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Hemorrage

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https://www.readbyqxmd.com/read/28732730/thermo-responsive-hydroxybutyl-chitosan-hydrogel-as-artery-intervention-embolic-agent-for-hemorrhage-control
#1
Guohui Sun, Chao Feng, Changqing Jiang, Tingting Zhang, Zixian Bao, Yajun Zuo, Ming Kong, Xiaojie Cheng, Ya Liu, Xiguang Chen
This work targeted to investigate the potential of thermo-responsive hydroxybutyl chitosan (HBC) hydrogel using as an embolic material for occlusion of selective blood vessels. HBC hydrogel was prepared via an etherification reaction between chitosan (CS) and 1, 2-butene oxide. The hydroxybutyl groups were introduced into CS backbone, which endowed HBC hydrogel with properties of porous structure, favorable hydrophilia and rapid sol-gel interconvertibility. The gelation temperatures and gelation time respectively decreased from 30...
July 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28677928/-clinical-scores-for-the-risk-of-bleeding-with-or-without-anticoagulation
#2
Alain Junod
The assessment of hemorragic risk related to therapeutic anticoagulation is made difficult because of the variety of existing drugs, the heterogeneity of treatment strategies and their duration. Six prognostic scores have been analyzed. For three of them, external validations have revealed a marked decrease in the discrimination power. One British study, Qbleed, based on the data of more than 1 million of ambulatory patients, has repeatedly satisfied quality criteria. Two scores have also studied the bleeding risk during hospital admission for acute medical disease...
September 14, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28634099/fatal-anaphylaxis-caused-by-gadolinium-due-to-beta-tryptase-induced-hemorragic-diathesis
#3
Alicia Prieto-García, Esther Pérez-David, Carolina Devesa, Pilar Tornero, Lawrence B Schwartz, Cristina Pascual, Mariana C Castells
No abstract text is available yet for this article.
June 17, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28559407/neutrophil-elastase-and-il17-expressed-in-the-pig-colon-during-brachyspira-hyodysenteriae-infection-synergistically-with-the-pathogen-induce-increased-mucus-transport-speed-and-production-via-mapk3
#4
Macarena P Quintana-Hayashi, Nazanin Navabi, Maxime Mahu, Vignesh Venkatakrishnan, Harvey R Fernandez, Freddy Haesebrouck, Frank Pasmans, Sara K Lindén
Brachyspira hyodysenteriae colonizes the pig colon resulting in mucoid hemorragic diarrhea and mucus layer changes. These changes are characterized by a disorganized mucus structure and a massive mucus induction with de novo expression of MUC5AC and increased production of MUC2. To investigate the mechanisms behind this altered mucin environment, we quantified the mRNA levels of mucin pathway genes and factors from the immune system in the colon of infected and control pigs, revealing upregulation of neutrophil elastase, SPDEF, FOXA3, MAPK3/ERK1, IL-17A, IL-1β, IL-6 and IL-8 expression...
May 30, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28559066/status-epilepticus-secondary-to-pseudonodular-hemorragic-occipital-lesion-with-edema-non-semper-ea-sunt-quae-videntur-decipit-frons-prima-multos-things-are-not-always-what-they-seem-the-first-appearance-deceives-many
#5
Davide Nasi, Franco Servadei, Antonio Romano
We report a case in which common radiologic images masked a rare case of supratentorial hemangioblastoma (HBL). Other peculiarities of this case are the clinical presentation with status epilepticus and the occurrence of a supratentorial HBL unrelated to von Hippel-Lindau syndrome. Based on clinical and radiologic findings, including massive cerebral edema and hemorrhagic presentation, our preoperative diagnosis was a cerebral metastasis. In this scenario, physicians must take into account the words of the Roman fabulist Phaedrus: "Non semper ea sunt, quae videntur, decipit frons prima multos" (things are not always what they seem; the first appearance deceives many)...
