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Meningococcal sepsis

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https://www.readbyqxmd.com/read/28081260/comparative-genome-sequencing-reveals-within-host-genetic-changes-in-neisseria-meningitidis-during-invasive-disease
#1
Johanna Klughammer, Marcus Dittrich, Jochen Blom, Vera Mitesser, Ulrich Vogel, Matthias Frosch, Alexander Goesmann, Tobias Müller, Christoph Schoen
Some members of the physiological human microbiome occasionally cause life-threatening disease even in immunocompetent individuals. A prime example of such a commensal pathogen is Neisseria meningitidis, which normally resides in the human nasopharynx but is also a leading cause of sepsis and epidemic meningitis. Using N. meningitidis as model organism, we tested the hypothesis that virulence of commensal pathogens is a consequence of within host evolution and selection of invasive variants due to mutations at contingency genes, a mechanism called phase variation...
2017: PloS One
https://www.readbyqxmd.com/read/28079790/ecthyma-gangrenosum-a-skin-manifestation-of-pseudomonas-aeruginosa-sepsis-in-a-previously-healthy-child-a-case-report
#2
Stephanie Biscaye, Diane Demonchy, Mickael Afanetti, Audrey Dupont, Herve Haas, Antoine Tran
RATIONALE: Ecthyma gangrenosum (Eg) is a necrotic lesion that is mostly seen in immunocompromised patients. It reflects a severe sepsis, possibly caused by Pseudomonas aeruginosa (Pa). PATIENT CONCERNS: A healthy 3-year-old girl admitted to the Pediatric Emergency Department presented a sepsis-associated purpura with neurological and respiratory distress. INTERVENTIONS: An empiric antibiotherapy (anti-meningococcal) was prescribed. DIAGNOSES: Forty-eight hours after admission, blood and wound cultures were positive for Pa...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28069783/secondary-asplenia-as-a-complication-of-severe-meningococcal-sepsis
#3
Lourdes Castillo-Campos, Luis Bachiller-Carnicero, María José Megía-Sevilla, María Isabel González-Tomé
We report the case of an 11-month-old infant who had a medical history of meningococcal septicaemia 6 months prior to this admission and presented to hospital with an episode of fever due to Streptococcus pneumoniae bacteraemia. During this second admission, an abdominal ultrasound scan revealed secondary asplenia.
January 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28024455/the-neisseria-meningitidis-lpxl1-mutant-induces-less-tissue-factor-expression-and-activity-in-primary-human-monocytes-and-monocyte-derived-microvesicles-than-the-wild-type-meningococcus
#4
Marit Hellum, Anne-Marie S Trøseid, Jens P Berg, Petter Brandtzaeg, Reidun Øvstebø, Carola E Henriksson
Neisseria meningitidis (N. meningitidis) may cause sepsis and meningitis. N. meningitidis with a mutated lpxL1 gene has five, instead of six, acyl chains in the lipid A moiety. Compared with patients infected with the wild type (wt) meningococcus, patients infected with the lpxL1 mutant have a mild meningococcal disease with less systemic inflammation and less coagulopathy. Circulating tissue factor (TF), the main initiator of coagulation, has a central role in the development of coagulation disturbances during sepsis...
January 1, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27994836/an-unexpected-fever-post-serogroup-b-meningococcal-sepsis
#5
Daniele Donà, Elisa Gnoato, Carlo Giaquinto, Carlo Moretti
This case report describes an invasive meningococcal group B infection followed by the development of Kawasaki disease (KD) complicated by macrophage activation syndrome (MAS) in a 2-year-old child. The presented case indicates the possible etiologic relationship between meningococcal sepsis and KD as support of bacterial toxin induced theory. It's important to maintain a high grade of suspicious for KD in every relapse of fever also during convalescence phase of severe infection. Usually, initial treatment with intravenous immunoglobulin is sufficient to control the disease; but, in case of refractory KD complicated by MAS, corticosteroid therapy represents a good option inducing prompt fever resolution and clinical improvement...
