keyword
https://read.qxmd.com/read/37522552/structural-morphological-and-photoluminescence-properties-of-re-re-dy-3-eu-3-sm-3-doped-caalbo-4-phosphor-synthesized-by-combustion-method
#1
JOURNAL ARTICLE
R T Maske, A N Yerpude, R S Wandhare, S J Dhoble
The CaAlBO4 : RE (RE= Dy3+ , Eu3+ , Sm3+ ) phosphor were prepared via combustion synthesis and studied by X-Ray diffraction, FTIR analysis, scanning electron microscope, EDS, photoluminescence spectra and CIE Coordinates. The phase formation of obtained phosphor was analyzed by XRD and its result confirmed by standard PDF card No. 1539083. XRD data successfully indicated pure phase of CaAlBO4 phosphor. The crystal structure of CaAlBO4 phosphor is orthorhombic with space group Ccc2 (37). The scanning electron microscope image of CaAlBO4 phosphor reveals an agglomerated morphology and non-uniform particle size...
July 31, 2023: Luminescence: the Journal of Biological and Chemical Luminescence
https://read.qxmd.com/read/35714767/elesclomol-elevates-cellular-and-mitochondrial-iron-levels-by-delivering-copper-to-the-iron-import-machinery
#2
JOURNAL ARTICLE
Natalie M Garza, Mohammad Zulkifli, Vishal M Gohil
Copper (Cu) and iron (Fe) are redox-active metals that serve as cofactors for many essential cellular enzymes. Disruption in the intracellular homeostasis of these metals results in debilitating and frequently fatal human disorders, such as Menkes disease and Friedreich's ataxia. Recently, we reported that an investigational anticancer drug, elesclomol (ES), can deliver Cu to critical mitochondrial cuproenzymes and has the potential to be repurposed for treatment of Cu deficiency disorders. Here, we sought to determine the specificity of ES and the ES-Cu complex in delivering Cu to cuproenzymes in different intracellular compartments...
June 14, 2022: Journal of Biological Chemistry
https://read.qxmd.com/read/35563497/yeast-as-a-model-to-find-new-drugs-and-drug-targets-for-vps13-dependent-neurodegenerative-diseases
#3
REVIEW
Joanna Kaminska, Piotr Soczewka, Weronika Rzepnikowska, Teresa Zoladek
Mutations in human VPS13A - D genes result in rare neurological diseases, including chorea-acanthocytosis. The pathogenesis of these diseases is poorly understood, and no effective treatment is available. As VPS13 genes are evolutionarily conserved, the effects of the pathogenic mutations could be studied in model organisms, including yeast, where one VPS13 gene is present. In this review, we summarize advancements obtained using yeast. In recent studies, vps13 Δ and vps13-I2749 yeast mutants, which are models of chorea-acanthocytosis, were used to screen for multicopy and chemical suppressors...
May 4, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/34867906/copper-tolerance-mechanism-of-the-novel-marine-multi-stress-tolerant-yeast-meyerozyma-guilliermondii-gxdk6-as-revealed-by-integrated-omics-analysis
#4
JOURNAL ARTICLE
Ru Bu, Bing Yan, Huijie Sun, Mengcheng Zhou, Huashan Bai, Xinghua Cai, Xueyan Mo, Guijiao Su, Chengjian Jiang
Various agricultural products used in food fermentation are polluted by heavy metals, especially copper, which seriously endangers human health. Methods to remove copper with microbial strategies have gained interests. A novel Meyerozyma guilliermondii GXDK6 could survive independently under high stress of copper (1400 ppm). The copper tolerance mechanism of GXDK6 was revealed by integrated omics in this work. Whole-genome analysis showed that nine genes (i.e., CCC2 , CTR3 , FRE2 , GGT , GST , CAT , SOD2 , PXMP4 , and HSP82 ) were related to GXDK6 copper tolerance...
2021: Frontiers in Microbiology
https://read.qxmd.com/read/33967692/occipital-horn-syndrome-as-a-result-of-splice-site-mutations-in-atp7a-no-activity-of-atp7a-splice-variants-missing-exon-10-or-exon-15
#5
JOURNAL ARTICLE
Lisbeth Birk Møller, Mie Mogensen, David D Weaver, Per Amstrup Pedersen
Disease-causing variants in ATP7A lead to two different phenotypes associated with copper deficiency; a lethal form called Menkes disease (MD), leading to early death, and a much milder form called occipital horn syndrome (OHS). Some investigators have proposed that an ATP7A transcript missing exon 10 leads to a partly active protein product resulting in the OHS phenotype. Here, we describe an individual with OHS, a biology professor, who survived until age 62 despite a splice site mutation, leading to skipping of exon 15...
