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https://www.readbyqxmd.com/read/28079861/endoscopic-vs-surgical-interventions-for-painful-chronic-pancreatitis-what-is-needed-for-future-clinical-trials
#1
REVIEW
John A Windsor, Nageshwar D Reddy
The treatment of painful chronic pancreatitis remains controversial. The available evidence from two randomized controlled trials favor surgical intervention, whereas an endotherapy-first approach is widely practiced. Chronic pancreatitis is complex disease with different genetic and environmental factors, different pain mechanisms and different treatment modalities including medical, endoscopic, and surgical. The widely practiced step-up approach remains unproven. In designing future clinical trials there are some important pre-requisites including a more comprehensive pain assessment tool, the optimization of conservative medical treatment and interventional techniques...
January 12, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28078107/phase-ii-study-of-bevacizumab-and-preoperative-chemoradiation-for-esophageal-adenocarcinoma
#2
Geoffrey Y Ku, Manjit S Bains, Do Joong Park, Yelena Y Janjigian, Valerie W Rusch, Nabil P Rizk, Sam S Yoon, Brittanie Millang, Marinela Capanu, Karyn A Goodman, David H Ilson
BACKGROUND: A standard-of-care for locally advanced esophageal and gastroesophageal junction (GEJ) adenocarcinoma is pre-operative chemoradiation. Elevated levels of vascular endothelial growth factor (VEGF) have been associated with worse outcomes following chemoradiation and anti-VEGF therapies can potentiate radiation efficacy. METHODS: In this single-arm phase II study, we added bevacizumab to induction chemotherapy and concurrent chemoradiation with cisplatin/irinotecan for locally advanced esophageal and GEJ adenocarcinomas...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28070213/lower-gastrointestinal-bleeding-computed-tomographic-angiography-colonoscopy-or-both
#3
Daniel Clerc, Fabian Grass, Markus Schäfer, Alban Denys, Nicolas Demartines, Martin Hübner
BACKGROUND: Lower endoscopy (LE) is the standard diagnostic modality for lower gastrointestinal bleeding (LGIB). Conversely, computed tomographic angiography (CTA) offers an immediate non-invasive diagnosis visualizing the entire gastrointestinal tract. The aim of this study was to compare these 2 modalities with regards to diagnostic value and bleeding control. METHODS: Tertiary center retrospective analysis of consecutive patients admitted for LGIB between 2006 and 2012...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28054189/endoscopic-stenting-does-not-worsen-long-term-outcomes-amongst-patients-presenting-with-obstruction-from-colorectal-cancers
#4
Tian-Zhi Lim, Dedrick Kok Hong Chan, Ker-Kan Tan
BACKGROUND: Stenting has been increasingly adopted in colorectal cancer patients presenting with acute large bowel obstruction. However, long-term outcomes of stenting are lacking in the literature. Our study attempts to compare the long-term outcomes of colonic stenting and emergency surgery amongst left-sided colorectal cancer patients presenting with acute large bowel obstruction. METHODS: A retrospective review of all patients who presented with nonmetastatic colorectal cancer who underwent either endoscopic stenting or emergency surgery for acute large bowel obstruction was performed from January 2007 to April 2016...
January 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28043931/similar-efficacies-of-endoscopic-ultrasound-gallbladder-drainage-with-a-lumen-apposing-metal-stent-vs-percutaneous-transhepatic-gallbladder-drainage-for-acute-cholecystitis
#5
Shayan Irani, Saowanee Ngamruengphong, Anthony Teoh, Uwe Will, Jose Nieto, Barham K Abu Dayyeh, S Ian Gan, Michael Larsen, Hon Chi Yip, Mark D Topazian, Michael J Levy, Christopher C Thompson, Andrew C Storm, Gulara Hajiyeva, Amr Ismail, Yen-I Chen, Majidah Bukhari, Yamile Haito Chavez, Vivek Kumbhari, Mouen A Khashab
BACKGROUND & AIMS: Acute cholecystitis in patients who are not candidates for surgery is often managed with percutaneous transhepatic gallbladder drainage (PT-GBD). Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) with a lumen-apposing metal stent (LAMS) is an effective alternative to PT-GBD. We compared the technical success of EUS-GBD vs PT-GBD, as well as patient outcomes, numbers of adverse events (AEs), length of hospital stay, pain scores, and repeat interventions. METHODS: We performed a retrospective study to compare EUS-GBD vs PT-GBD at 7 centers (5 in the United States, 1 in Europe, and 1 in Asia), from 2013 through 2015, in management of acute cholecystitis in patients who are not candidates for surgery...
