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Paul Holvoet, Maarten Vanhaverbeke, Katarzyna Bloch, Pieter Baatsen, Peter Sinnaeve, Stefan Janssens
BACKGROUND: Cytochrome oxidase (COX) IV complex regulates energy production in mitochondria. Impaired COX gene expression is related to obesity and type 2 diabetes mellitus, but whether it is directly related to the incidence of cardiovascular events is unknown. We investigated whether COX gene expression in monocytes is predictive for cardiovascular events in coronary artery disease patients. To avoid monocyte isolation from fresh blood, we then aimed to validate our findings in monocyte-derived microvesicles isolated from plasma...
December 5, 2016: Journal of the American Heart Association
Yu Wang, Xiao-Dong Yi, Chun-De Li
To investigate the role of mTOR signaling pathway in bone marrow mesenchymal stem cells (BMSCs) differentiation into osteoblast in degenerative scoliosis (DS). The rat model of DS was established. Thirty-two Sprague-Dawley (SD) rats were selected and divided into the normal control group, the positive control group (normal rats injected with rapamycin), the negative control group (DS rats injected with PBS) and the experiment group (DS rats injected with rapamycin). H&E staining was performed to observe the osteogenesis of scoliosis...
November 25, 2016: Molecular Biology Reports
Jaffarali H Abdul, Soban Akram, Kaleem M L Arshan
Ascidians (tunicates) are marine benthic organisms possessing various pharmacological activities, including anti-oxidant, anti-tumour, antimicrobial, etc. They also play a key role as model organisms to study various neurobehavioral disorders. Ascidian diversity is reportedly less in India due to lack of taxonomists as well as the limitations in morphology based taxonomy. Molecular taxonomy, comprising the sequencing of cytochrome c oxidase 1 gene (barcode region) otherwise known as DNA barcoding reduces these bottlenecks...
November 22, 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
Britta Vortmann-Westhoven, Constantin Lürenbaum, Martin Winter, Sascha Nowak
In this work we present a novel electrophoretic method that was developed for the determination of lithium and transition metals in LiNi1/3 Co1/3 Mn1/3 O2 (NCM) cathode material after microwave digestion. The cations in the digested NCM material was separated by capillary electrophoresis (CE) and the element content was determined by UV/Vis detection. To characterize the precision of the measurements, the relative standard deviations (RSD) and concentrations were calculated and compared to those obtained with inductively coupled plasma - optical emission spectrometry (ICP-OES)...
November 21, 2016: Electrophoresis
Yan-Qing Wang, Qi Yue, En-Qing Gao
A family of isomorphous three-dimensional metal-organic frameworks based on bimetallic (FeCo, FeNi, and CoNi) chains with random metal sites have been prepared and magnetically characterized. The solid-solution-type bimetallic materials inherit from the homometallic parent materials intrachain ferromagnetic interactions and single-chain-magnet (SCM) behaviors. Interestingly, different composition dependence of magnetic behaviors has been found. The FeII1-xNiIIx series (0 < x < 1) show an innocent composition dependence, where the blocking temperature of slow relaxation decreases monotonically as Fe(II) is replaced by less anisotropic Ni(II)...
November 15, 2016: Chemistry: a European Journal
Anna Gonchar, Kirill V Galaktionov
Notocotylids are common digeneans parasitising birds and mammals. They have a two-host life cycle with cercariae encysting in the open. Particular life cycles remain unknown for majority of notocotylid species, including a common parasite of sea ducks Tristriata anatis. Here we resolve the life cycle of T. anatis by means of D2 LSU, ITS1 and CO1 DNA sequence analysis, showing that the first intermediate hosts for this species are periwinkles Littorina spp. Morphological descriptions of rediae and cercariae are provided for the first time, and we also supplement the existing morphological data on adults...
October 7, 2016: Parasitology Research
Betul Sonmez, Ergun Koroglu, Sami Simsek
Taenia multiceps is a cestode (family Taeniidae) that in its adult stage lives in the small intestine of dogs and other canids. The metacestode, known as Coenurus cerebralis, is usually found in the central nervous system including brain and spinal card in sheep and other ruminants. The presence of cysts typically leads to neurological symptoms that in the majority of cases result in the death of the animal. Coenurosis could cause high losses in sheep farms because the disease commonly affects young animals...
