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https://www.readbyqxmd.com/read/28731440/challenges-and-considerations-related-to-studying-dementia-in-african-americans
#1
Eseosa T Ighodaro, Peter T Nelson, Walter A Kukull, Frederick A Schmitt, Erin L Abner, Allison Caban-Holt, Shoshana H Bardach, Derrick C Hord, Crystal M Glover, Gregory A Jicha, Linda J Van Eldik, Alexander X Byrd, Anita Fernander
Blacks/African Americans have been reported to be ∼2-4 times more likely to develop clinical Alzheimer's disease (AD) compared to Whites. Unfortunately, study design challenges (e.g., recruitment bias), racism, mistrust of healthcare providers and biomedical researchers, confounders related to socioeconomic status, and other sources of bias are often ignored when interpreting differences in human subjects categorized by race. Failure to account for these factors can lead to misinterpretation of results, reification of race as biology, discrimination, and missed or delayed diagnoses...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28729876/genetic-architecture-of-flooding-tolerance-in-the-dry-bean-middle-american-diversity-panel
#2
Ali Soltani, Samira MafiMoghaddam, Katelynn Walter, Daniel Restrepo-Montoya, Sujan Mamidi, Stephan Schroder, Rian Lee, Phillip E McClean, Juan M Osorno
Flooding is a devastating abiotic stress that endangers crop production in the twenty-first century. Because of the severe susceptibility of common bean (Phaseolus vulgaris L.) to flooding, an understanding of the genetic architecture and physiological responses of this crop will set the stage for further improvement. However, challenging phenotyping methods hinder a large-scale genetic study of flooding tolerance in common bean and other economically important crops. A greenhouse phenotyping protocol was developed to evaluate the flooding conditions at early stages...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28729127/variation-in-safe-sleep-and-breastfeeding-practices-among-non-hispanic-black-mothers-in-the-us-according-to-birth-country
#3
Margaret G K Parker, Eve R Colson, Lauren Provini, Denis V Rybin, Stephen M Kerr, Timothy Heeren, Michael J Corwin
OBJECTIVE: To examine variation in safe sleep and breastfeeding practices among US non-Hispanic black (NHB) mothers according to birth country METHODS: We analyzed NHB mothers that were surveyed regarding safe sleep and breastfeeding practices when their infants were 2-6 months of age in 2011-14, as part of a larger national study. We examined prevalences of safe sleep and breastfeeding practices according to birth country and examined odds of adherence to American Academy of Pediatrics recommended safe sleep and breastfeeding practices in foreign born NHBs, compared to US born NHBs...
July 17, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28727841/river-specific-macrogenomic-diversity-in-simulium-guianense-s-l-diptera-simuliidae-a-complex-of-tropical-american-vectors-associated-with-human-onchocerciasis
#4
Peter H Adler, Neusa Hamada, Jeane Marcelle Cavalcante do Nascimento, Maria Eugenia Grillet
Simulium guianense Wise is a Latin American vector complex of black flies associated with transmission of the causal agent of human onchocerciasis (river blindness). An analysis of the chromosomal banding patterns of 607 larvae of S. guianense s. l. revealed a high level of variation involving 83 macrogenomic rearrangements across 25 populations in Brazil, French Guiana, and Venezuela. The 25 populations were assigned to 13 cytoforms (A1, A2, B1-B4, C, D, E1-E4, and F), some of which are probably valid species...