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28515583/cavernous-sinus-melanoma-a-rare-tumor
#6
Shaileshkumar Garge, Sunithi Mani, Alfred Inbaraj, Vedantam Rajshekhar, Priyanka Mohapatra
Primay melanoma of the cavernous sinus is very rare with only few cases reported in the literature. We present the cross-sectional imaging findings of this rare tumor. The differential diagnosis for cavernous sinus mass lesion is wide as it contains vital neurovascular structures that may be affected by vascular, neoplastic, infective, and infiltrative lesions arising in the cavernous sinus proper or via extension from adjacent intra and/or extracranial regions. Radiologic imaging can narrow the differential diagnosis, however, imaging cannot definitely reach single diagnosis if they present in atypical form with hemorrage and cystic degeneration...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28494766/filmarray%C3%A2-gi-panel-performance-for-the-diagnosis-of-acute-gastroenteritis-or-hemorragic-diarrhea
#7
Antonio Piralla, Giovanna Lunghi, Gianluigi Ardissino, Alessia Girello, Marta Premoli, Erika Bava, Milena Arghittu, Maria Rosaria Colombo, Alessandra Cognetto, Patrizia Bono, Giulia Campanini, Piero Marone, Fausto Baldanti
BACKGROUND: Acute gastroenteritis is a common cause of morbidity and mortality in humans worldwide. The rapid and specific identification of infectious agents is crucial for correct patient management. However, diagnosis of acute gastroenteritis is usually performed with diagnostic panels that include only a few pathogens. In the present bicentric study, the diagnostic value of FilmArray™ GI panels was assessed in unformed stool samples of patients with acute gastroenteritis and in a series of samples collected from pediatric patients with heamorragic diarrhea...
May 12, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28461180/giant-symptomatic-aneurysm-secondary-to-hereditary-hemorrhagic-telangiectasia-of-a-main-hepatic-artery-with-aberrant-origin-in-superior-mesenteric-artery
#8
Francisco Javier Peinado Cebria N, Santiago Este Banez Seco, A Ngel Flores-Herrero, Ricardo Montoya Ching, Benito Mendez Feria, Diego Soto Valdés, Maria Pilar Lamarca Mendoza, Antonio Orgaz Pe Rez-Grueso
INTRODUCTION: Hereditary Hemorragic Telangiectasia (HHT) is a rare disease consistent in vascular dysplasias affecting different organs. Liver involvement includes telangiectases, arteriovenous shunting, and ischemic cholangitis, and its prevalence ranges from 8 to 31%. Spontaneous pseudo aneurysms have never been reported associated to HHT. Several variations in the origin of the main hepatic artery (MHA) have been described in large radiological series, and can be found in around 4% of general population...
April 28, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28457385/blood-lactate-concentrations-before-and-after-withdrawal-of-life-sustaining-treatments-in-controlled-donation-after-circulatory-death-a-case-report-from-italy
#9
F Baroncelli, M C Alberione, V Cacciotti, D Artusio, M Vergano, S Livigni
A 20-minute hands-off period with isoelectric electrocardiography (ECG) monitoring is currently required for the declaration of cardiac death in Italy, thus prolonging the warm ischemia time (WIT) during donation after circulatory death (DCD). Normothermic regional perfusion (NRP) can be a valid tool to optimize organ perfusion as a bridge to donation. A 62-year-old woman with catastrophic brain injury due to massive intracranial hemorrage, not fulfilling brain death criteria, underwent controlled DCD after withdrawal of life-sustaining therapies (WLST)...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28450213/isolation-characterization-virulence-and-immunogenicity-testing-of-field-isolates-of-pasteurella-multocida-staphylococcus-aureus-and-streptococcus-agalactiae-in-laboratory-settings
#10
Qudratullah, G Muhammad, M Saqib, M Qamar Bilal
The present study was designed to investigate isolation, characterization, virulence and immunogenicity testing of field isolates of Pasteurella multocida, Staphylococcus aureus, and Streptococcus agalactiae in rabbits and mice. Isolates of P. multocida, S. aureus and Str. agalactiae recovered from field cases of Hemorragic septicemia and mastitis were scrutinized for virulence/pathogenicity and immunogenicity. Mouse LD50 of P. multocida showed that P. multocida isolate No.1 was more virulent than isolates No...