October 6, 2016: Parasitology
Jeffery R Hughey, Max H Hommersand, Paul W Gabrielson, Kathy Ann Miller, Timothy Fuller
Next generation sequence data were generated and used to assemble the complete plastomes of the holotype of Membranoptera weeksiae, the neotype (designated here) of M. tenuis, and a specimen examined by Kylin in making the new combination M. platyphylla. The three plastomes were similar in gene content and length and showed high gene synteny to Calliarthron, Grateloupia, Sporolithon, and Vertebrata. Sequence variation in the plastome coding regions were 0.89% between M. weeksiae and M. tenuis, 5.14% between M...
September 30, 2016: Journal of Phycology
Jenna R McGugan, Gary D Byrd, Alexandre B Roland, Stephanie N Caty, Nisha Kabir, Elicio E Tapia, Sunia A Trauger, Luis A Coloma, Lauren A O'Connell
Our recent publication titled "Ant and Mite Diversity Drives Toxin Variation in the Little Devil Poison Frog" aimed to describe how variation in diet contributes to population differences in toxin profiles of poison frogs. Some poison frogs (Family Dendrobatidae) sequester alkaloid toxins from their arthropod diet, which is composed mainly of ants and mites. Our publication demonstrated that arthropods from the stomach contents of three different frog populations were diverse in both chemistry and species composition...
August 2016: Journal of Chemical Ecology
Wayne P Maddison
The lyssomanine jumping spider genus Sumakuru gen. n. is here described for Sumakuru bigal sp. n., from the Bigal River Biological Reserve in Ecuador. Known from a single male, the embolus of the palp takes the form of a smoothly arching curve, and appears fully mobile, being connected to the tegulum by a thin sclerite and a twisted hematodocha. Data from four gene regions (28S, 16SND1, CO1, wingless) indicate that Sumakuru is the sister group to all other sampled lyssomanines, diverging deeply on the stem lineage of the clade of other known lyssomanines...
2016: ZooKeys
S Manjura Hoque, Yuegao Huang, Emiliano Cocco, Samuel Maritim, Alessandro D Santin, Erik M Shapiro, Daniel Coman, Fahmeed Hyder
Ferrite-based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe-Co mixed spinel ferrites (i.e. Fex Co1-x Fe2 O4 , where x ranges from 0.2 to 0.8) synthesized by chemical co-precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant...
September 22, 2016: Contrast Media & Molecular Imaging
Areum Jun, Junyoung Kim, Jeeyoung Shin, Guntae Kim
Recently, there have been efforts to use clean and renewable energy because of finite fossil fuels and environmental problems. Owing to the site-specific and weather-dependent characteristics of the renewable energy supply, solid oxide electrolysis cells (SOECs) have received considerable attention to store energy as hydrogen. Conventional SOECs use Ni-YSZ (yttria-stabilized zirconia) and LSM (strontium-doped lanthanum manganites)-YSZ as electrodes. These electrodes, however, suffer from redox-instability and coarsening of the Ni electrode along with delamination of the LSM electrode during steam electrolysis...
September 26, 2016: Angewandte Chemie
Qi-Pin Qin, Jiao-Lan Qin, Ting Meng, Wan-Hua Lin, Chuan-Hui Zhang, Zu-Zhuang Wei, Jia-Nian Chen, Yan-Cheng Liu, Hong Liang, Zhen-Feng Chen
Two G-quadruplex ligands: [Co(H-L(a))2Cl2] (Co1) and [Co(L(b))2][CoCl4]⋅2H2O (Co2) have been synthesized and characterized. Two cobalt oxoisoaporphine complexes exhibited selective cytotoxicity to SK-OV-3/DDP cells than for HL-7702 cells. Cytotoxic mechanism studies indicated that both Co1 and Co2 were telomerase inhibitor targeting c-myc, telomere, and bcl-2 G4s, and triggering cell senescence and apoptosis, which caused S phase arrest. They also induced mitochondrial dysfunction. The better antitumor activity of Co2, which should be correlated with a moiety of 2-[5-(2-pyridinyl)-1H-pyrrol-2-yl]pyridine in the L(b)...
August 28, 2016: European Journal of Medicinal Chemistry
Md Razia Sultana, Pankaj K Bagul, Parameshwar B Katare, Soheb Anwar, Raju Padiya, Sanjay K Banerjee
BACKGROUND: Cardiac complications are major contributor in the mortality of diabetic people. Mitochondrial dysfunctioning is a crucial contributor for the cardiac complications in diabetes, and SIRT-3 remains the major mitochondrial deacetylase. We hypothesized whether garlic has any role on SIRT-3 to prevent mitochondrial dysfunction in diabetic heart. METHODS: Rats with developed hyperglycemia after STZ injection were divided into two groups; diabetic (Dia) and diabetic+garlic (Dia+Garl)...