November 17, 2016: Pediatric Reports
https://www.readbyqxmd.com/read/27921012/expression-of-the-gene-for-autotransporter-autb-of-neisseria-meningitidis-affects-biofilm-formation-and-epithelial-transmigration
#6
Jesús Arenas, Fernanda L Paganelli, Patricia Rodríguez-Castaño, Sara Cano-Crespo, Arie van der Ende, Jos P M van Putten, Jan Tommassen
Neisseria meningitidis is a Gram-negative bacterium that resides as a commensal in the upper respiratory tract of humans, but occasionally, it invades the host and causes sepsis and/or meningitis. The bacterium can produce eight autotransporters, seven of which have been studied to some detail. The remaining one, AutB, has not been characterized yet. Here, we show that the autB gene is broadly distributed among pathogenic Neisseria spp. The gene is intact in most meningococcal strains. However, its expression is prone to phase variation due to slipped-strand mispairing at AAGC repeats located within the DNA encoding the signal sequence and is switched off in the vast majority of these strains...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27893784/circadian-variation-of-plasminogen-activator-inhibitor-1-levels-in-children-with-meningococcal-sepsis
#7
Navin P Boeddha, Gertjan J Driessen, Marjon H Cnossen, Jan A Hazelzet, Marieke Emonts
OBJECTIVE: To study whether the circadian variation of plasminogen-activator-inhibitor-1 (PAI-1) levels, with high morning levels, is associated with poor outcome of children with meningococcal sepsis presenting in the morning hours. DESIGN: Retrospective analysis of prospectively collected clinical and laboratory data. SETTING: Single center study at Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands. SUBJECTS: 184 patients aged 3 weeks to 18 years with meningococcal sepsis...
2016: PloS One
https://www.readbyqxmd.com/read/27794168/cd46-accelerates-macrophage-mediated-host-susceptibility-to-meningococcal-sepsis-in-a-murine-model
#8
Xiao Wang, Ding Zhang, Mikael Sjölinder, Yi Wan, Hong Sjölinder
CD46, a membrane cofactor expressed on all nucleated human cells, plays an essential role in suppressing autoimmune reactions and protecting host cells from complement-mediated attack. Human transgenic CD46 homozygous mice (CD46(+/+) ) are prone to lethal sepsis upon infection with Neisseria meningitidis (N. meningitidis). However, the underlying mechanisms are poorly understood. Here, we determined thatCD46(+/+) mice produce large numbers of M1 type macrophages with enhanced surface expression of MHC II and production of pro-inflammatory mediators such as IL-6, TNF, IL-12, and IL-1β In the presence of M-CSF or GM-CSF, CD46 signaling enhances monocyte-macrophage differentiation...
October 28, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27584014/neisseria-meningitidis-isolated-in-postmortem-vitreous-humor-in-a-death-due-to-meningococcal-sepsis
#9
Jack Garland, Rexson Tse, Allan D Cala
Sepsis remains a difficult diagnosis at autopsy. With respect to meningococcal sepsis, a timely and definite diagnosis is critical because it requires public health department notification and the administration of prophylactic antibiotics to potential close contacts. A previous case series, in which both blood and cerebrospinal fluid were unavailable, suggested vitreous humor polymerase chain reaction might be a useful test in diagnosing meningococcal sepsis. We describe a fatal case of meningococcal sepsis where Neisseria meningitidis was detected in both vitreous humor and blood polymerase chain reaction, in addition to positive blood cultures...
December 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27566800/invasive-meningococcal-disease-in-children-in-ireland-2001-2011
#10
Cilian Ó Maoldomhnaigh, Richard J Drew, Patrick Gavin, Mary Cafferkey, Karina M Butler
BACKGROUND: In 1999, invasive meningococcal disease was hyperendemic in Ireland at 14.75/100 000 population, with 60% group B and 30% group C diseases. National sepsis guidelines and meningococcal C vaccines were introduced in 2000. Despite a spontaneous decline in group B infection, invasive meningococcal disease remains a leading cause of sepsis. This study characterises the epidemiology of invasive meningococcal disease in children in Ireland since the introduction of meningococcal C vaccine and reviews its clinical presentation, hospital course and outcome in anticipation of meningococcal B vaccine introduction...
