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Sagadevan Kalaiselvan, Sathish Sankar, Mageshbabu Ramamurthy, Asit Ranjan Ghosh, Balaji Nandagopal, Gopalan Sridharan
Hantavirus infections are now recognized to be a global problem. The hantaviruses include several genotypic variants of the virus with different distributions in varying geographical regions. The virus genotypes seem to segregate in association with certain manifestations specific for each syndrome. They primarily include HFRS, HCPS, febrile illness with or without mild involvement of renal diseases. In the course of our study on hantavirus etiology of febrile illnesses, we recovered a hantavirus strain identified by nPCR...
October 17, 2016: Journal of Cellular Biochemistry
Justine Perrin, Julien Carvelli, Bertrand Gondouin, Laurent Daniel, Megan Fraisse, Céline Gaudon, Fouad Bouzana, Henri Vacher-Coponat, Julie Moussi-Francès, Bertrand Dussol, Noémie Jourde-Chiche
Renal involvement of systemic vasculitides is an emergency in nephrology. Although it has become very rare, the diagnosis of polyarteritis nodosa must be considered in some patients. A 70-year-old patient, previously healthy, presented with acute renal failure and malignant hypertension and abundant albuminuria. Subcutaneous nodule, orchitis and mononeuritis appeared subsequently. The search for auto-immunity or viral infection was negative. Markers of thrombotic microangiopathy, present initially, resolved after blood pressure control...
September 24, 2016: Néphrologie & Thérapeutique
R Copotoiu, E Cinca, O Collange, F Levy, P-M Mertes
This review addresses the pathophysiology of hemorrhagic shock, a condition produced by rapid and significant loss of intravascular volume, which may lead to hemodynamic instability, decreases in oxygen delivery, decreased tissue perfusion, cellular hypoxia, organ damage, and death. The initial neuroendocrine response is mainly a sympathetic activation. Haemorrhagic shock is associated altered microcirculatory permeability and visceral injury. It is also responsible for a complex inflammatory response associated with hemostasis alteration...
August 24, 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
M L Muiesan, M Riviera, C Pintossi, F Bertacchini, E Colonetti, M Salvetti, A Paini, M Poli, F Semeraro, E Agabiti Rosei, A Russo
OBJECTIVE: The ocular fundus (FO) examination is infrequently and poorly performed in the emergency department (ED) clinical settings, placing patients at risk for missed diagnosis of hypertensive emergencies. AIM: to investigate the feasibility of the FO photography with a smartphone small optical device (D-Eye; J Ophtalmol. 2015) in a ED setting and to compare it to a traditional FO examination. DESIGN AND METHOD: The study included 41 consecutive patients (mean age 69 ± 16 years, 50% women) presenting to an hospital ED with an acute increase in blood pressure (SBP >180 and/or DBP >100 mmHg)...
September 2016: Journal of Hypertension
S Valles Angulo, M P Gracia Arnillas, I Dot Jordana, E Cuadrado Godia, A Ois Santiago, F Vasco Castaño, R Muñoz Bermudez, M Samper Sanchez, E Vivas Diaz, G Villalba Martinez
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Maeva Giraudo, Audrey Bruneau, Andrée D Gendron, Philippe Brodeur, Martin Pilote, David J Marcogliese, Christian Gagnon, Magali Houde
A multi-disciplinary approach was used to evaluate the health of yellow perch (Perca flavescens) in the St. Lawrence River (Quebec, Canada), which is experiencing a severe population decline in the downstream portion of the river. Physiological parameters, liver alterations, trace metal concentrations, parasite prevalence and abundance, stable isotope composition, and the presence/absence of the viral hemorragic septicemia virus (VHSV) were evaluated in perch collected at six sites along the river: Lake St...
September 2016: Environmental Science and Pollution Research International
Yomna I Mahmoud, Asmaa A Mahmoud
Acetaminophen is a widely used analgesic and antipyretic agent, which is safe at therapeutic doses. However, overdoses of acetaminophen induce severe oxidative stress, which leads to acute liver failure. Nicotinamide has proven effective in ameliorating many pathological conditions that occur due to oxidative stress. This study verifies the prophylactic and therapeutic effects of nicotinamide against the hepatic pathophysiological and ultrastructural alterations induced by acetaminophen. Wistar rats intoxicated with an acute overdose of acetaminophen (5g/kg b...
June 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
Satya Bhusan Senapati, Sudhansu Sekhar Mishra, Manmath Kumar Dhir, Srikanta Das
Hemophilia A is an inherited, X-linked, recessive disorder caused by deficiency of clotting factor VIII. Intracranial hemorrhage is the leading cause of morbidity and mortality in these patients. Use of factor replacement products and medications had improved outcome in these patients. But in developing countries many such patients are not able to afford factor replacement products. We report a case of traumatic intracerebellar hemorrage in a hemophilia child. This child presented to us as a case of sub-acute intracerebellar hemorrage, he was managed conservatively with six units of fresh frozen plasma transfusion...
