forces. The goal of the surgical procedures in skeletally immature patients is to restore joint stability avoiding the adverse effects on the growth process. The aim of this study was to verify the return of the skeletally immature professional athletes to sports in the long-term, following ACL reconstruction with the original all-inside technique and with manual drilling...
November 3, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27794622/mobile-bearing-medial-unicompartmental-knee-arthroplasty-restores-limb-alignment-comparable-to-that-of-the-unaffected-contralateral-limb
#16
Arun B Mullaji, Siddharth Shah, Gautam M Shetty
Background and purpose - Medial unicompartmental knee arthroplasty (UKA) is undertaken in patients with a passively correctable varus deformity. We investigated whether restoration of natural soft tissue tension would result in a lower limb alignment similar to that of the contralateral unaffected lower limb after mobile-bearing medial UKA. Patients and methods - In this retrospective study, hip-knee-ankle (HKA) angle, position of the weight-bearing axis (WBA), and knee joint line obliquity (KJLO) after mobile-bearing medial UKA was compared with that of the unaffected (clinically and radiologically) contralateral lower limb in 123 patients...
February 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/27779156/preoperative-measurement-of-tibial-resection-in-total-knee-arthroplasty-improves-accuracy-of-postoperative-limb-alignment-restoration
#17
Pei-Hui Wu, Zhi-Qi Zhang, Shu-Ying Fang, Zi-Bo Yang, Yan Kang, Ming Fu, Wei-Ming Liao
BACKGROUND: Accuracy of implant placement in total knee arthroplasty (TKA) is crucial. Traditional extramedullary alignment instruments are fairly effective for achieving the desired mean tibial component coronal alignment. We modified the traditional tibial plateau resection technique and evaluated its effect on alignment restoration. METHODS: Two hundred and eighty-two primary TKAs in our hospital between January 2013 and December 2014 were enrolled in this retrospective study...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27776793/how-accurately-does-high-tibial-osteotomy-correct-the-mechanical-axis-of-an-arthritic-varus-knee-a-systematic-review
#18
REVIEW
Maxim Van den Bempt, Wouter Van Genechten, Toon Claes, Steven Claes
BACKGROUND: The aim of this study was to give an overview of the accuracy of coronal limb alignment correction after high tibial osteotomy (HTO) for the arthritic varus knee by performing a systematic review of the literature. METHODS: The databases PubMed, MEDLINE and Cochrane Library were screened for relevant articles. Only prospective clinical studies with the accuracy of alignment correction by performing HTO as primary or secondary objective were included...
December 2016: Knee
https://www.readbyqxmd.com/read/27746585/prosthetic-leg-control-in-the-nullspace-of-human-interaction
#19
Robert D Gregg, Anne E Martin
Recent work has extended the control method of virtual constraints, originally developed for autonomous walking robots, to powered prosthetic legs for lower-limb amputees. Virtual constraints define desired joint patterns as functions of a mechanical phasing variable, which are typically enforced by torque control laws that linearize the output dynamics associated with the virtual constraints. However, the output dynamics of a powered prosthetic leg generally depend on the human interaction forces, which must be measured and canceled by the feedback linearizing control law...
July 2016: Proceedings of the ... American Control Conference
https://www.readbyqxmd.com/read/27741108/guided-growth-for-tibia-vara-blount-s-disease
#20
John A Heflin, Scott Ford, Peter Stevens
Blount's disease is commonly attributed to an intrinsic, idiopathic defect in the posteromedial proximal tibial physis resulting in progressive bowing of the leg, intoeing, and lateral knee thrust. Treatment has historically included bracing, physeal stapling, or corrective osteotomy, and was determined primarily by age at presentation. As we feel the pathology is not necessarily age dependent, we have elected to use the technique of guided growth using a lateral tension band plate to correct limb alignment as a first-line treatment in all patients presenting to our clinic as long as they had growth remaining and no evidence of a physeal bar...
October 2016: Medicine (Baltimore)
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