2017: PloS One
https://www.readbyqxmd.com/read/28727682/racial-and-ethnic-differences-in-homicides-of-adult-women-and-the-role-of-intimate-partner-violence-united-states-2003-2014
#5
Emiko Petrosky, Janet M Blair, Carter J Betz, Katherine A Fowler, Shane P D Jack, Bridget H Lyons
Homicide is one of the leading causes of death for women aged ≤44 years.* In 2015, homicide caused the death of 3,519 girls and women in the United States. Rates of female homicide vary by race/ethnicity (1), and nearly half of victims are killed by a current or former male intimate partner (2). To inform homicide and intimate partner violence (IPV) prevention efforts, CDC analyzed homicide data from the National Violent Death Reporting System (NVDRS) among 10,018 women aged ≥18 years in 18 states during 2003-2014...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28727535/civil-unrest-in-the-context-of-chronic-community-violence-impact-on-maternal-depressive-symptoms
#6
Doris P Yimgang, Yan Wang, Grace Paik, Erin R Hager, Maureen M Black
OBJECTIVES: To examine changes in maternal-child health surrounding the April 2015 civil unrest in Baltimore, Maryland, following Freddie Gray's death while in police custody. METHODS: We conducted cross-sectional Children's HealthWatch surveys January 2014 through December 2015 in pediatric emergency departments and primary care clinics on maternal-child health and June 2015 through October 2015 on daily and community routines. We used trend analysis and piecewise logistic regression to examine effects of time, residential proximity moderation, and mediation analysis to assess proximity and maternal-child health relations via maternal concerns...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28727136/a-multidimensional-view-of-racial-differences-in-access-to-prostate-cancer-care
#7
Craig Evan Pollack, Katrina A Armstrong, Nandita Mitra, Xinwei Chen, Katelyn R Ward, Archana Radhakrishnan, Michelle S Wong, Justin E Bekelman, Charles C Branas, Karin V Rhodes, David T Grande
BACKGROUND: Racial disparities in prostate cancer treatment and outcomes are widespread and poorly understood. In the current study, the authors sought to determine whether access to care, measured across multiple dimensions, contributed to racial differences in prostate cancer. METHODS: The Philadelphia Area Prostate Cancer Access Study (P(2) Access) included 2374 men diagnosed with localized prostate cancer between 2012 and 2014. Men were surveyed to assess their experiences accessing care (response rate of 51...
July 20, 2017: Cancer
https://www.readbyqxmd.com/read/28726083/exploring-factors-associated-with-declining-hiv-diagnoses-among-african-american-females
#8
Donna Hubbard McCree, William L Jeffries, Linda Beer, Zanetta Gant, Kimberlee Elmore, Madeline Sutton
HIV diagnoses among females in the USA declined 40% during 2005-2014 with the largest decline (42%) among Black/African Americans. African American females remain disproportionately affected. We explored contributions of STD rates and sexual risk behaviors among African American females, HIV diagnoses among potential male partners, and sexual risk behaviors and viral suppression rates among HIV-positive potential male partners to declining rates of HIV diagnoses among African American females. Results suggest temporal trends in the factors that increase HIV infectiousness and transmissibility within sexual networks, i...
July 19, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28722672/ethnic-heterogeneity-and-prostate-cancer-mortality-in-hispanic-latino-men-a-population-based-study
#9
Felix M Chinea, Vivek N Patel, Deukwoo Kwon, Narottam Lamichhane, Chris Lopez, Sanoj Punnen, Erin N Kobetz, Matthew C Abramowitz, Alan Pollack
BACKGROUND: Few studies focus on prostate cancer (PCa) outcomes in Hispanic/Latino men. Our study explores whether Hispanic/Latino subgroups demonstrate significantly different prostate cancer-specific mortality (PCSM) relative to Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men. METHODS: We extracted a population-based cohort of men diagnosed with local-regional PCa from 2000-2013 (n= 486,865). PCSM was measured in racial/ethnic groups: NHW (n=352,886), NHB (n= 70,983), Hispanic/Latino (n= 40,462), and Asian American/Pacific Islander (n= 22,534)...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721321/correlation-of-ventilation-perfusion-v-q-scan-results-as-compared-with-clinical-probability-of-pulmonary-embolism-in-african-american-population
#10
Fasil Tiruneh, Ahmad Awan, Nicole Hunt, Nahom Tegegn, Daniel Larbi
Introduction Current guidelines suggest the use of the more specific Wells' score could safely reduce the number of unnecessary scans. There is a lack of research to support whether these guidelines apply to the African American population. This study aims to evaluate the correlation of clinical pretest probability of pulmonary embolism (PE) with ventilation-perfusion (V/Q) scan results in a predominantly African American population and to test whether current guidelines based on studies conducted in other populations hold true in this group...