2021: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/33862618/role-of-the-high-affinity-reductive-iron-acquisition-pathway-of-candida-albicans-in-prostaglandin-e2-production-virulence-and-interaction-with-pseudomonas-aeruginosa
#6
JOURNAL ARTICLE
Bonang M Mochochoko, Obinna T Ezeokoli, Olihile Sebolai, Jacobus Albertyn, Carolina H Pohl
Components of the iron reductive pathway of Candida albicans have been implicated in the production of prostaglandin E2 (PGE2) and virulence. However, it is unknown whether other components of this pathway influence PGE2. We investigated the role of the iron reductive pathway of C. albicans in biofilm formation, PGE2 production, and virulence in Caenorhabditis elegans. Additionally, as the co-occurrence of C. albicans and Pseudomonas aeruginosa in host tissues is frequent and involves competition for host-associated iron, we examined the effects of this interaction...
April 16, 2021: Medical Mycology
https://read.qxmd.com/read/33668157/targeting-copper-homeostasis-improves-functioning-of-vps13-%C3%AE-yeast-mutant-cells-a-model-of-vps13-related-diseases
#7
JOURNAL ARTICLE
Piotr Soczewka, Déborah Tribouillard-Tanvier, Jean-Paul di Rago, Teresa Zoladek, Joanna Kaminska
Ion homeostasis is crucial for organism functioning, and its alterations may cause diseases. For example, copper insufficiency and overload are associated with Menkes and Wilson's diseases, respectively, and iron imbalance is observed in Parkinson's and Alzheimer's diseases. To better understand human diseases, Saccharomyces cerevisiae yeast are used as a model organism. In our studies, we used the vps13 Δ yeast strain as a model of rare neurological diseases caused by mutations in VPS13A - D genes. In this work, we show that overexpression of genes encoding copper transporters, CTR1 , CTR3, and CCC2 , or the addition of copper salt to the medium, improved functioning of the vps13 Δ mutant...
February 24, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33374484/larvicidal-activity-of-cinnamic-acid-derivatives-investigating-alternative-products-for-aedes-aegypti-l-control
#8
JOURNAL ARTICLE
Marianna O Araújo, Yunierkis Pérez-Castillo, Louise H G Oliveira, Fabíola C Nunes, Damião P de Sousa
The mosquito Aedes aegypti transmits the virus that causes dengue, yellow fever, Zika and Chikungunya viruses, and in several regions of the planet represents a vector of great clinical importance. In terms of mortality and morbidity, infections caused by Ae. aegypti are among the most serious arthropod transmitted viral diseases. The present study investigated the larvicidal potential of seventeen cinnamic acid derivatives against fourth stage Ae. aegypti larvae. The larvicide assays were performed using larval mortality rates to determine lethal concentration (LC50 )...
December 24, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/33116258/dynamic-transcriptional-response-of-saccharomyces-cerevisiae-cells-to-copper
#9
JOURNAL ARTICLE
Sebnem Oc, Serpil Eraslan, Betul Kirdar
Copper is a crucial trace element for all living systems and any deficiency in copper homeostasis leads to the development of severe diseases in humans. The observation of extensive evolutionary conservation in copper homeostatic systems between human and Saccharomyces cerevisiae made this organism a suitable model organism for elucidating molecular mechanisms of copper transport and homeostasis. In this study, the dynamic transcriptional response of both the reference strain and homozygous deletion mutant strain of CCC2, which encodes a Cu2+ -transporting P-type ATPase, were investigated following the introduction of copper impulse to reach a copper concentration which was shown to improve the respiration capacity of CCC2 deletion mutants...
October 28, 2020: Scientific Reports
https://read.qxmd.com/read/31901121/language-and-pragmatics-across-neurodevelopmental-disorders-an-investigation-using-the-italian-version-of-ccc-2
#10
JOURNAL ARTICLE
Marika Ferrara, Michela Camia, Valentina Cecere, Virginia Villata, Nataly Vivenzio, Maristella Scorza, Roberto Padovani
Impairments in structural language and pragmatics are well recognized in different neurodevelopmental disorders, yet in clinical work the discrimination of children with various language difficulties into different diagnostic profile is still a major challenge. Using the CCC-2 questionnaire this study assesses and compares language competences in a sample of Italian children (aged 8-10) with typical development (n = 26) and in children with different neurodevelopmental conditions: high-functioning Autism Spectrum Disorder (n = 19), Language Disorder with associated Developmental Dyslexia (n = 23), Developmental Dyslexia without linguistic impairments (n = 21)...