August 26, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27443594/meningococcal-pneumonia
#11
REVIEW
Matthias Vossen, Dieter Mitteregger, Christoph Steininger
Neisseria meningitidis remains the most important cause of bacterial meningitis worldwide, particularly in children and young adults. The second most common and a potentially severe end-organ manifestation of invasive meningococcal disease (excluding systemic sepsis) is meningococcal pneumonia. It occurs in between 5% and 15% of all patients with invasive meningococcal disease and is thus the second most common non-systemic end-organ manifestation. To establish the diagnosis requires a high level of clinical awareness - the incidence is therefore very likely underreported and underestimated...
August 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27228147/acute-hemorrhagic-edema-of-infancy-still-a-challenge-for-the-pediatrician
#12
Maria Ceci, Margherita Conrieri, Irene Raffaldi, Veronica Pagliardini, Antonio Francesco Urbino
We report a case of acute hemorrhagic edema of infancy (AHEI) occurred in an 11-month-old male infant after upper respiratory tract infection. The onset was dramatic with petechiae, ecchymosis, and annular, nummular, or targetoid purpuric plaques on the extremities, face, and ears. Acute hemorrhagic edema of infancy is a benign form of leukocytoclastic vasculitis that typically affects children between 4 and 24 months of age. The etiology remains still unknown. The potential triggers of AHEI include preceding bacterial or viral infections, immunizations, and drugs...
May 30, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27177946/evaluation-of-various-adjuvant-nanoparticulate-formulations-for-meningococcal-capsular-polysaccharide-based-vaccine
#13
Rikhav P Gala, Martin D'Souza, Susu M Zughaier
Neisseria meningitidis is a leading cause of bacterial meningitis and sepsis and its capsular polysaccharides (CPS) are a major virulence factor in meningococcal infections and form the basis for serogroup designation and preventive vaccines. We have formulated a novel meningococcal nanoparticulate vaccine formulation that does not require chemical conjugation, but encapsulates meningococcal CPS polymers in a biodegradable material that slowly release antigens, thereby has antigen depot effect to enhance antigenicity...
June 14, 2016: Vaccine
https://www.readbyqxmd.com/read/27175654/infections-revealing-complement-deficiency-in-adults-a-french-nationwide-study-enrolling-41-patients
#14
A Audemard-Verger, E Descloux, D Ponard, A Deroux, B Fantin, C Fieschi, M John, A Bouldouyre, L Karkowsi, G Moulis, H Auvinet, F Valla, C Lechiche, B Davido, M Martinot, C Biron, F Lucht, N Asseray, A Froissart, R Buzelé, A Perlat, D Boutboul, V Fremeaux-Bacchi, S Isnard, B Bienvenu
Complement system is a part of innate immunity, its main function is to protect human from bacterial infection. As genetic disorders, complement deficiencies are often diagnosed in pediatric population. However, complement deficiencies can also be revealed in adults but have been poorly investigated. Herein, we describe a case series of infections revealing complement deficiency in adults to study clinical spectrum and management of complement deficiencies.A nationwide retrospective study was conducted in French university and general hospitals in departments of internal medicine, infectious diseases enrolling patients older than 15 years old who had presented at least one infection leading to a complement deficiency diagnosis...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27133366/-two-case-reports-of-meningococcemia-review-of-the-literature-on-chronic-meningococcemia
#15
M Thimmesch, E Bodart, P Gavage, J-P Misson, J Frère
INTRODUCTION: Neisseria meningitidis is a Gram-negative bacteria that can be highly pathogenic in humans and responsible for life-threatening and acute diseases. In a few cases, it can lead to an atypical form of sepsis-acute, subacute, or chronic-which, even if progression is slower, may carry the same risks for patients as conventional acute forms. CASES: Case 1 presented with recurrent fever, polyarthralgia, and generalized macular rash. Case 2 had fever for the previous 10days with neck pain and macular rash...