April 2016: Asian Journal of Neurosurgery
Martha Casallas-Rivera, Álvaro Faccini-Martínez, Natalia Perdomo-Beltrán, Carlos Botero-García, Juan Bravo, Carlos Pérez-Díaz
We report the case of a 56-year-old female patient, with a three-day history of hematemesis, melena, abdominal wall hematoma and epistaxis associated with thrombocytopenia and anemia. Idiopathic thrombocytopenic purpura was diagnosed and she was treated with dexamethasone for four days. The patient developed acute respiratory failure with signs of systemic inflammatory response. Blood and pleural fluid cultures grew Pasteurella canis. This is the first case, to our knowledge, of P. canis empyema associated with hemorrhagic septicemia without epidemiological background and the third case of septicemia caused by P...
February 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Xianli Lv, Xiulan Hu, Jie Liu, Hongewei He, Youxiang Li
BACKGROUND AND PURPOSE: The major determinants of hemorrhage in an arteriovenous malformation (AVM) include its angioarchitecture, as well as the patient's age and clinical presentation. The aim of this study was to determine whether or not the risk of hemorrhage in an AVM differs based on the different clinical presentations and the initial age at diagnosis. METHODS: A consecutive case series of 496 patients having a brain AVM was retrospectively analyzed. The radiological evidence of hemorrhage was established in 84 of these cases after the initial diagnosis of AVM had been made...
March 2016: Neurology India
L M Tsentsiper, A N Kondrat'ev, N V Dryagina
Laboratory diagnostic is very important in treatment of acute brain injury, together with neurophysiology and neurovisualisation methods. Biomarkers measurements can provide early brain injury diagnostic, monitoring of treatment as well as outcome prediction. We studied dynamic of N-terminal pro-brain natriuretic peptide (n-proBNP) level in patients with acute brain injury (intracranial hemorrage, traumatic brain injury, tumors). All patients were divided into 3 groups (by etiology of injury), each group consist of 2 subgroups: a - survivors with good outcome (I-II group in Glasgow outcome scale (GOS)); b - dead or severe morbidity (III-V group in GOS)...
July 2015: Anesteziologiia i Reanimatologiia
Stephan von Düring, Stéphanie Bruchez, Laurent Suppan, Marc Niquille
Oxygen adiministration for both medical and traumatic emergencies is regarded as an essential component of resuscitation. However, many recent studies suggest that the use of oxygen should be more restrictive. Detrimental effects of normobaric oxygen therapy in patients suffering from hypercapnic respiratory diseases have been demonstrated, especially because of the suppression of the hypoxic drive. Apart from this particular situation, correction of hypoxemia is still a widely accepted treatment target, although there is growing evidence that hyperoxemia could be harmful in acute coronary syndromes and cardio-respiratory arrests...
August 12, 2015: Revue Médicale Suisse
Xueying Shang, Quanyuan Wan, Jianguo Su, Juanjuan Su
Retinoic acid-inducible gene I (RIG-I), a crucial member of cytoplasmic pattern recognition receptors (PRRs), is initially characterized as a dsRNA-binding protein triggering interferon (IFN) induction in response to virus invasion. While the antiviral regulatory mechanism of RIG-I remains largely unclear. In this study, the mechanism of CiRIG-I (Ctenopharyngodon idella RIG-I) against grass carp reovirus (GCRV) would be revealed from the perspective of epigenetics. By prediction, three CpG islands (CGIs) were located in 5'-flanking region and the first exon...
January 2016: Immunobiology
Alice Frigerio, Oon T Tan
BACKGROUND AND OBJECTIVE: Different subspecialists treat benign intraoral lesions using various approaches including surgical excision, medical therapy, sclerotherapy, and laser photocoagulation. The goal of this study was to establish whether lasers could effectively target and destroy oral lesions containing endogenous chromophores, while minimizing injury to unaffected adjacent tissues and critical structures. MATERIALS AND METHODS: This retrospective study involved 26 cases of benign oral lesions, both vascular and pigmented, which were addressed by means of selective laser treatment...
October 2015: Lasers in Surgery and Medicine
Andrea Fabiani, Alessandra Filosa, Tiziana Pieramici, Gabriele Mammana
OBJECTIVE: To evaluate the factors that influence decision-making after frozen section examination (FSE) when a urologist sends a surgical specimen of a testicular nodule to a pathologist. STUDY DESIGN: We retrieved, from surgical and pathological files of our center from 2008 to 2014, the clinical information of 15 patients who underwent an explorative inguinal testicular surgery for an intratesticular nodule suspected for malignancy and managed with intention of testicular-sparing surgery...