December 30, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28040751/minimally-invasive-endoscopic-surgery-versus-catheter-based-device-occlusion-for-atrial-septal-defects-in-adults-reconsideration-of-the-standard-of-care
#6
Yvonne Schneeberger, Andreas Schaefer, Lenard Conradi, Jens Brickwedel, Hermann Reichenspurner, Rainer Kozlik-Feldmann, Christian Detter
OBJECTIVES: Percutaneous ostium secundum atrial septal defect (ASD II) closure has become the standard of care for treatment of congenital ASD II in adults. Nevertheless, patients are frequently ineligible for this technique due to challenging morphology. In such cases, closure via minimally invasive cardiac surgery (MICS) is an appropriate treatment option. The aim of this study is to compare outcomes of MICS and use of a percutaneous Amplatzer septal occluder (ASO) device for treatment of ASD II in adults...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28039168/correlation-of-the-rutgeerts-score-and-recurrence-of-crohn-s-disease-in-patients-with-end-ileostomy
#7
Vasutakarn Chongthammakun, Andre Fialho, Andrea Fialho, Rocio Lopez, Bo Shen
BACKGROUND: Recurrence of Crohn's disease (CD) can occur after surgery, including end ileostomy (EI). The Rutgeerts score (RS) was developed to predict postsurgical CD recurrence via ileocolonoscopy in patients having ileocolonic resection. The role of ileoscopic evaluation via stoma for assessing recurrence of CD has not been investigated. The aim of this study was to evaluate the role of ileoscopy for predicting disease recurrence in CD patients after EI with the use of RS. METHODS: A total of 73 eligible CD patients with at least two ileoscopies in our institution following EI were included...
December 30, 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/28024730/-efficiency-of-laparoscopic-vs-endoscopic-management-in-cholelithiasis-and-choledocholithiasis-is-there-any-difference
#8
María de Los Angeles Herrera-Ramírez, Hugo López-Acevedo, Gustavo Adolfo Gómez-Peña, Carlos Javier Mata-Quintero
BACKGROUND: Concomitant cholelithiasis and choledocholithiasis is a disease where incidence increase with age and can have serious complications such as pancreatitis, cholangitis and liver abscesses, but its management is controversial, because there are minimally invasive laparoscopic and endoscopic surgical procedures. OBJECTIVE: To compare the efficiency in the management of cholelithiasis and choledocholithiasis with laparoscopic cholecystectomy with common bile duct exploration vs cholangiopancreatography endoscopic retrograde+laparoscopic cholecystectomy...
December 23, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28017845/endoscopic-sleeve-gastroplasty-significantly-reduces-body-mass-index-and-metabolic-complications-in-obese-patients
#9
Reem Z Sharaiha, Nikhil A Kumta, Monica Saumoy, Amit P Desai, Alex M Sarkisian, Andrea Benevenuto, Amy Tyberg, Rekha Kumar, Leon Igel, Elizabeth C Verna, Robert Schwartz, Christina Frissora, Alpana Shukla, Louis J Aronne, Michel Kahaleh
BACKGROUND & AIMS: Endoscopic sleeve gastroplasty (ESG) is an incisionless, minimally invasive bariatric procedure that reduces the length and width of the gastric cavity to facilitate weight loss. We performed a prospective study to evaluate the effects of ESG on total body weight loss and obesity-related comorbidities. METHODS: We collected data from 91 consecutive patients (mean age, 43.86 ± 11.26 years; 68% female) undergoing ESG from August 2013 through March 2016...
December 22, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28009738/lymph-node-metastasis-in-mucosal-gastric-cancer-reappraisal-of-expanded-indication-of-endoscopic-submucosal-dissection
#10
Seung-Young Oh, Kyung-Goo Lee, Yun-Suhk Suh, Min A Kim, Seong-Ho Kong, Hyuk-Joon Lee, Woo Ho Kim, Han-Kwang Yang
OBJECTIVE: To evaluate risk factors for lymph node (LN) metastasis in mucosal gastric cancer, particularly the effect of cellular differentiation, and implications for the indication of endoscopic submucosal dissection (ESD). SUMMARY BACKGROUND DATA: The indication of ESD has been expanded to undifferentiated-type (UD-type) gastric cancer despite risk of LN metastasis. METHODS: Patients who underwent radical gastrectomy for pT1a stage primary gastric adenocarcinoma between 2008 and 2012 were retrospectively analyzed...