June 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27092222/cloning-expression-and-purification-of-the-factor-h-binding-protein-and-its-interaction-with-factor-h
#16
Fatemeh Yarian, Mojgan Bandehpour, Negar Seyed, Bahram Kazemi
BACKGROUND AND OBJECTIVE: Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The factor H binding protein (fHBP) is a key virulence factor of Neisseria meningitidis that is able to selectively bind to human factor H, the key regulator of the alternative complement pathway, which it has important implications for meningococcal pathogenesis and vaccine design. The aims of present research were cloning, expression, purification of fHbp and confirmation of the interaction between serum factor H (fH) and produced factor H binding protein...
February 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/27085199/corrigendum-to-the-uk-joint-specialist-societies-guideline-on-the-diagnosis-and-management-of-acute-meningitis-and-meningococcal-sepsis-in-immunocompetent-adults-j-infect-72-2016-405-438
#17
F McGill, R S Heyderman, B D Michael, S Defres, N J Beeching, R Borrow, L Glennie, O Gaillemin, D Wyncoll, E Kaczmarski, S Nadel, G Thwaites, J Cohen, N W S Davies, A Miller, A Rhodes, R Read, T Solomon
No abstract text is available yet for this article.
June 2016: Journal of Infection
https://www.readbyqxmd.com/read/27021245/meningococcal-factor-h-binding-protein-vaccine-antigens-with-increased-thermal-stability-and-decreased-binding-of-human-factor-h
#18
Raffaella Rossi, Monica Konar, Peter T Beernink
Neisseria meningitidis causes cases of bacterial meningitis and sepsis. Factor H binding protein (FHbp) is a component of two licensed meningococcal serogroup B vaccines. FHbp recruits the complement regulator factor H (FH) to the bacterial surface, which inhibits the complement alternative pathway and promotes immune evasion. Binding of human FH impairs the protective antibody responses to FHbp, and mutation of FHbp to decrease binding of FH can increase the protective responses. In a previous study, we identified two amino acid substitutions in FHbp variant group 2 that increased its thermal stability by 21°C and stabilized epitopes recognized by protective monoclonal antibodies (MAbs)...
June 2016: Infection and Immunity
https://www.readbyqxmd.com/read/26984070/meningococcemia-in-adults-a-review-of-the-literature
#19
REVIEW
Shimon Takada, Sho Fujiwara, Toshiya Inoue, Yuki Kataoka, Yoshiro Hadano, Kentaro Matsumoto, Kyoko Morino, Taro Shimizu
We mainly refer to the acute setting of meningococcemia. Meningococcemia is an infection caused by Neisseria meningitidis, which has 13 clinically significant serogroups that are distinguishable by the structure of their capsular polysaccharides. N. meningitidis, also called meningococcus, is a Gram-negative, aerobic, diplococcus bacterium. The various consequences of severe meningococcal sepsis include hypotension, disseminated intravascular coagulation (DIC), multiple organ failure, and osteonecrosis due to DIC...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26974748/the-burden-of-pediatric-invasive-meningococcal-disease-in-spain-2008-2013
#20
MULTICENTER STUDY
Irene Rivero-Calle, Lucia Vilanova-Trillo, Jacobo Pardo-Seco, Lidia Blanco Salvado, Laura Illade Quinteiro, Federico Martinon-Torres
BACKGROUND: Invasive meningococcal disease remains a rare infectious disease not only with high mortality but also with important morbidity. Until recently no universal vaccine existed against serogroup B, which explains most of the cases in settings like Europe. The objective of this study was to analyze the clinical course and sequelae of meningococcal disease in Spain. METHODS: Retrospective review of all children younger than 15 years admitted to any of the 36 hospitals in the MENDICOS Spanish network (www...
April 2016: Pediatric Infectious Disease Journal
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