August 30, 2016: Life Sciences
Renata Oliveira, Ewen W Sommerville, Kyle Thompson, Joana Nunes, Angela Pyle, Manuela Grazina, Patrick F Chinnery, Luísa Diogo, Paula Garcia, Robert W Taylor
Mitochondrial translation defects are important causes of early onset mitochondrial disease. Although the biochemical (combined respiratory chain deficiency) signature and neuroimaging are usually distinctive, they are not diagnostic as the genetic origin of mitochondrial translation defects is heterogeneous. We report a female child, born at term to non-consanguineous parents, who exhibited global hypotonia, failure to thrive, persistent and progressive hyperlactacidaemia with lactic acidosis, liver dysfunction and encephalopathy and died at the age of 5 months...
August 30, 2016: JIMD Reports
Rodney N Nagoshi, Todd M Gilligan, Julieta Brambila
The recent establishment of the Old World pest Helicoverpa armigera (Hübner) into South America has had significant economic consequences and places the rest of the hemisphere at risk, emphasizing the need for improved methods of monitoring. A major complication is that a sibling species endemic to the New World, Helicoverpa zea (Boddie), is morphologically very similar, with the two species capable of producing fertile hybrids in the laboratory. The consequences of such hybridization in the field are uncertain, but could result in significant and unpredictable changes in the timing, range, and pesticide susceptibilities of Helicoverpa infestations...
October 2016: Journal of Economic Entomology
Jonathan A Coddington, Ingi Agnarsson, Ren-Chung Cheng, Klemen Čandek, Amy Driskell, Holger Frick, Matjaž Gregorič, Rok Kostanjšek, Christian Kropf, Matthew Kweskin, Tjaša Lokovšek, Miha Pipan, Nina Vidergar, Matjaž Kuntner
The use of unique DNA sequences as a method for taxonomic identification is no longer fundamentally controversial, even though debate continues on the best markers, methods, and technology to use. Although both existing databanks such as GenBank and BOLD, as well as reference taxonomies, are imperfect, in best case scenarios "barcodes" (whether single or multiple, organelle or nuclear, loci) clearly are an increasingly fast and inexpensive method of identification, especially as compared to manual identification of unknowns by increasingly rare expert taxonomists...
2016: PeerJ
Philippe Borsa, Kang-Ning Shen, Irma S Arlyza, Thierry B Hoareau
Previous investigations have uncovered divergent mitochondrial clades within the blue-spotted maskray, previously Neotrygon kuhlii (Müller and Henle). The hypothesis that the blue-spotted maskray may consist of a complex of multiple cryptic species has been proposed, and four species have been recently described or resurrected. To test the multiple cryptic species hypothesis, we investigated the phylogenetic relationships and coalescence patterns of mitochondrial sequences in a sample of 127 new individuals from the Indian Ocean and the Coral Triangle region, sequenced at both the CO1 and cytochrome b loci...
September 2016: Comptes Rendus Biologies
Thomas G Rosser, Wes A Baumgartner, Neely R Alberson, Ethan T Woodyard, Stephen R Reichley, David J Wise, Linda M Pote, Matt J Griffin
In the southeastern USA, catfish aquaculture is burdened by predation from piscivorous birds and the digenetic trematodes they carry. In addition to cultured ictalurid fish, other forage or incidental fish species inhabit catfish production ponds. Of these, the inland silverside Menidia beryllina was recently found to harbor larval metacercariae of several trematode species. Three species of metacercariae were reported, two of which represent the first morphological descriptions of an Austrodiplostomum sp. and Bolbophorus sp...
November 2016: Parasitology Research
Kun Feng, Jun Zhong, Binhua Zhao, Hui Zhang, Lai Xu, Xuhui Sun, Shuit-Tong Lee
Ammonia-borane (AB) is an excellent material for chemical storage of hydrogen. However, the practical utilization of AB for production of hydrogen is hindered by the need of expensive noble metal-based catalysts. Here, we report Cux Co1-x O nanoparticles (NPs) facilely deposited on graphene oxide (GO) as a low-cost and high-performance catalyst for the hydrolysis of AB. This hybrid catalyst exhibits an initial total turnover frequency (TOF) value of 70.0 (H2 ) mol/(Cat-metal) mol⋅min, which is the highest TOF ever reported for noble metal-free catalysts, and a good stability keeping 94 % activity after 5 cycles...
September 19, 2016: Angewandte Chemie
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