April 24, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28306635/ocular-fundus-photography-with-a-smartphone-device-in-acute-hypertension
#11
M Lorenza Muiesan, Massimo Salvetti, Anna Paini, Michela Riviera, Clara Pintossi, Fabio Bertacchini, Efrem Colonetti, Claudia Agabiti-Rosei, Maurizio Poli, Francesco Semeraro, Enrico Agabiti-Rosei, Andrea Russo
BACKGROUND: The ocular fundus examination is infrequently and poorly performed in the emergency department (ED) clinical settings, placing patients at risk for missed diagnosis of hypertensive emergencies. The aim of this study was to investigate the feasibility of the ocular fundus photography with a smartphone small optical device in an ED setting and to compare it with a traditional ocular fundus examination. METHODS: The study included 52 consecutive patients (mean age 69 ± 16 years, 50% women) presenting to a hospital ED with an acute increase in blood pressure (SBP > 180 and/or DBP > 100 mmHg)...
August 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28250262/increased-irisin-concentrations-in-patients-with-crimean-congo-hemorragic-fever
#12
Seyit Ali Büyüktuna, Halef Okan Doğan, Deniz Bakır, Serpil Erşan, Derya Koç, Sevtap Bakır
Crimean-Congo Hemorrhagic Fever (CCHF) is a life-threatening viral infection. The pathogenesis of the disease is not well understood. The aim of this study was to determine the change in irisin concentrations in patients with CCHF. The study included a total of 30 patients with CCHF and 30 control subjects. Irisin concentrations were determined using a commercial ELISA kit. Median irisin concentrations were 9.03 (5.81-12.22) µg/mL and 4,.2 (3.39-7.62) µg/mL , respectively. There was no correlation between irisin and disease severity...
February 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28223736/percutaneous-electrochemotherapy-in-the-treatment-of-portal-vein-tumor-thrombosis-at-hepatic-hilum-in-patients-with-hepatocellular-carcinoma-in-cirrhosis-a-feasibility-study
#13
Luciano Tarantino, Giuseppina Busto, Aurelio Nasto, Raffaele Fristachi, Luigi Cacace, Maria Talamo, Catello Accardo, Sara Bortone, Paolo Gallo, Paolo Tarantino, Riccardo Aurelio Nasto, Matteo Nicola Dario Di Minno, Pasquale Ambrosino
AIM: To treated with electrochemotherapy (ECT) a prospective case series of patients with liver cirrhosis and Vp3-Vp4- portal vein tumor thrombus (PVTT) from hepatocellular carcinoma (HCC), in order to evaluate the feasibility, safety and efficacy of this new non thermal ablative technique in those patients. METHODS: Six patients (5 males and 1 female), aged 61-85 years (mean age, 70 years), four in Child-Pugh A and two in Child-Pugh B class, entered our study series...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28206731/thrombus-resolution-and-right-ventricular-functional-recovery-using-ultrasound-accelerated-thrombolysis-in-acute-massive-and-submassive-pulmonary-embolism
#14
Evren Ozcinar, Mehmet Cakici, Nur Dikmen Yaman, Cagdas Baran, Anar Aliyev, Bahadir Inan, Serkan Durdu, Ahmet R Akar, Mustafa Sirlak
BACKGROUND: This study aims to evaluate the efficacy and safety of ultrasound-accelerated catheter- directed thrombolysis (UACDT) in the treatment of massive and submassive pulmonary embolism (PE). METHODS: We conducted a prospective, observational cohort study of consequtive patients with massive or submassive PE treated with low-dose UACDT using EKOS EkoSonic® system at single center from May 2014 until April 2015. Overall, thirty-eight patients (median age, 64...
February 15, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28008711/a-proteomics-assay-to-detect-eight-cbrn-relevant-toxins-in-food
#15
Benoit Gilquin, Michel Jaquinod, Mathilde Louwagie, Sylvie Kieffer-Jaquinod, Alexandra Kraut, Myriam Ferro, François Becher, Virginie Brun
A proteomics assay was set up to analyze food substrates for eight toxins of the CBRN (chemical, biological, radiological and nuclear) threat, namely ricin, Clostridium perfringens epsilon toxin (ETX), Staphylococcus aureus enterotoxins (SEA, SEB and SED), shigatoxins from Shigella dysenteriae and entero-hemorragic Escherichia coli strains (STX1 and STX2) and Campylobacter jejuni cytolethal distending toxin (CDT). The assay developed was based on an antibody-free sample preparation followed by bottom-up LC-MS/MS analysis operated in targeted mode...