January 4, 2020: Journal of Autism and Developmental Disorders
https://read.qxmd.com/read/30086201/maintenance-of-grafting-induced-epigenetic-variations-in-the-asexual-progeny-of-brassica-oleracea-and-b-juncea-chimera
#11
JOURNAL ARTICLE
Ningning Yu, Liwen Cao, Lu Yuan, Xiao Zhi, Yiqian Chen, Susheng Gan, Liping Chen
Grafting-induced variations have been observed in many plant species, but the heritability of variation in progeny is not well understood. In our study, adventitious shoots from the C cell lineage of shoot apical meristem (SAM) grafting chimera TCC (where the origin of the outmost, middle and innermost cell layers, respectively, of SAM is designated by 'T' for tuber mustard and 'C' for red cabbage) were induced and identified as r-CCC (r = regenerated). To investigate the maintenance of grafting variations during cell propagation and regeneration, different generations of asexual progeny (r-CCCn, n = generation) were established through successive regeneration of axillary shoots from r-CCC...
October 2018: Plant Journal
https://read.qxmd.com/read/29740406/two-p-1b-1-atpases-of-amanita-strobiliformis-with-distinct-properties-in-cu-ag-transport
#12
JOURNAL ARTICLE
Vojtěch Beneš, Tereza Leonhardt, Jan Sácký, Pavel Kotrba
As we have shown previously, the Cu and Ag concentrations in the sporocarps of Ag-hyperaccumulating Amanita strobiliformis are correlated, and both metals share the same uptake system and are sequestered by the same metallothioneins intracellularly. To further improve our knowledge of the Cu and Ag handling in A. strobiliformis cells, we searched its transcriptome for the P1B-1 -ATPases, recognizing Cu+ and Ag+ for transport. We identified transcripts encoding 1097-amino acid (AA) AsCRD1 and 978-AA AsCCC2, which were further subjected to functional studies in metal sensitive Saccharomyces cerevisiae ...
2018: Frontiers in Microbiology
https://read.qxmd.com/read/29415511/plant-cation-chloride-cotransporters-ccc-evolutionary-origins-and-functional-insights
#13
REVIEW
Sam W Henderson, Stefanie Wege, Matthew Gilliham
Genomes of unicellular and multicellular green algae, mosses, grasses and dicots harbor genes encoding cation-chloride cotransporters (CCC). CCC proteins from the plant kingdom have been comparatively less well investigated than their animal counterparts, but proteins from both plants and animals have been shown to mediate ion fluxes, and are involved in regulation of osmotic processes. In this review, we show that CCC proteins from plants form two distinct phylogenetic clades (CCC1 and CCC2). Some lycophytes and bryophytes possess members from each clade, most land plants only have members of the CCC1 clade, and green algae possess only the CCC2 clade...
February 6, 2018: International Journal of Molecular Sciences
https://read.qxmd.com/read/28882432/analysis-of-ambient-ph-stress-response-mediated-by-iron-and-copper-intake-in-schizosaccharomyces-pombe
#14
JOURNAL ARTICLE
Yujiro Higuchi, Hikari Mori, Takeo Kubota, Kaoru Takegawa
The molecular mechanism of tolerance to alkaline pH is well studied in model fungi Aspergillus nidulans and Saccharomyces cerevisiae. However, how fission yeast Schizosaccharomyces pombe survives under alkaline stress remains largely unknown, as the genes involved in the alkaline stress response pathways of A. nidulans and S. cerevisiae were not found in the genome of this organism. Since uptake of iron and copper into cells is important for alkaline tolerance in S. cerevisiae, here we examined whether iron and copper uptake processes were involved in conferring tolerance to alkaline stress in S...
January 2018: Journal of Bioscience and Bioengineering
https://read.qxmd.com/read/26275420/influence-of-ogg1-repair-on-the-genetic-stability-of-ccc2-mutant-of-saccharomyces-cerevisiae-chemically-challenged-with-4-nitroquinoline-1-oxide-4-nqo
#15
JOURNAL ARTICLE
Claudia R da Silva, Gabriella S Almeida, Adriano Caldeira-de-Araújo, Alvaro C Leitão, Marcelo de Pádula
In Saccharomyces cerevisiae, disruption of genes by deletion allowed elucidation of the molecular mechanisms of a series of human diseases, such as in Wilson disease (WD). WD is a disorder of copper metabolism, due to inherited mutations in human copper-transporting ATPase (ATP7B). An orthologous gene is present in S. cerevisiae, CCC2 gene. Copper is required as a cofactor for a number of enzymes. In excess, however, it is toxic, potentially carcinogenic, leading to many pathological conditions via oxidatively generated DNA damage...
January 2016: Mutagenesis
https://read.qxmd.com/read/26127016/the-gene-ics3-from-the-yeast-saccharomyces-cerevisiae-is-involved-in-copper-homeostasis-dependent-on-extracellular-ph
#16
JOURNAL ARTICLE
C A Alesso, K F Discola, G Monteiro
In the yeast Saccharomyces cerevisiae, many genes are involved in the uptake, transport, storage and detoxification of copper. Large scale studies have noted that deletion of the gene ICS3 increases sensitivity to copper, Sortin 2 and acid exposure. Here, we report a study on the Δics3 strain, in which ICS3 is related to copper homeostasis, affecting the intracellular accumulation of this metal. This strain is sensitive to hydrogen peroxide and copper exposure, but not to other tested transition metals. At pH 6...