June 2015: Analytical and Quantitative Cytopathology and Histopathology
Tiziana Fierro, Anna Bartolini, Anna Maria Mezzasoma, Giuseppe Guglielmini, Emanuela Falcinelli, Sara Orsini, Stefania Momi, Carlo Cagini, Paolo Gresele
BACKGROUND: Subconjunctival hemorrage (SCH) is a frequent, mild bleeding manifestation and a common cause of consultation. Hemostatic alterations are possible causes of SCH but their role and prevalence is unknown. We assessed the prevalence of hemostatic abnormalities in patients with spontaneous, recurrent SCH to clarify the role of the hemostasis laboratory in this clinical setting. METHODS: A total of 105 SCH patients (21-78 years, 65 females) with no identifiable cause (hypertension-trauma-conjunctivitis) or concomitant treatments (NSAIDs- aspirin-oral anticoagulants-antiplatelet agents) and 53 age and sex-matched healthy controls (HCs) (22-72 years, 29 females) were evaluated for skin bleeding time, PFA-100®, blood clotting screening, platelet count, light transmission aggregomery, VWF:Ag, VWF:RCo, RIPA, FVIII activity, FXIII antigen and activity and ISTH Bleeding Severity Score (BSS)...
January 2016: Clinical Chemistry and Laboratory Medicine: CCLM
María Gracia Pereda, Maríanelly López, Melissa Mariluz
Hemorragic dengue fever is a prevalent infection in many countries around the world. Myocarditis is a severe manifestation of dengue virus infection. With prompt intervention and an early diagnosis, the outcome of this condition can be improve. We report a adult patient with complicated dengue, myocarditis, cardiac and respiratory insufficiency with acute renal injury.
April 2015: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Erbu Yarci, Sema Arayici, Fatma Nur Sari, Fuat Emre Canpolat, Nurdan Uras, Ugur Dilmen
Neonatal adrenal hemorrhage is uncommon. It is present in 0,2% of newborns. Ten percent of the cases occur bilaterally. It can be associated with birth trauma, large birth weight, or neonatal course complicated by hypoxia and asphyxia, hypotension, or coagulopathy. Scrotal hematoma is an extremely rare manifestation of NAH. Most patients present scrotal swelling with bluish discolouration. Scrotal swelling with/without bluish discoloration in newborns may result from different causes. We report an unusual case of neonatal adrenal hemorrhage secondary to perinatal asphyxia, associated with SH...
June 2015: Archivos Argentinos de Pediatría
Salvatore D'Angelo, Domenico Germano, Teresa Zolfino, Domenico Sansonno, Lydia Giannitrapani, Antonio Benedetti, Vincenzo Montesarchio, Adolfo Attili, Angela Buonadonna, Sandro Barni, Antonio Gasbarrini, Michela E Burlone, Umberto Cillo, Simona Marenco, Erica Villa, Petros Giovanis, Ilaria Proserpio, Carlo Saitta, Giulia Magini, Rita Cengarle, Giammarco Fava, Filiana Cuttone, Nicola Calvani, Mario Angelico, Francesco Di Costanzo, Alfonso Noto, Guido Poggi, Massimo Marignani, Stefano Cascinu, Domenico Amoroso, Vincenzo Palmieri, Elena Massa, Lory Saveria Crocè, Antonio Picardi, Salvatore Tumulo, Claudia Erminero, Riccardo Lencioni, Vito Lorusso
INTRODUCTION: Sorafenib, an oral multikinase inhibitor, is the only targeted agent approved for the treatment of patients with hepatocellular carcinoma (HCC) after demonstration to increase overall survival compared to placebo in two randomized phase III study. GIDEON (Global Investigation of therapeutic DEcisions in HCC and Of its treatment with sorafeNib) is the largest, global, non-interventional, prospective study of patients with uHCC (n>3200) treated with sorafenib in real-life clinical practice conditions...
May 2015: Recenti Progressi in Medicina
S Silvestri, A Franchello, F Gonella, G Deiro, D Campra, D Cassine, A Fiore, E Ostuni, M Garino, A Resegotti, E C Farina, G R Fronda
AIM: Distal pancreatectomies (DP) are associated with high risk of postoperative complications, and in many series higher morbidity rate than duodenopancreatectomies has been reported. To evaluate the role of a collagen sponge with human fibrinogen and thrombin film (TachoSil®) in limiting the incidence of complications after DP. METHODS: From 1996 to 2013, 221 patients have been submitted to distal pancreatectomy (± splenectomy) in our Division. A retrospective analysis has been conducted in a group of 36 consecutive and prospectively collected DP treated with intraoperative placement of TachoSil® on pancreatic stump from 2010 to 2013 (group 1)...
June 2015: Minerva Chirurgica
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