June 14, 2017: Curēus
https://www.readbyqxmd.com/read/28720914/examining-the-association-between-the-naplex-pre-naplex-and-pre-and-post-admission-factors
#11
Marie A Chisholm-Burns, Christina A Spivey, Debbie C Byrd, Sharon L K McDonough, Stephanie J Phelps
Objective. To examine the relationship between the NAPLEX and Pre-NAPLEX among pharmacy graduates, as well as determine effects of pre-pharmacy, pharmacy school, and demographic variables on NAPLEX performance. Methods. A retrospective review of pharmacy graduates' NAPLEX scores, Pre-NAPLEX scores, demographics, pre-pharmacy academic performance factors, and pharmacy school academic performance factors was performed. Bivariate (eg, ANOVA, independent samples t-test) and correlational analyses were conducted, as was stepwise linear regression to examine the significance of Pre-NAPLEX score and other factors as related to NAPLEX score...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28719727/the-ability-of-a-single-bmd-and-fracture-history-assessment-to-predict-fracture-over-25-years-in-postmenopausal-women-the-study-of-osteoporotic-fractures
#12
Dennis M Black, Jane A Cauley, Rachel Wagman, Kristine Ensrud, Howard A Fink, Teresa A Hillier, Li-Yung Lui, Steven R Cummings, John T Schousboe, Nicola Napoli
The ability of bone mineral density (BMD) and other risk factors to predict fracture risk is well-established for as long as 5 to 10 years. However, their value to predict risk over a longer term has not been directly studied. We investigated whether a single assessment of femoral neck BMD and fracture history can predict fracture risk over 20 to 25 years. We used data from the Study of Osteoporotic Fractures (SOF) that assessed BMD and risk factors in 7959 women age ≥67 (mean = 73.4) in 1988-1990. Follow-up for fractures continued for 25 years for hip fracture, and for 20 years for any nonvertebral fracture...
July 18, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28718431/racial-differences-in-cancer-susceptibility-and-survival-more-than-the-color-of-the-skin
#13
REVIEW
Berna C Özdemir, Gian-Paolo Dotto
Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race (distinguishing 'black versus white'), individuals of African ancestry have a globally increased risk of malignancies compared with Caucasians and Asian Americans. Differences in socioeconomic status and health-care access play a key role. However, the lesser disease susceptibility of Hispanic populations with comparable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the concomitant importance of genetic determinants...
March 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28715553/validation-of-the-children-s-hospital-of-philadelphia-retinopathy-of-prematurity-chop-rop-model
#14
Gil Binenbaum, Gui-Shuang Ying, Lauren A Tomlinson
Importance: The Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP ROP) model uses birth weight (BW), gestational age at birth (GA), and weight gain rate to predict the risk of severe retinopathy of prematurity (ROP). In a model development study, it predicted all infants requiring treatment, while greatly reducing the number of examinations compared with current screening guidelines. Objective: To validate the CHOP ROP model in a multicenter cohort that is large enough to obtain a precise estimate of the model's sensitivity for treatment-requiring ROP...
July 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28715473/population-and-colony-structure-and-morphometrics-in-the-queen-dimorphic-little-black-ant-monomorium-sp-az-02-with-a-review-of-queen-phenotypes-in-the-genus-monomorium
#15
Robert A Johnson, Rick P Overson
The North American little black ant, Monomorium sp. AZ-02 (subfamily Myrmicinae), displays a dimorphism that consists of alate (winged) and ergatoid (wingless) queens. Surveys at our field site in southcentral Arizona, USA, demonstrated that only one queen phenotype (alate or ergatoid) occurred in each colony during the season in which reproductive sexuals were produced. A morphometric analysis demonstrated that ergatoid queens retained all specialized anatomical features of alate queens (except for wings), and that they were significantly smaller and had a lower mass than alate queens...