September 2015: Fungal Genetics and Biology: FG&B
https://read.qxmd.com/read/26004889/functional-characterization-of-new-mutations-in-wilson-disease-gene-atp7b-using-the-yeast-model
#17
JOURNAL ARTICLE
Ozlenen Simsek Papur, Orhan Terzioglu, Ahmet Koc
The Wilson disease gene, a copper transporting ATPase (Atp7b), is responsible for the sequestration of Cu into secretory vesicles, and this function is exhibited by the orthologous Ccc2p in the yeast. In this study, we aimed to characterize clinically relevant new mutations of human ATP7B (p.T788I, p.V1036I and p.R1038G-fsX83) in yeast lacking the CCC2 gene. Expression of human wild type ATP7B gene in ccc2Δ mutant yeast restored the growth deficiency and copper transport activity; however, expression of the mutant forms did not restore the copper transport functions and only partially supported the cell growth...
2015: Journal of Trace Elements in Medicine and Biology
https://read.qxmd.com/read/25860654/ultrasound-assisted-dynamic-extraction-coupled-with-parallel-countercurrent-chromatography-for-simultaneous-extraction-purification-and-isolation-of-phytochemicals-application-to-isoflavones-from-red-clover
#18
JOURNAL ARTICLE
Yuchi Zhang, Chunming Liu, Yan Pan, Yanjuan Qi, Yuchun Li, Sainan Li
A novel procedure comprising ultrasonic-assisted dynamic extraction (UADE) coupled with two countercurrent-chromatography systems (parallel countercurrent chromatography, PCCC) was developed. This technique offers the possibility for simultaneous extraction, solvent configuration, purification, and isolation of target compounds. This new approach was applied to the fractionation and purification of isoflavones from red clover. The two-phase solvent system was prepared by automating the equipment. The lower aqueous phase of the two-phase solvent system was used as the UADE solution and as the mobile phase for PCCC...
June 2015: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/25321842/a-simple-approach-for-sample-size-calculation-for-comparing-two-concordance-correlation-coefficients-estimated-on-the-same-subjects
#19
JOURNAL ARTICLE
Hung-Mo Lin, John M Williamson
Some studies are designed to assess the agreement between different raters and/or different instruments in the medical sciences and pharmaceutical research. In practice, the same sample will be used to compare the agreement of two or more assessment methods for simplicity and to take advantage of the positive correlation of the ratings. The concordance correlation coefficient (CCC) is often used as a measure of agreement when the rating is a continuous variable. We present an approach for calculating the sample size required for testing the equality of two CCCs, H0: CCC1 = CCC2 vs...
2015: Journal of Biopharmaceutical Statistics
https://read.qxmd.com/read/24760210/mixed-ligand-hydroxocopper-ii-pyridazine-clusters-embedded-into-3d-framework-lattices
#20
JOURNAL ARTICLE
Anna S Degtyarenko, Marcel Handke, Karl W Krämer, Shi-Xia Liu, Silvio Decurtins, Eduard B Rusanov, Laurence K Thompson, Harald Krautscheid, Konstantin V Domasevitch
Rational combination of pyridazine, hydroxo and carboxylate bridging ligands led to the assembly of three types of mixed-ligand polynuclear Cu(II) clusters (A: [Cu2(μ-OH)(μ-pdz)(μ-COO)]; B: [Cu4(μ3-OH)2(μ-pdz)2]; C: [Cu5(μ-OH)2(μ-pdz)4(μ-COO)2(μ-H2O)2]) and their integration into 3D framework structures. Mixed-ligand complexes [Cu2(μ-OH){TMA}(L)(H2O)] (1), [Cu4(μ3-OH)2{ATC}2(L)2(H2O)2]·H2O (2) [Cu4(μ3-OH)2{TDC}3(L)2(H2O)2]·7H2O (3) (L = 1,3-bis(pyridazin-4-yl)adamantane; TMA(3-) = benzene-1,3,5-tricarboxylate, ATC(3-) = adamantane-1,3,5-tricarboxylate, TDC(2-) = 2,5-thiophenedicarboxylate) and [Cu5(μ-OH)2{X}4(L)2(H2O)2]·nH2O (X = benzene-1,3-dicarboxylate, BDC(2-), n = 5 (4) and 5-hydroxybenzene-1,3-dicarboxylate, HO-BDC(2-), n = 6 (5)) are prepared under hydrothermal conditions...
June 14, 2014: Dalton Transactions: An International Journal of Inorganic Chemistry
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