January 2017: Annals of Surgery
https://www.readbyqxmd.com/read/27997526/organ-preservation-with-local-excision-or-active-surveillance-following-chemoradiotherapy-for-rectal-cancer
#11
B Creavin, E Ryan, S T Martin, A Hanly, P R O'Connell, K Sheahan, D C Winter
BACKGROUND: Organ preservation has been proposed as an alternative to radical surgery for rectal cancer to reduce morbidity and mortality, and to improve functional outcome. METHODS: Locally advanced non-metastatic rectal cancers were identified from a prospective database. Patients staged ⩾T3 or any stage N+ were referred for neoadjuvant chemoradiotherapy (CRT) (50-54 Gy and 5-fluorouracil), and were reassessed 6-8 weeks post treatment. An active surveillance programme ('watch and wait') was offered to patients who were found to have a complete endoluminal response...
December 20, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27995482/comparison-of-long-term-outcomes-of-endoscopic-submucosal-dissection-and-surgery-for-esophagogastric-junction-adenocarcinoma
#12
Eun Jeong Gong, Do Hoon Kim, Ji Yong Ahn, Kee Wook Jung, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Hee Sung Kim, In-Seob Lee, Beom Su Kim, Moon-Won Yoo, Sung Tae Oh, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) has become accepted as the standard treatment for early gastric cancer. However, comparative outcomes of ESD and surgery have not been evaluated for adenocarcinoma in the esophagogastric junction (EGJ). We investigated the long-term outcomes of ESD compared with those of surgery for adenocarcinoma in the EGJ. METHODS: Patients who underwent ESD or surgery for Siewert type II adenocarcinoma between 2005 and 2010 and who met the absolute and expanded criteria for endoscopic resection were eligible...
December 19, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27990004/endoscopic-and-surgical-ampullectomy-for-non-invasive-ampullary-tumors-short-term-outcomes
#13
Margaux Dubois, Ismail Labgaa, Gian Dorta, Nermin Halkic
Non-invasive ampullary tumors, may be treated with endoscopic (EA) or surgical ampullectomy (SA). However, evidence on the morbidity of these techniques remains limited. This pilot study aimed to assess and compare morbidity of EA and SA. Patients undergoing EA or SA for non-invasive ampullary tumors were retrospectively analyzed and compared. Outcomes were postoperative complications graded with Clavien Classification and Comprehensive Complication Index (CCI), and length of stay (LoS). A review of the literature was performed to propose an evidence-based algorithm to treat ampullary tumors...
December 18, 2016: Bioscience Trends
https://www.readbyqxmd.com/read/27981825/laparo-endoscopic-rendez-vous-versus-sequential-delayed-approach-in-patients-with-choledocholithiasis
#14
Antonio Pesce, Gaetano LA Greca, Saverio Latteri, Vincenzo Guardabasso, Federica DI Marco, Michele DI Blasi, Domenico Russello, Stefano Puleo
BACKGROUND: To compare the efficacy and safety of synchronous laparoscopic cholecystectomy with laparo-endoscopic rendez-vous technique vs sequential "delayed" approach with the main goal to compare the conversion rate and post-operative complications. METHODS: Patients diagnosed as having gallstones and CBD stones or sludge were enrolled in this study. From January 2013 to June 2015, 43 consecutive patients were submitted to the sequential treatment (ERCP prior to laparoscopic cholecystectomy) and the next consecutive 46 patients were submitted to undergo the rendez-vous technique...