2017: PloS One
https://www.readbyqxmd.com/read/28713584/fitness-adjusted-racial-disparities-in-central-adiposity-among-women-in-the-usa-using-quantile-regression
#16
S McDonald, A Ortaglia, C Supino, M Kacka, M Clenin, M Bottai
OBJECTIVE: This study comprehensively explores racial/ethnic disparities in waist circumference (WC) after adjusting for cardiorespiratory fitness (CRF), among both adult and adolescent women, across WC percentiles. METHODS: Analysis was conducted using data from the 1999 to 2004 National Health and Nutrition Examination Survey. Female participants (n = 3,977) aged 12-49 years with complete data on CRF, height, weight and WC were included. Quantile regression models, stratified by age groups (12-15, 16-19 and 20-49 years), were used to assess the association between WC and race/ethnicity adjusting for CRF, height and age across WC percentiles (10th, 25th, 50th, 75th, 90th and 95th)...
June 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28709773/demographic-psychosocial-clinical-and-neurocognitive-baseline-characteristics-of-black-americans-in-the-raise-etp-study
#17
Arundati Nagendra, Nina R Schooler, John M Kane, Delbert G Robinson, Kim T Mueser, Sue E Estroff, Jean Addington, Patricia Marcy, David L Penn
This study compared baseline characteristics of Black Americans and Caucasians with first-episode psychosis in the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP). Black American (N=152) and Caucasian (N=218) participants were compared on demographic, psychosocial, clinical, and neurocognitive measures. Results indicated several notable racial differences in baseline characteristics: a greater proportion of Black Americans than Caucasians were female, and Black Americans reported less personal and parental education than Caucasians...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28708010/the-cost-of-minority-stress-risky-alcohol-use-and-coping-motivated-drinking-behavior-in-african-american-college-students
#18
Delishia M Pittman, Jessica J Brooks, Paramjit Kaur, Ezemenari M Obasi
A motivational drinking framework is utilized to understand the relationship between minority stressors (e.g., race-related stress and acculturative stress) and alcohol use behaviors (risky alcohol use and coping-motivated drinking) among a large sample of Black American college students. Six hundred forty-nine Black college students from 8 colleges and universities in the United States were recruited as part of a large, multiwave, cross-sectional study investigating the stress and coping experiences of Black emerging adults...
July 14, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28707547/-we-need-a-safe-walkable-way-to-connect-our-sisters-and-brothers-a-qualitative-study-of-opportunities-and-challenges-for-neighborhood-based-physical-activity-among-residents-of-low-income-african-american-communities
#19
Stephanie T Child, Andrew T Kaczynski, Melissa L Fair, Ellen W Stowe, S Morgan Hughey, Lauren Boeckerman, Sally Wills, Yvonne Reeder
OBJECTIVE: The purpose of this study was to explore perceptions of the benefits of and influencing factors for neighborhood-based physical activity (PA), and elicit suggestions for increasing neighborhood-based PA among primarily Black residents living in lower income neighborhoods. DESIGN: Eight focus groups were conducted in low-income, predominantly Black neighborhoods (n = 8) in Greenville, SC during Spring 2014. Using a semi-structured focus group guide with open-ended questions, residents were asked to describe benefits of PA, neighborhood factors associated with PA, and ways to increase PA within their neighborhoods...
July 14, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28707284/fixed-dose-versus-off-label-combination-of-isosorbide-dinitrate-plus-hydralazine-hydrochloride-retrospective-propensity-matched-analysis-in-black-medicare-patients-with-heart-failure
#20
Elizabeth Ofili, Inder Anand, Richard Allen Williams, Ola Akinboboye, Liou Xu, Gary Puckrein
INTRODUCTION: Based upon the findings of the African-American Heart Failure Trial, the US Food and Drug Administration approved the fixed-dose combination of isosorbide dinitrate (ISDN) and hydralazine hydrochloride (HYD) (FDC-ISDN/HYD) as a new drug for treatment of heart failure (HF) in self-identified African Americans. According to the FDA, FDC-ISDN/HYD has no therapeutic equivalent. However, off-label combinations of the separate generic drugs ISDN and HYD (OLC-ISDN+HYD) or isosorbide mononitrate (ISMN) and HYD (OLC-ISMN+HYD) are routinely substituted without any supporting outcome data...
July 13, 2017: Advances in Therapy
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