January 2017: Proteomics
https://www.readbyqxmd.com/read/27941589/treatment-of-stroke-with-early-imaging-and-revascularization-when-to-be-aggressive
#16
REVIEW
Danilo Toni, Alessio Pieroni
Neuroimaging has a key role in the assessment and treatment of acute stroke. Cerebral computer tomography is the first step to differentiate hemorragic from ischemic stroke and to detect, in the latter, early signs representative of the lesion severity and predicting a possible hemorrhagic infarction after thrombolytic treatment.Advanced neuroimaging techniques are relevant in the assessment of the ischemic and/or hypo-perfused area, being an essential tool in uncertain situations or when the time of symptoms onset is unavailable, increasing the efficacy and safety of endovenous thrombolysis by enlarging its therapeutic window and leading to more accurate selection of patients to be treated...
January 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27855688/fatal-varicella-pneumonia-in-an-unvaccinated-child-with-down-syndrome-a-case-report
#17
Diletta Valentini, Simona Bianchi, Chiara Di Camillo, Anna Chiara Vittucci, Michaela Veronika Gonfiantini, Rita De Vito, Alberto Villani
BACKGROUND: Varicella is an acute infectious disease common during childhood. It has mostly an uncomplicated course in early childhood. Neverthless, it may result in severe complications, especially in particular age groups and clinical conditions. Down Syndrome represents a risk factor for developing complications, because of the frequent comorbidities and their immunodeficiency. CASE PRESENTATION: A 2-year-old white Caucasian female affected by Down Syndrome was referred to our hospital for cardiac arrest in course of varicella disease...
November 17, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27748540/prediction-of-b-cell-epitopes-among-hantavirus-strains-causing-hemorragic-fever-with-renal-syndrome
#18
Sagadevan Kalaiselvan, Sathish Sankar, Mageshbabu Ramamurthy, Asit Ranjan Ghosh, Balaji Nandagopal, Gopalan Sridharan
Hantavirus infections are now recognized to be a global problem. The hantaviruses include several genotypic variants of the virus with different distributions in varying geographical regions. The virus genotypes seem to segregate in association with certain manifestations specific for each syndrome. They primarily include HFRS, HCPS, febrile illness with or without mild involvement of renal diseases. In the course of our study on hantavirus etiology of febrile illnesses, we recovered a hantavirus strain identified by nPCR...
May 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27686032/-beware-polyarteritis-nodosa-still-exists-in-nephrology
#19
Justine Perrin, Julien Carvelli, Bertrand Gondouin, Laurent Daniel, Megan Fraisse, Céline Gaudon, Fouad Bouzana, Henri Vacher-Coponat, Julie Moussi-Francès, Bertrand Dussol, Noémie Jourde-Chiche
Renal involvement of systemic vasculitides is an emergency in nephrology. Although it has become very rare, the diagnosis of polyarteritis nodosa must be considered in some patients. A 70-year-old patient, previously healthy, presented with acute renal failure and malignant hypertension and abundant albuminuria. Subcutaneous nodule, orchitis and mononeuritis appeared subsequently. The search for auto-immunity or viral infection was negative. Markers of thrombotic microangiopathy, present initially, resolved after blood pressure control...
November 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27567990/-pathophysiology-of-hemorragic-shock
#20
R Copotoiu, E Cinca, O Collange, F Levy, P-M Mertes
This review addresses the pathophysiology of hemorrhagic shock, a condition produced by rapid and significant loss of intravascular volume, which may lead to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage, and death. The initial neuroendocrine response is mainly a sympathetic activation. Haemorrhagic shock is associated altered microcirculatory permeability and visceral injury. It is also responsible for a complex inflammatory response associated with hemostasis alteration...
November 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
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