December 16, 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27957517/crohn-s-disease-activity-abdominal-computed-tomography-histopathology-correlation
#15
N Paquet, J N Glickman, S M Erturk, P R Ros, J T Heverhagen, M A Patak
PURPOSE: Crohn's disease is a type of inflammatory bowel disease affecting estimated 4 million people worldwide. Therapy stratification of Crohn's disease (CD) is mainly based on the inflammatory activity being assessed by endoscopic biopsy and clinical criteria. Cross-sectional imaging allows for the assessment of structural characteristics of the entire gastrointestinal tract including small bowel loops and may provide potential non-invasive image-based biomarkers for the inflammatory activity of CD...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27943564/factors-affecting-the-incidence-of-early-endoscopic-recurrence-after-ileocolonic-resection-for-crohn-s-disease-a-multicentre-observational-study
#16
I F de Barcelos, P G Kotze, A Spinelli, Y Suzuki, F V Teixeira, I C de Albuquerque, R Saad-Hossne, L M da Silva Kotze, T Yamamoto
AIM: Early endoscopic recurrence is frequently observed in patients following resection for Crohn's disease (CD). However, factors affecting the incidence of an early postoperative endoscopic recurrence (EPER) have not been fully determined. The aim of this study was to evaluate risk factors for EPER after ileocolonic resection for CD. METHOD: This was a retrospective, international multicentre study, in which 127 patients with a first ileocolonoscopy conducted between 6 and 12 months after ileocolonic resection for CD were included...
January 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27928446/gastrostomy-with-peritoneal-collar-versus-percutaneous-endoscopic-gastrostomy
#17
Tudor C, Branescu C, Savlovschi C, El-Khatib A, Pantu H, Nica A, Dascalu Am, Masoumeh B, Tudor As, Oprescu Sm, Serban D
Aim. The present study aimed to perform a medico-surgical comparative analysis of the 2 most widely used techniques: gastrostomy with peritoneal collar versus percutaneous endoscopic gastrostomy, based on the vast clinical experience in an Upper Digestive Surgery Clinic. Materials and method. A retrospective study was carried out between January 2010 and January 2015 on the patients admitted for a surgical solution for feeding. The indications, preoperative preparation, surgical techniques, and postoperative outcomes were analyzed...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27926556/natural-orifice-specimen-extraction-with-single-stapling-colorectal-anastomosis-for-laparoscopic-anterior-resection-feasibility-outcomes-and-technical-considerations
#18
Bansal Saurabh, Sheng-Chi Chang, Tao-Wei Ke, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, William Tzu-Liang Chen, Abe Fingerhut
BACKGROUND: Double and triple stapling techniques to close the rectal stump in laparoscopic anterior resection are fraught with technical drawbacks that could possibly be avoided with the use of the single stapling technique. However, little is known of its safety in laparoscopic surgery or outcomes when combined with natural orifice specimen extraction. OBJECTIVE: This study aims to analyze the feasibility and the operative and immediate postoperative outcomes of single-stapled anastomosis and natural orifice specimen extraction with conventional techniques...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27925255/the-course-of-achalasia-one-to-four-decades-after-initial-treatment
#19
T Sawas, K Ravi, D M Geno, F Enders, K Pierce, D Wigle, D A Katzka
BACKGROUND: Most follow-up studies of achalasia are limited to <5 years. AIMS: To study the long-term efficacy of pneumatic dilation (PD) and myotomy in achalasia at least 10 years after treatment. METHODS: We performed a retrospective cohort study of achalasia patients with >10 years follow-up after initial myotomy or pneumatic dilation. Symptom recurrence which required repeat dilation or surgery was compared between pneumatic dilation and myotomy...
December 7, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27911976/demographic-and-clinical-characteristics-of-a-predominantly-hispanic-population-with-inflammatory-bowel-disease-on-the-us-mexico-border
#20
Antonio Mendoza Ladd, Yi Jia, Christine Yu, Sherif Elhanafi, Alok Dwivedi, Jiayang Liu, Giangqing Song, Mark Hall, Marc J Zuckerman
OBJECTIVES: Information regarding Hispanics with inflammatory bowel disease (IBD) is scarce. In this study we aimed to describe a predominantly Hispanic population with IBD in a city located along the US-Mexico border and to identify clinical or demographic differences between Hispanics and non-Hispanics. METHODS: Retrospective cohort analysis of patients with IBD between 2003 and 2013 at a tertiary care center. Information collected included age, sex, ethnicity, diagnosis, diagnosis status (new vs old), endoscopic extent of disease (EOD), extraintestinal manifestations, medical treatment, and surgeries performed...
December 2016: Southern Medical Journal
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